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Our Pediatric Environmental Exposure Study (PEES) is a 400
child case-control study that is evaluating
associations between environmental exposures and biomarkers of oxidative stress
and whether or not these biomarkers will better predict risk of
severe/uncontrolled childhood asthma compared to parental report of exposure
alone (previous NIEHS R21 and CCTST KL2). Exposures include diesel exhaust
particle and second hand tobacco smoke exposures, as well as obesity levels.
Biomarkers of inflammation and antioxidant status, genetic and
socioeconomic factors, and DNA methylation patterns are being considered. Collaborators
include Dr. Lisa Martin in the Division of Molecular Genetics, Drs. Gurjit
Khurana Hershey, Jocelyn Biagini Myers and Hong Ji in the Division of Asthma
Research, Dr. Patrick Ryan in the Division of Biostatistics and Epidemiology,
Dr. Tianying Wu in the Department of Environmental Health at UC.
As low income families also experience low literacy, we have evaluated
associations between low literacy and asthma control in PEES children ages 4 to
11 years. As an extension of this project, we are collaborating with clinicians
targeting low-income and low-literacy caregivers of hospitalized asthmatic
children to develop unique multimedia discharge materials that will improve use
and sharing of asthma action plans, improve correct use of asthma inhalers and
increase asthma control (funding from previous Schroth Foundation grant). Partners
include Dr. Carolyn Kercsmar the director of Asthma Center and co-director of
the Pediatric Pulmonology Division, Dr. Jeffrey Simmons in General and
Community Pediatrics, Dr. Lisa Vaughn in the Emergency Medicine, and Dr.
Michael Seid in the Division of Pulmonary Medicine.
We are currently enrolling for our longitudinal epidemiological study
seeking to evaluate environmental and sexual exposure to human papillomavirus
(HPV) in families with children diagnosed with Fanconi anemia (current NHLBI
R01 and foundation grants). Individuals with Fanconi anemia are genetically
vulnerable to squamous head and neck cancers previously shown to be positively
associated with HPV. Our team is testing for oral HPV DNA, HPV serological
markers as well as markers of immune response. In addition, we are collecting
urine samples for NMR/metabolomic studies in collaboration with Dr. Susan Wells
in the Hematology/Oncology at CCHMC. As part of this study, we regularly
interact with a community of families associated with the Fanconi Anemia
Research Fund, a strong parent led advocacy group focused on the improving the
lives of children with Fanconi anemia, to design,
optimize and disseminate the findings from our study. Other collaborators
include Dr. Stella Davies, Dr. Parinda Mehta, and Dr. Kasiani Myers all in the
Blood and Marrow Transplant Program at CCHMC, Dr. Darron Brown, Director of the
Indiana University Center for Vaccine Research, Dr. Rachel Winer at the University
of Washington and Dr. Denise Galloway at the Fred Hutchinson Cancer Research
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