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The Khurana Hershey Lab is committed to developing new prevention and treatment strategies for allergic diseases that target high-risk populations at the critical time periods. The current research interests of the Khurana Hershey Laboratory are:
Genetic- U19 Asthma and Allergic Diseases Cooperative Research Center (AADCRC). This project is focused
on delineating the role of epithelial genes in allergic inflammation. The central focus is to elucidate the
mechanisms by which epithelial cells contribute to the pathogenesis of allergic
disorders. Using the Greater Cincinnati
Pediatric Clinic Repository (GCPCR) cohort, we have identified several
epithelial genes with previously unrecognized roles in asthma. Further analyses of these genes suggest that
some of these genes are specific to one epithelial surface and are associated
with one allergic disease, while others are common to multiple epithelial
surfaces and allergic disorders.
Diesel exposure in lung
Environmental- Diesel Particles (DEP). An increasing
body of evidence implicates exposure of traffic-related air pollution (DEP is
the major component of traffic related particulate matter) as playing a
significant role in the development of asthma and expression of asthma
symptoms. Our findings in the Cincinnati
Childhood Allergy and Air Pollution Study (CCAAPS) longitudinal birth cohort
demonstrate that DEP exposure during infancy conferred risk for wheezing in a
dose-dependent fashion. We have recently
found that DEP contributes to asthma severity by increasing IL-17A levels and
neutralization of IL-17A can effectively counteract the effects of DEP. The goals if this project is to further
dissect these relationships.
Exposure-Induced Asthma. Numerous
studies have implicated mold exposure in the development and prevalence of
asthma, as well as with asthma symptoms and exacerbations. These studies underscore the importance of
mold exposure as a public health concern and relevance of mold exposure to
asthma. We have recently developed a
model of mold exposure-induced asthma using A.
versicolor or C. cladosporioides mold spores. The goal of this project is
to identify the key molds and determine the mechanistic bases for the
differential mold effects so that effective interventions can be designed.
Reprinted from J Allergy Clin Immunol, Nov 1, 2013, Wood RA, Togias A, Wildfire J, Visness
CM, Matsui EC, Gruchalla R, Hershey G, Liu AH, O'Connor GT, Pongracic JA,
Zoratti E, Little F, Granada M, Kennedy S, Durham SR, Shamji MH, Busse WW,
Development of Cockroach immunotherapy by the Inner-City Consortium.,p.5 ,
Copyright © 2013, with permission from Elsevier
Inner City Asthma Consortium (ICAC). ICAC is the third in a series of inner-city
asthma initiatives funded by the National Institute of Allergy and Infectious
Disease (NIAID). ICAC is a nationwide clinical trials network to
evaluate promising new therapies to reduce asthma severity and prevent disease. The primary goal of ICAC
is to reduce the burden of asthma in children and adolescents living in the
inner city. The central goal is to
understand the factors that promote asthma in an inner city environment,
delineate inner city asthma phenotypes, and determine the most optimal
treatments for disproportionately affected population.
Created by Mark Lindsey-
Phenotype- Ohio Pediatric Asthma Repository (OPAR). OPAR is a valuable network of children’s hospitals
across the state of Ohio and is a unique and flexible study that can rapidly
implement study changes across multiple sites. OPAR analyzes data to identify distinct
asthma phenotypes, compare the utilization practices of the different asthma
phenotypes at each hospital, and determine how/ why these phenotypes differ in
their health outcomes. The goal is of
this project is to conduct a comparative effectiveness study that can be used
to design management strategies and interventions that can be targeted to
specific asthma phenotypes.
Reprinted from J Allergy Clin Immunol, February 2005, Guajardo J, Schleifer K, Daines M, Ruddy R, Aronow B, Wills-Karp M, Khurana Hershey G, Altered gene expression profiles in nasal respiratory epithelium reflect stable versus childhood asthma, pg. 243-251, Copyright © 2005, with permission from Elsevier.
project stems from our observations including (a) there are distinct and
consistent gene expression profile signatures present in nasal epithelial RNA
samples from children experiencing an asthma exacerbation at the time they
present in the emergency department; (b) the observed heterogeneity in the clinical
response to standard treatment among individual children hospitalized with
asthma is reflected by differential gene expression patterns at 24 hours after
treatment; (c) our recent findings that 8 differentially expressed genes can
distinguish asthmatic children who respond poorly to standard treatment for
hospitalized asthma exacerbation compared to children who respond well; and (d) the pattern of expression of these
genes is consistent in the same individual longitudinally across exacerbations. The goal of this project is to test whether
temporal gene expression patterns in individual patients hospitalized for
asthma exacerbation will predict clinical response to treatment, and whether
this pattern will be consistent and evident in repeat exacerbations among
Statistics are based on annual reports and are for the United States unless otherwise noted.
Over 10 Million
* Source: Health Statistics for U.S. Children: National Health Interview Survey 2011
Ohio Statewide Asthma Plan: Stated Goal- “Facilitate research on asthma in Ohio. Research translated to the clinic is critical to expand current knowledge and improve asthma health.
Asthma Prevalence, Ages 1-17 yrs., 2001-2005
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