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Gurjit Khurana Hershey, MD, PhD Director, Division of Asthma Research
is the principal investigator of a federally funded Asthma and Allergic Diseases Cooperative Research Center which supports, in part, the asthma and allergy-based Greater Cincinnati Pediatric Clinic Repository. She also focuses on elucidating the genetic and environmental factors that contribute to the development of asthma and eczema.
Visit the Khurana Hershey Lab.
Director, Division of Asthma Research
Co-Director, Office of Pediatric Clinical Fellowships
Professor, UC Department of Pediatrics
Asthma; allergic rhinitis; food allergy; urticaria
Gurjit Khurana Hershey, MD, PhD, received a BS degree from the University of Iowa, and MD and PhD degrees from Washington University School of Medicine. After completing pediatric residency and an allergy/immunology fellowship at St. Louis Children’s Hospital, Dr. Khurana Hershey joined the faculty at Cincinnati Children’s Hospital Medical Center within the University of Cincinnati College of Medicine. She now directs the Division of Asthma Research at Cincinnati Children’s Hospital Medical Center and is the director of the Medical Scientist Training Program at the University of Cincinnati College of Medicine.
In addition to her clinical duties, Dr. Khurana Hershey directs an NIH-funded research program focused on the genetics and genomics of allergic inflammation with a focus on cytokines and signal transduction. Her research has been continuously funded for over fifteen years. She is the principal investigator of an NIH-funded Asthma and Allergic Diseases Cooperative Research Center (AADCRC), and is also the PI of the Inner City Asthma Consortium, an NIH funded subcontract. She is the PI of the UC T32 MSTP training grant. In addition to her research contributions, she is an outstanding clinician and teacher/mentor. Several of her trainees now hold academic faculty positions. She is the recipient of the 2013 Cincinnati Children’s Educational Achievement Award.
Dr. Khurana Hershey is a fellow of the American Pediatric Society and the American Academy of Allergy, Asthma and Immunology. She serves on the Executive Council of the American Academy of Asthma, Allergy and Immunology Program Committee, is the chair of the Grant Review Committee and appointed vice chair of the Basic and Immunology Interest Section. She is a member of the Editorial Board of the Journal of Allergy and Clinical Immunology. She was recently named One of the Five Leading Women in Healthcare in the Greater Cincinnati Metropolitan Area, and Outstanding Woman at Cincinnati Children’s Hospital Medical Center.
BS: University of Iowa, Iowa City, IA, 1985.
PhD: Washington University School of Medicine, St. Louis, MO, 1990.
MD: Washington University School of Medicine, St. Louis, MO, 1992.
Residency: St. Louis Children's Hospital, St. Louis, MO, 1992-1995.
Fellowship: St. Louis Children's Hospital, St. Louis, MO, 1995-1997.
Board Certification: American Board of Pediatrics, 2009 - Present.
Board Certification: American Board of Allergy and Immunology, 2008 - Present.
Biagini Myers JM, Martin LJ, Butsch Kovacic M, Mersha TB, He H, Pilipenko V, Lindsey MA, Ericksen MB, Bernstein DI, LeMasters GK, Lockey JE, Khurana Hershey GK. Epistasis between serine protease inhibitor Kazal-type 5 (SPINK5) and thymic stromal lymphopoietin (TSLP) genes contributes to childhood asthma. J Allergy Clin Immunol. 2014 May 13. pii: S0091-6749(14)00520-X.
Wood RA, Togias A, Wildfire J, Visness CM, Matsui EC, Gruchalla R, Hershey G, Liu AH, O’Connor GT, Pongracic JA, Zoratti E, Little F, Granada M, Kennedy S, Durham SR, Shamji MH, Busse WW. Development of cockroach immunotherapy by the Inner-City Asthma Consortium. J Allergy Clin Immunol. 2014 Mar;133(3)846-52.
Zhang Z, Xiao C, Gibson AM, Bass SA, Khurana Hershey GK. EGFR signaling blunts allergen-induced IL-6 production and Th17 responses in the skin and attenuates development and relapse of atopic dermatitis. J Immunol. 2014 Feb 1:192(3):859-66.
Kinker KG, Gibson AM, Bass SA, Day BP, Deng, J, Medvedovic M, Figueroa JA, Hershey GK, Chen W. Overexpression of dimethylarginine dimethylaminohydrolase 1 attenuates airway inflammation in a mouse model of asthma. PloS One. 2014 Jan 10;9 (1):e85148.
Acciani TH, Brandt EB, Khurana Hershey GK, Le Cras TD. Diesel exhaust particle exposure increases severity of allergic asthma in young mice and children. Clin Exp Allergy. 2013 Dec;43(12):1406-18.
Brandt EB, Kovacic MB, Lee GB, Gibson AM, Acciani TH, Le Cras TD, Budelsky AL, Khurana Hershey GK. Diesel exhaust particle induction of IL17A contributes to severe asthma. J Allergy Clin Immunol. 2013 Nov:132(5);1194-1204.
Brandt EB, Gibson AM, Bass S, Khurana Hershey GK. Exacerbation of Allergen-Induced Eczema in TLR4- and TRIF-Deficient Mice. J Immunol. 2013 Oct 1;191(7):3519-25.
Chen W, Sivaprasad U, Gibson AM, Ericksen MB, Cunningham CM, Bass SA, Kinker KG, Finkelman FD, Wills-Karp M, Khurana Hershey GK. IL-13 receptor α2 contributes to development of experimental allergic asthma. J Allergy Clin Immunol. 2013 Oct;132(4):951-958.
Lee GB, Brandt EB, Xiao C, Gibson AM, Le Cras TD, Brown LA, Fitzpatrick AM, Khurana Hershey GK. Diesel exhaust particles induce cysteine oxidation and S-glutathionylation in house dust mite induced murine asthma. PLoS One. 2013;8(3):e60632.
Mintz-Cole RA, Brandt EB, Bass SA, Gibson AM, Reponen T, Khurana Hershey GK. Surface availability of beta-glucans is critical determinant of host immune response to C. cladosporioides. J Allergy Clin Immunol. 2013 Jul;132(1):159-69.
Jocelyn M. Biagini Myers, PhD
is a molecular epidemiologist whose long-term goal is to develop a research career with a focus on reducing pediatric allergic disease. Her current research seeks to identify genetic and environmental causes of asthma, with a focus secondhand smoke exposure. She is interested also in interventions for reduction and prevention of smoke exposure and providing an evidence base for policy on smoking bans around children.
Visit the Biagini Myers Lab.
Assistant Professor, UC Department of Pediatrics
Molecular epidemiology; secondhand smoke exposures and biomarkers; genetic and environmental causes of asthma and allergic disease
Dr. Biagini Myers is a molecular epidemiologist who began her training with a master’s degree in epidemiology 2004 and subsequent doctorate in molecular epidemiology at the University of Cincinnati (UC) in 2008. She was also a fellow in the Molecular Epidemiology in Children’s Environmental Health training program at UC from 2001-2004. During her time at UC, she was an integral part of building a new birth cohort of children at high risk for developing allergic disease and her research interests in secondhand smoke exposures and allergic disease pathogenesis were established. Her dissertation work evaluated genetic variation in nicotine metabolism-related genes and their effects on hair cotinine levels and wheezing in young children.
Following her successful dissertation defense in 2008, she began a postdoctoral fellowship at Cincinnati Children's. From 2008-2011, she collaborated on a project focused on characterizing epithelial genes in allergic diseases and delineating the mechanisms by which they contribute to the allergic response. She also assisted collaborators in developing a custom SNP-chip for studying genes related to asthma and atopic dermatitis. In addition, she was successful in receiving funding in 2009 with a PI at UC to evaluate the contributions of genetic variation in nicotine metabolism and oxidative stress-related genes in pediatric asthma development.
Dr. Biagini Myers’ long-term goal is to develop her research career as a molecular epidemiologist focused on reducing and preventing secondhand smoke-related pediatric asthma and allergic disease. She is also interested in intervention-based research for early-life prevention and reduction of smoke exposures in children and providing further evidence to promote public policies for smoking bans around children.
BS: Xavier University, Cincinnati, OH, 2001.
MS: University of Cincinnati, Cincinnati, OH, 2004.
PhD: University of Cincinnati, Cincinnati, OH, 2008.
Postdoctoral Fellowship: Division of Asthma Research, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 2008-2011.
Somineni HK, Zhang X, Biagini Myers JM, Kovacic MB, Ulm A, Jurcak N, Ryan PH, Khurana Hershey GK, Ji H. Ten-eleven translocation 1 (TET1) methylation is associated with childhood asthma and traffic-related air pollution. J Allergy Clin Immunol. 2015 Dec 9.
Ghosh D, Ding L, Sivaprasad U, Geh E, Biagini Myers J, Bernstein JA, Khurana Hershey GK, Mersha TB. Multiple Transcriptome Data Analysis Reveals Biologically Relevant Atopic Dermatitis Signature Genes and Pathways. PLoS One. 2015 Dec 30;10(12):e0144316.
Butsch Kovacic M, Martin LJ, Biagini Myers JM, He H, Lindsey M, Mersha TB, Ji H, Khurana Hershey GK. Genetic Approach Identifies Distinct Asthma Pathways In Overweight vs. Normal Weight Children. Allergy. 2015 Aug;70(8):1028-32.
Xiao C, Biagini Myers JM, Ji H, Metz K, Martin LJ, Lindsey M, He H, Powers R, Ulm A, Ruff B, Ericksen MB, Somineni HK, Simmons J, Strait RT, Kercsmar CM, Khurana Hershey GK. Vanin-1 expression and methylation discriminate pediatric asthma corticosteroid treatment response. J Allergy Clin Immunol. 2015 Oct;136(4):923-31.e3.
Mersha TB, Martin LJ, Biagini Myers JM, Kovacic MB, He H, Lindsey M, Sivaprasad U, Chen W, Khurana Hershey GK. Genomic Architecture of Asthma Differs by Sex. Genomics. 2015 Mar 25.
Brandt EB, Biagini Myers JM, Acciani TH, Ryan PH, Sivaprasad U, Ruff B, LeMasters GK, Bernstein DI, Lockey JE, LeCras TD, Khurana Hershey GK. Exposure to allergen and diesel exhaust particles potentiates secondary allergen-specific memory responses, promoting asthma susceptibility. J Allergy Clin Immunol. 2015 Mar 3.
Codispoti CD, Bernstein DI, Levin L, Reponen T, Ryan PH, Biagini Myers JM, Villareal M, Burkle J, Lummus Z, Lockey JE, Khurana Hershey GK, LeMasters GK. Early-life mold and tree sensitivity is associated with allergic eosinophilic rhinitis at 4 years of age. Ann Allergy Asthma Immunol. 2015 Mar;114(3):193-198.
Biagini Myers JM, Simmons JM, Kercsmar CM, Martin LJ, Pilipenko VV, Austin SR, Lindsey MA, Amalfitano KM, Guilbert TW, McCoy KS, Forbis SG, McBride JT, Ross KR, Vauthy PA, Khurana Hershey GK. Heterogeneity in Asthma Care in a Statewide Collaborative: the Ohio Pediatric Asthma Repository. Pediatrics. 2015 Feb;135(2):271-9.
Codispoti CD, LeMasters GK, Levin L, Reponen T, Ryan PH, Biagini Myers JM, Villareal M, Burkle J, Evans S, Lockey JE, Khurana Hershey GK, Bernstein DI. Traffic pollution is associated with early childhood aeroallergen sensitization. Ann Allergy Asthma Immunol. 2015 Feb;114(2):126-33.
LeMasters GK, Khurana Hershey GK, Sivaprasad U, Martin LJ, Pilipenko V, Ericksen MB, Burkle JW, Lindsey MA, Bernstein DI, Lockey JE, Gareri J, Lubetsky A, Koren G, Biagini Myers JM. N-acetyltransferase 1 polymorphism increases cotinine levels in Caucasian children exposed to secondhand smoke: the CCAAPS birth cohort. Pharmacogenomics J. 2015 Apr;15(2):189-95.
Melinda S. Butsch Kovacic, MPH, PhD
is an epidemiologist who has clinical, translational and community-based participatory research projects. Her research group studies the genetic/epigenetic, environmental and socioeconomic basis of chronic diseases such as cancer, asthma and obesity, with specific interest in understanding how environmental exposures modify risk in vulnerable families. Her research is highly interdisciplinary with collaborators across the academic health center and in the community.
Visit the Butsch Kovacic Lab.
Associate Professor, UC Department of Pediatrics
Clinical and molecular epidemiology; gene-environment interactions; biomarkers; community-based participatory research
One of Dr. Butsch Kovacic’s long-term goals is to improve the understanding of how the environment modifies chronic disease risk in genetically and/or economically vulnerable children. To this end, she is the PI of an ongoing study that is evaluating associations between environmental exposures and biomarkers of oxidative stress and whether or not these biomarkers will better predict risk of severe/uncontrolled childhood asthma compared to parental report of exposure alone (previous NIEHS R21 and CCTST KL2). As part of this study, her team is evaluating diesel exhaust particle and second hand tobacco smoke exposures, as well as obesity levels, markers of inflammation and antioxidant status, genetic and socioeconomic factors, and DNA methylation patterns. As her preliminary data revealed strong associations between her outcomes and socioeconomic factors, over the last year, she has partnered with Cincinnati’s CoreChange, a grassroots advocacy group, and Seven Hills Neighborhood Houses (SHNH; http://7hillsnh.org/), a full service social service agency and community center in the West End of Cincinnati, to expand her research into the community using a community-based participatory research (CBPR) approach. To this end, she has implemented a community-based research registry and begun needs assessments using a child-centered PhotoVoice approach and adult focus groups. A peer family health COACH (Coaching On Achieving Community Health) program will begin soon. To inform these community-based studies, she is collaborating on a project seeking to develop unique multimedia educational materials targeting low-income and low-literacy caregivers with asthmatic children.
In addition to these studies, she is also the PI of an ongoing longitudinal epidemiological study seeking to evaluate environmental and sexual exposure to human papillomavirus (HPV) in families with children diagnosed with Fanconi anemia (current NHLBI R01). Individuals with Fanconi anemia are genetically vulnerable to squamous head and neck cancers previously shown to be positively associated with HPV. Her team is testing for oral HPV DNA, HPV serological markers as well as markers of immune response. As part of this study, Dr. Butsch Kovacic regularly interacts with a community of families associated with the Fanconi Anemia Research Fund, a strong parent-led advocacy group focused on the improving the lives of children with Fanconi anemia, to design, optimize and disseminate the findings from her study.
MPH: Quantitative Methods, Harvard University School of Public Health, Boston, MA, 2003.
PhD: Biochemistry, the Ohio State University, Columbus, OH, 2002.
Postdoctoral Fellowship: Epidemiology/Public Health, Cancer Prevention Fellowship, Hormonal and Reproductive Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, 2002-2006.
Sauter SL, Wells SI, Zhang X, Hoskins EE, Davies SM, Myers KC, Mueller R, Panicker G, Unger ER, Sivaprasad U, Brown DR, Mehta PA, Butsch Kovacic M. Oral human papillomavirus is common in individuals with Fanconi Anemia. Cancer Epidemiol Biomarker Prev. 2015 Mar.
Katzenellenbogen RA, Carter JJ, Stern JE, Butsch Kovacic MS, Mehta PA, Sauter SL, Galloway DA, Winer RL. Skin and Mucosal Human Papillomavirus Seroprevalence in Persons with Fanconi Anemia. Clin Vaccine Immunol. 2015 Apr;22(4):413-20.
Kovacic MB, Stigler S, Smith A, Kidd A, Vaughn LM. Beginning a Partnership with Photo Voice to Explore Environmental Health and Health Inequities in Minority Communities. Int J Environ Res Public Health. 2014 Oct 27;11(11):11132-51.
Winer RL, Huang CE, Cherne S, Stern JE, Butsch Kovacic MS, Mehta PA, Sauter SL, Galloway DA, Katzenellenbogen RA. Detection Of Human Papillomavirus In The Oral Cavities Of Persons With Fanconi Anemia. Oral Dis. 2015 Apr;21(3):349-54.
Biagini Myers JM, Martin LJ, Butsch Kovacic M, Mersha TB, He H, Pilipenko V, Lindsey MA, Ericksen MB, Bernstein DI, LeMasters GK, Lockey JE, Khurana Hershey GK. Epistasis between serine protease inhibitor Kazal-type 5 (SPINK5) and thymic stromal lymphopoietin (TSLP) genes contributes to childhood asthma. J Allergy Clin Immunol. 2014 Oct;134(4):891-899.
Brandt EB, Kovacic MB, Lee GB, Gibson AM, Acciani TH, Le Cras TD, Ryan PH, Budelsky AL, Khurana Hershey GK. Diesel exhaust particle induction of IL-17A contributes to severe asthma. J Allergy Clin Immunol. 2013 Nov:132(5): 1194-1204.
Epstein TG, LeMasters GK, Bernstein DI, Ericksen MB, Martin LJ, Ryan PH, Biagini Myers JM, Butsch Kovacic MS, Lindsey MA, He H, Reponen T, Villareal MS, Lockey JE, Bernstein CK, Khurana Hershey GK. Genetic variation in small proline rich protein 2B as a predictor for asthma among children with eczema. Ann Allergy Asthma Immunol. 2012 Mar;108(3):145-50.
Martin LJ, Gupta J, Butsch Kovacic M, Biagini Myers JM, Patterson TL, Ericksen MB, He H, Gibson AM, Baye TM, Heeman AM, Sha S, Eissa T, Khurana Hershey GK. Functional variants in the autophagy-related 5gene promotor associated with childhood asthma. PLoS One. 2012;7(4):e33454.
Hoskins EE, Morreale RJ, Werner SP, Higginbotham JM, Brown DR, Laimins LA, Lambert PF, Gillison ML, Nuovo GJ, Wikenheiser-Brokamp KA, Witte DP, Kim MO, Davies SM, Mehta PA, Butsch Kovacic M*, Wells SI* (*Co-corresponding authors). The Fanconi Anemia Pathway Limits Human Papillomavirus Replication. J Virol. 2012 Aug;86(15):8131-8.
Fanconi Anemia as a Model for Susceptibility to Human Papillomavirus Infection. Principal Investigator. NIH/NHLBI. July 2011-Jun 2016.
Epithelial Genes in Allergic Inflammation. Co-Investigator. NIH/NIAID Asthma and Allergic Diseases Cooperative Research Center. July 2011-June 2016.
Hong Ji, PhD
is a molecular biologist and epigeneticist who has a long-term interest in epigenetic basis of development and disease. Dr. Ji’s current research interests include: (a) studying epigenetic responses of epithelial cells to environmental exposure and how this relates to the pathogenesis of allergic disorders and (b) epigenetic plasticity of cells involved in allergic immune responses is a second focus.
Visit the Ji Lab.
Epigenetic plasticity of development and disease; asthma epigenetics; genome-wide and locus specific DNA methylation analysis; epigenetic regulation of gene expression
During her postdoc training, Hong Ji, PhD, applied microarray approaches to study DNA methylation in a genome-wide scale and its role in regulating gene expression. Dr. Ji identified the methylome maps of hematopoietic progenitor cells and demonstrated the dynamic methylation changes during myeloid and lymphoid commitment in hematopoiesis, evocative of Waddington’s illustration of epigenetic landscape in development. The methylome maps she generated successfully assessed the lineage memory of induced programmed stem cells (iPS) derived from blood cells, which provides a valuable cool to evaluate to what extent iPS cells are reprogrammed compared to ES cells. In collaboration with biostatisticians, Dr. Ji provided a novel web platform with which the methylation status of any genomic locus of interest can be easily queried to generate output methylation plots, greatly facilitates the general accessibility of these datasets and identification of novel regulators of hematopoiesis. Her findings also explained the therapeutic specificity of DNA demethylating drug treatment of myelodysplasia, in which malignant cells arrested in early development may be induced to differentiate by DNA demethylation.
BS: University of Science and Technology of China, China, 2002.
PhD: Vanderbilt University, Nashville, TN, 2007.
Fellowship: Johns Hopkins School of Medicine, MD, 2008-2011.
Ji H, Zhang X, Oh S, Mayhew CN, Ulm A, Somineni HK, Ericksen M, Wells JM, Khurana Hershey GK. Dynamic transcriptional and epigenomic reprogramming from pediatric nasal epithelial cells to induced pluripotent stem cells. J Allergy Clin Immunol. 2015 Jan;135(1):236-44.
Zhang X, Ulm A, Somineni HK, Oh S, Weirauch MT, Zhang HX, Chen X, Lehn MA, Janssen EM, Ji H. DNA methylation dynamics during ex vivo differentiation and maturation of human dendritic cells. Epigenetics Chromatin. 2014 Aug 20;7:21.
Abdel-Hameed EA, Ji H, Sherman KE, Shata MT. Epigenetic Modification of FOXP3 in Patients with Chronic HIV Infection. J Acquir Immune Defic Syndr. 2014 Jan 1;65(1):19-26.
Brunst KJ, Leung YK, Ryan PH, Khurana Hershey GK, Levin L, Ji H, Lemasters GK, Ho SM. Forkhead box protein 3 (FOXP3) hypermethylation is associated with diesel exhaust exposure and risk for childhood asthma. J Allergy Clin Immunol. 2013 Feb;131(2):592-4.
Ji H, Khurana Hershey GK. Genetic and epigenetic influence on the response to environmental particulate matter. J Allergy Clin Immunol. 2012 Jan;129(1):33-41.
Ji H*, Ehrlich LIR*, Seita J*, Murakami P, Doi A, Lindau P, Lee H, Aryee MJ, Irizarry RA, Kim K, Rossi DJ, Inlay MA, Serwold T, Karsunky H, Ho L, Daley GQ, Weissman IL, Feinberg AP. Comprehensive methylome map of lineage commitment from hematopoietic progenitors. Nature. 2010 Sep 16:467(7313):338-42.
Kim K, Doi A, Wen B, Ng K, Zhao R, Cahan P, Kim J, Aryee M J, Ji H., Ehrlich LIR, Yabuuchi A, Takeuchi A, Cunniff KC, Hongguang H, Mckinney-Freeman S, Naveiras O, Yoon T, Irizarry RA, Hanna J, Jaenisch R, Weissleder R, Orkin S, Weissman I L, Feinberg AP, Daley GQ. Epigenetic memory in induced pluripotent stem cells. Nature. 2010 Sep 16;467(7313):285–90.
Irizarry RA, Ladd-Acosta C, Wen B, Wu Z, Montano C, Onyango P, Cui H, Gabo K, Rongione M, Webster M, Ji H, Potash JB, Sabunciyan S, Feinberg AP. The human colon cancer methylome shows similar hypo- and hypermethylation at conserved tissue-specific CpG island shores. Nat Genet. 2009 Feb;41(2):178-86.
Ji H, Adkins CJ, Cartwright BR, Friedman KL. Yeast Est2p affects telomere length by influencing association of Rap1p with telomeric chromatin. Mol Cell Biol. 2008 Apr;28(7):2380-90.
Ji H, Platts MH, Dharamasi L, Friedman KL. Regulation of Telomere Length by an N-terminal Region of the Yeast Telomerase Reverse Transcriptase. Mol Cell Biol. 2005 Oct;25(20):9103-14.
Andrew W. Lindsley, MD, PhD
and his lab focuses on two major research questions with significant clinical relevance; the role of sphingolipid signaling in the pathogenesis of pediatric-onset asthma and the mechanisms of humoral immune deficiency. Current B cell projects focus on the B cell defects associated with Kabuki syndrome and abnormal non-canonical NFkB signaling.
Instructor, UC Department of Pediatrics
PhD: Anatomy and Cell Biology, Indiana University School of Medicine, Indianapolis, IN, 2005.
MD: Indiana University School of Medicine, Indianapolis, IN, 2007.
Residency: Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 2007-10.
Fellowship: Allergy & Immunology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 2010-13.
Certifications: Pediatrics 2013, Allergy & Immunology 2014.
Lindsley AW, Saal HM, Burrow TA, Hopkin RJ, Shchelochkov O, Khandelwal P, Xie C, Bleesing J, Filipovich L, Risma K, Assa’ad AH, Roehrs PA, Bernstein JA. Defects of B Cell Terminal Differentiation in Patients with Type-1 Kabuki Syndrome. J Allergy Clin Immunol. 2015.
Lindsley AW, Qian Y, Valencia CA, Shah K, Zhang K, Assa'ad A. Combined Immune Deficiency in a Patient with a Novel NFKB2 Mutation. J Clin Immunol. 2014 Nov;34(8):910-5.
Lyons JJ, Sun G1, Stone KD, Nelson C1, Wisch L, O'Brien M, Jones N, Lindsley A, Komarow HD, Bai Y, Scott LM, Cantave D, Maric I, Abonia J, Rothenberg ME, Schwartz LB, Milner JD, Wilson TM. Mendelian inheritance of elevated serum tryptase associated with atopy and connective tissue abnormalities. J Allergy Clin Immunol. 2014 May;133(5):1471-4.
Baye T, Kovacic M, Biagini-Myers J, Martin L, Lindsey M, Patterson T, He H, Ericksen M, Gupta J, Tsoras A, Lindsley A, Rothenberg M, Wills-Karp M, Eissa N, Borish L, Hershey G. Differences in Candidate Gene Association between European Ancestry and African American Asthmatic Children. PLoS One. 2011 Feb 28;6(2):e16522.
Snider P, Hinton RB, Moreno-Rodriguez RA, Wang J, Rogers R, Lindsley A, Li F, Ingram DA, Menick D, Field L, Firulli AB, Molkentin JD, Markwald R, Conway SJ. Periostin is required for maturation and extracellular matrix stabilization of noncardiomyocyte lineages of the heart. Circ Res. 2008 Apr 11;102(7):752-60.
Lindsley A, Snider P, Zhou H, Rogers R, Wang J, Olaopa M, Kruzynska-Frejtag A, Koushik SV, Lilly B, Burch JB, Firulli AB, Conway SJ. Identification and characterization of a novel Schwann and outflow tract endocardial cushion lineage-restricted periostin enhancer. Dev Biol. 2007 Jul 15;307(2):340-55.
Lindsley A, Li W, Wang J, Maeda N, Rogers R, Conway SJ. Comparison of the four mouse fasciclin-containing genes expression patterns during valvuloseptal morphogenesis. Gene Expr Patterns. 2005 Jun;5(5):593-600.
Rios H, Koushik S, Wang J, Lindsley A, Wang H, Rogers R, Chen Z, Maeda M, Kruzynska-Frejtag A, Markwald R, Feng J, Conway S. Periostin null mice exhibit dwarfism, cardiac valve anomalies, incisor enamel defects, & an early onset periodontal disease-like phenotype. Mol Cell Biol. 2005 Dec;25(24):11131-44.
Tesfaye B. Mersha, PhD
Allergy and allergy related disorders
Tesfaye B. Mersha, PhD, is a quantitative geneticist. His background includes an early exposure to the many facets of biology and statistics and interested in cross-line disciplines to understand and solve complex genetic problems. During his post-doctoral fellowship program in statistical and human genetics, Dr. Mersha worked on statistical genetics methodologies and applied genetical data analysis to localize disease genes. Particularly, he focused on genetic analyses of metabolic and mental disorders using linkage, association and admixture mapping approach.
He developed genome-wide ancestry informative markers (AIMs) panel by mining databases including HapMap, Affymetrix and Illumina. The AIM markers are useful in ancestry inference, admixture mapping and structured association testing. He used over 4 million HapMap SNP data and developed approaches of chromosomal based finer population genetic structure characterization, localization of private SNPs and associated genes and pathways that could have pharmacogenomics implication.
In addition, Dr. Mersha is working on gene regulatory networks, gene ontology enrichment analysis and molecular profiling using various biologic and bioinformatic methodology for prioritizing asthma candidate genes. Dr. Mersha’s overall research interest and goal includes the use of population genomics, quantitative genetics, statistical genetics as well as proteomics and biological profiling and pathway methods to understand and dissect common complex diseases.
BS: Alemaya University, Ethiopia, 1992.
MS: Alemaya University, Ethiopia, 1996.
PhD: University of Göttingen, Germany, 2004.
Mersha TB, Abebe T. Self-reported race/ethnicity in the age of genomic research: its potential impact on understanding health disparities. Hum Genomics. 2015 Jan 7;9(1):1.
Sadhasivam S, Zhang X, Chidambaran V, Mavi J, Pilipenko V, Mersha TB, Meller J, Kaufman KM, Martin LJ, McAuliffe J. Novel associations between FAAH genetic variants and postoperative central opioid-related adverse effects. Pharmacogenomics J. 2015 Jan 6.
Fardo DW, Zhang X, Ding L, He H, Kurowski B, Alexander ES, Mersha TB, Pilipenko V, Kottyan L, Nandakumar K, Martin L. On family-based genome-wide association studies with large pedigrees: observations and recommendations. BMC Proc. 2014 Jun 17;8(Suppl 1 Genetic Analysis Workshop 18Vanessa Olmo):S26.
Pilipenko VV, He H, Kurowski BG, Alexander ES, Zhang X, Ding L, Mersha TB, Kottyan L, Fardo DW, Martin LJ. Using Mendelian inheritance errors as quality control criteria in whole genome sequencing data set. BMC Proc. 2014 Jun 17;8(Suppl 1 Genetic Analysis Workshop 18Vanessa Olmo):S21.
Ding L, Kurowski BG, He H, Alexander ES, Mersha TB, Fardo DW, Zhang X, Pilipenko VV, Kottyan L, Martin LJ. Modeling of multivariate longitudinal phenotypes in family genetic studies with Bayesian multiplicity adjustment. BMC Proc. 2014 Jun 17;8(Suppl 1):S69.
Biagini Myers JM, Martin LJ, Butsch Kovacic M, Mersha TB, He H, Pilipenko V, Lindsey MA, Ericksen MB, Bernstein DI, LeMasters GK, Lockey JE, Khurana Hershey GK. Epistasis between serine protease inhibitor Kazal-type 5 (SPINK5) and thymic stromal lymphopoietin (TSLP) genes contributes to childhood asthma. J Allergy Clin Immunol. 2014 Oct;134(4):891-899.e3.
Ding L, Abebe T, Beyene J, Wilke RA, Goldberg A, Woo JG, Martin LJ, Rothenberg ME, Rao M, Hershey GK, Chakraborty R, Mersha TB. 2013. Rank-based genome-wide analysis reveals the association of Ryanodine receptor-2 gene variants with childhood asthma among human populations. Hum Genomics. 2013 Jul 5;7:16.
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