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Gurjit Khurana Hershey, MD, PhD
Director, Division of Asthma Research
is the Principal Investigator of a federally funded Asthma and Allergic Diseases Cooperative Research Center which supports, in part, the asthma and allergy-based Greater Cincinnati Pediatric Clinic Repository. She also focuses on elucidating the genetic and environmental factors that contribute to the development of asthma and eczema.
Director, Division of Asthma Research
Professor, UC Department of Pediatrics
Asthma; allergic rhinitis; food allergy; urticaria
Genetics of allergy and asthma; cytokines; signaling pathways
Khurana Gurjit Hershey, MD, PhD, received a BS degree from the University of Iowa, and MD and PhD degrees from Washington University School of Medicine. After completing pediatric residency and an allergy/immunology fellowship at St. Louis Children’s Hospital, Dr. Khurana Hershey joined the faculty at Cincinnati Children’s Hospital Medical Center. She now directs the Division of Asthma Research at Cincinnati Children’s Hospital Medical Center and is the Associate Director of the Physician Scientist Training Program at the University of Cincinnati College of Medicine.
In addition to her clinical duties, Dr. Khurana Hershey directs an NIH-funded research program focused on the genetics and genomics of allergic inflammation with a focus on cytokines and signal transduction. She is the Principal Investigator of an NIH-funded Asthma and Allergic Diseases Cooperative Research Center (AADCRC) and serves on the AADCRC steering committee. This Center is focused on characterizing epithelial genes in allergic diseases, and delineating the mechanisms by which they contribute to the allergic response. She is also a co-investigator of the NIEHS-funded Cincinnati Childhood Asthma and Air Pollution Study, a birth cohort study designed to elucidate gene:environment interactions relevant to the development of allergic disease in early life. In addition to her research contributions, she is an outstanding clinician and teacher/mentor. Several of her trainees now hold academic faculty positions.
Dr. Khurana Hershey is a fellow of the American Pediatric Society and the American Academy of Allergy, Asthma and Immunology. She serves on the Executive Council of the American Academy of Asthma, Allergy and Immunology Program Committee and is the Chair of the Genetics, Molecular Biology, and Epidemiology Committee. She serves on the Editorial Board of the Journal of Allergy and Clinical Immunology and on a regular NIH study section. She was recently named One of the Five Leading Women in Healthcare in the Greater Cincinnati Metropolitan Area, and Outstanding Woman at Cincinnati Children’s Hospital Medical Center.
Le Cras TD, Acciani TH, Mushaben EM, Kramer EL, Pastura PA, Hardie WD, Korfhagen TR, Sivaprasad U, Ericksen M, Gibson AM, Holtzman MJ, Whitsett JA, Khurana Hershey GK. Epithelial EGF receptor signaling mediates airway hyperreactivity and remodeling in a mouse model of chronic asthma. Am J Physiol Lung Cell Mol Physiol. 2011 Mar;300(3):L414-21.
Baye TM, Butsch Kovacic M, Biagini Myers JM, Martin LJ, Lindsey M, Patterson TL, He H, Ericksen MB, Gupta J, Tsoras AM, Lindsley A, Rothenberg ME, Wills-Karp M, Eissa NT, Borish L, Khurana Hershey GK. Differences in Candidate Gene Association between European Ancestry and African American Asthmatic Children. PLoS One. 2011 Feb 28;6(2):e16522.
Cortina SD, Drotar D, Ericksen M, Lindsey M, Patterson TL, Biagini Myers JM, Kovacic MB, Khurana Hershey GK. Genetic Biomarkers of Health-Related Quality of Life in Pediatric Asthma. J Pediatr. 2011 Feb 14.
Epstein TG, Bernstein DI, Levin L, Khurana Hershey GK, Ryan PH, Reponen T, Villareal M, Lockey JE, Lemasters GK. Opposing effects of cat and dog ownership and allergic sensitization on eczema in an atopic birth cohort. J Pediatr. 2011 Feb;158(2):265-271.e5.
Newcomb DC, Boswell MG, Zhou W, Huckabee MM, Goleniewska K, Sevin CM, Khurana Hershey GK, Kolls JK, Peebles RS Jr. Human T(H)17 cells express a functional IL-13 receptor and IL-13 attenuates IL-17A production. J Allergy Clin Immunol. 2011 Jan 12.
Sivaprasad U, Askew DJ, Ericksen MB, Gibson AM, Stier MT, Brandt EB, Bass SA, Daines MO, Chakir J, Stringer KF, Wert SE, Whitsett JA, Le Cras TD, Wills-Karp M, Silverman GA, Khurana Hershey GK. A nonredundant role for mouse Serpinb3a in the induction of mucus production in asthma. J Allergy Clin Immunol. 2011 Jan;127(1):254-61, 261.e1-6.
Sivaprasad U, Warrier MR, Gibson AM, Chen W, Tabata Y, Bass SA, Rothenberg ME, Khurana Hershey GK. IL-13Rα2 has a protective role in a mouse model of cutaneous inflammation. J Immunol. 2010 Dec 1;185(11):6802-8.
Biagini Myers JM, Khurana Hershey GK. Eczema in early life: genetics, the skin barrier, and lessons learned from birth cohort studies. J Pediatr. 2010 Nov;157(5):704-14.
Baye TM, Martin LJ, Khurana Hershey GK. Application of genetic/genomic approaches to allergic disorders. J Allergy Clin Immunol. 2010 Sep;126(3):425-36; quiz 437-8.
Codispoti CD, Levin L, LeMasters GK, Ryan P, Reponen T, Villareal M, Burkle J, Stanforth S, Lockey JE, Khurana Hershey GK, Bernstein DI. Breast-feeding, aeroallergen sensitization, and environmental exposures during infancy are determinants of childhood allergic rhinitis. J Allergy Clin Immunol. 2010 May;125(5):1054-1060.e1.
Jocelyn M. Biagini Myers, PhD
is a molecular epidemiologist whose long-term goal is to develop a research career with a focus on reducing pediatric allergic disease. Her current research seeks to identify genetic and environmental causes of asthma, with a focus secondhand smoke exposure. She is also interested in interventions for reduction and prevention of smoke exposure and providing an evidence base for policy on smoking bans around children.
Assistant Professor, UC Department of Pediatrics
Molecular epidemiology; secondhand smoke exposures and biomarkers; genetic and environmental causes of asthma and allergic disease
Dr. Biagini Myers is a molecular epidemiologist who began her training with a Master’s degree in Epidemiology 2004 and subsequent Doctorate in Molecular Epidemiology at the University of Cincinnati (UC) in 2008. She was also a fellow in the Molecular Epidemiology in Children’s Environmental Health training program at UC from 2001-2004. During her time at UC, she was an integral part of building a new birth cohort of children at high risk for developing allergic disease and her research interests in secondhand smoke exposures and allergic disease pathogenesis were established. Her dissertation work evaluated genetic variation in nicotine metabolism-related genes and their effects on hair cotinine levels and wheezing in young children.
Following her successful dissertation defense in 2008, she began a postdoctoral fellowship at CCHMC. From 2008-2011, she collaborated on a project focused on characterizing epithelial genes in allergic diseases and delineating the mechanisms by which they contribute to the allergic response. She also assisted collaborators in developing a custom SNP-chip for studying genes related to asthma and atopic dermatitis. In addition, she was successful in receiving funding in 2009 with a PI at UC to evaluate the contributions of genetic variation in nicotine metabolism and oxidative stress-related genes in pediatric asthma development.
Dr. Biagini Myers’ long-term goal is to develop her research career as a molecular epidemiologist focused on reducing and preventing secondhand smoke-related pediatric asthma and allergic disease. She is also interested in intervention-based research for early-life prevention and reduction of smoke exposures in children and providing further evidence to promote public policies for smoking bans around children.
BS: Xavier University, Cincinnati, OH, 2001.
MS: University of Cincinnati, Cincinnati, OH, 2004.
PhD: University of Cincinnati, Cincinnati, OH, 2008.
Postdoctroal Fellowship: Division of Asthma Research, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 2008-2011.
Ryan PH, LeMasters G, Biagini J, Bernstein D, Grinshpun SA, Shukla R, Wilson K, Villareal M, Burkle J, Lockey J. Is it traffic type, volume or distance? Wheezing in infants living near truck and bus traffic. J Allergy Clin Immunol. 2005 Aug:116(2):279-284.
Biagini JM, LeMasters GK, Ryan PH, Levin L, Reponen T, Bernstein DI, Villareal M, Khyrana Hershey GK, Burkle J, Lockey J. Environmental risk factors of rhinitis in early infancy.Pediatr Allergy Immunol. 2006 Jun:17(4):278-284.
Karla M, Biagini J, Bernstein D, Stanforth S, Burkle J, Cohen A, LeMasters G. Effect of asthma on the risk of obstructive sleep apnea syndrome in atopic women. Ann Allergy Asthma Immunol. 2006 Aug:97(2):231-235.
LeMasters GK, Wilson K, Levin L, Biagini J, Ryan P, Lockey JE, Stanforth S, Maier S, Yang J, Burkle J, Villareal M, Khurana Hershey GK, Bernstein DI. High prevalence of aeroallergen sensitization among infants of atopic parents. J Pediatr. 2006 Oct:149(4):505-511.
Shroer KT, Biagini Myers JM, Ryan PH, LeMasters GK, Bernstein DI, Villareal M, Lockey J, Reponen T, Grinshpun S, Khyrana Hershey GK. Associations between multiple environmental exposures and glutathonine s-transferase P1 on persistent wheezing in a birth cohort. J Pediatr. 2009 Mar:154(3):401-408.
Biagini Myers JM, Wang N, LeMasters G, Bernstein DI, Epstein T, Lindsey M, Ericksen M, Chakraborty R, Ryan P, Villareal M, Burkle J, Lockey J, Reponen T, Khurana Hershey GK. Genetic and environmental risk factors for childhood eczema development and allergic sensitization in the CCAAPS cohort.J Inves Dermatol. 2010 Feb:130(2):430-437.
Biagini Myers JM, Khurana Hershey GK. Eczema in early life: lessons learned from birth cohort studies.J Pediatr. 2010 Nov:157(7):704-714.
Cortina S, Drotar D, Ericksen M, Lindsey M, Patterson TL, Biagini Myers JM, Butsch Kovacic M, Khurana Hershey GK. Genomic biomarkers of health-related quality of life in pediatric asthma. J Pediatr. 2010 Feb:159(1):21-26.
Baye TM, Butsch Kovacic M, Biagini Myers JM, Martin LJ, Lindsey M, Patterson TL, He H, Ericksen MB, Gupta J, Tsoras AM, Lindsley A, Rothenberg ME, Wills-Karp N, Eissa T, Borish L, Khurana Hershey GK. Differences in candidate gene association between european ancestry and african american asthmatic children. PLoS One. 2011 Feb:6(2):e16522.
Butsch Kovacic M, Biagini Myers JM, Wang N, Martin LJ, Lindsey M, Ericksen MB, He H, Patterson TL, Baye TM, Torgerson D, Roth LA, Gupta J, Sivaprasad U, Gibson AM, Tsoras AM, Hu D, Eg C, Chapela R, Rodriguez-Santana JR, Rodriguez-Cintron W, Avila PC, Beckman K, Seibold MA, Gignoux C, Musaad SM, Chen W, Gonzalez Burchard E, Khurana Hershey GK. Identification of KIF3A as a novel candidate gene for childhood asthma using RNA expression and population allelic frequencies differences. PLoS One. 2011:6(8):e23714.
Melinda S. Butsch Kovacic, MPH, PhD
is an epidemiologist who has clinical, translational and community-based participatory research projects. Her research group studies the genetic/epigenetic, environmental and socioeconomic basis of chronic diseases such as cancer, asthma and obesity, with specific interest in understanding how environmental exposures modify risk in vulnerable families. Her research is highly interdisciplinary with collaborators across the academic health center and in the community.
Clinical and molecular epidemiology; gene-environment interactions; biomarkers; community-based participatory research
Martin LJ, Gupta J, Butsch Kovacic M, Biagini Myers JM, Patterson TL, Ericksen MB, He H, Gibson AM, Baye TM, Heeman AM, Sha S, Eissa T, Khurana Hershey GK. Variants in the autophagy-related 5 gene (ATG5) are associated with asthma. PLoS One. 2012;7(4):e33454.
Hoskins EE, Morreale RJ, Werner SP, Higginbotham JM, Brown DR, Laimins LA, Lambert PF, Gillison ML, Nuovo GJ, Wikenheiser-Brokamp KA, Witte DP, Kim MO, Davies SM, Mehta PA, Butsch Kovacic M*, Wells SI* (*Co-corresponding authors). The Fanconi Anemia Pathway Limits Human Papillomavirus Replication. J Virol. 2012 Aug;86(15):8131-8.
Butsch Kovacic M, Biagini Myers JM, Martin LJ, Lindsey M, Patterson TL, Sauter S, Ericksen MB, Ryan PH, Assa’ad A, Lierl M, Fischer T, Kercsmar C, McDowell K, Lucky AW, Sheth, AP, Hershey AD, Ruddy RM, Rothenberg M, Khurana Hershey GK. The Greater Cincinnati Pediatric Clinic Repository (GCPCR): A Novel Framework for Asthma and Allergy Research. Pediatr Allergy Immunol Pulmonol. 2012 Jun;25(2):104-113.
Butsch Kovacic M, Biagini Myers JM, Patterson TL, Lindsey M, Ericksen MB, He H, Gupta J, Sivaprasad U, Gibson AM, Tsoras AM, Chen W, Musaad S, Baye TM, Khurana Hershey GK. Identification of KIF3A as a Novel Candidate Gene for Childhood Asthma Using RNA Expression and Population Allelic Frequencies Differences. PLoS One. 2011;6(8):e23714.
Myers KC, Bleesing JJ, Davies SM, Zhang X, Martin LJ, Mueller R, Harris RE, Filipovich AH, Butsch Kovacic M, Wells SI, Mehta PA. Impaired Immune Function in Children with Fanconi Anemia. British Journal of Hematology. 2011 Jul;154(2):234-40.
Cortina S, Drotar D, Ericksen M, Lindsey M, Patterson TL, Biagini Myers JM, Butsch Kovacic M, Khurana Hershey GK. Genetic Biomarkers of Health-Related Quality of Life in Pediatric Asthma. Journal of Pediatrics. 2011 Jul;159(1):21-26.e1.
Baye TM, Butsch Kovacic M, Biagini Myers JM, Martin LJ, Lindsey M, Patterson TL, He H, Ericksen MB, Gupta J, Tsoras AM, Lindsley A, Rothenburg M, Wills-Karp M, Eissa T, Borrish L, Khurana Hershey GK. A comprehensive association of common genetic variation in candidate genes reveals IL-4 variants as genetic biomarkers of asthma in Caucasian and African American children. PLoS One. 2011 Feb 28;6(2):e16522.
Reszka, KJ, Sallans L, Brown K, McGraw DW, Butsch Kovacic M, Britigan BE. Airway peroxidases catalyze nitration of the β2-agonist salbutamol and decrease its pharmacological activity. Journal of Pharmacology and Experimental Therapeutics. 2011;336:1–10.
Butsch Kovacic M, Katki H, Kreimer A, Sherman ME. Epidemiologic Analysis of Histologic Cervical Inflammation: Relationship to Human Papillomavirus Infections. Human Pathology. 2008;39: 1088-1095.
Gravitt P, Butsch Kovacic M (co-first authors), Castle PE, Herrero R, Schiffman M, Concepción Bratti M, Hildesheim A, Morales J, Alfaro M, Sherman ME, Wacholder Rodriguez AC, Burk RD. Viral Load of Human Papillomavirus Type 16 is Uniquely Associated with Cervical Disease. Inter. Journal of Cancer. 2007;121(12):2787-93.
Fanconi Anemia as a Model for Susceptibility to Human Papillomavirus Infection. Principal Investigator. NIH/NHLBI. 07/01/2011-06/30/2016.
Serology as a Biomarker for Immune Response to Vaccination and Exposure in Fanconi Anemia. Co-Investigator. Fanconi Anemia Research Fund. 07/01/2012-06/30/2013.
COACHing to Improve the Health of Youth Living in the Urban Core. Principal Investigator. Cincinnati Children’s Hospital Medical Center/CoreChange. 07/01/2012-06/30/2013.
Epithelial Genes in Allergic Inflammation. Co- Investigator. NIH/NIAID Asthma and Allergic Diseases Cooperative Research Center. 07/01/2011-06/30/2016.
Asthma Intervention. Co- Investigator. The John A Schroth Family Charitable Trust Foundation. 1/01/2012-12/31/2012.
Epigenetic influences of diesel exhaust particles in asthmatic children and their unaffected siblings. Co-Investigator. University of Cincinnati Center for Environmental Genetics. 4/01/2012-3/30/2012.
Weiguo Chen, MD, PhD
is seeking to understand the biological role of interleukin-13 receptor alpha2 in the development of allergic asthma as well as to assess the role of the asymmetric dimethylarginine (ADMA)/dimethylarginine dimethylaminohydrolase (DDAH) pathway in allergic asthma. He is also participating in collaborative research with the Divisions of Immunobiology and Pulmonary Biology at Cincinnati Children’s.
Sivaprasad U, Warrier MR, Gibson AM, Chen W, Tabata Y, Bass SA, Rothenberg ME, Khurana Hershey GK. IL-13Rα2 has a protective role in a mouse model of cutaneous inflammation. J Immunol. 2010 Dec 1;185(11):6802-8. Epub 2010 Oct 22.
Chen W, Sivaprasad U, Tabata Y, Gibson AM, Stier MT, Finkelman FD, Hershey GK. IL-13R alpha 2 membrane and soluble isoforms differ in humans and mice. J Immunol. 2009 Dec 15;183(12):7870-6.
Chen W, Tabata Y, Gibson AM, Daines MO, Warrier MR, Wills-Karp M, Khurana Hershey GK. Matrix metalloproteinase-8 contributes to solubilization of interleukin-13 receptor alpha-2 in vivo. Journal of Allergy and Clinical Immunology. 2008;122(3):625-632.
Chen W, Khurana Hershey GK. Signal transducer and activator of transcription signals in allergic disease. Journal of Allergy and Clinical Immunology. 2007;119(3):529-541.
Daines MO, Chen W, Tabata Y, Walker BA, Gibson AM, Masino JA, Warrier MR, Daines CL, Wenzel SE, Hershey GK. Allergen-dependent solubilization of IL-13 receptor alpha2 reveals a novel mechanism to regulate allergy. Journal of Allergy and Clinical Immunology. 2007;119(2):375-83.
Tabata Y, Chen W, Warrier MR, Gibson AM, Daines MO, Hershey GK. Allergy-driven alternative splicing of IL-13 receptor alpha2 yields distinct membrane and soluble forms. Journal of Immunology. 2006;177(11):7905-7912.
Daines MO, Tabata Y, Walker BA, Chen W, Warrier MR, Basu S, Hershey GK. Level of expression of interleukin-13 receptor alpha 2 impacts receptor distribution and IL-13 signaling. Journal of Immunology. 2006;176(12):7495-7501.
Ponthier JL, Schluepen C, Chen W, Lersch RA, Gee SL, Hou VC, Lo AJ, Short SA, Chasis JA, Winkelmann JC, Conboy JC. Fox-2 splicing factor binds to a conserved intron motif to promote inclusion of protein 4.1R alternative exon 16. Journal of Biological Chemistry. 2006;281:12468-12474.
Lili Ding, PhD
is a biostatistician with research interest in Bayesian modeling and inference, and its applications in various fields of biomedical research, including statistical genetics, population pharmacokinetics and pharmacodynamics, multivariate survival analysis, and multilevel latent variable modeling. Dr. Ding mentors junior faculty, fellows and students in DBE and several other divisions within the hospital.
Biostatistics, Bayesian statistics, statistical genetics, population PK/PD study design and modeling
Dr. Ding has been actively involved in collaborative research with faculty members from Adolescent Medicine, Asthma Research, Human Genetics, and Pharmacology on the design, plan, statistical analysis and report of medical research studies. She is a statistician with a keen interest in the development and application of statistical methods in biomedical research. She has published multiple research papers on statistical genetics; design of pediatric population pharmacokinetic studies; and on cancer prevention behaviors and sexually transmitted infections in adolescents. She has participated in several NIH sponsored grants and serves as Principle Investigator in a CCTST method grant. Dr. Ding is Review Editor for the Journal of Frontiers in Genetics and Reviewer for the Journal of Pediatric Research.
Mullins TLK, Zimet GD, Rosenthal SL, Morrow C, Ding LL, Shew, M, Kahn, JA. Adolescent Perceptions of Risk and Need for Safer Sexual Behaviors After First Human Papillomavirus Vaccination. [Article]. Archives of Pediatrics & Adolescent Medicine, 166(1), 82-88. 2012.
Baye TM, He H, Ding L, Kurowski BG, Zhang X, Martin LJ. Population structure analysis using rare and common functional variants. BMC Proc, 5 Suppl 9, S8. doi: 10.1186/1753-6561-5-s9-s8. 2011.
Ding L, Baye TM, He H, Zhang X, Kurowski BG, Martin LJ. Detection of associations with rare and common SNPs for quantitative traits: a nonparametric Bayes-based approach. BMC Proc, 5 Suppl 9, S10. doi: 10.1186/1753-6561-5-s9-s10. 2011.
Ding L, Wiener H, Abebe T, Altaye M, Go RC, Kercsmar C, Baye TM. Comparison of measures of marker informativeness for ancestry and admixture mapping. BMC genomics, 12, 622. 2011.
He H, Zhang X, Ding L, Baye TM, Kurowski BG, Martin LJ. Effect of population stratification analysis on false-positive rates for common and rare variants. BMC Proc, 5 Suppl 9, S116. doi: 10.1186/1753-6561-5-s9-s116.2011.
Kahn JA, Huang B, Ding LL, Geller A, Frazier AL. Impact of Maternal Communication About Skin, Cervical, and Lung Cancer Prevention on Adolescent Prevention Behaviors. [Article]. Journal of Adolescent Health, 49(1), 93-96. doi: 10.1016/j.jadohealth.2010.11.247. 2011.
Sherwin C, Ding L, Kaplan J, Vinks A. Optimal design for a single dose pharmacokinetic study of Pioglitazone in septic pediatric patients. Journal of Pharmacokinetics and Pharmacodynamics, 38(4), 433-447. 2011.
Zhang X, He H, Ding L, Baye TM, Kurowski BG, Martin LJ. Family- and population-based designs identify different rare causal variants. BMC Proc, 5 Suppl 9, S36. doi: 10.1186/1753-6561-5-s9-s36. 2011.
Kahn JA, Ding LL, Huang B, Zimet GD, Rosenthal SL, Frazier AL. Mothers' Intention for Their Daughters and Themselves to Receive the Human Papillomavirus Vaccine: A National Study of Nurses. [Article; Proceedings Paper]. Pediatrics, 123(6), 1439-1445. doi: 10.1542/peds.2008-1536. 2009.
Pattullo L, Griffeth S, Ding LL, Mortensen J, Reed J, Kahn J, Huppert J. Stepwise Diagnosis of Trichomonas vaginalis Infection in Adolescent Women. [Article]. Journal of Clinical Microbiology, 47(1), 59-63. doi: 10.1128/jcm.01656-08. 2009.
Bayesian Semi-Parametric Joint Modeling of Item Response and Clinical Outcomes. Principal Investigator. Center for Clinical and Translational Science and Training. 2012-2013.
Genetic and Environmental Risk Factors for Hemorrhagic Stroke. Statistician. National Institutes of Health. 2008-2013. # R01NS36695.
Behavioral and Virologic Impact of HPV Immunization. Statistician. National Institutes of Health. 2008-2012. #1R01AI070755-01.
Development of an Asthma Research Core Center. Statistician. National Institutes of Health. 2009-2012. #P30HL101333-01.
Hong Ji, PhD
is a molecular biologist and epigeneticist who has a long-term interest in epigenetic basis of development and disease. Dr. Ji’s current research interests include: (a) studying epigenetic responses of epithelial cells to environmental exposure and how this relates to the pathogenesis of allergic disorders and (b) epigenetic plasticity of cells involved in allergic immune responses is a second focus.
Epigenetic plasticity of development and disease; asthma epigenetics; genome-wide and locus specific DNA methylation analysis; epigenetic regulation of gene expression
During her postdoc training, Hong Ji, PhD, applied microarray approaches to study DNA methylation in a genome-wide scale and its role in regulating gene expression. Dr. Ji identified the methylome maps of hematopoietic progenitor cells and demonstrated the dynamic methylation changes during myeloid and lymphoid commitment in hematopoiesis, evocative of Waddington’s illustration of epigenetic landscape in development. The methylome maps she generated successfully assessed the lineage memory of induced programmed stem cells (iPS) derived from blood cells, which provides a valuable cool to evaluate to what extent iPS cells are reprogrammed compared to ES cells. In collaboration with biostatisticians, Dr. Ji provided a novel web platform with which the methylation status of any genomic locus of interest can be easily queried to generate output methylation plots, greatly facilitates the general accessibility of these datasets and identification of novel regulators of hematopoiesis. Her findings also explained the therapeutic specificity of DNA demethylating drug treatment of myelodysplasia, in which malignant cells arrested in early development may be induced to differentiate by DNA demethylation.
Tesfaye B. Mersha, PhD
Allergy and allergy related disorders
Quantitative and statistical genetics and genomics; genetic linkage, association and admixture analysis; expression analysis; network and pathway analysis; gene ontology and functional commonalities analysis
Visit the Mersha Lab.
Tesfaye B. Mersha, PhD, is a quantitative geneticist. His background includes an early exposure to the many facets of biology and statistics and interested in cross-line disciplines to understand and solve complex genetic problems. During his post-doctoral fellowship program in statistical and human genetics, Dr. Mersha worked on statistical genetics methodologies and applied genetical data analysis to localize disease genes. Particularly, he focused on genetic analyses of metabolic and mental disorders using linkage, association and admixture mapping approach.
He developed genome-wide ancestry informative markers (AIMs) panel by mining databases including HapMap, Affymetrix and Illumina. The AIM markers are useful in ancestry inference, admixture mapping and structured association testing. He used over 4 million HapMap SNP data and developed approaches of chromosomal based finer population genetic structure characterization, localization of private SNPs and associated genes and pathways that could have pharmacogenomics implication. In addition, Dr. Mersha is working on gene regulatory networks, gene ontology enrichment analysis and molecular profiling using various biologic and bioinformatic methodology for prioritizing asthma candidate genes. Dr. Mersha’s overall research interest and goal includes the use of population genomics, quantitative genetics, statistical genetics as well as proteomics and biological profiling and pathway methods to understand and dissect common complex diseases.
Baye TM. Inter-chromosomal variation in the pattern of human population genetic structure. Human Genomics. 2011;5(4):220–240.
Baye TM, Abebe T, Wilke RA. Genotype-environment interactions and their translational implications. Personalized Medicine. 2011;8:59-70. Baye TM, Wilke RA. Mapping genes that predict treatment outcome in admixed populations. Pharmacogenomics J. 2010 Dec;10(6):465-77.
Baye TM, Wilke RA. Mapping genes that predict treatment outcome in admixed populations. Pharmacogenomics J. 2010 Dec;10(6):465-77.
Gawrieh S, Baye TM, Carless M, Wallace J, Komorowski R, Kleiner DE, Andris D, Makladi B, Cole R, Charlton M, Curran J, Dyer TD, Charlesworth J, Wilke R, Blangero J, Kissebah AH, Olivier M. Hepatic gene networks in morbidly obese patients with nonalcoholic fatty liver disease.Obes Surg. 2010 Dec;20(12):1698-709.
Zhang Y, Smith EM, Baye TM, Eckert JV, Abraham LJ, Moses EK, Kissebah AH, Martin LJ, Olivier M. Serotonin (5-HT) receptor 5A sequence variants affect human plasma triglyceride levels.Physiol Genomics. 2010 Jul 7;42(2):168-76.
Baye TM, Wilke RA, Olivier M. Genomic and geographic distribution of private SNPs and pathways in human populations.Per Med. 2009 Nov 1;6(6):623-641.
Smith EM, Zhang Y, Baye TM, Gawrieh S, Cole R, Blangero J, Carless MA, Curran JE, Dyer TD, Abraham LJ, Moses EK, Kissebah AH, Martin LJ, Olivier M. INSIG1 influences obesity-related hypertriglyceridemia in humans.J Lipid Res. 2010 Apr;51(4):701-8.
Umasundari Sivaprasad, PhD
Visit the Sivaprasad Lab.
Allergic inflammation; atopic dermatitis; asthma; development of anti-inflammatory therapies
Sivaprasad, U., Canfield, J. M., Brooks, C. L. Mechanism of Ordered Lactogen Receptor Binding by Human Prolactin. Biochemistry. 43(43):13755-65. 2004.
Senga, T.S.*, Sivaprasad, U.*, Zhu, W.*, Park, J.H., Arias, E., Walter, J.C., Dutta, A., PCNA is a cofactor for Cdt1 degradation by CUL4/DDB1-mediated N-terminal ubiquitination. J. Biol Chem. 281(10): 6246-52. * Co-first authors. 2005.
Sivaprasad, U., Abbas, T., Dutta, A., Differential efficacy of 3-hydroxy 3-methylglutaryl CoA reductase inhibitors on the cell cycle of prostate cancer cells. Mol. Cancer Ther. 5(9):2310-16. 2006.
Abbas, T., Sivaprasad, U., Terai, K., Amador, V., Pagano M., Dutta, A., PCNA-dependent regulation of p21 ubiquitylation and degradation via the CRL4Cdt2 ubiquitin ligase complex. Genes and Dev. 22(18):2496-2506. PMCID: PMC2546691. 2008.
Chen, W., Sivaprasad, U., Tabata, Y., Gibson, A.M., Stier, M.T., Finkelman, F.D., Hershey, G.K., IL-13R alpha 2 membrane and soluble isoforms differ in humans and mice. J Immunol. 183(12): 7870-76. PMCID: PMC2822278. 2009.
Sivaprasad, U., Warrier, M.R., Gibson, A.M., Chen, W., Tabata, Y., Bass, S.A., Rothenberg, M.E., Khurana Hershey, G.K., IL-13 Receptor Alpha2 has a protective role in a mouse model of cutaneous inflammation. J Immunol. 185(11):6802-8. 2010.
Sivaprasad, U., Askew, D.J., Ericksen, M.B., Gibson, A.M., Stier, M.S., Brandt, E., Bass, S.A., Daines, M.O., Chakir, J., Stringer, K.F., Wert, S.E., Whitsett, J.A., Le Cras, T.D., Wills-Karp, M., Silverman, G.A., Khurana Hershey, G.K., A non-redundant role for mouse Serpinb3a in the induction of mucus production in asthma. J Allergy Clin. Immunol. 127(1):254-261.e6. PMCID: PMC3058372. 2010.
Butsch Kovacic, M., Biagini Myers, JM., Patterson, TL, Lindsey, M., Ericksen, MB, He, H., Gupta, J., Sivaprasad, U., Gibson, AM., Tsoras, AM, Chen, W., Musaad, S., Baye, TM, Khurana Hershey, G.K. Identification of KIF3A as a Novel Candidate Gene for Childhood Asthma Using RNA Expression and Population Allelic Frequencies Differences. PLoS One 6(8):e23714 PMCID: PMC3166061. 2011.
Wills-Karp, M., Rani, R., Dienger, K., Lewkowich, I., Fox, J.G., Perkins, C., Lewis, L., Finkelman, F.D., Smith, D.E., Bryce, P.J., Kurt-Jones, E.A., Wang, T.C., Sivaprasad, U., Hershey, G.K., Herbert, D.R. Trefoil factor 2 rapidly induces interleukin 33 to promote type 2 immunity during allergic asthma and hookworm infection. J. Exp. Med. 209(3):607-22. PMCID: PMC3302229. 2012.
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