• Center for Autoimmune Genomics and Etiology

    The primary focus of the Center for Autoimmune Genomics and Etiology (CAGE) is to gain a better understanding of the genesis of lupus and other immunological diseases.  The long-term goal of our research is to elucidate the mechanisms of disease through the complex interactions of genetics, environmental factors (stress, exercise, diet) and the immune system.  An understanding of these complex interactions may provide a better understanding of the etiology and treatment of these clinical disorders.

    We also seek to function as a biorepository by providing genetically defined samples from people with and without lupus and other immune-mediated disorders. 

    Our interdisciplinary laboratories are led by nationally recognized investigators who employ state-of-the-art model systems for genetic, biochemical, immunological and physiological analysis.  Novel models of rheumatologic diseases are developed and applied to investigate the key etiological steps involved in generating immunological diseases. Our research strives to identify and exploit initiating events in inflammatory disorders for a more relevant understanding of disease origins. 

    Our principal investigators, leading individual teams of scientists, work by sharing a common open laboratory and participating in a vigorous exchange of scientific ideas and study results.  Collaborations are under way with investigators locally, nationally, and internationally.

    The general goals of our lab are:

    • To be a major leader in innovative basic, translational and clinical research
    • To translate fundamental basic research toward clinical utility
    • To train the next generation of leaders in translational research and clinical practice
  • Center for Autoimmune Genetics and Etiology

    Click image for caption

  • Division Data Summary

    Research and Training Details

    Number of Faculty10
    Number of Research Fellows4
    Number of Research Students20
    Number of Support Personnel32
    Direct Annual Grant Support$2,296,435
    Direct Annual Industry Support$220,000
    Peer Reviewed Publications41

    Clinical Activities and Training

  • Contact Us

    The Center for Autoimmune Genetics and Etiology (CAGE)

    3333 Burnet Ave.
    MLC 15012
    Cincinnati, OH  45229-3039

    Phone: 513-803-3278
    Fax: 513-803-5246