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NIH/NIAID5 R37 AI024717-24Harley (PI)07/01/87 – 02/28/15Current studies support infrastructure and genetic association discovery and characterization mainly in European-derived subjects. The stimulus package supplement has provided a 36 terabyte server which is installed and operational. Resources from this R37 will be used to evaluate functional variants in IRF5, IRFB, LYN, MECP2, and TLR7.
NIH/NIAID5 P01 AI083194-03Harley (PI) Harley (PI)-Administrative Core A and Project 208/15/09 – 07/31/14 The program project goals for the International Consortium for the Genetics of Lupus are to explore the HLA region in samples from four different populations and to perform genome wide association studies in African-Americans, Amerindian Hispanics, and Asians. The African-American GWAS is being led by the PI. Part of the Hispanic GWAS is funded from this science.
NIH/NIAID 5 U19 AI082714-03 Harley (PI)-Project 2, “Genetics of Interferon Pathway of Dysregulation in Sjögren’s Syndrome”05/01/09 – 04/30/14This Autoimmunity Center of Excellence (ACE) focuses on understanding early events in systemic autoimmune diseases. This project focuses on candidate gene and genome wide approaches to describe the genetics of Sjögren’s syndrome.
5 P01 AR049084-09 NIH/NIAMSHarley (PI)-Project 2,“Genomics of Lupus Associations in the Hispanic 12q24 Linkage” 09/24/02 – 03/31/13This project will evaluate a promising candidate gene in Amerindian admixed Hispanics from the 11q24 association interval that shows strong association in our sample of Amerindian admixed Hispanics. We will explore this and other associations specific to Amerindian admixed Hispanics.
Department of Defense (DOD)PR094002 Harley (PI) 09/01/10 – 08/31/13African-Americans have a 3.5-fold greater incidence of SLE than do European-derived populations. We will identify genetic risk factors for SLE in AA populations by genotyping at a much higher density than would otherwise be possible without this support.
NIH/NCRR3 UL 1RR026314-03S2 Harley (Supplement PI)09/01/11 – 03/31/12The goal of this project is to collect 800 trios, develop a database of relevant clinical data post sample deidentification and associate these data with our sample tracking system.
University of Cincinnati University Research Council Interdisciplinary Faculty Research Support Grant ProgramHarley (Co-PI)07/01/11 – 06/30/12The aim of this pilot grant is to identify increased lupus incidence and somatic mutation in community residents near an Uranium plant at Fernald, OH.
US Department of Veterans Affairs IMMA 9 Harley (PI) 04/01/08 – 03/31/12The major goals of this project are to identify the causative polymorphism(s) for lupus risk and to explain its biology for generating disease risk, the genetic pathophysiology.
NIH Merit Award/NIAID (ARRA)3 R37 AI024717-23S1 Harley (PI)09/07/10 – 08/31/15The goal of this minority supplement is to evaluate micro-RNAs in the genetics of lupus.
NIH/NIAID5 U19 AI062629-08Kaufman (PI)-Project 5, “Reverse Genomics of Anti-Protective Antigen Responses”09/01/09 – 08/31/14The results of this renewal project should identify many new genes important for the future development of vaccines and for understanding resistance to lethal anthrax.
Division of RheumatologyThe Center for Autoimmune Genetics and Etiology (CAGE)
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