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Maurizio Macaluso, MD, DPH Director, Biostatistics and Epidemiology
has researched topics including epidemiologic research methods; cancer epidemiology; occupational epidemiology; health effects of sexual, reproductive and contraceptive behavior; acceptability, efficacy and safety of contraceptive technology; efficacy and safety of assisted reproductive technology; infectious disease epidemiology; surveillance systems; and immunology.
Director, Biostatistics and Epidemiology
Professor, UC Department of Pediatrics
Research methods; cancer; infectious disease; occupational health; sexual and reproductive health; contraception; assisted reproductive technology; surveillance systems
Dr. Macaluso has authored over 190 publications and a larger number of presentations made at national and international conferences. During his academic career at UAB, he taught advanced doctoral courses on the analysis of epidemiologic research studies and advised over 50 master's students in all areas of public health and 15 doctoral students in epidemiology, biostatistics, nutrition sciences, and medical sociology. In addition to providing guidance and advice to the DBE faculty, Dr. Macaluso mentors postdoctoral fellows and junior faculty in several Cincinnati Children’s divisions. At CDC he mentored junior scientists, Association of Schools of Public Health fellows, preventive effectiveness fellows, and epidemiologic intelligence service officers. He has taught in Italy, China, and Botswana.
MD: University of Palermo, Italy, 1979.
Fellowship: Experimental Oncology, Istituto Nazionale Tumori, Milano, Italy, 1981.
Residency: Hygiene and Preventive Medicine, University of Palermo, Italy, 1982.
DrPH: Epidemiology, University of Alabama at Birmingham, 1991.
Kulkarni AD, Jamieson DJ, Jones HW, Jr., et al. Fertility Treatments and Multiple Births in the United States. New England Journal of Medicine. Dec 5 2013;369(23):2218-2225.
Piyathilake CJ, Macaluso M, Alvarez RD, Chen M, Badiga S, Edberg JC, Partridge EE, Johanning GL. A higher degree of methylation of the HPV 16 E6 gene is associated with a lower likelihood of being diagnosed with cervical intraepithelial neoplasia. Cancer. 2011 Mar 1;117(5):957-63.
Macaluso M, Wright-Schnapp TJ, Chandra A, Johnson R, Satterwhite CL, Pulver A, Berman SM, Wang RY, Farr SL, Pollack LA. A public health focus on infertility prevention, detection, and management. Fertil Steril. 2010 Jan; 93(1):16.e1-10.
Macaluso M, Blackwell R, Jamieson DJ, Kulczycki A, Chen MP, Akers R, Kim D-j, Duerr A. Efficacy of the male latex condom and of the female polyurethane condom as barriers to semen during intercourse: a randomized clinical trial. Am J Epidemiol. 2007; 166(1):88-96.
Macaluso M, Larson R, Lynch J, Lipton S, Delzell E. Historical estimation of exposure to 1,3-butadiene, styrene, and dimethyldithiocarbamate among synthetic rubber workers. J Occup Environ Hyg. 2004 Jun;1(6):371-90.
Macaluso M, Lawson L, Akers R, Valappil T, Hammond K, Blackwell R, Hortin G. Prostate-specific antigen in vaginal fluid as a biologic marker of condom failure.Contraception. 1999 Mar;59(3):195-201.
Macaluso M, Demand MJ, Artz LM, Hook EW 3rd. Partner type and condom use. AIDS. 2000 Mar 31;14(5):537-46.
Macaluso M, Larson R, Delzell E, Sathiakumar N, Hovinga M, Julian J, Muir D, Cole P. Leukemia and cumulative exposure to butadiene, styrene and benzene among workers in the synthetic rubber industry. Toxicology. 1996 Oct 28;113(1-3):190-202.
Macaluso M. Exact stratification of person-years. Epidemiology. 1992 Sep;3(5):441-8.
Butterworth CE Jr, Hatch KD, Macaluso M, Cole P, Sauberlich HE, Soong SJ, Borst M, Baker VV. Folate deficiency and cervical dysplasia. JAMA. 1992 Jan 22-29; 267(4):528-33.
Mekibib Altaye, PhD
is a biostatistician interested in the design and analysis of correlated data, including developing inference procedures for intraclass correlation, and kappa statistic for binary and polynomial outcomes. Current research interest focused in modeling issues associated with high dimensional data that arise from fMRI, MRI and microbiome studies. He also mentors junior faculty, staff and students.
Design and analysis of correlated data. This includes developing inference procedures for intraclass correlation, and kappa statistic for binary and polynomial outcomes. Recent research interest includes modeling issues associated with high dimensional data that arise from fMRI, MRI and microbiome studies.
Dr. Altaye has published more than 60 peer-reviewed articles and more than 70 abstracts/posters. He has been invited to present his work in national meetings and co-author a book chapter. He has been a co-investigator, collaborator or biostatistician in more than 20 NIH funded projects. Dr. Altaye provides support for researchers in multiple divisions as well as for the Center for Clinical and Translational Sciences and Training (CCTST). He taught biostatistics courses for the Master of Science Clinical and Translational Research program. He has obtained travel awards to attend workshops from NSF and NIH. One of his articles received a Caffey award for best clinical science or education paper from the Pediatric Radiology Society.
PhD: The University of Western Ontario, London, Canada, 1998.
MSc: Oklahoma State University, Stillwater, OK, 1991.
BSc: Addis Ababa Universtiy, Addis Ababa, Ethiopia, 1983.
Szaflarski JP, Rajagopal A, Altay M, Byars AW, Jacola L, Schmithorst VJ, Schaprio MB, Plante E, Holland SK. Left-handedness and language lateralization in children. Brain Research. 1433: 85-97. 2012.
Cecil KM, Dietrich KN, Altaye M, Egelhoff JC, Lindquist DM, Brubaker CJ, Lanphear BP. Proton magnetic resonance spectroscopy in adults with childhood lead exposure. Environmental Health Perspective. Mar;119(3):403-8. 2011.
Yuan W, Altaye M, Ret J, Schmithorst VJ Byars AW, Plante E, Holland SK. Quantification of children’s head motion in various fMRI language tasks. Human Brain Mapping. 30(5): 1481-9. 2009.
Langberg, JM., Epstein, JN., Altaye M., Molina, B., Arnold, E., Vitiello, B. The transition to middle school is associated with changes in the developmental trajectory of ADHD symptomatology in young adolescents with ADHD. Journal of Clinical Child and Adolescent Psychology. 37(3): 651-63. 2008.
Eaton KP, Szaflarski JP, Altaye M, Ball AL, Kissela BM, Banks C, Holland SK. Reliability of fMRI for studies of language in post-stroke aphasia subjects. NeuroImage. 41(2): 311-22. 2008.
Wilke M, Holland SK, Altaye M, Gaser C. Template-o-matic: a toolbox for creating customized pediatric templates. NeuroImage. 41(3): 903-13. 2008.
Altaye M, Holland SK, Wilke M, Gaser C. Infant brain probability templates for MRI segmentation and normalization. NeuroImage. 43(4): 721-30. 2008.
Szaflarski JP, Schmithorst VJ, Altaye M, Byars AW, Rett J, Plante E, Holland SK. A longitudinal fMRI study of language development in children age 5-11. Annals of Neurology. 59(5): 796-807. 2006.
Altaye M, Donner A, Eliasziw M. A general goodness of fit approach for inference procedures concerning the kappa statistic. Statistics in Medicine. 16: 2479-2488. 2001.
Altaye M, Donner A, Klar N. Inference procedures for assessing interobserver agreement among multiple raters. Biometrics. 57: 584-588. 2001.
Katherine A. Bowers, PhD, MPH
is a perinatal epidemiologist interested in pre-conceptual and prenatal exposures in combination with genetic effects in relation to metabolic and neurodevelopmental consequences for the offspring.
Assistant Professor, UC Department of Pediatrics
Perinatal and genetic epidemiology; autism spectrum disorders; prenatal exposures; pregnancy complications
Bowers K, Tobias DK, Yeung E, Hu FB, Zhang C. A prospective study of pre-pregnancy dietary fat intake and risk for gestational diabetes. Am J of Clin Nutr. 2012; 95: 446-53.
Tobias DK, Zhang C, Chavarro J, Bowers K, Rich-Edwards J, Rosner B, Mozaffarian D, Hu FB. Pre-pregnancy adherence to dietary patterns and decreased risk of gestational diabetes mellitus. Am J Clin Nutr. 2012 Aug; 96 (2): 289-95.
Bowers K, Zhang C. The association between obesity and diabetes in pregnancy and neurodevelopmental outcomes in the offspring. North American Journal of Medicine and Science. 20114(4): 217-22.
Bowers K, Yeung E, Williams MA, Qi L, Tobias DK, Hu FB, Zhang C. A prospective study of prepregnancy dietary iron intake and risk for gestational diabetes mellitus. Diabetes Care. 2011 Jul; 34(7):1557-63.
Bowers K, Li Q, Bressler J, Avramopoulos D, Newschaffer C, Fallin MD. Glutathione pathway gene variation and risk of autism spectrum disorders. J Neurodev Disord. 2011 Jun; 3(2):132-43.
Bowers K, Liu G, Wang P, Ye T, Tian Z, Liu E, Yu Z, Yang X, Klebanoff M, Yeung E, Hu G, Zhang C. Birth weight, postnatal weight change, and risk for high blood pressure among Chinese children. Pediatrics. 2011 May; 127(5):e1272-9.
Schwender H, Bowers K, Fallin MD, Ruczinski I. Importance measures for epistatic interactions in case-parent trios. Ann Hum Genet. 2011 Jan;75(1):122-32.
Tobias DK, Zhang C, van Dam RM, Bowers K, Hu FB. Physical activity before and during pregnancy and risk of gestational diabetes mellitus: a meta-analysis. Diabetes Care. 2011 Jan;34(1): 223-9.
Schisterman E, Whitcomb B, Bowers K. Invited commentary: causation or “noitasuac”? Am J Epidemiol. 2011 May 1;173(9):984-7.
Bowers K, Albanes D, Limburg P, Pietinen P, Taylor PR, Virtamo J, Stolzenberg-Solomon R. A prospective study of anthropometric and clinical measurements associated with insulin resistance syndrome and colorectal cancer in male smokers. Am J Epidemiol. 2006 Oct;164(7):652-64.
Lili Ding, PhD
is a biostatistician with research interest in Bayesian modeling and inference, and its applications in various fields of biomedical research, including statistical genetics, population pharmacokinetics and pharmacodynamics, multivariate survival analysis, and multilevel latent variable modeling. Dr. Ding mentors junior faculty, fellows and students in DBE and several other divisions within the hospital.
Biostatistics; Bayesian statistics; statistical genetics; population PK/PD study design and modeling
PhD: University of Cincinnati, OH, 2010.
MS: University of Cincinnati, OH, 2006.
BS: Changchun University of Science and Technology, Jilin, China, 1999.
Mullins TLK, Zimet GD, Rosenthal SL, Morrow C, Ding LL, Shew, M, Kahn, JA. Adolescent Perceptions of Risk and Need for Safer Sexual Behaviors After First Human Papillomavirus Vaccination. Arch Pediatr Adolesc Med. 2012 Jan;166(1):82-8.
Baye TM, He H, Ding L, Kurowski BG, Zhang X, Martin LJ. Population structure analysis using rare and common functional variants. BMC Proc. 2011 Nov 29;5 Suppl 9:S8.
Ding L, Baye TM, He H, Zhang X, Kurowski BG, Martin LJ. Detection of associations with rare and common SNPs for quantitative traits: a nonparametric Bayes-based approach. BMC Proc. 2011 Nov 29; 5 Suppl 9:S10.
Ding L, Wiener H, Abebe T, Altaye M, Go RC, Kercsmar C, Baye TM. Comparison of measures of marker informativeness for ancestry and admixture mapping. BMC genomics. 2011 Dec 20;12:622.
He H, Zhang X, Ding L, Baye TM, Kurowski BG, Martin LJ. Effect of population stratification analysis on false-positive rates for common and rare variants. BMC Proc. 2011;5 Suppl 9:S116.
Kahn JA, Huang B, Ding LL, Geller A, Frazier AL. Impact of Maternal Communication About Skin, Cervical, and Lung Cancer Prevention on Adolescent Prevention Behaviors. Journal of Adolescent Health. 2011 Jul;49(1):93-96.
Sherwin C, Ding L, Kaplan J, Vinks A. Optimal design for a single dose pharmacokinetic study of Pioglitazone in septic pediatric patients. Journal of Pharmacokinetics and Pharmacodynamics. 2011 Aug;38(4):433-447.
Zhang X, He H, Ding L, Baye TM, Kurowski BG, Martin LJ. Family- and population-based designs identify different rare causal variants. BMC Proc. 2011;5 Suppl 9:S36.
Kahn JA, Ding LL, Huang B, Zimet GD, Rosenthal SL, Frazier AL. Mothers' Intention for Their Daughters and Themselves to Receive the Human Papillomavirus Vaccine: A National Study of Nurses. Pediatrics 2009;123(6):1439-1445.
Pattullo L, Griffeth S, Ding LL, Mortensen J, Reed J, Kahn J, Huppert J. Stepwise Diagnosis of Trichomonas vaginalis Infection in Adolescent Women. Journal of Clinical Microbiology. 2009 Jan;47(1):59-63.
Shelley R. Ehrlich, MD, ScD, MPH
Environmental molecular and perinatal epidemiology; obstetrics, gynecology and reproductive medicine; endocrine disrupting chemicals; epigenetics; novel biomarkers; fetal programming of childhood diseases.
ScD: Environmental Molecular and Perinatal Epidemiology, Harvard University School of Public Health, Cambridge, MA.
Residency: Obstetrics and Gynecology, Hadassah Medical Center, Jerusalem, Israel.
MPH: Hebrew University, Jerusalem, Israel.
MD: Fluminense Federal University of Rio de Janeiro; Hadassah Medical Center – Hebrew University, Jerusalem, Israel.
Ehrlich S, Calafat AM, Humblet O, Smith T, Hauser R. Handling of thermal receipts as a source of exposure to bisphenol A. JAMA. 2014 Feb 26;311(8):859-60.
Vandenberg LN, Ehrlich S, Ben-Jonathan N, Dolinoy DC, Heindel JJ, Hugo ER, Hunt PA, Rubin BS, Saili KS, Soto AM, Wang HS, Vom Saal FS. Low Dose Effects of Bisphenol A: An Integrated Review of In Vitro, Laboratory Animal and Human Studies. Endocrine Disruptors. 2013 Vol 1:Issue 1.
Ehrlich S, Williams PL, Hauser R, Missmer SA, Peretz J, Calafat AM, Flaws JA. Urinary bisphenol A concentrations and cytochrome P450 19 A1 (Cyp19) gene expression in ovarian granulosa cells: an in vivo human study. Reprod Toxicol. 2013 Dec;42:18-23.
Smith KW, Souter I, Dimitriadis I, Ehrlich S, Williams PL, Calafat AM, Hauser R. Urinary paraben concentrations and ovarian aging among women from a fertility center. Environ Health Perspect. 2013 Nov-Dec;121(11-12):1299-305.
Ehrlich S, Williams PL, Missmer SA, Flaws JA, Ye X, Calafat AM, Petrozza JC, Wright D, Hauser R. Urinary bisphenol A concentrations and early reproductive health outcomes among women undergoing IVF. Hum Reprod. 2012 Dec;27(12):3583-92.
Ehrlich S, Williams PL, Missmer SA, Flaws JA, Berry KF, Calafat AM, Ye X, Petrozza JC, Wright DL, Hauser R. Urinary bisphenol A concentrations and implantation failure among women undergoing in vitro fertilization. Environ Health Perspect. 2012 Jul;120(7):978-83.
Chavarro JE, Ehrlich S, Colaci DS, Wright DL, Toth TL, Petrozza JC, Hauser R. Body mass index and short-term weight change in relation to treatment outcomes in women undergoing assisted reproduction. Fertil Steril. 2012 Jul;98(1):109-16.
Meeker JD, Ehrlich S, Toth TL, Wright DL , Calafat AM, Hauser R. Semen quality and sperm DNA damage in relation to urinary bisphenol A among men from an infertility clinic. Reprod Toxicol. 2010 Dec;30(4):532-9.
Mok-Lin E, Ehrlich S, Williams PL, Petrozza J, Wright DL, Calafat AM, Ye X, Hauser R. Urinary bisphenol A concentrations and ovarian response among women undergoing IVF. Int J Androl. 2010 Apr;33(2):385-93.
Lin Fei, PhD
Associate Professor, UC Department of Pediatrics
Mathematical statistics; clinical trial design and analysis; statistical and probability models
BS, MS: Shanghai Jiaotong University, Shanghai, China, 1984.
MS: The Ohio State University, Columbus, OH, 1988.
PhD: The Ohio State University, Columbus, OH, 1992.
Lin Fei, Jie Mi. Some Aspects of Probability of Correct Selection. Communications in Statistics – Theory and Methods. 2011;40:4484-4495.
Karita E, Price M, Hunter E, Chomba E, Allen E, Fei L, Kamali A, Sanders E, Anzala O, Katende M, Ketter N. Investigating the utility of the HIV-1 BED capture enzyme immunoassay using cross-sectional and longitudinal seroconverter specimens from Africa. AIDS. 2007;21:403-408.
Lin Fei. A Probability Inequality and its Applications in Selecting Best Normal Means. Communications in Statistics – Theory and Methods. 2004;33:321-330.
Wei-Ping Lu, Lin Fei. A logarithmic approximation to initial rates of enzyme reactions. Analytical Biochemistry. 2003;316:58-65.
Md Monir Hossain, PhD, MSc
is a biostatistician whose methodologic research interests include the development of statistical methods for modeling spatial-temporal disease clusters; spatial structure equation modeling; mixture models; inter-rater reliability; multi-level modeling; health services and patient outcomes; and clinical trials. Areas of application include perinatal health; access to primary health care; and childhood cancer incidences.
PhD: Statistics, Institute of Statistical Mathematics, Japan.
MSc: Statistics, University of Dhaka, Bangladesh.
Hossain MM, Lawson AB, Cai B, Jungsoon C, Liu J, Kirby RS. Space-Time mixture models for small area disease risk and cluster estimation: model selection and optimum allocation. Environmetrics. 2014 25:84-96.
Eberth JM, Eschbach K, Morris J, Nguyen H, Hossain MM, Elting L. Geographic disparities in mammography capacity in the South: a longitudinal assessment of supply and demand. Health Serv Res. 2014 Feb;49(1):171-85.
Cai B, Lawson AB, Hossain MM, Choi J, Kirby RS, Liu J. Bayesian semiparametric model with with spatially-temporally varying coefficients selection. Stat Med. 2013 Sep 30;32(21):3670-85.
Hasbun R, Khoury N, Hadi C, Wootton S, Hossain MM, Beilke M. Risk score for identifying adults with CSF pleocytosis and negative CSF gram stain at low risk for an urgent treatable cause. J Infect. 2013 Aug;67(2):102-10.
Mirza S, Hossain MM, Mathews C, Martinez PJ, Gay J, Pino P, Rentfro A, McCormick JB, Fisher-Hoch SP. Type 2-Diabetes is Associated with Elevated Levels of TNF-alpha, IL-6 and Adiponectin and Low Levels of Leptin in a Population of Mexican American: A Cross-Sectional Study. Cytokine. 2012 Jan;57(1)136-42.
Kirby RS, Liu J, Lawson AB, Jungsoon C, Cai B, Hossain MM. Spatio-temporal Patterning of Small Area Low Birth Weight Incidence and Its Correlates: A Latent Spatial Structure Approach. Spat Spatiotemporal Epidemiol. 2011 Dec;2(4):265-71.
Jungsoon C, Lawson AB, Cai B, Hossain MM. Evaluation of Bayesian spatial-temporal latent models in small area health data. Environmetrics. 2011 Dec;22(8):1008-1022.
Lawson AB, Song HR, Cai B, Hossain MM, Huang K. Space-Time latent component modeling for Geo-referenced health data. Stat Med. 2010 Aug 30;29(19):2012-27.
Hossain MM, Lawson AB. Space-time Bayesian small area disease risk models: Development and evaluation with a focus on cluster detection. Environ Ecol Stat. 2010 Mar 1;17(1):73-95.
Hossain MM, Laditka J. Using hospitalization for ambulatory care sensitive conditions to measure access to primary health care: an application of spatial structural equation modeling. IntJ Health Geogr. 2009 Aug 28;8:51.
Bin Huang, PhD Biostatistician, Division of Biostatistics and Epidemiology
is an experienced biostatistician with research interests in mediation analysis, statistical causal inference, observational / epidemiological analyses, item response modeling, and spatially correlated data. Areas of application include: pubertal development, bio-behavior, health disparity, health related quality of life (HRQoL), patient-reported outcomes (PRO), substance use risk, STI, asthma and JIA research.
Biostatistician, Division of Biostatistics and Epidemiology
Affiliated Assistant Professor, Department of Mathematical Sciences, University of Cincinnati A&S College
Biostatistics; puberty; substance use/abuse; STI; GE interaction; quality of life
Dr. Huang earned a Bachelor of Science degree in civil engineering from Shanghai Jiao Tong University (1991) and a Master of Science degree in mathematical statistics (1995) and a PhD in biostatistics (2001) from the University of Cincinnati. Dr. Huang joined Cincinnati Children’s in 1999 as a biostatistician and was promoted to a research associate in 2002. She started faculty appointment in 2003 at the rank of research assistant professor of pediatrics. In 2008 she received an affiliated assistant professor appointment with the University of Cincinnati Department of Mathematical Sciences, and in 2009 she was promoted to the rank of research associate professor of pediatrics and mathematical sciences within the UC College of Medicine. Dr. Huang actively collaborates with researchers in adolescent health, juvenile rheumatoid arthritis, health disparity, health related quality of life (HRQoL), patient-reported outcomes (PRO), injury prevention and sports medicine.
BS: Shanghai Jiao Tong University, Shanghai, China, 1991.
MS: University of Cincinnati, Cincinnati, OH, 1995.
PhD: Environmental Health, University of Cincinnati, Cincinnati, OH, 2002.
Seid M, Huang B, Niehaus S, Brunner HI, Lovell DJ. Determinants of health-related quality of life in children newly diagnosed with juvenile idiopathic arthritis. Arthritis Care Res (Hoboken). 2014 Feb;66(2):263-9.
Huang B, Giannini EH, Lovell DJ, Ding L, Liu Y, Hashkes PJ. Enhancing crossover trial design for rare disease: limiting ineffective exposure and increasing study power by enabling patient choice to escape early. Contemporary Clinical Trials. 2014 Jul;38(2): 204-212.
Beck AF, Huang B, Simmons JM, Moncrief T, Sauers HS, Chen C, Ryan PH, Newman NC, Kahn RS. Role of Financial and social hardships in asthma racial disparities. Pediatrics. 2014;133(3): 431-9.
Beck AF, Moncrief T, Huang B, Simmons JM, Sauers H, Chen C, Kahn RS. Inequalities in neighborhood child asthma admission rates and underlying community characteristics in one US County. J Pediatr. 2013;163(2): 574-80.
Hashkes PJ, Spalding SJ, Giannini EH, Huang B, et al. Rilonacept for Colchicine Resistant for Intolerant Familial Mediterranean Fever: A Randomized Controlled Trial. Annals of Internal Medicine. 2012;157:533-41.
Beck AF, Simmons JM, Huang B, Kahn RS. Geomedicine: Using area-based socioeconomic measures to assess risk of reutilization among children admitted for asthma. AJPH. 2012;102(12):2308-14.
Huang B, Hillman J, Ding, L, Biro FM, Dorn LD, Susman EJ. Correspondence Between Gonadal Steroid Hormone Concentrations and Secondary Sexual Characteristics Assessed by Clinicians, Adolescents, and Parents. Journal of Research on Adolescence. 2012;22(2), 381-391.
Huang J, Huang B*. Proportion of Treatment Effects Explained by a Continuous Surrogate Marker in Randomized Clinical Trial. Statistics in Pharmaceutical Research. 2010;2(2): 229-238. (*corresponding author).
Huang B, Biro FM, Dorn LD. Determination of Relative Timing of Pubertal Maturation through Ordinal Logistic Modeling: Evaluation of Growth and Timing Parameters. Journal of Adolescent Health. 2009;45(4): 383-8.
Huang B, Sivaganasen S, Succop P, Goodman E. Statistical assessment of mediational effects for logistic mediational models. Statistics in Medicine. 2004;23(17):2713-28.
Epidemiologic Impact of HPV Vaccination. Co-investigator (PI, J Kahn). Jan 2013–Dec 2017.
Inpatient Asthma Care for Children: Adding a Place-Based Community-Focused Approach. Statistics Advisor (PI, Beck). National Institutes of Health. July 2014–June 2019.
Prospective Study of Biomechanics and Early Degeneration after ACL Reconstruction. Co-investigator (PI, Paterno/Schemit). National Institutes of Health / National Institute of Arthritis and Musculoskeletal and Skin Diseases. April 2014-March 2016.
Richard F. Ittenbach, PhD
is a biostatistician who specializes in the development, validation and analysis of scales for measurement of biomedical and biobehavioral factors. He mentors junior faculty, staff and students in DBE, cardiology, cardiac surgery, biomedical informatics, and psychology. He has contributed extensively to the training curricula of the Fellows Core Curriculum in biostatistics and data management.
Scale development; statistical consulting; study design.
Dr. Ittenbach has authored or co-authored more than 90 peer-reviewed publications in the behavioral and biomedical sciences. He has been funded as a co-investigator and biostatistician on a number of NIH / CDC grants. He currently serves on the editorial board of four journals and reviews for several others. Dr. Ittenbach is a certified professional statistician (PStat) through the American Statistical Association and remains active in the American Statistical Association’s Section on Statistical Consulting. Areas of current professional interest include measure and scale development, mixed methods designs, as well as empirical bioethics.
>BS: Butler University, Indianapolis, IN, 1980.
MED: :Auburn University, Auburn, AL, 1984.
PhD: University of Alabama, Tuscaloosa, AL, 1989.
Postdoctoral Fellowship: University of Minnesota, Minneapolis, MN 1989-1991.
MHS: Johns Hopkins University, Baltimore, MD, 2001.
Standridge S, Faist R, Pestian J, Glauser T, Ittenbach RF. The reliability of an epilepsy treatment clinical decision support system. J Med Syst. 2014 Oct;38(10):119.
Maglo KN, Rubinstein J, Huang B, Ittenbach RF. BiDil in the clinic: An interdisciplinary investigation of physicians’ prescription patterns of a genomics-free race-based therapy. AJOB Empir Bioeth. 2014 Oct 2;5(4):37-52.
Ittenbach RF, Baker CL, Corsmo JJ. A tiered quality assurance review process for clinical data management standard operating procedures in an academic health center. Acad Med. 2014 May;89(5):745-48.
Gaynor JW, Ittenbach RF, Gerdes M, Bernbaum J, Clancy RR, McDonald-McGinn DM, Zackai EJ, Wernovsky G, Nicolson SC, Spray TL. Neurodevelopmental outcomes in preschool survivors of the Fontan procedures. J Thorac Cardiovasc Surg. 2014 Apr;147(4):1276-82.
Drotar D, Ittenbach R, Rohan JM, Gupta R, Pendley JS, Delameter A. Diabetes management and glycemic control in youth with type 1 diabetes: Test of a predictive model. J Behav Med. 2013 Jun;36(3): 234-45.
Ittenbach RF, Cassedy AE, Rohan JM, Hood KK, Harris MA, Delamater A, Pendley J, Drotar D. Diabetes Self-Management Profile Short Form: A Preliminary report. J Clin Psychol Med Settings. 2013 Mar;20(1):107-13.
Gupta R, Marino BS, Cnota JF, Ittenbach RF. Finding the right distribution for highly skewed zero-inflated data. Biomedical Statistics and Clinical epidemiology. Epidemiol, Biostatistics and Pub Health. 2013;10(1): e87321-e8732-10.
Quatman-Yates CC, Gupta R, Paterno MV, Schmitt LC, Quatman CE, Ittenbach RF. Internal consistency and validity of the QuickDASH instrument for upper extremity injuries in older children. J Pediatr Orthop. 2013 Dec;33(8):838-42.
Ittenbach RF, DeAngelis FD, Altaye M. Communicating with investigators about financial compensation in statistical collaboration. Res Management Rev. 2013;19(2),1-9.
Ittenbach RF, DeAngelis F. Percent effort vs. Fee-for-service: A Comparison of models for statistical collaboration. Res Management Rev. 2012;19(1):24-41.
Jane C. Khoury, PhD
is the senior biostatistician for the study of the epidemiology of stroke in Cincinnati, and is principal investigator for the biostatistical core of a Special Program Of Translational Research In Acute Stroke. She holds a joint appointment in the Division of Endocrinology within the UC Department of Pediatrics and works with many of the faculty and fellows on study design and statistical methods in development of their research studies. Her personal research interests involve the effect of intra-uterine exposure to type 1 diabetes on childhood growth, metabolism and cardiac function.
Stroke, diabetes in pregnancy; research design and analysis.
BSc: Bath University, Bath, England, 1973.
MS: University of Cincinnati College of Medicine, Department of Environmental Health, Division of Epidemiology and Biostatistics, Cincinnati, OH, 1989.
PhD: University of Cincinnati College of Medicine, Department of Environmental Health, Division of Epidemiology and Biostatistics, 2006.
Yolton K, Xu Y, Sucharew H, Succop P, Altaye M, Popelar A, Montesano MA, Calafat AM, Khoury JC. Impact of low-level gestational exposure to organophosphate pesticides on neurobehavior in early infancy: a prospective study. Environ Health. 2013 Sep 13;12(1):79.
Sucharew H, Khoury J, Moomaw CJ, Alwell K, Kissela BM, Belagaje S, Adeoye O, Khatri P, Woo D, Flaherty ML, Ferioli S, Heitsch L, Broderick JP, Kleindorfer D. Profiles of the National Institutes of Health Stroke Scale items as a predictor of patient outcome. Stroke. 2013 Aug;44(8):2182-7.
Khoury JC, Kleindorfer D, Alwell K, Moomaw CJ, Woo D, Adeoye O, Flaherty ML, Khatri P, Ferioli S, Broderick JP, Kissela BM. Diabetes Mellitus: a Risk Factor for Ischemic Stroke in a Large Bi-Racial Population. Stroke. 2013. 44(6):1500-1504.
Mahabee-Gittens EM, Xiao Y, Gordon JS, Khoury JC. The dynamic role of parental influences in preventing adolescent smoking initiation. Addict Behav. 2013 Jan 11;38(4):1905-1911.
Khoury JC, Dolan LM, VanDyke R, Rosenn B, Feghali M, Miodovnik M. Fetal development in women with diabetes: imprinting for a life-time?Journal of Maternal-Fetal & Neonatal Medicine. 2012; 25(1), 11-14.
VanDyke R, Ren Y, Sucharew HJ, Miodovnik M, Rosenn B, Khoury JC. Characterizing maternal glycemic control: a more informative approach using semiparametric regression. Journal of Maternal-Fetal & Neonatal Medicine. 2012; 25(1), 15-19.
Yolton K, Xu YY, Strauss D, Altaye M, Calafat AM, Khoury J. Prenatal exposure to bisphenol A and phthalates and infant neurobehavior. Neurotoxicology and Teratology. 2011; 33(5), 558-566.
Xu YY, Yolton K, Khoury J. Earliest Appropriate Time for Administering Neurobehavioral Assessment in Newborn Infants. Pediatrics. 2011;127(1), E69-E75.
Bollepalli S, Dolan LM, Miodovnik M, Feghali M, Khoury JC. Asymmetric large-for-gestational-age infants of type 1 diabetic women: Morbidity and abdominal growth. Am J Perinatol. 2010; 27(8), 603-610.
Kleindorfer D, Khoury J, Moomaw CJ, Alwell K, Woo D, Flaherty ML, Khatri P, Adeoye O, Ferioli S, Broderick JP, Kissela BM. Stroke Incidence is Decreasing in Whites, but Not in Blacks: A Population-Based Estimate of Temporal Trends in Stroke Incidence from the Greater Cincinnati/Northern Kentucky Stroke Study. Stroke. 2010;41(7):1326-31.
Neurobehavioral and Neuroimaging Effects of Traffic Exposure in Children. Co-Investigator. R01 NIH. July 2012-March 2017.
Improving post-discharge outcomes by facilitating family-centered transitions from hospital to home. Co-Investigator. PCORI. July 2014-June 2017.
Mi-Ok Kim, PhD Biostatistician, Biostatistics and Epidemiology
is a biostatistician with research interests in advanced clinical trial designs and complex longitudinal and survival data analysis. Her method research on causal inference of observational studies is currently supported by a mid-career award from AHRQ and Improving PCOR Methodology award. Her collaborative research focuses on comparative effectiveness research and PCOR in pediatric IBD and cancer.
Biostatistician, Biostatistics and Epidemiology
Fax 513- 636-7509
Causal inference; comparative effectiveness research; longitudinal and survival data analysis; adaptive clinical trial designs
MS: Statistics, University of Illinois, Urbana-Champaign, IL.
PhD: Statistics, University of Illinois, Urbana-Champaign, IL, 2003.
Kim MO, Liu C, Hu F, Lee JJ. Outcome-Adaptive Randomization for a Delayed Outcome with a Short-Term Predictor: Imputation Based Designs. Statistics in Medicine. 2014 May 29.
Minar P, Haberman Y, Jurickova I, Wen T, Rothenberg ME, Kim MO, Saeed SA, Baldassano RN, Stephens M, Markowitz J, Rosh J, Crandall WV, Heyman MB, Mack DR, Griffiths AM, Baker SS, Hyams JS, Kugathasan S, Denson LA. Utility of Neutrophil Fcγ Receptor I (CD64) Index as a Biomarker for Mucosal Inflammation in Pediatric Crohn's Disease. Inflamm Bowel Dis. 2014 Jun;20(6):1037-48.
Walters TD, Kim MO*, Denson LA, Griffiths AM, Dubinsky M, Markowitz J, Baldassano R, Crandall W, Rosh J, Pfefferkorn M, Otley A, Heyman MB, LeLeiko N, Baker S, Guthery SL, Evans J, Ziring D, Kellermayer R, Stephens M, Mack D, Oliva-Hemker M, Patel AS, Kirschner B, Moulton D, Cohen S, Kim S, Liu C, Essers J, Kugathasan S, Hyams JS; PRO-KIIDS Research Group. Increased effectiveness of early therapy with anti-tumor necrosis factor-α vs an immunomodulator in children with Crohn's disease. Gastroenterology. 2014 Feb;146(2):383-91. (*co-primary authors)
Dykes DM, Towbin AJ, Bonkowski E, Chalk C, Bezold R, Lake K, Kim MO, Heubi JE, Trapnell BC, Podberesky DJ, Denson LA. Increased Prevalence of Luminal Narrowing and Stricturing Identified by Enterography in Pediatric Crohn's Disease Patients With Elevated Granulocyte-Macrophage Colony Stimulating Factor Autoantibodies. Inflammatory Bowel Diseases. 2013 Sep;19(10):2146-54.
Gathungu G, Kim MO, Ferguson JP, Sharma Y, Zhang W, Ng SM, Bonkowski E, Ning K, Simms LA, Croft AR, Stempak JM, Walker N, Huang N, Xiao Y, Silverberg MS, Trapnell B, Cho JH, Radford-Smith GL, Denson LA. Granulocyte-Macrophage Colony-Stimulating Factor Autoantibodies: A Marker of Aggressive Crohn's Disease. Inflammatory Bowel Diseases. 2013 Jul;19(8):1671-1680.
Choi D, Hoffman KA, Kim MO, McCarty D. A High Resolution Evaluation of Process Improvement:Use of Quantile Regression for Wait Time. Health Services Research. 2013 Feb;48(1):333-47.
Kim MO, Yang Y. Semiparametric Approach to a Random Effects Quantile Regression Model. Journal of the American Statistical Association. 2011, Dec 1: 106(496): 1405-1417.
Denson LA, Kim MO, Bezold R, Carey R, Osuntokun B, Nylund C, Willson T, Bonkowski E, Li D, Ballard E, Collins M, Moyer MS, Klein DJ. A Randomized Controlled Trial of Growth Hormone in Active Pediatric Crohn's Disease. Journal of Pediatric Gastroenterology and Nutrition. 2010; Aug;51(2):130-9.
Han X, Uchida K, Jurickova I, Koch D, Willson T, Samson C, Bonkowski E, Trauernicht A, Kim MO, Tomer G, Dubinsky M, Plevy S, Kugathsan S, Trapnell BC, Denson LA. Granulocyte-macrophage colony-stimulating factor autoantibodies in murine ileitis and progressive ileal Crohn's disease. Gastroenterology. 2009 Apr;136(4):1261-71, e1-3.
Kim M-O. Quantile Regression with Varying Coefficients. Annals of Statistics. 2007;35(1): 92-108.
Lineage Determination and Tissue HomeOstasis in the aged Hematopoietic System. Biostatistician. National Institutes of Health. Aug 2011–July 2016. R01 AG040118 (Zheng).
Risk Stratification & Identification of immunogenic and microbial markers of rapid disease progression in children with Crohn’s disease. Co-Investigator. Crohn's & Colitis Foundation of America. July 2008-June 2017. R01 (Denson/Kugathasan).
Causes and Consequences of Neutrophil Dysfunction in Pediatric Crohns Disease. Director (Biostatistics Core). National Institutes of Health. Sep 2013–July 2018. R01DK098231 (Denson).
Neurofibroma Preclinical Therapeutics. Co-Investigator. The Children’s Tumor Foundation. July 2013–July 2016. CTF (Ratner).
Macrophage Based Gene Therapy for Hereditary Pulmonary Alveolar Proteinosis. Co-Investigator. National Institutes of Health. April 2014–March 2018. R01 (Trapnell).
Rigor of Multi-Registry CER Studies: Towards Patient-Centered Treatment Planning. Principal Investigator. National Institutes of Health / Agency for Healthcare Research and Quality. July 2014–June 2016. K18 (Kim).
Eileen C. King, PhD
has 24 years of experience in the design and analysis of clinical trials for health care and pharmaceutical research studies. She enjoys collaborative research and has research interests in nonparametric regression using smoothers, comparative effectiveness research using clinical data from large multi-site registries, and statistical quality control approaches for clustered data for quality improvement initiatives in health outcomes.
Clinical trials; statistical process control; data management; nonparametric regression using linear smoothers.
Dr. King has provided biostatistical leadership in the design, analysis, and interpretation of results from animal and human clinical research studies supporting drug discovery, early and late stage drug development, commercialization, and market support. She provided statistical expertise and oversight for the development, review, and defense of 10 new drug application submissions in the areas of gastrointestinal, cardiac, bone diseases and female sexual health. She is currently leading the growing Data Management Center to assure appropriate data management processes for data collection, data cleaning and validation, and data finalization, documentation and archival are used which lead to high quality data that can be shared with the research community at large.
Dr. King is active in the American Statistical Association and is currently chair of the Council of Sections Governing Board. She is an associate editor for the Journal of Statistical Education. Dr. King mentors junior faculty, staff and students in DBE and Gastroenterology and the Anderson Center. She is the primary instructor of “Statistical Principles for Clinical Research Studies” in the UC College of Pharmacy.
BS: Regis College, Weston, MA, 1976.
MS: University of Wyoming, Laramie, WY, 1980.
PhD: Texas A&M University, College Station, TX, 1988.
Crandall WV, Margolis PA, Kappelman MD, King EC, Pratt JM, Boyle BM,Colletti RB. Improved Outcomes in a Quality Improvement Collaborative for Pediatric Inflammatory Bowel Disease. Pediatrics. 2012.
Presicce P, Orsborn K, King E, Pratt J, Fichtenbaum CJ, et al. Frequency of Circulating Regulatory T Cells Increases during Chronic HIV Infection and Is Largely Controlled by Highly Active Antiretroviral Therapy. PLoS ONE. 2011; 6(12): e28118.
Seid M, D’Amico EJ, Varni JW, Munafo JK, Britto MT, Kercsmar CM, Drotar D, King EC, Darbie L. The In Vivo Adherence Intervention For at Risk Adolescents with Asthma: Report of a Randomized Pilot Trial. J Pediatr Psychol. 2012 May;37(4):390-403.
Setchell K, Brown N, Zhao X, Lindley S, Heubi J, King E, Messina J. Soy isoflavone phase II metabolism differs between rodents and humans: implications for the effect on breast cancer risk. Am J Clin Nutr. 2011; 94:1284-94.
Debrosse CW, Franciosi JP, King EC, Buckmeier Butz BK, Greenberg AB, Collins MH, Abonia JP, Assa'ad A, Putnam PE, Rothenberg ME. Long-term outcomes in pediatric-onset esophageal eosinophilia. J Allergy Clin Immunol. 2011.
DeBrosse CW, Collins MH, Butz BK Allen CL, King EC, Assa’ad AH, Abonia JP, Putnam PE, Rothenberg ME, Franciosi JP. Identification, epidemiology and chronicity of pediatric esophageal eosinophilia, 1982-1999. Journal of Allergy and Clinical Immunology. 2010; 126 (1), pp. 112-119.
Corey AE, Agnew JR, King EC, Parekh NJ, Powell JH, Thompson GA. Effect of Mild and Moderate Hepatic Impairment on Azimilide Pharmacokinetics Following Single Dose Oral Administration. Journal of Pharmaceutical Sciences. 2004; 93 (5), pp. 1279-1286.
Sorof JM, Cargo P, Graepel J, Humphrey D, King E, Rolf C, Cunningham R. b-Blocker/thiazide combination for treatment of hypertensive children: a randomized double-blind, placebo-controlled trial. Pediatric Nephrology. 2002; 17, pp. 345-350.
Chen KS, Bharaj SS, King EC. Induction and relief of nasal congestion in ferrets infected with influenza virus. International Journal of Experimental Pathology. 1995; 76, pp. 55-64.
King EC, Hart JD, Wehrly TE. Testing the Equality of Two Regression Curves Using Linear Smoothers. Statistics and Probability Letters. 1991; 12, pp. 239-247.
Ping-I (Daniel) Lin, MD, PhD
is a genetic epidemiologist and psychiatrist. His research interests have been focused on identifying genetic variants associated with neuropsychiatric diseases. Dr. Lin has discovered variants linked to clinical heterogeneity in bipolar disorder, Alzheimer’s disease and autism. He is also interested in paradoxical association findings and selection sweeps for candidate loci for schizophrenia and autism.
Genetic epidemiology; pharmacogenomics; clinical psychiatry
PhD: Johns Hopkins University, Baltimore, MD, 2005.
MD: National Taiwan University, Taiwan.
Residency: Psychiatry, National Taiwan University Hospital, Taiwan.
Certification: Psychiatry, 2012.
Lin PI, Chien YL, Wu YY, Chen CH, Gau SS, Huang YS, Liu SK, Tsai WC, Chiu YN. The WNT2 gene polymorphism associated with speech delay inherent to autism. Research in Developmental Disabilities. 2012;33(5):1533-40.
Lin PI, Shuldiner AR. Rethinking the genetic basis of diabetes and schizophrenia. Schizophr Res. 2010;123(2-3):234-43.
Tarasov KV, Sanna S, Scuteri A, Strait JB, Orrù M, Parsa A, Lin PI, Maschio A, et al. COL4A1 is associated with arterial stiffness by genome-wide association scan. Circulation Cardiovasc Genet. 2009;2(2):151-8.
Lin PI, Mitchell BM. Approaches for deciphering joint genetic determinants for schizophrenia and bipolar disorder. Schizophr Bull. 2008;34(4):791-7.
Lin PI, Vance JM, Pericak-Vance MA, Martin ER. No gene is an island: the flip-flop phenomenon. American Journal Human Genetics. 2007;80(3):531-8.
Lin PI, Martin ER, Bronson PG, Browning-Large CA, Small GW, Schmechel DE, Welsh-Bohmer KA, Haines JL, Gilbert JR, Pericak-Vance MA. Exploring the association of GAPD genes and late-onset Alzheimer disease. Neurology. 2006;67(1):64-8.
Chong RY, Uhart M, Yang X, Lin PI, Wand GS. The A118G Mu opioid receptor polymorphism is associated with heightened HPA axis response to opioid receptor blockade but not psychosocial stress. Neuropsychopharmacology. 2006;31(1):204-11.
Li YJ, Scott WS, Zhang L, Lin PI, Oliveira SA, Skelly T, Schmechel DE, Martin ER, Haines JL, Pericak-Vance MA, Vance JM. Revealing the role of Glutathione S-Transferace Omega-1 in age-of-onset data of Alzheimer disease. Neurobiology Aging. 2006;27(8):1087-93.
Lin PI, McInnis MG, Potash JB, MacKinnon DF, Willour V, DePaulo JR Jr, Zandi PP. Clinical correlates and familial aggregation of age at onset in bipolar disorder. American Journal of Psychiatry. 2006;163(2):240-6.
Lin PI, McInnis MG, Potash JB, MacKinnon DF, Willour V, Miao K DePaulo JR Jr, Zandi, PP. Assessment of the effect of age at onset on linkage to bipolar disorder: evidence on chromosomes 18p and 21q. American Journal of Human Genetics. 2005;77(4):545-55.
Jareen K. Meinzen-Derr, PhD
UC Department of Otolaryngology, Head & Neck Surgery, UC Department of Environmental Health
Pediatric hearing impairment; cochlear implant research; neonatal outcomes
Visit the More Than Hearing Loss web page.
Dr. Meinzen-Derr has a prolific publication background in the areas of health outcomes and clinical care for children who are deaf / hard of hearing and developmental disabilities. She is focused specifically on understanding the mechanisms behind language and functional outcomes in the subset of children with hearing loss who also have an additional developmental disability. In addition to hearing and deafness research, Dr. Meinzen-Derr collaborates on clinical research regarding premature infants. She currently teaches courses as part of the Clinical Research Training Program at the University of Cincinnati, Department of Environmental Health and supports the educational curricula for fellow research education within the Divisions of Neonatology, Developmental and Behavioral Pediatrics, and Pediatric Otolaryngology. She contributes to the biostatistics and epidemiology modules of the Pediatrics Fellowship Core curriculum and leads the experimental design lectures in neonatology and developmental and behavioral pediatrics. She has developed an online curriculum for the graduate program in biostatistics and epidemiology in the Department of Environmental Health and for the Center for Clinical and Translational Science and Training.
PhD: University of Cincinnati, Cincinnati, OH, 2006.
MPH: Univeristy of Alabama at Birmingham, Birmingham, AL, 1997.
South AP, Jones DE, Hall ES, Huo S, Meinzen-Derr J, Liu L, Greenberg JM. Spatial Analysis of Preterm Birth Demonstrates Opportunities for Targeted Intervention. Matern Child Health J. 2011 Feb 3.
Binder S, Hill K, Meinzen-Derr J, Greenberg JM, Narendran V. Increasing VLBW Deliveries at Subspecialty Perinatal Centers via Perinatal Outreach. Pediatrics. 2011 Mar;127(3):487-93.
Morrow AL, Meinzen-Derr J, Huang P, Schibler KR, Cahill T, Keddache M, Kallapur SG, Newburg DS, Tabangin M, Warner BB, Jiang X. Fucosyltransferase 2 Non-Secretor and Low Secretor Status Predicts Severe Outcomes in Premature Infants. J Pediatr. 2011 May;158(5):745-51.
Meinzen-Derr J, Wiley S, Grether S, Choo DI. Children with cochlear implants and developmental disabilities: A language skills study with developmentally matched hearing peers. Res Dev Disabil. 2011 Mar-Apr;32(2):757-67.
Slaughter JL, Meinzen-Derr J, Rose SR, Leslie ND, Chandrasekar R, Linard SM, Akinbi HT. The effects of gestational age and birth weight on false-positive newborn-screening rates. Pediatrics. 2010 Nov;126(5):910-6.
Choo D, Meinzen-Derr J. Universal newborn hearing screening in 2010. Curr Opin Otolaryngol Head Neck Surg. 2010 Oct;18(5):399-404. Review.
Akinbi H, Meinzen-Derr J, Auer C, Ma Y, Pullum D, Kusano R, Reszka KJ, Zimmerly K. Alterations in the host defense properties of human milk following prolonged storage or pasteurization. J Pediatr Gastroenterol Nutr. 2010 Sep;51(3):347-52.
Kaplan HC, Tabangin ME, McClendon D, Meinzen-Derr J, Margolis PA, Donovan EF. Understanding variation in vitamin A supplementation among NICUs. Pediatrics. 2010 Aug;126(2):e367-73.
Isemann B, Meinzen-Derr J, Akinbi H. Maternal and neonatal factors impacting response to methadone therapy in infants treated for neonatal abstinence syndrome. J Perinatol. 2011 Jan;31(1):25-9.
Giambra BK, Meinzen-Derr J. Exploration of the relationships among medical health history variables and aspiration. Int J Pediatr Otorhinolaryngol. 2010 Apr;74(4):387-92.
Early Language and Independent Functional Expectations (LIFE) of children who are deaf or hard of hearing. Principal Investigator. March of Dimes. 2014-2017.
Patterned experience for preterm infants. Co-Investigator. National Institutes of Health. 2011-2016.
Nicholas J. Ollberding, PhD
is a nutritional epidemiologist with research interests focused on the role of diet in the etiology and the survival of cancer, dietary assessment and analysis methodology, and the molecular epidemiology of cancer. His research incorporates the use of observational and experimental research designs, as well as innovative molecular-based technologies to examine diet-disease associations.
Nutritional epidemiology; cancer epidemiology; dietary assessment and analysis methodology; molecular epidemiology
Dr. Ollberding earned his PhD in behavioral nutrition with a specialization in nutritional epidemiology from Columbia University and completed postdoctoral fellowships in cancer epidemiology and prevention at the University of Hawaii Cancer Center and the University of Chicago. To date, he has published more than 20 peer-reviewed research articles in prestigious journals including the Journal of the National Cancer Institute, Blood, and Cancer Prevention Research. In addition, his research has been presented at national conferences and he has authored a book chapter in the area of nutritional epidemiology. Dr. Ollberding was the recipient of the Zerkowski Habas Foundation and Grace McLeod Scholarships while at Columbia University and received a National Cancer Institute funded postdoctoral fellowship.
Dr. Ollberding’s research is motivated by the fact that while diet and obesity are major contributors to morbidity and mortality in the U.S., few Americans consume diets in accordance with recommendations for optimal health or disease prevention. Specifically, his work aims to better understand the role of diet in the etiology and progression of cancer and other chronic diseases, as well as the impact of environmental- and policy-level factors on dietary behaviors including obesity. At Cincinnati Children’s, Dr. Ollberding conducts and provides support for nutritional and cancer epidemiology studies.
PhD: Columbia University, New York, 2009.
MPhil: Columbia University, New York, 2009.
MS: University of Cincinnati, Cincinnati, OH, 2008.
BS: Miami University, Oxford, OH, 2004.
Ollberding NJ, Kim Y, Wilkens LR, Shvetsov YB, Henderson BE, Le Marchand L, Kolonel LN, Goodman MT. Prediagnostic adiponectin, leptin, and C-reactive protein and breast cancer risk among postmenopausal women in the Multiethnic Cohort Study. Cancer Prev Res (Phila). 2013 Mar;6(3):188-95.
Ollberding NJ, Aschebrook-Kilfoy B, Caces DB, Smith SM, Wright ME, Weisenburger DD, Chiu B C-H. Phytanic acid and the risk of non-Hodgkin lymphoma. Carcinogenesis. 2013 Jan;34(1):170-5.
Ollberding NJ, Maskarinec G, Conroy SM, Morimoto Y, Franke AA, Cooney RV, Wilkens LR, Le Marchand L, Goodman MT, Hernandez BY, Henderson BE, Kolonel LN. Prediagnostic Carotenoid Levels and the Risk of Non-Hodgkin Lymphoma: The Multiethnic Cohort. Blood. 2012 Jun 14;119(24):5817-23.
Ollberding NJ, Wilkens LR, Henderson BE, Kolonel LN, Le Marchand L. Meat consumption, heterocyclic amines and colorectal cancer risk: The Multiethnic Cohort Study. Int J Cancer. 2012 Oct 1;131(7):E1125-33.
Ollberding NJ, Cheng I, Wilkens LR, Henderson BE, Kolonel LN, Le Marchand L. Genetic variants, prediagnostic circulating levels of insulin-like growth factors, insulin, and glucose and the risk of colorectal cancer: The Multiethnic Cohort Study. Cancer Epidemiol Biomarkers Prev. 2012 May;21(5):810-20.
Ollberding NJ, Lim U, Wilkens LR, Setiawan VW, Shvetsov YB, Henderson BE, Kolonel LN, Goodman MT. Legume, Soy, and Isoflavone Intake and Endometrial Cancer Risk: The Multiethnic Cohort Study. J Natl Cancer Inst. 2012 Jan 4;104(1):67-76.
Ollberding NJ, Nigg CR, Geller KS, Horwath CC, Motl RW, Dishman RK. Food outlet accessibility and fruit and vegetable consumption. Am J Health Promot. 2012 Jul;26(6):366-70.
Ollberding NJ, Maskarinec G, Wilkens LR, Henderson BE, Kolonel LN. Comparison of modifiable health behaviors between persons with and without cancer: The Multiethnic Cohort. Public Health Nutr. 2011 Oct;14(10):1796-804.
Ollberding NJ, Nomura AY, Wilkens LR, Henderson BE, Kolonel LN. Racial/Ethnic Differences in Colorectal Cancer Risk: The Multiethnic Cohort Study. Int J Cancer. 2011 Oct 15;129(8):1899-906.
Ollberding NJ, Wolf RL, Contento I. Food label use and its relation to dietary intake among US adults. J Am Diet Assoc. 2010 Aug;110(8):1233-7.
Patrick H. Ryan, PhD, MS
is an environmental epidemiologist with research interests in the fields of air pollution epidemiology and exposure assessment.
UC Department of Environmental Health
Epidemiology; air pollution; exposure assessment
To date, Dr. Ryan has authored more than 30 publications and has presented his research at numerous national and international conferences. He has received research funding from the National Institute of Environmental Health Sciences, the U.S. Environmental Protection Agency, the U.S. Department of Housing and Urban Development, the Centers for Disease Control and Prevention, as well as industry and private foundations. Dr. Ryan has also been an invited speaker at numerous national conferences and universities, a guest lecturer for environmental epidemiology courses at the University of Cincinnati, and has advised masters and doctoral students in epidemiology, biostatistics, and industrial hygiene in the Department of Environmental Health at the University of Cincinnati. In 2006 Dr. Ryan received a STAR award from the American Academy of Allergy, Asthma, and Immunology and in 2010 he was selected as one of ten science communication fellows by Environmental Health Sciences.
Dr. Ryan is the principal investigator of the Cincinnati Anti-Idling Campaign Study, an academic-community partnership to examine and reduce the impact of traffic-related air pollution at schools on children with asthma. He is also co-PI of a collaborative study to develop and field test, in a cohort of asthmatic children, a personal sensor to measure exposure to ultrafine particles. Dr. Ryan also serves as co-investigator of the Cincinnati Childhood Allergy and Air Pollution Study (CCAAPS), a longitudinal birth cohort study of the effects of diesel exhaust particles on the development of allergies and asthma. His research with the CCAAPS study includes the development of land-use regression models for air pollution exposure assessment and the association between air pollution and neurobehavioral development. Additional research includes studies of indoor pollutants and mold, environmental exposure to asbestos in Libby, MT, and the elemental composition of PM2.5.
PhD: Epidemiology, University of Cincinnati, Cincinnati, OH.
MS: Epidemiology, University of Cincinnati, OH.
Ryan PH, Reponen T, Simmons M, Yermakov M, Sharkey K, Garland-Porter D, Eghbalnia C, Grinshpun S. The Impact of an Anti-Idling Campaign on Outdoor Air Quality at Four Urban Schools. Environmental Science: Processes & Impacts. 2013; 15(11):2030-2037.
Newman NC, Ryan PH, LeMasters GK, Levin L, Bernstein D, Khurana-Hershey GK, Lockey JE, Villareal M, Reponen T, Grinshpun S, Sucharew H, Dietrich KN. Traffic Related Air Pollution Exposure in the First Year of Life and Behavioral Scores at Age Seven. Environmental Health Perspectives. 2013;121:731-736.
Eghbalnia C, Sharkey K, Garland-Porter D, Alam M, Crumpton M, Jones C, Ryan PH. A Community-Based Participatory Research Partnership to Reduce Vehicle Idling Near Public Schools. Journal of Environmental Health. 2013;75(9):14-20.
Ryan PH, Dihle M, Griffin S, Taylor R, Hilbert T, Adjei S, Lockey JE. Erionite in road gravel associated with interstitial and pleural changes – an occupational hazard in the western United States. Journal of Occupational and Environmental Medicine. 2011;53(8):893-899.
Ryan PH, Bernstein D, Reponen T, Levin L, Grinshpun S, Villareal M, Lockey J, Hershey GK, Burkle J, LeMasters GK. Exposure to traffic related-particles and endotoxin during infancy is associated with wheezing at age three. American Journal Respiratory and Critical Care Medicine. 2009;180:1068-1075.
Appatova AS, Ryan PH, LeMasters GK, Grinshpun SA. Proximal Exposure of Public Schools and Students to Major Roadways: A Nationwide US Survey. Journal of Environmental Planning and Management. 2008; 51(5):631-646.
Ryan PH, LeMasters GK, Levin L, Burkle J, Biswas P, Hu S, Grinshpun S, Reponen T. A Land-Use Regression Model for Estimating Microenvironmental Diesel Exposure Given Multiple Addresses From Birth Through Childhood. Science of the Total Environment. 2008;404:139-147.
Ryan PH, LeMasters GK. A review of land-use regression models for characterizing intraurban air pollution exposure. Inhalation Toxicology. 2007;19(Suppl 1):127-133.
Ryan PH, LeMasters GK, Biswas P, Levin L, Hu S, Lindsey M, Bernstein DI, Lockey J, Villareal M, Hershey GKK, Grinshpun SA. A comparison of proximity and land use regression traffic exposure models and wheezing in infants. Environmental Health Perspectives. 2007;115(2):278-284.
Ryan PH, LeMasters G, Biagini J, Bernstein D, Grinshpun SA, Shukla R, Wilson K, Villareal M, Burkle J, Lockey J. Is it traffic type, volume, or distance? Wheezing in infants living near truck and bus traffic. Journal of Allergy and Clinical Immunology. 2005;116:279-284. (Editor’s Choice article)
Heidi J. Sucharew, PhD
is a biostatistician with research interests in structural equation modeling, latent profile analysis, and latent variable modeling. Her recent areas of application include infant neurobehavior, stroke severity, adolescent menstrual symptoms and depression, and glucose control during pregnancy.
Structural equation modeling; latent profile analysis; latent variable modeling
Dr. Sucharew is a biostatistician with research interests in structural equation modeling, latent profile analysis, and latent variable modeling. Her recent areas of application include infant neurobehavior and stroke severity. Areas of applied research interest include infant neurobehavioral outcomes, stroke severity, and environmental exposures. To date, she has authored over 35 publications and has presented her research at numerous national and international conferences. Dr. Sucharew has been very active as a teacher. She contributes to the biostatistics and epidemiology modules of the Pediatrics Fellowship Core curriculum. She has also developed and is the primary instructor of "Introduction to Biostatistics" online course and has served as an invited lecturer in "Design and Management of Field Studies in Epidemiology" in the graduate program in biostatistics and epidemiology in the Department of Environmental Health.
BA: Statistics, The College of New Jersey, Ewing, NJ, 2000.
MS: Biostatistics, University of Washington, Seattle, WA, 2002.
PhD: Biostatistics, University of Cincinnati, Cincinnati, OH, 2009.
Sucharew H, Khoury J, Moomaw CH, Alwell K, Kissela BM, Belagaje S, Adeoye O, Khatri P, Woo D, Flaherty ML, Ferioli S, Heitsch L, Broderick JP, Kleindorfer D. Profiles of the National Institutes of Health stroke scale items as a predictor of patient outcome. Stroke. 44(9):2381-7. 2013.
Sucharew H, Khoury JC, Rao MB, Succop P, Bernstein D, Ryan PH, LeMasters G. Predicting allergic disease at age four using an atopy predisposition score at age two: the application of Item Response Theory. Pediatr Allergy Immunol. 23(2):195-201. 2012.
Sucharew H, Khoury JC, Xu Y, Succop P, Yolton K. NICU Network Neurobehavioral Scale profiles predict developmental outcomes in a low-risk sample. Paediatr Perinat Epidemiol. 26(4):344-52. 2012.
VanDyke R, Ren Y, Sucharew H, Miodovnik M, Rosenn B, Khoury JC. Characterizing maternal glycemic control: a more informative approach using semiparametric regression. J Matern Fetal Neonatal Med, 25(1):15-9. 2012.
Mackey J, Kleindorfer DO, Sucharew H, Moomaw CJ, Kissela BM, Alwell K, Flaherty ML, Woo D, Khatri P, Adeoye O, Ferioli S, Khoury JC, Hornung R, Broderick JP. Population-based study of wake-up strokes. Neurology. 76(19):1662-7. 2011.
Sucharew H, Ryan PH, Bernstein D, Succop P, Khurana Hershey GK, Lockey J, Villareal M, Reponen T, Grinshpun S, LeMasters G. Exposure to traffic exhaust and night cough during early childhood: the CCAAPS birth cohort. Pediatr Allergy Immunol. 21(2): 253-9. 2010.
Lerner S, Tangen C, Sucharew H, Wood D, Crawford ED. Failure to achieve a complete response to induction BCG therapy is associated with increased risk of disease worsening and death in patients with high risk non-muscle invasive bladder cancer. Urol Oncol. 27(2), 155-159. 2009.
Lerner S, Tangen C, Sucharew H, Wood D, Crawford ED. Patterns of recurrence and outcomes following bacillus calmette-guerin for high risk TA, T1 bladder cancer. J Urol. 177(5), 1727-1731. 2007.
Sucharew H, Goss CH, Millard SP, Ramsey B. Respiratory adverse event profiles in placebo subjects in short and long-term inhaled therapy trials. Contemp Clin Trials. 27(6), 561-70. 2006.
Brody AS, Sucharew H, Campbell JD, Millard SP, Molina PL, Klein JS, Quan J. Computed tomography correlates with pulmonary exacerbations in children with cystic fibrosis. Am J Respir Crit Care Med. 172(9), 1128-32. 2005.
Rhonda D. Szczesniak, PhD
is currently interested in statistical and epidemiological research, including functional data analysis applications, classification methods, self-modeling regressions, instrumental variables regression, and outcomes research for children with cystic fibrosis and obstructive sleep apnea. She was recently awarded a statistical methods development grant to further her research on ambulatory blood pressure monitoring and cardiac outcomes in children with obstructive sleep apnea.
PhD: Statistics, University of Kentucky, Lexington, KY, 2007.
MS: Statistics, University of Kentucky, Lexington, KY, 2005.
BS: Mathematics, Radford University, Radford, VA, 2003.
Grossoehme DH, Szczesniak R, Dodd C, Opipari-Arrigan L. Dyadic Adjustment and Spiritual Activities in Parents of Children with Cystic Fibrosis. Religions. Jun 2014;5(2):385-401.
Tan CC, McDowell KM, Fenchel M, Szczesniak R, Kercsmar CM. Spirometry Use in Children Hospitalized With Asthma. Pediatr Pulmonol. May 2014;49(5):451-457.
Szczesniak RD, McPhail GL, Duan LL, Macaluso M, Amin RS, Clancy JP. A semiparametric approach to estimate rapid lung function decline in cystic fibrosis. Annals of epidemiology. Dec 2013 2013;23(12):771-777.
Clancy JP, Szczesniak RD, Ashlock MA, et al. Multicenter Intestinal Current Measurements in Rectal Biopsies from CF and Non-CF Subjects to Monitor CFTR Function. PLoS One. Sep 2013;8(9):13.
Cudzilo CJ, Szczesniak RD, Brody AS, et al. Lymphangioleiomyomatosis Screening in Women With Tuberous Sclerosis. Chest. Aug 2013;144(2):578-585.
Pediatric Sleep Research Program. Biostatistics Mentor. K24 NIH/NHLBI. March 2011-Feb 2016.
MR predictors of infection, inflammation, and structural lung damage in CF. Biostatistician. R01 NIH. Sep 2012-June 2016.
Jessica Graus Woo, MHSA, PhD
is a molecular epidemiologist with particular research interest in the developmental pathways leading to pediatric obesity. She is specifically interested in how genetics and early life influences, especially early diet, may impact a child’s likelihood of developing obesity and specific metabolic complications of obesity, such as insulin resistance and dyslipidemia.
Molecular epidemiology; pediatric obesity; genetics and early life influences on obesity; insulin resistance; dyslipidemia
BA: Cornell University, Ithaca, NY, 1993.
MHSA: University of Michigan, Ann Arbor, MI, 1995.
PhD: University of Cincinnati, Cincinnati, OH, 2004.
Krawczeski CD, Vandevoorde RG, Kathman T, Bennett MR, Woo JG, Wang Y, Griffiths RE, Devarajan P. Serum cystatin C is an early predictive biomarker of acute kidney injury after pediatric cardiopulmonary bypass. Clin J Am Soc Nephrol. 2010 Sep;5(9):1552-7.
Elder DA, Woo JG, D'Alessio DA. Impaired beta-cell sensitivity to glucose and maximal insulin secretory capacity in adolescents with type 2 diabetes. Pediatr Diabetes. 2010 Aug;11(5):314-21.
Martin LJ, Woo JG, Morrison JA. Evidence of shared genetic effects between pre- and postobesity epidemic BMI levels. Obesity (Silver Spring).2010 Jul;18(7):1378-82.
Tabangin ME, Woo JG, Martin LJ. The effect of minor allele frequency on the likelihood of obtaining false positives. BMC Proc. 2009 Dec 15;3 Suppl 7:S41.
Woo JG, Guerrero ML, Altaye M, Ruiz-Palacios GM, Martin LJ, Dubert-Ferrandon A, Newburg DS, Morrow AL. Human milk adiponectin is associated with infant growth in two independent cohorts. Breastfeed Med. 2009 Jun;4(2):101-9.
Lomenick JP, Reifschneider KL, Lucky AW, Adams D, Azizkhan RG, Woo JG, Backeljauw PF. Prevalence of adrenal insufficiency following systemic glucocorticoid therapy in infants with hemangiomas. Arch Dermatol. .2009 Mar;145(3):262-6.
Woo JG, Zeller MH, Wilson K, Inge T. Obesity identified by discharge ICD-9 codes underestimates the true prevalence of obesity in hospitalized children. J Pediatr. 2009 Mar;154(3):327-31.
Martin LJ, Gao G, Kang G, Fang Y, Woo JG. Improving the signal-to-noise ratio in genome-wide association studies. Genet Epidemiol. 2009;33 Suppl 1:S29-32.
Woo JG. Using body mass index Z-score among severely obese adolescents: a cautionary note. Int J Pediatr Obes. 2009;4(4):405-10.
Hugo ER, Brandebourg TD, Woo JG, Loftus J, Alexander JW, Ben-Jonathan N. Bisphenol A at environmentally relevant doses inhibits adiponectin release from human adipose tissue explants and adipocytes. Environ Health Perspect. 2008 Dec;116(12):1642-7.
Bin Zhang, PhD
conducts research on statistical methods in clinical trials, survival analysis, longitudinal data analysis and optimal designs. Areas of interest: cancer, infectious diseases, asthma, cardiovascular diseases, health behavior, cohort studies, case-control studies, and clinical trials.
BS: University of Science and Technology of China, Hefei, Anhui, China.
PhD: University of Missouri, Columbia, Missouri.
Acelajado MC, Pisoni R, Dudenbostel T, Dell’Italia LJ, Cartmill F, Zhang B, Cofield SS, Oparil S, Calhoun DA. Refractory hypertension: definition, prevalence and patient characteristics. J Clin Hyperten. 2012;14(1):7-12.
Katkoori VR, Shanmugam C, Jia X, Salih C, Sthanam M, Chen D, Zhang B, Bumpers HL, Callens T, Messiaen LM, Grizzle WE, Manne U. Prognostic significance and gene expression profiles of p53 mutations in microsatellite-stable stage III colorectal adenocarcinomas. PloS One. 2012;7(1):1-10.
Bovell L, Shanmugam C, Katkoori VR,; Zhang B, Vogtmann E, Grizzle WE, Manne U. microRNAs are Stable in Colorectal Cancers Archival Tissue Blocks. Frontiers in Bioscience. 2012 Jan 1;4:1937-40.
Gerald LB, McClure LA, Gerald JK, Zhang B, Harrington K, Bailey WC. Seasonal Influenza and H1N1 vaccine prevalence among children with asthma. Am J Respiratory Critical Care Medicine. 2011 May;183:A4153.
Shanmugam C, Hines RB, Jhala NC, Katkoori VR, Zhang B, Posey JA, Bumpers HL, Grizzle WE, Eltoum IE, Siegal GP, Manne U. Evaluation of lymph node numbers for adequate staging of Stage II and III colon cancers. J Hematol and Oncolo. 2011 May;4(1):25.
Gerald JK, McClure LA, Zhang B, Harrington K, Bailey WC, Gerald LB. Predictors of hand sanitizer use at home among children with asthma. Am J Respiratory Critical Care Medicine. 2011 May;183:A3792.
Yang M, Zhang B, Huang SG. Optimal designs for generalized linear models with multiple design variables. Statistica Sinica. 2011;21:1415-1430
Subramaniam A, Kim KH, Bryant SA, Zhang B, Sikes C, Kimball KJ, Kilgore LC, Huh WK, Straughn JM Jr., Alvarez RD. A cohort study evaluating robotic versus laparotomy surgical outcomes of obese women with endometrial carcinoma. Gynecology Oncology. 2011;122(3):604-7.
Fauci J, Whitworth J, Subramanian A, Zhang B, Frederick PJ, Schneider K, Straughn JM, Kilgore LC. Prognostic significance of the relative dose intensity of chemotherapy in primary treatment of epithelial ovarian cancer. Gynecology Oncology. 2011;122(3):532-5.
Zhang B, Tong XW, Sun JG. Efficient estimation for the proportional odds model with bivariate current status data. Far East J Theoretical Statistics. 2009;(1):113-132.
Nanhua Zhang, PhD
is a faculty biostatistician with research interests in developing new methods for handling missing data, comparative effectiveness research, clinical trial design, meta-analysis, scale development, and joint modeling. His applied interests include environmental health, community-based intervention, health disparity, behavioral intervention and health psychology.
Missing data; comparative effectiveness; clinical trial design; meta-analysis; scale development; joint modeling; environmental health; community-based intervention; health disparity; behavioral intervention; health psychology
Dr. Zhang earned his PhD in biostatistics from the University of Michigan in Ann Arbor. Prior to joining Cincinnati Children’s Hospital Medical Center, he was a faculty member at the University of South Florida in Tampa. His statistical methodology research has covered missing data, causal inference, clinical trial design, joint modeling and meta-analysis. His applied research interests include environmental health, community-based intervention, health disparity, behavioral intervention and health psychology. His research “early childhood lead exposure on academic achievement” received media coverage on TV, radio, newspapers, magazines, and various online media such as Time.com and Yahoo.com.
Dr. Zhang has authored 20 published papers and made numerous presentations at national and international conferences. He has served as a reviewer for 15 different journals including: Biometrika, Statistics in Medicine, Statistics Sinica, Annals of Applied Statistics, American Journal of Public Health, Annals of Epidemiology, Health Education Research. He has taught graduate and advanced doctoral courses in linear models, survival analysis and statistical computing.
BS: Shanghai University of Finance and Economics, Shanghai, China.
MS: Bowling Green State University, Bowling Green, OH.
PhD: University of Michigan, Ann Arbor, MI.
Zhang N, Little RJA. Subsample ignorable likelihood for accelerated failure time models with missing predictors. Lifetime Data Anal. 2014 Aug 5.
Huang Y, Xing D, Zhang N, Chen H. Jointly Modeling Event Time and Skewed-Longitudinal Data with Missing Response and Mismeasured Covariate. J Biopharm Stat. 2014 Jun 6.
Zhang N, Chen H, Zou Y. A joint model of binary and longitudinal data with non-ignorable missingness, with application to marital stress and late life depression. J Applied Statistics. 2014;41(5);1028-39.
Brannick MT, Zhang N. Bayesian Meta-analysis of Coefficient Alpha. Res Synthesis Methods. 2013;4(2):198-207.
Chen H, Zhang N, Lu X, Chen S. Caution regarding the choice of standard deviations to guide sample size calculations in clinical trials. Clin Trials. 2013 Aug;10(4)522-9.
Zhang N, Baker HW, Tufts M, Raymond RE, Salihu H, Elliott MR. Early childhood lead exposure and academic achievement: evidence from Detroit Public Schools (2008-2010). Am J Public Health. 2013 Mar;103(3):e72-7.
Zhang N, Little RJA. A pseudo-Bayesian approach to regression with missing covariates. Biometrics. 2012 Sep;68(3):933-42.
Little RJA, Zhang N. Subsample ignorable likelihood for regression with missing data. J R Stat Soc Ser C Appl Stat. 2011;60, 591-605.
Resnicow K, Zhang N, Vaughan R, Reddy SP, James S, Murry DM. When intraclass correlation coefficients go awry: a case study from a school-based smoking prevention study in South Africa. Am J Public Health. 2010 Sep;100(9):1714-48.
Resnicow K, Davis RE, Zhang N, Strecher VJ, Tolsma D, Calvi J, Alexander G, Anderson JP, Wiese C. Tailoring a fruit and vegetable intervention on ethnic identity: results of a randomized study. Health Psychol. 2009 Jul;28(4):394–403.
Melinda S. Butsch Kovacic, MPH, PhD
is an epidemiologist who has clinical, translational and community-based participatory research projects. Her research group studies the genetic/epigenetic, environmental and socioeconomic basis of chronic diseases such as cancer, asthma and obesity, with specific interest in understanding how environmental exposures modify risk in vulnerable families. Her research is highly interdisciplinary with collaborators across the academic health center and in the community.
Visit the Butsch Kovacic Lab.
Clinical and molecular epidemiology; gene-environment interactions; biomarkers; community-based participatory research
One of Dr. Butsch Kovacic’s long-term goals is to improve the understanding of how the environment modifies chronic disease risk in genetically and/or economically vulnerable children. To this end, she is the PI of an ongoing study that is evaluating associations between environmental exposures and biomarkers of oxidative stress and whether or not these biomarkers will better predict risk of severe/uncontrolled childhood asthma compared to parental report of exposure alone (previous NIEHS R21 and CCTST KL2). As part of this study, her team is evaluating diesel exhaust particle and second hand tobacco smoke exposures, as well as obesity levels, markers of inflammation and antioxidant status, genetic and socioeconomic factors, and DNA methylation patterns. As her preliminary data revealed strong associations between her outcomes and socioeconomic factors, over the last year, she has partnered with Cincinnati’s CoreChange, a grassroots advocacy group, and Seven Hills Neighborhood Houses (SHNH; http://7hillsnh.org/), a full service social service agency and community center in the West End of Cincinnati, to expand her research into the community using a community-based participatory research (CBPR) approach. To this end, she has implemented a community-based research registry and begun needs assessments using a child-centered PhotoVoice approach and adult focus groups. A peer family health COACH (Coaching On Achieving Community Health) program will begin soon. To inform these community-based studies, she is collaborating on a project seeking to develop unique multimedia educational materials targeting low-income and low-literacy caregivers with asthmatic children.
In addition to these studies, she is also the PI of an ongoing longitudinal epidemiological study seeking to evaluate environmental and sexual exposure to human papillomavirus (HPV) in families with children diagnosed with Fanconi anemia (current NHLBI R01). Individuals with Fanconi anemia are genetically vulnerable to squamous head and neck cancers previously shown to be positively associated with HPV. Her team is testing for oral HPV DNA, HPV serological markers as well as markers of immune response. As part of this study, Dr. Butsch Kovacic regularly interacts with a community of families associated with the Fanconi Anemia Research Fund, a strong parent-led advocacy group focused on the improving the lives of children with Fanconi anemia, to design, optimize and disseminate the findings from her study.
MPH: Quantitative Methods, Harvard University School of Public Health, Boston, MA, 2003.
PhD: Biochemistry, the Ohio State University, Columbus, OH, 2002.
Postdoctoral Fellowship: Epidemiology/Public Health, Cancer Prevention Fellowship, Hormonal and Reproductive Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, 2002-2006.
Somineni HK, Zhang X, Biagini Myers JM, Kovacic MB, Ulm A, Jurcak N, Ryan PH, Khurana Hershey GK, Ji H. Ten-eleven translocation 1 (TET1) methylation is associated with childhood asthma and traffic-related air pollution. J Allergy Clin Immunol. 2015 Dec 9.
Butsch Kovacic M, Martin LJ, Biagini Myers JM, He H, Lindsey M, Mersha TB, Ji H, Khurana Hershey GK. Genetic Approach Identifies Distinct Asthma Pathways In Overweight vs. Normal Weight Children. Allergy. 2015 May 23.
Mersha TB, Martin LJ, Biagini Myers JM, Kovacic MB, He H, Lindsey M, Sivaprasad U, Chen W, Khurana Hershey GK. Genomic Architecture of Asthma Differs by Sex. Genomics. 2015 Mar 25.
Sauter SL, Wells SI, Zhang X, Hoskins EE, Davies SM, Myers KC, Mueller R, Panicker G, Unger ER, Sivaprasad U, Brown DR, Mehta PA, Butsch Kovacic M. Oral human papillomavirus is common in individuals with Fanconi Anemia. Cancer Epidemiol Biomarker Prev. 2015 Mar.
Katzenellenbogen RA, Carter JJ, Stern JE, Butsch Kovacic MS, Mehta PA, Sauter SL, Galloway DA, Winer RL. Skin and Mucosal Human Papillomavirus Seroprevalence in Persons with Fanconi Anemia. Clin Vaccine Immunol. 2015 Apr;22(4):413-20.
Kovacic MB, Stigler S, Smith A, Kidd A, Vaughn LM. Beginning a Partnership with Photo Voice to Explore Environmental Health and Health Inequities in Minority Communities. Int J Environ Res Public Health. 2014 Oct 27;11(11):11132-51.
Winer RL, Huang CE, Cherne S, Stern JE, Butsch Kovacic MS, Mehta PA, Sauter SL, Galloway DA, Katzenellenbogen RA. Detection Of Human Papillomavirus In The Oral Cavities Of Persons With Fanconi Anemia. Oral Dis. 2015 Apr;21(3):349-54.
Biagini Myers JM, Martin LJ, Butsch Kovacic M, Mersha TB, He H, Pilipenko V, Lindsey MA, Ericksen MB, Bernstein DI, LeMasters GK, Lockey JE, Khurana Hershey GK. Epistasis between serine protease inhibitor Kazal-type 5 (SPINK5) and thymic stromal lymphopoietin (TSLP) genes contributes to childhood asthma. J Allergy Clin Immunol. 2014 Oct;134(4):891-899.
Brandt EB, Kovacic MB, Lee GB, Gibson AM, Acciani TH, Le Cras TD, Ryan PH, Budelsky AL, Khurana Hershey GK. Diesel exhaust particle induction of IL-17A contributes to severe asthma. J Allergy Clin Immunol. 2013 Nov:132(5): 1194-1204.
Epstein TG, LeMasters GK, Bernstein DI, Ericksen MB, Martin LJ, Ryan PH, Biagini Myers JM, Butsch Kovacic MS, Lindsey MA, He H, Reponen T, Villareal MS, Lockey JE, Bernstein CK, Khurana Hershey GK. Genetic variation in small proline rich protein 2B as a predictor for asthma among children with eczema. Ann Allergy Asthma Immunol. 2012 Mar;108(3):145-50.
Fanconi Anemia as a Model for Susceptibility to Human Papillomavirus Infection. Principal Investigator. NIH/NHLBI. July 2011-Jun 2016.
Epithelial Genes in Allergic Inflammation. Co-Investigator. NIH/NIAID Asthma and Allergic Diseases Cooperative Research Center. July 2011-June 2016.
David M. Hartley, PhD, MPH
investigates the factors governing the emergence and transmission of infectious diseases by applying mathematical modeling and computer simulation methods. He is also interested in data analytic and information technology approaches for understanding and improving communications in healthcare settings and improving patient safety.
Infectious disease epidemiology; public health surveillance; mathematical and computer modeling
PhD: University of Maryland Baltimore County, Baltimore, MD, 1996.
MPH: George Washington University, Washington, DC, 2006.
Smith DL, Perkins TA, Reiner Jr RC, Barker CM, Niu T, Chaves LF, Ellis AM, George DB, Le Menach A, Pulliam J, Bisanzio D, Buckee C, Chiyaka C, Cummings DAT, Garcia AJ, Gatton ML, Gething PW, Hartley DM, Johnston G, Klein EY, Michael E, Lindsay SW, Lloyd AL, Pigott DM, Reisen WK, Ruktanonchai N, Singh B, Stoller J, Tatem AJ, Kitron U, Hay SI, Scott TW. Recasting the Theory of Mosquito-Borne Pathogen Transmission Dynamics and Control. Trans R Soc Trop Med Hyg. 2014 Apr;108(4):185-87.
Hartley DM. Using social media and other Internet data for public health surveillance: The importance of talking. Milbank Q. 2014 Mar;92(1):34-9.
Barboza P, Vaillant L, Le Strat Y, Hartley DM, Nelson NP, Mawudeku A, Madoff LC, Linge JP, Collier N, Brownstein JS, Astagneau P. Factors influencing performance of Internet-based biosurveillance systems used in epidemic intelligence for early detection of infectious diseases outbreaks. PLoS One. 2014 Mar 5;9(3):e90536.
Hartley DM, Nelson NP, Arthur RR, Barboza P, Collier N, Lightfoot N, Linge JP, van der Goot E, Mawudeku A, Madoff LC, Vaillant L, Walters R, Yangarber R, Mantero J, Corley CD, Brownstein JS. An overview of Internet biosurveillance. Clin Microbiol Infect. 2013 Nov;19(11):1006-13.
Barker CM, Niu T, Reisen WK, Hartley DM. Data-driven modeling to assess receptivity for Rift Valley fever virus. PLoS Negl Trop Dis. 2013 Nov 14;7(11): e2515.
Nelson NP, Brownstein J, Hartley DM. Event-based biosurveillance of respiratory disease in Mexico, 2007-2009: Connection to influenza A(H1N1)v? Euro Surveill. 2010 Jul 29;15(30).
Nelson NP, Yang L, Reilly AR, Hardin JE, Hartley DM. Event-based Internet Biosurveillance: Relation to Epidemiological Observation. Emerg Themes Epidemiol. 2012 Jun 18;9(1):4.
Hartley DM, Barker CM, Le Menach A, Niu T, Gaff HD, Reisen WK. The effects of temperature on the emergence and seasonality of West Nile virus in California. Am J Trop Med Hyg. 2012 May;86(5):884-94.
Hartley DM, Morris JG Jr, Smith DL. Epidemiological Implications of Hyperinfectivity: A critical element in the ability of V. Cholerae to cause epidemics? PloS Med. 2006 Jan;3(1):e7.
Niu T, Gaff HD, Papelis YE, Hartley DM. An epidemiological model of Rift Valley fever with spatial dynamics. Comput Math Methods Med. 2012;2012:138757.
Adam Lane, PhD
has methodological research interests in designs for phase I/II clinical trials, survival analysis and structural equation modeling. Dr. Lane is also a dedicated collaborator with both clinical and basic science researchers in bone marrow transplantation, hematology, oncology and cancer biology.
Clinical trials; survival analysis; structural equation modeling
Dr. Lane joined Cincinnati Children's in July 2013. He has published novel statistical methods in the areas of adaptive and optimal experimental designs with applications to phase I and phase II clinical trials. As a graduate student he received funding from the NIH to spend the fall semester of 2011 at the University of Cambridge in the Isaac Newton Institute for Mathematical Sciences. He has also received NSF travel awards to present his research at national and international conferences.
Lane A, Ping Y, Flournoy N. Information in a two-stage adaptive optimal design. J Statist Plan Inference. 2014 Jan 144:173-87.
Lane A, Segura-Cabrera A, Komurov K. A comparative survey of functional footprints of EGFR pathway mutations in human cancers. Oncogene. 2014 Oct 23;33(43):5078-89.
Lane A, Flournoy N. Two-stage adaptive optimal design with fixed first stage sample size. Journal of Probability and Statistics. 2012.
Lisa J. Martin, PhD
is a statistical geneticist. Dr. Martin’s goal is to advance knowledge of disease processes by integrating statistical genetics with biology and epidemiology. Through independent and collaborative research, she expects to translate genetic findings to clinical utility by developing of innovative methods and aiding researchers in designing appropriate studies to address the questions at hand.
Statistical genetics; allergic conditions; pediatric heart conditions; obesity
As a statistical geneticist, Dr. Martin’s goal is to advance
knowledge of underlying disease processes by improving our understanding of
genetic variation in human populations through the integration of statistical
genetics with biology and epidemiology. Since joining Cincinnati Children’s in
2002, Dr. Martin has become a leader in quantitative genetics through independent
and collaborative research, leadership, and teaching/mentoring. Her independent
research focuses on development of novel statistical methods and the evaluation
of methods for next generation data.
Recently, Dr. Martin published a novel statistical method
(Variant Impact On Linkage Effect Test; VIOLET), which overcomes a
methodological barrier to gene discovery.
Her collaborative research focuses on allergic conditions (asthma,
eosinophilic esophagitis), pediatric heart conditions, and obesity. In addition, Dr. Martin assists researchers
with an interest in incorporating genetics into their research. At the end of 2013, Dr. Martin had published
116 peer-reviewed publications (journals include Nature Genetics, PNAS, Journal
of Clinical Endocrinology and Metabolism) and two book chapters.
She has a strong commitment to teaching and mentorship.
Beyond teaching, she has mentored over 30 individuals. Additionally, Dr. Martin
is the co-director of the Cincinnati Genomic Control Cohort, an institutional resource
of 1,020 population representative children with phenotypic and genetic
information. Under Dr. Martin’s
leadership, utilization of this cohort has increased.
In summary, Dr. Martin’s work has resulted in the
development of an exciting research program as well as fruitful collaborations
while balancing mentoring and service. She expects that this research will enable the translation of genetic
findings to clinical utility through the development of innovative methods and
greater capacity to perform complex genetic analyses particularly given the
rapid evolution of technologies.
PhD: (with Honors) University of Kansas, Lawrence, KS, 1999.
Post-doctoral fellow: Southwest Foundation for Biomedical Research, San Antonio, TX, 2002.
Martin LJ, Ding L, Zhang X, Kissebah AH, Olivier M, Benson
novel method, the Variant Impact On Linkage Effect Test (VIOLET), leads to
improved identification of causal variants in linkage regions. Eur J
Hum Genet. 2014 Feb;22(2):243-7.
Martin LJ, Gupta J, Jyothula SSSK, Butsch Kovacic M, Biagini
Myers JM, Patterson TL, Ericksen MB, He H, Gibson AM, Baye TM, Amirisetty S,
Tsoras AM, Sha Y, Eissa NT, Hershey GK. Functional variant in the autophagy-related
5 gene promoter is associated with childhood asthma. PLoS One. 2012;7(4):e33454.
Kottyan LC, Woo JG, Keddache M, Banach W, Crimmins NA, Dolan
LM, Martin LJ. Novel variations in the
adiponectin gene (ADIPOQ) may affect distribution of oligomeric complexes. SpringerPlus.
Chidambaran C, Ngamprasertwong P, Esslinger HR, Prows C, Zhang X, Martin
LJ, McAuliffe J. Race and unequal burden
of perioperative pain and opioid related adverse effects in children. Pediatrics.
Martin LJ, Lee SY, Couch SC, Morrison J, Woo JG. Shared
genetic contributions of fruit and vegetable consumption with body mass index
in families 20 years after sharing a household. Am J Clin
Nutr. 2011 Oct;94(4):1138-43.
Martin LJ, Hinton RB, Zhang Z, Cripe LH, Benson DW. Aorta
measurements are heritable and influenced by bicuspid aortic valve. Front Genet.
2011 Sep 5;2:61.
Martin LJ, Woo JG, Morrison JA. Evidence Of Shared Genetic Effects Between Pre And Post Obesity Epidemic
BMI Levels. Obesity. 2010 Jul;18(7):1378-82.
Rothenberg ME, Spergel JM, Sherrill JD, Annaiah K, Martin
LJ, Cianferoni A, Gober L, Kim C, Glessner J, Frackelton E, Thomas K, Blanchard
C, Liacouras C, Verma R, Aceves S, Collins MH, Brown-Whitehorn T, Putnam PE,
Franciosi JP, Chiavacci RM, Grant SF, Abonia JP, Sleiman PM, Hakonarson H. Common variants at 5q22 associate with
pediatric eosinophilic esophagitis. Nat
Genet. 2010 Apr;42(4):289-91.
Martin LJ, Ramachandran V, Cripe LH, Hinton RB, Andelfinger
G, Tabangin M, Shooner K, Keddache M, Benson DW. Evidence in Favor of Linkage to Human Chromosomal Regions 18q, 5q and
13q for Bicuspid Aortic Valve and Associated Cardiovascular Malformations. Hum Gen.
Martin LJ, Woo JG, Daniels SR, Goodman E, Dolan
LM. The Relationships of Adiponectin
with Insulin and Lipids Are Strengthened with Increasing Adiposity. J Clin Endocrinol
Metab. 2005 Jul;90(7):4255-9.
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