Mekibib Altaye, PhD
is a biostatistician interested in the design and analysis of correlated data, including developing inference procedures for intraclass correlation, and kappa statistic for binary and polynomial outcomes. Current research interest focused in modeling issues associated with high dimensional data that arise from fMRI, MRI and microbiome studies. He also mentors junior faculty, staff and students.
513-636-5849
mekibib.altaye@cchmc.org
Mekibib Altaye, PhD
Academic Information
Associate Professor, UC Department of Pediatrics
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Specialties
Design and analysis of correlated data. This includes developing inference procedures for intraclass correlation, and kappa statistic for binary and polynomial outcomes. Recent research interest includes modeling issues associated with high dimensional data that arise from fMRI, MRI and microbiome studies.
Biography
Dr. Altaye has published more than 60 peer-reviewed articles, more than 70 abstracts/posters, invited to present his work in national meetings and co-author a book chapter. He has been a co-investigator, collaborator or biostatistician in more than 20 NIH funded projects. Dr. Altaye provides support for researchers in multiple divisions as well as for the Center for Clinical and Translational Sciences and Training (CCTST). He taught biostatistics courses for the Master of Science Clinical and Translational Research program. He has obtained travel awards to attend workshops from NSF and NIH. One of his articles received a Caffey award for best clinical science or education paper from the Pediatric Radiology Society.
Education and Training
PhD: The University of Western Ontario, London, Canada, 1998. MSc: Oklahoma State University, Stillwater, OK, 1991. BSc: Addis Ababa Universtiy, Addis Ababa, Ethiopia, 1983.
Publications
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Szaflarski JP, Rajagopal A, Altay M, Byars AW, Jacola L, Schmithorst VJ, Schaprio MB, Plante E, Holland SK. Left-handedness and language lateralization in children. Brain Research. 1433: 85-97. 2012. Cecil KM, Dietrich KN, Altaye M, Egelhoff JC, Lindquist DM, Brubaker CJ, Lanphear BP. Proton magnetic resonance spectroscopy in adults with childhood lead exposure. Environmental Health Perspective. Mar;119(3):403-8. 2011. Yuan W, Altaye M, Ret J, Schmithorst VJ Byars AW, Plante E, Holland SK. Quantification of children’s head motion in various fMRI language tasks. Human Brain Mapping. 30(5): 1481-9. 2009. Langberg, JM., Epstein, JN., Altaye M., Molina, B., Arnold, E., Vitiello, B. The transition to middle school is associated with changes in the developmental trajectory of ADHD symptomatology in young adolescents with ADHD. Journal of Clinical Child and Adolescent Psychology. 37(3): 651-63. 2008. Eaton KP, Szaflarski JP, Altaye M, Ball AL, Kissela BM, Banks C, Holland SK. Reliability of fMRI for studies of language in post-stroke aphasia subjects. NeuroImage. 41(2): 311-22. 2008. Wilke M, Holland SK, Altaye M, Gaser C. Template-o-matic: a toolbox for creating customized pediatric templates. NeuroImage. 41(3): 903-13. 2008. Altaye M, Holland SK, Wilke M, Gaser C. Infant brain probability templates for MRI segmentation and normalization. NeuroImage. 43(4): 721-30. 2008. Szaflarski JP, Schmithorst VJ, Altaye M, Byars AW, Rett J, Plante E, Holland SK. A longitudinal fMRI study of language development in children age 5-11. Annals of Neurology. 59(5): 796-807. 2006. Altaye M, Donner A, Eliasziw M. A general goodness of fit approach for inference procedures concerning the kappa statistic. Statistics in Medicine. 16: 2479-2488. 2001. Altaye M, Donner A, Klar N. Inference procedures for assessing interobserver agreement among multiple raters. Biometrics. 57: 584-588. 2001.
Grants
Pediatric Functional Neuroimaging Research Network. Biostatistician. NIH/NICHD. 09/2009-09/2014. Neurobehavioral Effects of Insecticide Exposure in Pregnancy and Early Childhood. Biostatistician. NIH. 09/2009-06/2012. Role of Human Milk in Infant Nutrition and Health. Co-Investigator. NIH/NICHD. 08/2009-06/2013. Longitudinal DTI Study in Children Treated for congenital Hydrocephalus. Biostatistician. NIH. 09/2009-06/2013. Center for Clinical and Translational Science and Training. Biostatistician NIH/NCRR. 04/2009-03/2014. Treatment of maternal depression in home visitation: Mother and Child impacts. Co-investigator. NIH/NIMH. 12/2009-11/2014. Imaging the effect of centrotemporal spikes and seizures. Biostatistician. NIH/NIND. 09/2011-06/2016. Multisite Study of School Based Treatment Approaches for ADHD Adolescents. Biostatistician. NIH/NIMH. 08/2009-03/2014.
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Katherine A. Bowers, PhD, MPH
Academic Information
Assistant Professor, UC Department of Pediatrics
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Specialties
Perinatal and genetic epidemiology; autism spectrum disorders; prenatal exposures; pregnancy complications
Education and Training
PhD: Johns Hopkins Bloomberg School of Public Health, Baltimore, MD.
Publications
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Bowers K, Tobias DK, Yeung E, Hu FB, Zhang C. A prospective study of pre-pregnancy dietary fat intake and risk for gestational diabetes. Am J of Clin Nutr. 2012; 95: 446-53. Tobias DK, Zhang C, Chavarro J, Bowers K, Rich-Edwards J, Rosner B, Mozaffarian D, Hu FB. Pre-pregnancy adherence to dietary patterns and decreased risk of gestational diabetes mellitus. Am J Clin Nutr. 2012 Aug; 96 (2): 289-95. Bowers K, Zhang C. The association between obesity and diabetes in pregnancy and neurodevelopmental outcomes in the offspring. North American Journal of Medicine and Science. 20114(4): 217-22. Bowers K, Yeung E, Williams MA, Qi L, Tobias DK, Hu FB, Zhang C. A prospective study of prepregnancy dietary iron intake and risk for gestational diabetes mellitus. Diabetes Care. 2011 Jul; 34(7):1557-63. Bowers K, Li Q, Bressler J, Avramopoulos D, Newschaffer C, Fallin MD. Glutathione pathway gene variation and risk of autism spectrum disorders. J Neurodev Disord. 2011 Jun; 3(2):132-43. Bowers K, Liu G, Wang P, Ye T, Tian Z, Liu E, Yu Z, Yang X, Klebanoff M, Yeung E, Hu G, Zhang C. Birth weight, postnatal weight change, and risk for high blood pressure among Chinese children. Pediatrics. 2011 May; 127(5):e1272-9. Schwender H, Bowers K, Fallin MD, Ruczinski I. Importance measures for epistatic interactions in case-parent trios. Ann Hum Genet. 2011 Jan;75(1):122-32. Tobias DK, Zhang C, van Dam RM, Bowers K, Hu FB. Physical activity before and during pregnancy and risk of gestational diabetes mellitus: a meta-analysis. Diabetes Care. 2011 Jan;34(1): 223-9. Schisterman E, Whitcomb B, Bowers K. Invited commentary: causation or “noitasuac”? Am J Epidemiol. 2011 May 1;173(9):984-7. Bowers K, Albanes D, Limburg P, Pietinen P, Taylor PR, Virtamo J, Stolzenberg-Solomon R. A prospective study of anthropometric and clinical measurements associated with insulin resistance syndrome and colorectal cancer in male smokers. Am J Epidemiol. 2006 Oct;164(7):652-64.
Grants
Supplemental iron, oxidative stress and gestational diabetes. Principal Investigator. Office of Dietary Supplements, NIH. Jun 2012-Jun 2013.
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Melinda S. Butsch Kovacic, MPH, PhD
is an epidemiologist who has clinical, translational and community-based participatory research projects. Her research group studies the genetic/epigenetic, environmental and socioeconomic basis of chronic diseases such as cancer, asthma and obesity, with specific interest in understanding how environmental exposures modify risk in vulnerable families. Her research is highly interdisciplinary with collaborators across the academic health center and in the community.
513-803-0130
melinda.butsch.kovacic@cchmc.org
Melinda S. Butsch Kovacic, MPH, PhD
Academic Information
Assistant Professor, UC Department of Pediatrics
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Specialties
Clinical and molecular epidemiology; gene-environment interactions; biomarkers; community-based participatory research
Biography
One of Dr. Butsch Kovacic’s long-term goals is to improve the understanding of how the environment modifies chronic disease risk in genetically and/or economically vulnerable children. To this end, she is the PI of an ongoing study that is evaluating associations between environmental exposures and biomarkers of oxidative stress and whether or not these biomarkers will better predict risk of severe/uncontrolled childhood asthma compared to parental report of exposure alone (previous NIEHS R21 and CCTST KL2). As part of this study, her team is evaluating diesel exhaust particle and second hand tobacco smoke exposures, as well as obesity levels, markers of inflammation and antioxidant status, genetic and socioeconomic factors, and DNA methylation patterns. As her preliminary data revealed strong associations between her outcomes and socioeconomic factors, over the last year, she has partnered with Cincinnati’s CoreChange, a grassroots advocacy group, and Seven Hills Neighborhood Houses (SHNH; http://7hillsnh.org/), a full service social service agency and community center in the West End of Cincinnati, to expand her research into the community using a community-based participatory research (CBPR) approach. To this end, she has implemented a community-based research registry and begun needs assessments using a child-centered PhotoVoice approach and adult focus groups. A peer family health COACH (Coaching On Achieving Community Health) program will begin soon. To inform these community-based studies, she is collaborating on a project seeking to develop unique multimedia educational materials targeting low-income and low-literacy caregivers with asthmatic children. In addition to these studies, she is also the PI of an ongoing longitudinal epidemiological study seeking to evaluate environmental and sexual exposure to human papillomavirus (HPV) in families with children diagnosed with Fanconi anemia (current NHLBI R01). Individuals with Fanconi anemia are genetically vulnerable to squamous head and neck cancers previously shown to be positively associated with HPV. Her team is testing for oral HPV DNA, HPV serological markers as well as markers of immune response. As part of this study, Dr. Butsch Kovacic regularly interacts with a community of families associated with the Fanconi Anemia Research Fund, a strong parent led advocacy group focused on the improving the lives of children with Fanconi anemia, to design, optimize and disseminate the findings from her study.
Education and Training
MPH: Quantitative Methods, Harvard University School of Public Health, Boston, MA, 2003.
PhD: Biochemistry, the Ohio State University, Columbus, OH, 2002.
Postdoctoral Fellowship: Epidemiology/Public Health, Cancer Prevention Fellowship, Hormonal and Reproductive Epidemiology Branch, Division of of Cancer Epidemiology and Genetics, National Cancer Institute, 2002-2006.
Publications
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Martin LJ, Gupta J, Butsch Kovacic M, Biagini Myers JM, Patterson TL, Ericksen MB, He H, Gibson AM, Baye TM, Heeman AM, Sha S, Eissa T, Khurana Hershey GK. Variants in the autophagy-related 5 gene (ATG5) are associated with asthma. PLoS One. 2012;7(4):e33454. Hoskins EE, Morreale RJ, Werner SP, Higginbotham JM, Brown DR, Laimins LA, Lambert PF, Gillison ML, Nuovo GJ, Wikenheiser-Brokamp KA, Witte DP, Kim MO, Davies SM, Mehta PA, Butsch Kovacic M*, Wells SI* (*Co-corresponding authors). The Fanconi Anemia Pathway Limits Human Papillomavirus Replication. J Virol. 2012 Aug;86(15):8131-8. Butsch Kovacic M, Biagini Myers JM, Martin LJ, Lindsey M, Patterson TL, Sauter S, Ericksen MB, Ryan PH, Assa’ad A, Lierl M, Fischer T, Kercsmar C, McDowell K, Lucky AW, Sheth, AP, Hershey AD, Ruddy RM, Rothenberg M, Khurana Hershey GK. The Greater Cincinnati Pediatric Clinic Repository (GCPCR): A Novel Framework for Asthma and Allergy Research. Pediatr Allergy Immunol Pulmonol. 2012 Jun;25(2):104-113. Butsch Kovacic M, Biagini Myers JM, Patterson TL, Lindsey M, Ericksen MB, He H, Gupta J, Sivaprasad U, Gibson AM, Tsoras AM, Chen W, Musaad S, Baye TM, Khurana Hershey GK. Identification of KIF3A as a Novel Candidate Gene for Childhood Asthma Using RNA Expression and Population Allelic Frequencies Differences. PLoS One. 2011;6(8):e23714. Myers KC, Bleesing JJ, Davies SM, Zhang X, Martin LJ, Mueller R, Harris RE, Filipovich AH, Butsch Kovacic M, Wells SI, Mehta PA. Impaired Immune Function in Children with Fanconi Anemia. British Journal of Hematology. 2011 Jul;154(2):234-40. Cortina S, Drotar D, Ericksen M, Lindsey M, Patterson TL, Biagini Myers JM, Butsch Kovacic M, Khurana Hershey GK. Genetic Biomarkers of Health-Related Quality of Life in Pediatric Asthma. Journal of Pediatrics. 2011 Jul;159(1):21-26.e1. Baye TM, Butsch Kovacic M, Biagini Myers JM, Martin LJ, Lindsey M, Patterson TL, He H, Ericksen MB, Gupta J, Tsoras AM, Lindsley A, Rothenburg M, Wills-Karp M, Eissa T, Borrish L, Khurana Hershey GK. A comprehensive association of common genetic variation in candidate genes reveals IL-4 variants as genetic biomarkers of asthma in Caucasian and African American children. PLoS One. 2011 Feb 28;6(2):e16522. Reszka, KJ, Sallans L, Brown K, McGraw DW, Butsch Kovacic M, Britigan BE. Airway peroxidases catalyze nitration of the β2-agonist salbutamol and decrease its pharmacological activity. Journal of Pharmacology and Experimental Therapeutics. 2011;336:1–10. Butsch Kovacic M, Katki H, Kreimer A, Sherman ME. Epidemiologic Analysis of Histologic Cervical Inflammation: Relationship to Human Papillomavirus Infections. Human Pathology. 2008;39: 1088-1095. Gravitt P, Butsch Kovacic M (co-first authors), Castle PE, Herrero R, Schiffman M, Concepción Bratti M, Hildesheim A, Morales J, Alfaro M, Sherman ME, Wacholder Rodriguez AC, Burk RD. Viral Load of Human Papillomavirus Type 16 is Uniquely Associated with Cervical Disease. Inter. Journal of Cancer. 2007;121(12):2787-93.
Grants
Fanconi Anemia as a Model for Susceptibility to Human Papillomavirus Infection. Principal Investigator. NIH/NHLBI. 07/01/2011-06/30/2016. Serology as a Biomarker for Immune Response to Vaccination and Exposure in Fanconi Anemia. Co-Investigator. Fanconi Anemia Research Fund. 07/01/2012-06/30/2013. COACHing to Improve the Health of Youth Living in the Urban Core. Principal Investigator. Cincinnati Children’s Hospital Medical Center/CoreChange. 07/01/2012-06/30/2013. Epithelial Genes in Allergic Inflammation. Co- Investigator. NIH/NIAID Asthma and Allergic Diseases Cooperative Research Center. 07/01/2011-06/30/2016. Asthma Intervention. Co- Investigator. The John A Schroth Family Charitable Trust Foundation. 1/01/2012-12/31/2012. Epigenetic influences of diesel exhaust particles in asthmatic children and their unaffected siblings. Co-Investigator. University of Cincinnati Center for Environmental Genetics. 4/01/2012-3/30/2012.
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Lili Ding, PhD
is a biostatistician with research interest in Bayesian modeling and inference, and its applications in various fields of biomedical research, including statistical genetics, population pharmacokinetics and pharmacodynamics, multivariate survival analysis, and multilevel latent variable modeling. Dr. Ding mentors junior faculty, fellows and students in DBE and several other divisions within the hospital.
513-803-0931
lili.ding@cchmc.org
Lili Ding, PhD
Academic Information
Assistant Professor, UC Department of Pediatrics
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Specialties
Biostatistics, Bayesian statistics, statistical genetics, population PK/PD study design and modeling
Biography
Dr. Ding has been actively involved in collaborative research with faculty members from Adolescent Medicine, Asthma Research, Human Genetics, and Pharmacology on the design, plan, statistical analysis and report of medical research studies. She is a statistician with a keen interest in the development and application of statistical methods in biomedical research. She has published multiple research papers on statistical genetics; design of pediatric population pharmacokinetic studies; and on cancer prevention behaviors and sexually transmitted infections in adolescents. She has participated in several NIH sponsored grants and serves as Principle Investigator in a CCTST method grant. Dr. Ding is Review Editor for the Journal of Frontiers in Genetics and Reviewer for the Journal of Pediatric Research.
Education and Training
PhD: University of Cincinnati, OH, 2010.
MS: University of Cincinnati, OH, 2006.
BS: Changchun University of Science and Technology, Jilin, China, 1999
Publications
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Mullins TLK, Zimet GD, Rosenthal SL, Morrow C, Ding LL, Shew, M, Kahn, JA. Adolescent Perceptions of Risk and Need for Safer Sexual Behaviors After First Human Papillomavirus Vaccination. [Article]. Archives of Pediatrics & Adolescent Medicine, 166(1), 82-88. 2012. Baye TM, He H, Ding L, Kurowski BG, Zhang X, Martin LJ. Population structure analysis using rare and common functional variants. BMC Proc, 5 Suppl 9, S8. doi: 10.1186/1753-6561-5-s9-s8. 2011. Ding L, Baye TM, He H, Zhang X, Kurowski BG, Martin LJ. Detection of associations with rare and common SNPs for quantitative traits: a nonparametric Bayes-based approach. BMC Proc, 5 Suppl 9, S10. doi: 10.1186/1753-6561-5-s9-s10. 2011. Ding L, Wiener H, Abebe T, Altaye M, Go RC, Kercsmar C, Baye TM. Comparison of measures of marker informativeness for ancestry and admixture mapping. BMC genomics, 12, 622. 2011. He H, Zhang X, Ding L, Baye TM, Kurowski BG, Martin LJ. Effect of population stratification analysis on false-positive rates for common and rare variants. BMC Proc, 5 Suppl 9, S116. doi: 10.1186/1753-6561-5-s9-s116.2011. Kahn JA, Huang B, Ding LL, Geller A, Frazier AL. Impact of Maternal Communication About Skin, Cervical, and Lung Cancer Prevention on Adolescent Prevention Behaviors. [Article]. Journal of Adolescent Health, 49(1), 93-96. doi: 10.1016/j.jadohealth.2010.11.247. 2011. Sherwin C, Ding L, Kaplan J, Vinks A. Optimal design for a single dose pharmacokinetic study of Pioglitazone in septic pediatric patients. Journal of Pharmacokinetics and Pharmacodynamics, 38(4), 433-447. 2011. Zhang X, He H, Ding L, Baye TM, Kurowski BG, Martin LJ. Family- and population-based designs identify different rare causal variants. BMC Proc, 5 Suppl 9, S36. doi: 10.1186/1753-6561-5-s9-s36. 2011. Kahn JA, Ding LL, Huang B, Zimet GD, Rosenthal SL, Frazier AL. Mothers' Intention for Their Daughters and Themselves to Receive the Human Papillomavirus Vaccine: A National Study of Nurses. [Article; Proceedings Paper]. Pediatrics, 123(6), 1439-1445. doi: 10.1542/peds.2008-1536. 2009. Pattullo L, Griffeth S, Ding LL, Mortensen J, Reed J, Kahn J, Huppert J. Stepwise Diagnosis of Trichomonas vaginalis Infection in Adolescent Women. [Article]. Journal of Clinical Microbiology, 47(1), 59-63. doi: 10.1128/jcm.01656-08. 2009.
Grants
Bayesian Semi-Parametric Joint Modeling of Item Response and Clinical Outcomes. Principal Investigator. Center for Clinical and Translational Science and Training. 2012-2013. Genetic and Environmental Risk Factors for Hemorrhagic Stroke. Statistician. National Institutes of Health. 2008-2013. # R01NS36695. Behavioral and Virologic Impact of HPV Immunization. Statistician. National Institutes of Health. 2008-2012. #1R01AI070755-01. Development of an Asthma Research Core Center. Statistician. National Institutes of Health. 2009-2012. #P30HL101333-01.
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Lin Fei, PhD
is a biostatistician who is experienced in clinical trial research, drug and cosmetics discovery and development, and consumer product research. His research interests are in multivariate methods, discrete data analysis, probability theory and Bayesian modeling, and experimental designs. Dr. Fei serves as a reviewer to Communications in Statistics – Theory and Methods, and Journal of Biopharmaceutical Statistics.
513-636-2947
lin.fei@cchmc.org
Lin Fei, PhD
Academic Information
Associate Professor, UC Department of Pediatrics
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Specialties
Mathematical statistics; clinical trial design and analysis; statistical and probability models
Education and Training
BS, MS: Shanghai Jiaotong University, Shanghai, China, 1984. MS: The Ohio State University, Columbus, OH, 1988. PhD: The Ohio State University, Columbus, OH, 1992.
Publications
Lin Fei, Jie Mi. Some Aspects of Probability of Correct Selection. Communications in Statistics – Theory and Methods. 2011;40:4484-4495.
Karita E, Price M, Hunter E, Chomba E, Allen E, Fei L, Kamali A, Sanders E, Anzala O, Katende M, Ketter N. Investigating the utility of the HIV-1 BED capture enzyme immunoassay using cross-sectional and longitudinal seroconverter specimens from Africa. AIDS. 2007;21:403-408.
Lin Fei. A Probability Inequality and its Applications in Selecting Best Normal Means. Communications in Statistics – Theory and Methods. 2004;33:321-330.
Wei-Ping Lu, Lin Fei. A logarithmic approximation to initial rates of enzyme reactions. Analytical Biochemistry. 2003;316:58-65.
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Jessica Graus Woo, MHSA, PhD
is a molecular epidemiologist with particular research interest in the developmental pathways leading to pediatric obesity. She is specifically interested in how genetics and early life influences, especially early diet, may impact a child’s likelihood of developing obesity and specific metabolic complications of obesity, such as insulin resistance and dyslipidemia.
513-636-9598
jessica.woo@cchmc.org
Jessica Graus Woo, MHSA, PhD
Academic Information
Associate Professor, UC Department of Pediatrics
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Specialties
Molecular epidemiology; pediatric obesity; genetics and early life influences on obesity; insulin resistance; dyslipidemia
Education and Training
BA: Cornell University, Ithaca, NY 1993.
MHSA: University of Michigan, Ann Arbor, MI 1995.
PhD: University of Cincinnati, Cincinnati, OH 2004.
Publications
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Krawczeski CD, Vandevoorde RG, Kathman T, Bennett MR, Woo JG, Wang Y, Griffiths RE, Devarajan P. Serum cystatin C is an early predictive biomarker of acute kidney injury after pediatric cardiopulmonary bypass. Clin J Am Soc Nephrol. 2010 Sep;5(9):1552-7.
Elder DA, Woo JG, D'Alessio DA. Impaired beta-cell sensitivity to glucose and maximal insulin secretory capacity in adolescents with type 2 diabetes. Pediatr Diabetes. 2010 Aug;11(5):314-21.
Martin LJ, Woo JG, Morrison JA. Evidence of shared genetic effects between pre- and postobesity epidemic BMI levels. Obesity (Silver Spring). 2010 Jul;18(7):1378-82.
Tabangin ME, Woo JG, Martin LJ. The effect of minor allele frequency on the likelihood of obtaining false positives. BMC Proc. 2009 Dec 15;3 Suppl 7:S41.
Woo JG, Guerrero ML, Altaye M, Ruiz-Palacios GM, Martin LJ, Dubert-Ferrandon A, Newburg DS, Morrow AL. Human milk adiponectin is associated with infant growth in two independent cohorts. Breastfeed Med. 2009 Jun;4(2):101-9.
Lomenick JP, Reifschneider KL, Lucky AW, Adams D, Azizkhan RG, Woo JG, Backeljauw PF. Prevalence of adrenal insufficiency following systemic glucocorticoid therapy in infants with hemangiomas. Arch Dermatol. 2009 Mar;145(3):262-6.
Woo JG, Zeller MH, Wilson K, Inge T. Obesity identified by discharge ICD-9 codes underestimates the true prevalence of obesity in hospitalized children. J Pediatr. 2009 Mar;154(3):327-31.
Martin LJ, Gao G, Kang G, Fang Y, Woo JG. Improving the signal-to-noise ratio in genome-wide association studies. Genet Epidemiol. 2009;33 Suppl 1:S29-32.
Woo JG. Using body mass index Z-score among severely obese adolescents: a cautionary note. Int J Pediatr Obes. 2009;4(4):405-10.
Hugo ER, Brandebourg TD, Woo JG, Loftus J, Alexander JW, Ben-Jonathan N. Bisphenol A at environmentally relevant doses inhibits adiponectin release from human adipose tissue explants and adipocytes. Environ Health Perspect. 2008 Dec;116(12):1642-7.
Grants
Genetic and Environmental Risk Factors in Hemorrhagic Stroke. Principal Investigator of Subcontract. National Institute of Health. 2008 - 2013 Charlotte M. Schmidlapp Women’s Scholars Award. 2011 – 2012.
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Monir Hossain, PhD, MSc
is a biostatistician. His methodologic research interests include the development of statistical methods for modeling spatial-temporal disease clusters; spatial structure equation modeling; mixture models; inter-rater reliability; multi-level modeling; health services and patient outcomes; and clinical trials. Areas of application include perinatal health; access to primary health care; and childhood cancer incidences
513-803-8051
md.hossain@cchmc.org
Monir Hossain, PhD, MSc
Academic Information
Assistant Professor, UC Department of Pediatrics
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Biography
Dr. Hossain’s research interests focus on developing innovative statistical methods motivated by complex biomedical and environmental applications. He has developed novel spatial and spatiotemporal models for cluster detection and also in the area of cluster detection diagnostics for small area health data. Dr. Hossain's methodologic work has been published in several top biostatistics/statistics journals such as Statistics in Medicine, Computational Statistics and Data Analysis, etc. His application research in health services and patient outcomes has received numerous public attentions. He has been successfully funded via NCI and NHLBI grants for his work. Dr. Hossain has over 20 peer reviewed journal papers and has also been an ad hoc reviewer of several top statistical journals. He is an Elected Member of the International Statistical Institute.
Education and Training
PhD: Statistics, Institute of Statistical Mathematics, Japan. MSc: Statistics, University of Dhaka, Bangladesh.
Publications
Mirza S, Hossain MM, Mathews C, Martinez PJ, Gay J, Pino P, Rentfro A, McCormick JB, Fisher-Hoch SP. Type 2-Diabetes is associated with elevated levels of TNF-alpha, IL-6 and adiponectin and low levels of leptin in a population of Mexican American: a cross-sectional study. Cytokine. 2012;136-142. Hossain MM, Laditka JN. The influence of rurality on the volume of non-urgent emergency department visits. Spatial and Spatio-Temporal Epidemiology. 2011;311-319. Kirby RS, Liu J, Lawson AB, Jungsoon C, Cai B, Hossain MM. Spatio-temporal patterning of small area low birth weight incidence and its correlates: a latent spatial structure approach. Spatial and Spatio-Temporal Epidemiology. 2011;265-271. Jungsoon C, Lawson AB, Cai B, Hossain MM. Evaluation of Bayesian spatial-temporal latent models in small area health data. Environmetrics. 2011;1008-1022. Salinas J, McCormick JB, Rentfro A, Hanis CM, Hossain MM, Fisher-Hoch SP. The missing men: high risk of disease in men of Mexico origin. American Journal of Men's Health. 2011;5:332-40. Lawson AB, Song HR, Cai B, Hossain MM, Huang K. Space-Time latent component modeling for Geo-referenced health data. Statistics and Medicine. 2010;29:2012-2027. Hossain MM, Lawson AB. Space-time Bayesian small area disease risk models: Development and evaluation with a focus on cluster detection. Environmental and Ecological Statistics. 2010;17:73-95. Fisher-Hoch SP, Rentfro AR, Salinas JJ, Perez A, Brown HS, Reininger BM, Wilson JG, Hossain MM, Rahbar MH, Hanis CM, McCormick JB. Socioeconomic status and prevalence of obesity and diabetes in a Mexican American Community, Cameron County, Texas, 2004-2007. Prev Chronic Dis. 2010 May;7(3):A53. Epub 2010 May 15. Hossain MM Laditka J. Using hospitalization for ambulatory care sensitive conditions to measure access to primary health care: an application of spatial structural equation modeling. International Journal of Health Geographics. 2009;8:51. Foppa IM, Hossain MM. Revised estimates of influenza-associated excess mortality, United States, 1995 through 2005. Emerging Themes in Epidemiology. 2008;5:26.
Grants
Latent structure modeling of small area health data. National Heart, Lung, and Blood Institute. Jul 2009–Apr 2012. University of Texas Specialized Program in Acute Stroke (UT SPOTRIAS). Statistician. National Institute of Neurological Disorders and Stroke. Oct 2008–Sept 2013. Training Excellence in Aging Studies (TEXAS). Statistician. Donald W. Reynolds Foundation. Jan 2009-Dec 2012. Center of Excellence for Diabetes in Americans of Mexican Descent. Statistician. National Institute on Minority Health and Health Disparities. Mar 2008–Feb 2013.
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Bin Huang, PhD
Biostatistician
is an experienced biostatistician with research interests in mediation analysis, statistical causal inference, observational/epidemiological analyses, item response modeling, and spatially correlated data. Areas of application include: pubertal development, bio-behavior, health disparity, health related quality of life (HRQoL), patient-reported outcomes (PRO), substance use risk, STI, Asthma and JIA research.
513-636-6712
bin.huang@cchmc.org
Bin Huang, PhD
Biostatistician
Academic Information
Associate Professor, UC Department of Pediatrics
Associate Professor, Affiliated Assistant Professor, Department of Mathematical Sciences, University of Cincinnati A&S College
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Specialties
Biostatistics; puberty; juvenile rheumatoid/idiopathic arthritis; substance use/abuse; STI; GE interaction; quality of life
Biography
Dr. Huang has more than 10 years of statistical consulting experience in pediatric research. She has contributed to 60 peer reviewed publications in statistics and medical research journals. She has been funded as principal investigator by a NIH/NIDA RO1 grant; and as co-investigator/biostatistician by more than 20 NIH grants. She is editor for Pediatric Research, Section of Public Health; served as a reviewer to journals such as Biometrics, Statistics in Medicine, Journal of Pediatrics, American Journal of Public Health, Child Development and Journal of Adolescent Health. She also serves on NIH Special Emphasis Panel (ZRG1 PSEC). Dr. Huang leads a collaborative education program with the UC Department of Mathematics, through which five PhD graduate students in Applied Statistics are currently engaged in research at Cincinnati Children's.
Education and Training
BS: Shanghai Jiao Tong University, Shanghai, China, 1991.
MS: University of Cincinnati, Cincinnati, Ohio, 1995.
PhD: Environmental Health, University of Cincinnati, Cincinnati, OH, 2002.
Publications
View PubMed Publications
Huang B, Hillman J, Ding, L, Biro FM, Dorn LD, Susman EJ, Correspondence Between Gonadal Steroid Hormone Concentrations and Secondary Sexual Characteristics Assessed by Clinicians, Adolescents, and Parents. Journal of Research on Adolescence 2012, Jan 10 online early view, doi: 10.1111/j.1532-7795.2011.00773.x. Huang J, Huang B, Proportion of Treatment Effects Explained by a Continuous Surrogate Marker in Randomized Clinical Trial. Statistics in Pharmaceutical Research, 2010; 2(2): 229-238. doi:10.1198/sbr.2009.0070. Huang B, Biro FM, Dorn LD, Determination of Relative Timing of Pubertal Maturation through Ordinal Logistic Modeling: Evaluation of Growth and Timing Parameters. Journal of Adolescent Health 2009: 45(4): 383-8. PMID 19766943 Huang B, Sivaganasen S, Succop P, Goodman E. Statistical assessment of mediational effects for logistic mediational models. Statistics in Medicine 2004; 23(17):2713-28.
Grants
Behavioral and Virologic Impact of HPV Immunization, Co-I, NIH/NIAID, Nov 2008 – Dec 2012. Impact of peripubertal exposure to xenohormones on fat distribution and cytokines, Co-I, NIH/NIEHS, Apr 2010 – Mar 2012. Continued Studies of Environment on Puberty: GUF2, Statistician, NIH/NIEHS, Sept 2010 – Apr 2015. Determinants of Health-Related Quality of Life in Children with JIA, Co-I, NIH/NIAMS, Aug 2008 – July 2013. Explaining Racial Disparities in Child Asthma Morbidity, Biostatistician, NIH/NICHD, May 2010 – Apr 2012. Bayesian Spatial Modeling of Asthma Related Hospital Readmission, Co-PI, CCTST Methodology Research Award, Apr 2011 – Mar 2012. Enhancing PROMIS in Pediatric Pain, Rheumatology, and Rehabilitation Research, Biostatistician, NIH/NIAMS, Sept 2009 – Aug 2013. The Cincinnati Home Injury Prevention (CHIP) Trial, Biostatistician, NIH/NICHD, Sept 2010 – July 2015. “Multidisciplinary Clinical Research Center in Cincinnati" Methodology Core, Principal Biostatistician, NIH/NIAMS, Aug 2008 – July 2013
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Richard F. Ittenbach, PhD
is a biostatistician who specializes in the development, validation and analysis of scales for measurement of biomedical and biobehavioral factors. He mentors junior faculty, staff and students in DBE, Cardiology, Cardiac Surgery, Biomedical Informatics, and Psychology. He has contributed extensively to the training curricula of the Fellows Core Curriculum in biostatistics and data management. Visit the Ittenbach Lab.
513-803-3310
richard.ittenbach@cchmc.org
Richard F. Ittenbach, PhD
Academic Information
Professor, UC Department of Pediatrics
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Specialties
Biography
Dr. Ittenbach has authored or co-authored more than 90 peer-reviewed publications in the behavioral and biomedical sciences. He has been funded as a co-investigator and biostatistician on a number of NIH / CDC grants. He currently serves on the editorial board of four journals and reviews for several others. Dr. Ittenbach is a certified professional statistician (PStat) through the American Statistical Association and remains active in the American Statistical Association’s Section on Statistical Consulting. Areas of current professional interest include measure and scale development, mixed methods designs, as well as empirical bioethics.
Education and Training
PhD: University of Alabama, 1989. Postdoctoral Fellowship: University of Minnesota, Minneapolis, MN 1989-1991
MHS: Johns Hopkins University, 2001.
MED: Auburn University, 1984.
BS: Butler University, 1980.
Publications
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Quatman-Yates, C.C., Gupta, R., Paterno, M.V., Schmitt, L.C., Quatman, C.E., & Ittenbach, R.F. Internal consistency and validity of the QuickDASH instrument for upper extremity injuries in older children. J Pediatr Orthopedics. In Press. Hangge, P.T., Cnota, J.F., Woo, J.G., Hinton, A.C., Divanovic, A.A., Manning, P.B., Ittenbach, R.F. & Hinton, R.B. Microcephaly is associated with early adverse neurologic outcomes in hypoplastic left heart syndrome. Pediatr Res. In Press. Brier, M.J., Kazak, A.E., DeRosa, B.W., Hocking, M.C., Schwartz, L.A., Ginsberg, J.P., Hobbie, W., & Ittenbach, R.F. Profiles of health competence beliefs among young adult survivors of childhood cancer. J Adolesc Young Adult Oncol. In Press. Drotar, D., Ittenbach, R.F., Rohan, J.M., Gupta, R., Pendley, J.S., & Delameter, A. Diabetes management and glycemic control in youth with type 1 diabetes: Test of a predictive model. J Behav Med. In Press. Ittenbach, R.F., Cassedy, A.E., Rohan, J.M., Hood, K.K., Harris, M.A., Delamater, A., Pendley, J., Drotar, D. Diabetes Self-Management Profile Short Form: A Preliminary report. J Clin Psychol Med. In Press. Gupta, R., Marino, B.S., Cnota, J.F., & Ittenbach, R.F. Finding the right distribution for highly skewed zero-inflated data. Biomedical Statistics and Clinical epidemiology. Epidemiol, Biostatistics and Pub Health. In Press. Hocking, M.C., Schwartz, L.A., Hobbie, W.L., DeRosa, B.W., Ittenbach, R.F., Ginsberg, J.P., & Kazak, A.E. Prospectively examining physical activity in young adult survivors of childhood cancer and healthy controls. Pediatr Blood Cancer, 60(2), 309-315. 2013. Uzark, K., Wang, U., Rudd, N., Elixson, E.M., Strawn, J., Nieves, J.A., Smith, C., Staveski, S., O’Brien, P., Tong, E., & Ittenbach, R.F. Interstage feeding and weight gain in infants following the Norwood Operation: Can we change the outcome? Cardiol Young; 22:520-527. 2012. Ittenbach, R.F., & DeAngelis, F. Percent effort vs. Fee-for-service: A Comparison of models for statistical collaboration. Res Management Rev; 19(1):1-18. 2012. Kazak, A.E., Hocking, M.C., Ittenbach, R.F., Meadows, A.T., Hobbie, W., DeRosa, B.W., Leahey, A., Kersun, L., & Reilly, A. A revision of the Intensity of Treatment Rating Scale: Classifying the intensity of pediatric cancer treatment. Pediatr Blood Cancer; 59(1):96-99. 2012.
Grants
Center for Clinical and Translational Science and Training. Biostatistician. National Institutes of Health. April 2009 – March 2014. Tele-health Enhancement of Adherence to Medication. Co-Investigator (K. Hommel, PI). National Institutes of Health. December 2010 – Nov 2015.
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Jane C. Khoury, PhD
is the senior biostatistician for the study of the epidemiology of stroke in Cincinnati, and is principal investigator for the biostatistical core of a Special Program Of Translational Research In Acute Stroke. Her personal research interests involve the effect of intra-uterine exposure to type 1 diabetes on childhood growth, metabolism and cardiac function.
513-636-3690
Jane.Khoury@cchmc.org
Jane C. Khoury, PhD
Academic Information
Associate Professor, UC Department of Pediatrics
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Specialties
Stroke, Diabetes in Pregnancy. Research design and analysis.
Biography
Dr. Khoury has contributed to over 200 peer reviewed publications in medical and epidemiological research journals. She has obtained internal funding to obtain pilot data to pursue her diabetes research described above, results were recently presented and published. Dr. Khoury collaborates with researchers in General and Community Pediatrics (Environmental toxin exposure related to childhood neurodevelopment), Sports Medicine (ACL injury risk), Emergency Medicine and Endocrinology. She has been funded by over 25 NIH grants as co-investigator/biostatistician. She has served on peer review panels for grant applications and as a journal reviewer for Stroke, Pediatrics, Journal of Pediatrics, Archives of Pediatrics and Adolescent Medicine, Public Health Reports and American Journal of Epidemiology. |
Education and Training
PhD: University of Cincinnati College of Medicine, Department of Environmental Health, Division of Epidemiology and Biostatistics, 2006.
MS: University of Cincinnati College of Medicine, Department of Environmental Health, Division of Epidemiology and Biostatistics, 1989.
BSc: Bath University, Bath, England, 1973.
Publications
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Mahabee-Gittens E.M., Xiao Y., Gordon J.S., Khoury J.C. Continued Importance of Family Factors in Youth Smoking Behavior. Nicotine & Tobacco Research; doi: 10.1093/ntr/nts078. 2012. Khoury, J. C., Dolan, L. M., VanDyke, R., Rosenn, B., Feghali, M., & Miodovnik, M. Fetal development in women with diabetes: imprinting for a life-time? Journal of Maternal-Fetal & Neonatal Medicine, 25(1), 11-14. doi: 10.3109/14767058.2012.626921. 2012. VanDyke, R., Ren, Y., Sucharew, H. J., Miodovnik, M., Rosenn, B., & Khoury, J. C. Characterizing maternal glycemic control: a more informative approach using semiparametric regression. Journal of Maternal-Fetal & Neonatal Medicine, 25(1), 15-19. doi: 10.3109/14767058.2012.626922. 2012. Yolton, K., Xu, Y. Y., Strauss, D., Altaye, M., Calafat, A. M., & Khoury, J. Prenatal exposure to bisphenol A and phthalates and infant neurobehavior. Neurotoxicology and Teratology, 33(5), 558-566. doi: 10.1016/j.ntt.2011.08.003. 2011. Phelan, K. J., Khoury, J., Xu, Y. Y., Liddy, S., Hornung, R., & Lanphear, B. P. A Randomized Controlled Trial of Home Injury Hazard Reduction The HOME Injury Study. Archives of Pediatrics & Adolescent Medicine, 165(4), 339-345. 2011. Xu, Y. Y., Yolton, K., & Khoury, J. Earliest Appropriate Time for Administering Neurobehavioral Assessment in Newborn Infants. Pediatrics, 127(1), E69-E75. doi: 10.1542/peds.2010-1121. 2011. Armour, A. D., Khoury, J. C., Kagan, R. J., & Gottschlich, M. M. Clinical Assessment of Sleep Among Pediatric Burn Patients Does Not Correlate With Polysomnography. Journal of Burn Care & Research, 32(5), 529-534. doi: 10.1097/BCR.0b013e31822ac844. 2011. Mahabee-Gittens E. M., Xiao Y., Gordon J.S., Khoury J.C. The Role of Family Influences on Adolescent Smoking in Different Racial/Ethnic Groups. Nicotine & Tobacco Research; doi: 10.1093/ntr/ntr192. 2011. Bollepalli S., Dolan L.M., Miodovnik M., Feghali M., Khoury J.C. Asymmetric large-for-gestational-age infants of type 1 diabetic women: Morbidity and abdominal growth. Am J Perinatol, 27(8), 603-610, PMID: 20225174, PMC. 2010. Kleindorfer D, Khoury J, Moomaw CJ, Alwell K, Woo D, Flaherty ML, Khatri P, Adeoye O, Ferioli S, Broderick JP, Kissela BM. Stroke Incidence is Decreasing in Whites, but Not in Blacks: A Population-Based Estimate of Temporal Trends in Stroke Incidence from the Greater Cincinnati/Northern Kentucky Stroke Study. Stroke, Stroke, 41(7):1326-31, PMID. 2010.
Grants
Hemorrhagic and Ischemic Stroke Among Blacks and Whites. Subsite PI. NINDS/NIH Sub-award from University of Cincinnati. 07/01/2009 – 06/30/2014. Recanalization Therapies and Markers of Stroke Outcome. PI Biostatistical Core. NIH/NINDS / Sub-award from University of Cincinnati 07/01/2008-4/30/2013. NIH Mechanisms of ACL Load in Female Athletes. Biostatistician. NIH. 09/01/2008-08/30-2012. The Influence of Child Care Center Environment on Physical Activity. Biostatistician. NIH/NHLBI. 04/01/2008-03/21/2013 Neurobehavioral Effects of Insecticide Exposure in Pregnancy and Early Childhood. Biostatistician. NIH/NCE.09/01/2009-08/31/2012 Intervention to reduce body burden in PCBs in residents of Anniston Alabama. Biostatistician. NIH/NIEHS 07/01/2012-06/302012 Profiles of fetal exposure to pregestational diabetes. PI, CCTST Internal Grant 04/01/2011-03/31/2012
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Mi-Ok Kim, PhD
Biostatistician
is a biostatistician with interest in optimizing clinical trial designs to maximize patient benefits and incorporating genomic/genetic data to better predict survival times, and quantile regression analysis of clustered data. Dr. Kim mentors junior faculty, staff and students in DBE, and the Cancer and Blood Disorders Institute. She organizes a webinar series for the Biopharmaceutical section of the American Statistical Association.
513-636-1895
miok.kim@cchmc.org
Mi-Ok Kim, PhD
Biostatistician
Academic Information
Associate Professor, UC Department of Pediatrics
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Specialties
Methodology and biomedical applications in nonparametric regression; longitudinal data and survival analysis; emprical likelihood; quantile regression; Bioinfomatics
Education and Training
PhD: Statistics, University of Illinois at Urbana-Champaign, 2003.
MS: Statistics, University of Illinois at Urbana-Champaign.
Publications
View PubMed Publications
Zhou M, Kim MO, Bathke A. Empirical likelihood analysis for the heteroscedastic accelerated failure time model. Statistica Sinica. 2011. Kim MO, Yang Y. Semiparametric approach to a random effects quantile regression model. J Am Stat Assoc. 2011. George A, Benton J, Pratt J, Kim MO, Kalinyak KA, Kalfa TA, Joiner CH. The impact of the 2009 H1N1 influenza pandemic on pediatric patients with sickle cell disease. Pediatr Blood Cancer. 2011 Feb 25. Wu J, Dombi E, Jousma E, Scott Dunn R, Lindquist D, Schnell BM, Kim MO, Kim A, Widemann BC, Cripe TP, Ratner N. Preclincial testing of Sorafenib and RAD001 in the Nf(flox/flox) ;DhhCre mouse model of plexiform neurofibroma using magnetic resonance imaging. Pediatr Blood Cancer. 2011 Feb 11. Sundaram N, Bennett M, Wilhelm J, Kim MO, Atweh G, Devarajan P, Malik P. Biomarkers for early detection of sickle nephropathy. Am J Hematol. 2011 Jul;86(7):559-66. Nylund CM, D'Mello S, Kim MO, Bonkowski E, Däbritz J, Foell D, Meddings J, Trapnell BC, Denson LA. Granulocyte macrophage-colony-stimulating factor autoantibodies and increased intestinal permeability in Crohn disease. J Pediatr Gastroenterol Nutr. 2011 May;52(5):542-8.
Mehta PA, Harris RE, Davies SM, Kim MO, Mueller R, Lampkin B, Mo J, Myers K, Smolarek TA. Numerical chromosomal changes and risk of development of myelodysplastic syndrome -- acute myeloid leukemia in patients with Fanconi anemia. Cancer Genet Cytogenet. 2010 Dec;203(2):180-6. Marsh RA, Vaughn G, Kim MO, Li D, Jodele S, Joshi S, Mehta PA, Davies SM, Jordan MB, Bleesing JJ, Filipovich AH. Reduced-intensity conditioning significantly improves survival of patients with hemophagocytic lymphohistiocytosis undergoing allogeneic hematopoietic cell transplantation.Blood. 2010 Dec 23;116(26):5824-31. Crombleholme TM, Lim FY, Habli M, Polzin W, Jaekle R, Michelfelder E, Cnota J, Liu C, Kim MO. Improved recipient survival with maternal nifedipine in twin-twin transfusion syndrome complicated by TTTS cardiomyopathy undergoing selective fetoscopic laser photocoagulation.Am J Obstet Gynecol. 2010 Oct;203(4):397.e1-9. Brown NM, Belles CA, Lindley SL, Zimmer-Nechemias L, Witte DP, Kim MO, Setchell KD. Mammary gland differentiation by early life exposure to enantiomers of the soy isoflavone metabolite equol. Food Chem Toxicol. 2010 Nov;48(11):3042-50.
Grants
Proof of Concept Study of Percentile Specific Higher Resolution Quantile Regression Analysis of Age Related Lung Function Decline in Cystic Fibrosis Patients. Principal Investigator. Cincinnati Center for Clinical and Translational Science and Training. Apr 2011 - Mar 2012. Extension of Quantile Regression and Empirical Likelihood Analysis for Censored Data. Principal Investigator. National Science Foundation. Oct 2010 - Sep 2013. #DMS-1007535. Cincinnati Center of Neurofibromatosis Research. Biostatistician. National Institutes of Health. Sep 2008 - Jun 2013. #P50 NS057531. Biomarkers of IBD Behavior and Treatment Response. Co-investigator. National Institutes of Health. Apr 2009 - Mar 2013. R01DK078683-01. Risk stratification & identification of immunogenic and microbial markers of rapid disease progression in children with Crohn’s disease. Consortium Principal Investigator. Emory University. Mar 2009 - Feb 2013. Fanconi Anemia and HPV Transformation. Biostatistician. National Institutes of Health. Sep 2009 - Aug 2014. #2 R01 CA102357. Center for Clinical and Translational Science and Training. Biostatistician. National Center for Research Resources. Apr 2009 - Mar 2014. #ULRRR026314. Cincinati Center for Excellence in Moelcular Hematology. Biostatistician. National Institutes of Health. Sep 2010 - Jun 2015.
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Eileen C. King, PhD
has 24 years of experience in the design and analysis of clinical trials for health care and pharmaceutical research studies. She enjoys collaborative research and has research interests in nonparametric regression using smoothers, comparative effectiveness research using clinical data from large multi-site registries, and statistical quality control approaches for clustered data for quality improvement initiatives in health outcomes.
513-803-1819
eileen.king@cchmc.org
Eileen C. King, PhD
Academic Information
Associate Professor, UC Department of Pediatrics
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Specialties
Clinical Trials, Statistical Process Control, Data Management, Nonparametric Regression using Linear Smoothers.
Biography
Dr. King has provided biostatistical leadership in the design, analysis, and interpretation of results from animal and human clinical research studies supporting drug discovery, early and late stage drug development, commercialization, and market support. She provided statistical expertise and oversight for the development, review, and defense of 10 New Drug Application submissions in the areas of gastrointestinal, cardiac, bone diseases and female sexual health. She is currently leading the growing Data Management Center to assure appropriate data management processes for data collection, data cleaning and validation, and data finalization, documentation and archival are used which lead to high quality data that can be shared with the research community at large. Dr. King is active in the American Statistical Association and is currently chair of the Council of Sections Governing Board. She is an Associate Editor for the Journal of Statistical Education. Dr. King mentors junior faculty, staff and students in DBE and Gastroenterology and the Anderson Center. She is the primary instructor of “Statistical Principles for Clinical Research Studies” in the UC College of Pharmacy.
Education and Training
PhD: Texas A&M University, 1988.
MS: University of Wyoming, 1980.
BS: Regis College, 1976.
Publications
Crandall, W. V., Margolis, P. A., Kappelman, M. D., King, E. C., Pratt, J. M., Boyle, B. M.,Colletti, R. B. Improved Outcomes in a Quality Improvement Collaborative for Pediatric Inflammatory Bowel Disease. Pediatrics. doi: 10.1542/peds.2011-1700. 2012. Presicce P, Orsborn K, King E, Pratt J, Fichtenbaum CJ, et al. Frequency of Circulating Regulatory T Cells Increases during Chronic HIV Infection and Is Largely Controlled by Highly Active Antiretroviral Therapy. PLoS ONE 6(12): e28118.doi:10.1371/journal.pone.0028118. 2011. Seid M, D’Amico EJ, Varni JW, Munafo JK, Britto MT, Kercsmar CM, Drotar D, King EC, Darbie L. The In Vivo Adherence Intervention For at Risk Adolescents with Asthma: Report of a Randomized Pilot Trial. Journal of Pediatric Psychology. doi:10.1093/jpepsy/jsr107. 2011. Setchell K, Brown N, Zhao X, Lindley S, Heubi J, King E, Messina J. Soy isoflavone phase II metabolism differs between rodents and humans: implications for the effect on breast cancer risk. Am J Clin Nutr. 94:1284-94. 2011. Debrosse, C. W., Franciosi, J. P., King, E. C., Buckmeier Butz, B. K., Greenberg, A. B., Collins, M. H., Abonia, J. P., Assa'ad, A., Putnam, P. E., & Rothenberg, M. E. Long-term outcomes in pediatric-onset esophageal eosinophilia. J Allergy Clin Immunol, 2011. DeBrosse CW, Collins MH, Butz BK Allen CL, King EC, Assa’ad AH, Abonia JP, Putnam PE, Rothenberg ME, Franciosi JP. Identification, epidemiology and chronicity of pediatric esophageal eosinophilia, 1982-1999. Journal of Allergy and Clinical Immunology. 126 (1), pp. 112-119. 2010. Corey AE, Agnew,JR, King EC, Parekh NJ, Powell JH, Thompson GA. Effect of Mild and Moderate Hepatic Impairment on Azimilide Pharmacokinetics Following Single Dose Oral Administration. Journal of Pharmaceutical Sciences, 93 (5), pp. 1279-1286. 2004. Sorof JM, Cargo P, Graepel J, Humphrey D, King E, Rolf C, Cunningham R. b-Blocker/thiazide combination for treatment of hypertensive children: a randomized double-blind, placebo-controlled trial. Pediatric Nephrology. 17, pp. 345-350. 2002. Chen KS, Bharaj SS, and King EC. Induction and relief of nasal congestion in ferrets infected with influenza virus. International Journal of Experimental Pathology, 76, pp. 55-64. 1995. King EC, Hart JD, and Wehrly TE. Testing the Equality of Two Regression Curves Using Linear Smoothers. Statistics and Probability Letters, 12, pp. 239-247. 1991.
Grants
Digestive Health Center: Bench to Bedside Research in Pediatric Digestive Disease. Biostatistician. National Institutes of Health. August 2007 – May 2012. Open Source Science: Transforming Chronic Illness Care. Statistician. National Institutes of Health. September 2009 – August 2014. Cincinnati Center for Clinical and Translational Science and Training. Biostatistician. National Institutes of Health. March 2009 – February 2014. Building Modular Pediatric Chronic Disease Registries for QI and CE Research. Biostatistician. National Institutes of Health. September 2010 – September 2013. The Pedi IBD Network for Res & Improvement. Biostatistician. PIBDNet Trailblazer Collaborative. October 2010 – June 2012.
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Ping-I (Daniel) Lin, MD, PhD
is a genetic epidemiologist and psychiatrist. His research interests have been focused on identifying genetic variants associated with neuropsychiatric diseases. Dr. Lin has discovered variants linked to clinical heterogeneity in bipolar disorder, Alzheimer’s disease and autism. He is also interested in paradoxical association findings and selection sweeps for candidate loci for schizophrenia and autism.
513-636-2710
ping-i.lin@cchmc.org
Ping-I (Daniel) Lin, MD, PhD
Academic Information
Assistant Professor, UC Department of Pediatrics
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Specialties
Genetic epidemiology; pharmacogenomics; clinical psychiatry
Biography
Dr. Lin earned his PhD from Johns Hopkins University and MD from National Taiwan University. He has published 16 peer-review research articles and one book chapter in the field of neuropsychiatric genetics. His publications in the past 7 years have been cited by more than 350 publications. One of his research articles, entitled “No Gene Is an Island: The Flip-Flop Phenomenon,” published on American Journal of Human Genetics, alone has obtained nearly 260 citations within 5 years. He received a Travel Award (only 10 recipients were selected) from 11th International Congress of Human Genetics in 2006. In 2007, Dr. Lin was invited to the press debriefing at American Society of Human Genetics Meeting. Additionally, he received an award for his genetic research of autism by Taiwan Society of Child and Adolescent Psychiatry in 2010. His current research interests are focused on pharmacogenomics research related to neuropsychiatric diseases.
Education and Training
PhD: Johns Hopkins University, Baltimore, MD, 2005. MD: National Taiwan University, Taiwan. Residency: Psychiatry, National Taiwan University Hospital, Taiwan. Certification: Psychiatry, 2012.
Publications
View PubMed Publications
Lin PI, Chien YL, Wu YY, Chen CH, Gau SS, Huang YS, Liu SK, Tsai WC, Chiu YN. The WNT2 gene polymorphism associated with speech delay inherent to autism. Research in Developmental Disabilities. 2012;33(5):1533-40. Lin PI, Shuldiner AR. Rethinking the genetic basis of diabetes and schizophrenia. Schizophr Res. 2010;123(2-3):234-43. Tarasov KV, Sanna S, Scuteri A, Strait JB, Orrù M, Parsa A, Lin PI, Maschio A, et al. COL4A1 is associated with arterial stiffness by genome-wide association scan. Circulation Cardiovasc Genet. 2009;2(2):151-8. Lin PI, Mitchell BM. Approaches for deciphering joint genetic determinants for schizophrenia and bipolar disorder. Schizophr Bull. 2008;34(4):791-7. Lin PI, Vance JM, Pericak-Vance MA, Martin ER. No gene is an island: the flip-flop phenomenon. American Journal Human Genetics. 2007;80(3):531-8. Lin PI, Martin ER, Bronson PG, Browning-Large CA, Small GW, Schmechel DE, Welsh-Bohmer KA, Haines JL, Gilbert JR, Pericak-Vance MA. Exploring the association of GAPD genes and late-onset Alzheimer disease. Neurology. 2006;67(1):64-8. Chong RY, Uhart M, Yang X, Lin PI, Wand GS. The A118G Mu opioid receptor polymorphism is associated with heightened HPA axis response to opioid receptor blockade but not psychosocial stress. Neuropsychopharmacology. 2006;31(1):204-11. Li YJ, Scott WS, Zhang L, Lin PI, Oliveira SA, Skelly T, Schmechel DE, Martin ER, Haines JL, Pericak-Vance MA, Vance JM. Revealing the role of Glutathione S-Transeferace Omega-1 in age-of-onset data of Alzheimer disease. Neurobiology Aging. 2006;27(8):1087-93. Lin PI, McInnis MG, Potash JB, MacKinnon DF, Willour V, DePaulo JR Jr, Zandi PP. Clinical correlates and familial aggregation of age at onset in bipolar disorder. American Journal of Psychiatry. 2006;163(2):240-6. Lin PI, McInnis MG, Potash JB, MacKinnon DF, Willour V, Miao K DePaulo JR Jr, Zandi, PP. Assessment of the effect of age at onset on linkage to bipolar disorder: evidence on chromosomes 18p and 21q. American Journal of Human Genetics. 2005;77(4):545-55.
Grants
The effect of FOXP2-CNTNAP2 pathway modulated by parental age on language development. Principal Investigator. NTUH, Taiwan. Jan 2012 - Jan 2013.
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Lisa J. Martin, PhD
is a genetic epidemiologist with a focus on common complex traits. Using both family and population-based analytical strategies, she studies the genetics of heart malformations as well as obesity and it’s co-morbidities.
513-636-1244
lisa.martin@cchmc.org
Lisa J. Martin, PhD
Academic Information
Associate Professor, UC Department of Pediatrics
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Specialties
Clinical InterestsObesity; genetics; complex traits Research InterestsThe genetics of normal variation, obesity, reproduction, and asthma
Biography
Dr. Martin is an internationally recognized genetic epidemiologist. She has performed genetic analysis of complex traits for over 10 years and has published over 60 peer-reviewed publications (nearly half of which she is first or senior author) in prestigious journals including Nature Genetics, PNAS, and Diabetes. During her post-doctoral training, she received the James V. Neel Young Investigator Award for work on obesity genetics. At Cincinnati Children's, she received the Charlotte R. Schmidlapp Award for being an outstanding female investigator. Her research skills are further reflected in her grant funding; she held a PI on American Diabetes Association Career Development Award and has worked as co-I on multiple grants focusing on the genetics of complex traits. At Cincinnati Children's, Dr. Martin provides statistical support for human genetic studies. She has been involved in family and population based genetic analyses by collaborating with numerous investigators. As part of this support, Dr. Martin assists in project planning, writing the statistical section of grant proposals, and assists with writing research papers. Recently, Dr. Martin has studied methodological considerations of genome wide association (GWA), especially how to reduce the number of false positives in the context of a million statistical tests1, 2. This work served as a basis for performing GWA at Cincinnati Children's. Indeed, she has designed several GWA studies under consideration for funding.
Education and Training
PhD: (with Honors) University of Kansas, Lawrence KS, 1999 Post-doctoral fellow: Southwest Foundation for Biomedical Research, San Antonio TX, 2002
Publications
View PubMed Publications
Baye TM, Martin LJ, Khurana Hershey GK. Application of genetic/genomic approaches to allergic disorders. J Allergy Clin Immunol. 2010 Sep;126(3):425-36; quiz 437-8. Sherrill JD, Gao PS, Stucke EM, Blanchard C, Collins MH, Putnam PE, Franciosi JP, Kushner JP, Abonia JP, Assa'ad AH, Kovacic MB, Biagini Myers JM, Bochner BS, He H, Hershey GK, Martin LJ, Rothenberg ME. Variants of thymic stromal lymphopoietin and its receptor associate with eosinophilic esophagitis. J Allergy Clin Immunol. 2010 Jul;126(1):160-5.e3. Doughty Rice C, Ruschman JG, Martin LJ, Manders JB, Miller E. Retrospective comparison of patient outcomes after in-person and telephone results disclosure counseling for BRCA1/2 genetic testing. Fam Cancer. 2010 Jun;9(2):203-12. Bollepalli S, Dolan LM, Deka R, Martin LJ. Association of FTO gene variants with adiposity in African-American adolescents. Obesity (Silver Spring). 2010 Oct;18(10):1959-63. Rothenberg ME, Spergel JM, Sherrill JD, Annaiah K, Martin LJ, Cianferoni A, Gober L, Kim C, Glessner J, Frackelton E, Thomas K, Blanchard C, Liacouras C, Verma R, Aceves S, Collins MH, Brown-Whitehorn T, Putnam PE, Franciosi JP, Chiavacci RM, Grant SF, Abonia JP, Sleiman PM, Hakonarson H. Common variants at 5q22 associate with pediatric eosinophilic esophagitis. Nat Genet. 2010 Apr;42(4):289-91. Blanchard C, Stucke EM, Burwinkel K, Caldwell JM, Collins MH, Ahrens A, Buckmeier BK, Jameson SC, Greenberg A, Kaul A, Franciosi JP, Kushner JP, Martin LJ, Putnam PE, Abonia JP, Wells SI, Rothenberg ME. Coordinate interaction between IL-13 and epithelial differentiation cluster genes in eosinophilic esophagitis. J Immunol. 2010 Apr 1;184(7):4033-41. Zarate YA, Martin LJ, Hopkin RJ, Bender PL, Zhang X, Saal HM. Evaluation of growth in patients with isolated cleft lip and/or cleft palate. Pediatrics. 2010 Mar;125(3):e543-9. Tabangin ME, Woo JG, Martin LJ. The effect of minor allele frequency on the likelihood of obtaining false positives. BMC Proc. 2009 Dec 15;3 Suppl 7:S41. Martin LJ, Gao G, Kang G, Fang Y, Woo JG. Improving the signal-to-noise ratio in genome-wide association studies. Genet Epidemiol. 2009;33 Suppl 1:S29-32. Martin LJ, Woo JG, Morrison JA. Evidence of shared genetic effects between pre- and post-obesity epidemic BMI levels. Obesity (Silver Spring). 2010 Jul;18(7):1378-82.
Grants
Genetic and Environmental Risk Factors for Hemorrhagic Stroke. Co-Investigator. National Institute of Health. Jul 2008 - Jun 2013. #R01NS036695.
Center Grant, Asthma and Allergic Diseases Cooperative Research Centers (AADCRC) program. Principal Investigator. National Institute of Health. Sep 206 - Aug 2011. #U19 A1070235.
Genetic Studies of Food Allergies Research Program: Candidate Gene Approach for Eosinophilic Esophagitis. Co-Investigator. Department of Defense. Mar 2010 - Feb 2012.
Pursing Perfection in Pediatric Therapeutics. Co-Investigator. National Institute of Health. Sep 2007 - Aug 2011. #U18 HS016957.
USAMRAA Genetic and Epigenetic Differences in Monozygotic Twins with NF1. Co-Investigator. Department of Defense. Jan 2010 - Dec 2011. #NF 093100.
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Jareen K. Meinzen-Derr, PhD
is a quantitative epidemiologist focused on improving health outcomes and clinical care for children who are deaf or hard of hearing by understanding the mechanisms behind language and functional outcomes in the subset of children with hearing loss and developmental disability. She also collaborates on clinical research regarding premature infants.
513-636-7789
jareen.meinzen-derr@cchmc.org
Jareen K. Meinzen-Derr, PhD
Academic Information
Assistant Professor, UC Department of Pediatrics
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Specialties
Pediatric hearing impairment; cochlear implant research; neonatal outcomes
Biography
Jareen Meinzen-Derr, PhD, is a quantitative epidemiologist with a joint appointment with the Division of Pediatric Otolaryngology. Her overall goal is to improve outcomes in children who are deaf/hard of hearing. Her currently funded research involves understanding the needs of children who are deaf/hard of hearing and have a co-existing disability. She has a prolific publication background in the areas of necrotizing enterocolitis, children with hearing loss, and breastfeeding. She is involved with teaching courses at the University of Cincinnati Department of Environmental health as well as in supporting the educational curricula for fellow research education within the Divisions of Neonatology, Developmental and Behavioral Pediatrics, and Pediatric Otolaryngology.
Education and Training
PhD: University of Cincinnati, Cincinnati, OH 2006.
MPH: Univeristy of Alabama at Birmingham, Birmingham, AL, 1997.
Publications
View PubMed Publications
South AP, Jones DE, Hall ES, Huo S, Meinzen-Derr J, Liu L, Greenberg JM. Spatial Analysis of Preterm Birth Demonstrates Opportunities for Targeted Intervention. Matern Child Health J. 2011 Feb 3. Binder S, Hill K, Meinzen-Derr J, Greenberg JM, Narendran V. Increasing VLBW Deliveries at Subspecialty Perinatal Centers via Perinatal Outreach. Pediatrics. 2011 Mar;127(3):487-93. Morrow AL, Meinzen-Derr J, Huang P, Schibler KR, Cahill T, Keddache M, Kallapur SG, Newburg DS, Tabangin M, Warner BB, Jiang X. Fucosyltransferase 2 Non-Secretor and Low Secretor Status Predicts Severe Outcomes in Premature Infants. J Pediatr. 2011 May;158(5):745-51. Meinzen-Derr J, Wiley S, Grether S, Choo DI. Children with cochlear implants and developmental disabilities: A language skills study with developmentally matched hearing peers. Res Dev Disabil. 2011 Mar-Apr;32(2):757-67. Slaughter JL, Meinzen-Derr J, Rose SR, Leslie ND, Chandrasekar R, Linard SM, Akinbi HT. The effects of gestational age and birth weight on false-positive newborn-screening rates. Pediatrics. 2010 Nov;126(5):910-6. Choo D, Meinzen-Derr J. Universal newborn hearing screening in 2010. Curr Opin Otolaryngol Head Neck Surg. 2010 Oct;18(5):399-404. Review. Akinbi H, Meinzen-Derr J, Auer C, Ma Y, Pullum D, Kusano R, Reszka KJ, Zimmerly K. Alterations in the host defense properties of human milk following prolonged storage or pasteurization. J Pediatr Gastroenterol Nutr. 2010 Sep;51(3):347-52. Kaplan HC, Tabangin ME, McClendon D, Meinzen-Derr J, Margolis PA, Donovan EF. Understanding variation in vitamin A supplementation among NICUs. Pediatrics. 2010 Aug;126(2):e367-73. Isemann B, Meinzen-Derr J, Akinbi H. Maternal and neonatal factors impacting response to methadone therapy in infants treated for neonatal abstinence syndrome. J Perinatol. 2011 Jan;31(1):25-9. Giambra BK, Meinzen-Derr J. Exploration of the relationships among medical health history variables and aspiration. Int J Pediatr Otorhinolaryngol. 2010 Apr;74(4):387-92.
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Nicholas J. Ollberding, PhD
is a nutritional epidemiologist with research interests focused on the role of diet in the etiology and the survival of cancer, dietary assessment and analysis methodology, and the molecular epidemiology of cancer. His research incorporates the use of observational and experimental research designs, as well as innovative molecular-based technologies to examine diet-disease associations.
513-803-4432
nicholas.ollberding@cchmc.org
Nicholas J. Ollberding, PhD
Academic Information
Assistant Professor, UC Department of Pediatrics
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Specialties
Nutritional epidemiology; cancer epidemiology; dietary assessment and analysis methodology; molecular epidemiology
Biography
Dr. Ollberding earned his PhD in Behavioral Nutrition with a specialization in Nutritional Epidemiology from Columbia University and completed postdoctoral fellowships in cancer epidemiology and prevention at the University of Hawaii Cancer Center and the University of Chicago. To date, he has published more than 20 peer-reviewed research articles in prestigious journals including the Journal of the National Cancer Institute, Blood, and Cancer Prevention Research. In addition, his research has been presented at national conferences and he has authored a book chapter in the area of nutritional epidemiology. Dr. Ollberding was the recipient of the Zerkowski Habas Foundation and Grace McLeod Scholarships while at Columbia University and received a National Cancer Institute funded postdoctoral fellowship. Dr. Ollberding’s research is motivated by the fact that while diet and obesity are major contributors to morbidity and mortality in the U.S., few Americans consume diets in accordance with recommendations for optimal health or disease prevention. Specifically, his work aims to better understand the role of diet in the etiology and progression of cancer and other chronic diseases, as well as the impact of environmental- and policy-level factors on dietary behaviors including obesity. At Cincinnati Children’s, Dr. Ollberding conducts and provides support for nutritional and cancer epidemiology studies.
Education and Training
PhD: Columbia University, New York, 2009. MPhil: Columbia University, New York, 2009. MS: University of Cincinnati, Cincinnati, OH, 2008. BS: Miami University, Oxford, OH, 2004.
Publications
View PubMed Publications
Ollberding NJ, Kim Y, Wilkens LR, Shvetsov YB, Henderson BE, Le Marchand L, Kolonel LN, Goodman MT. Prediagnostic adiponectin, leptin, and C-reactive protein and breast cancer risk among postmenopausal women in the Multiethnic Cohort Study. Cancer Prev Res (Phila). 2013 Mar;6(3):188-95. Ollberding NJ, Aschebrook-Kilfoy B, Caces DB, Smith SM, Wright ME, Weisenburger DD, Chiu B C-H. Phytanic acid and the risk of non-Hodgkin lymphoma. Carcinogenesis. 2013 Jan;34(1):170-5. Ollberding NJ, Maskarinec G, Conroy SM, Morimoto Y, Franke AA, Cooney RV, Wilkens LR, Le Marchand L, Goodman MT, Hernandez BY, Henderson BE, Kolonel LN. Prediagnostic Carotenoid Levels and the Risk of Non-Hodgkin Lymphoma: The Multiethnic Cohort. Blood. 2012 Jun 14;119(24):5817-23. Ollberding NJ, Wilkens LR, Henderson BE, Kolonel LN, Le Marchand L. Meat consumption, heterocyclic amines and colorectal cancer risk: The Multiethnic Cohort Study. Int J Cancer. 2012 Oct 1;131(7):E1125-33. Ollberding NJ, Cheng I, Wilkens LR, Henderson BE, Kolonel LN, Le Marchand L. Genetic variants, prediagnostic circulating levels of insulin-like growth factors, insulin, and glucose and the risk of colorectal cancer: The Multiethnic Cohort Study. Cancer Epidemiol Biomarkers Prev. 2012 May;21(5):810-20. Ollberding NJ, Lim U, Wilkens LR, Setiawan VW, Shvetsov YB, Henderson BE, Kolonel LN, Goodman MT. Legume, Soy, and Isoflavone Intake and Endometrial Cancer Risk: The Multiethnic Cohort Study. J Natl Cancer Inst. 2012 Jan 4;104(1):67-76. Ollberding NJ, Nigg CR, Geller KS, Horwath CC, Motl RW, Dishman RK. Food outlet accessibility and fruit and vegetable consumption. Am J Health Promot. 2012 Jul;26(6):366-70. Ollberding NJ, Maskarinec G, Wilkens LR, Henderson BE, Kolonel LN. Comparison of modifiable health behaviors between persons with and without cancer: The Multiethnic Cohort. Public Health Nutr. 2011 Oct;14(10):1796-804. Ollberding NJ, Nomura AY, Wilkens LR, Henderson BE, Kolonel LN. Racial/Ethnic Differences in Colorectal Cancer Risk: The Multiethnic Cohort Study. Int J Cancer. 2011 Oct 15;129(8):1899-906. Ollberding NJ, Wolf RL, Contento I. Food label use and its relation to dietary intake among US adults. J Am Diet Assoc. 2010 Aug;110(8):1233-7.
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Patrick H. Ryan, PhD, MS
Academic Information
Assistant Professor, UC Department of Pediatrics
Assistant Professor, Department of Environmental Health
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Specialties
Epidemiology; air pollution; exposure assessment
Biography
To date, Dr. Ryan has authored more than 30 publications and has presented his research at numerous national and international conferences. He has received research funding from the National Institute of Environmental Health Sciences, the U.S. Environmental Protection Agency, the U.S. Department of Housing and Urban Development, the Centers for Disease Control and Prevention, as well as industry and private foundations. Dr. Ryan has also been an invited speaker at numerous national conferences and universities, a guest lecturer for environmental epidemiology courses at the University of Cincinnati, and has advised masters and doctoral students in epidemiology, biostatistics, and industrial hygiene in the Department of Environmental Health at the University of Cincinnati. In 2006 Dr. Ryan received a STAR award from the American Academy of Allergy, Asthma, and Immunology and in 2010 he was selected as one of ten Science Communication Fellows by Environmental Health Sciences. Dr. Ryan is the principal investigator of the Cincinnati Anti-Idling Campaign Study, an academic-community partnership to examine and reduce the impact of traffic-related air pollution at schools on children with asthma. He is also co-PI of a collaborative study to develop and field test, in a cohort of asthmatic children, a personal sensor to measure exposure to ultrafine particles. Dr. Ryan also serves as co-investigator of the Cincinnati Childhood Allergy and Air Pollution Study (CCAAPS), a longitudinal birth cohort study of the effects of diesel exhaust particles on the development of allergies and asthma. His research with the CCAAPS study includes the development of land-use regression models for air pollution exposure assessment and the association between air pollution and neurobehavioral development. Additional research includes studies of indoor pollutants and mold, environmental exposure to asbestos in Libby, MT, and the elemental composition of PM2.5.
Education and Training
PhD: Epidemiology, University of Cincinnati, Cincinnati, OH. MS: Epidemiology, University of Cincinnati, OH.
Publications
Sebastian KJ, Ryan PH, Lockey JE, Bernstein DI, McKay RT, Hershey GKK, Villareal M, Biagini Myers JM, Levin L, Burkle J, Evans S, LeMasters GK. Unraveling the relationship between aeroallergen sensitization, gender, second hand smoke exposure and impaired lung function. Pediat Allergy and Immunol. In press. Hochstetler HA, Yermakov M, Reponen T, Ryan PH, Grinshpun SA. Aerosol Particles Generated by Diesel-Powered School Buses at Urban Schools as a Source of Children’s Exposure. Atmospheric Environment. 2011;45:1444-1453. Ryan PH, Dihle M, Griffin S, Taylor R, Hilbert T, Adjei S, Lockey JE. Radiographic Changes Associated with Exposure to Erionite in Road Gravel in North Dakota. J Occup Environ Med. 2011;53(8):893-899. Sucharew H, Ryan PH, Bernstein D, Succop D, Khurana Hershey GK, Lockey J, Villareal M, Reponen T, Grinshpun S, LeMasters G. Exposure to Traffic Exhaust and Night Cough During Early Childhood: the CCAAPS Cohort. Pediatr Allergy Immunol. 2010;21(2 Pt 1):253-9. Li C, Nguyen Q, Ryan PH, LeMasters GK, Spitz H, Lobaugh M, Glover S, Grinshpun SA. School bus pollution and changes in the air quality at schools: a case study. J Environ Monit. 2009;11:1037. Ryan PH, Bernstein D, Reponen T, Levin L, Grinshpun S, Villareal M, Lockey J, Hershey GK, Burkle J, LeMasters GK. Exposure to traffic related-particles and endotoxin during infancy is associated with wheezing at age three. Am J Respir Criti Care. 2009;180:1068-1075 Appatova AS, Ryan PH, LeMasters GK, Grinshpun SA. Proximal Exposure of Public Schools and Students to Major Roadways: A Nationwide US Survey. Journal of Environmental Planning and Management. 2008; 51(5):631-646. Ryan PH, LeMasters GK, Levin L, Burkle J, Biswas P, Hu S, Grinshpun S, Reponen T. A Land-Use Regression Model for Estimating Microenvironmental Diesel Exposure Given Multiple Addresses From Birth Through Childhood. Sci Total Environ. 2008;404:139-147. Ryan PH, LeMasters GK, Biswas P, Levin L, Hu S, Lindsey M, Bernstein DI, Lockey J, Villareal M, Hershey GKK, Grinshpun SA. A comparison of proximity and land use regression traffic exposure models and wheezing in infants. Environ Health Perspect. 2007;115(2):278-284. Ryan PH and LeMasters GK. A review of land-use regression models for characterizing intraurban air pollution exposure. Inhal Toxicol. 2007;19(Suppl 1):127-133. Ryan PH, LeMasters G, Biagini J, Bernstein D, Grinshpun SA, Shukla R, Wilson K, Villareal M, Burkle J, Lockey J. Is it traffic type, volume, or distance? Wheezing in infants living near truck and bus traffic. J Allergy Clin Immunol. 2005;116:279-284.(Editor’s Choice article)
Grants
Impact of Traffic-Related Particles on Asthma for Students in an Urban School District. Principal Investigator. National Institute of Health (NIH) National Institute of Environmental Health Sciences (NIEHS). Oct 2009 – Sept 2012. Analysis of Personal and Home Characteristics Associated with the Elemental Composition of PM2.5 in Indoor, Outdoor, and Personal Air in the RIOPA Study. Principal Investigator. Health Effects Institute (HEI). Aug 2010 – July 2012. Field Validation of a Personal Sensor for Ultrafine PM in Asthmatic Children. Co-Principal Investigator. NIEHS. July 2011 – June 2013. Diesel, Allergens, and Gene-Environment Interactions. Co-Investigator. NIEHS. July 2007 – June 2012. The Libby Community Childhood Health Investigation and Exposure Follow-Up Study. Co-Investigator. Co-Investigator. NIEHS. October 2009 – Sept 2013. Synergistic Effect of Home Exposure to Aeroallergens and Traffic-Related Air Pollution. Department of Housing and Urban Development (HUD). Co-Investigator. Apr 2011 – March 2013.
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Shelia Salisbury, PhD
has worked in design, analysis and interpretation of results from clinical trials and observational studies. She provides statistical support for researchers in a number of divisions and provided support to assist in the development of Children’s Hospital biostatistical consulting component of the CCTST. She is also the biostatistician for Cincinnati Children’s Hospital Medical Center’s Cancer Program Data Safety Monitoring Board (DSMB).
(513) 636-2947
shelia.salisbury@cchmc.org
Shelia Salisbury, PhD
Academic Information
Assistant Professor, UC Department of Pediatrics
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Education and Training
PhD: University of Cincinnati, 2008. MS: Applied Statistics, Wright State University, 1992. BS: Mathematics/Statistics, Wright State University, 1990.
Publications
View PubMed Publications
Talbert RJ, Michaud LJ, Mehlman CT, Kinnett DG, Laor T, Foad SL, Schnell B, Salisbury S. EMG and MRI are Independently Related to Shoulder External Rotation Function in Neonatal Brachial Plexus Palsy. J Pediatr Orthop. 2011 Mar;31(2):194-204. Larson DB, Johnson LW, Schnell BM, Salisbury SR, Forman HP. National trends in CT use in the emergency department: 1995-2007. Radiology. 2011 Jan;258(1):164-73. Kim HK, Gottliebson W, Hor K, Backeljauw P, Gutmark-Little I, Salisbury SR, Racadio JM, Helton-Skally K, Fleck R. Cardiovascular anomalies in Turner syndrome: spectrum, prevalence, and cardiac MRI findings in a pediatric and young adult population. AJR Am J Roentgenol. 2011 Feb;196(2):454-60. Staat MA, Rice MA, Donauer S, Payne DC, Bresee JS, Mast TC, Curns AT, Cortese MM, Connelly B, McNeal M, Ward RL, Bernstein DI, Parashar UD, Salisbury S. Estimating the rotavirus hospitalization disease burden and trends, using capture-recapture methods. Pediatr Infect Dis J. 2010 Dec;29(12):1083-6.
Staat MA, Stadler LP, Donauer S, Trehan I, Rice M, Salisbury S. Serologic testing to verify the immune status of internationally adopted children against vaccine preventable diseases. Vaccine. 2010 Nov 23;28(50):7947-55.
Kim HK, Laor T, Graham TB, Anton CG, Salisbury SR, Racadio JM, Dardzinski BJ. T2 relaxation time changes in distal femoral articular cartilage in children with juvenile idiopathic arthritis: a 3-year longitudinal study. AJR Am J Roentgenol. 2010 Oct;195(4):1021-5.
Parikh SN, Grice SS, Schnell BM, Salisbury SR. Operating room traffic: is there any role of monitoring it?J Pediatr Orthop. 2010 Sep;30(6):617-23.
Habli M, Cnota J, Michelfelder E, Salisbury S, Schnell B, Polzin W, Lim FY, Crombleholme TM. The relationship between amniotic fluid levels of brain-type natriuretic peptide and recipient cardiomyopathy in twin-twin transfusion syndrome. Am J Obstet Gynecol. 2010 Oct;203(4):404.e1-7. Mahmoud M, Sadhasivam S, Salisbury S, Nick TG, Schnell B, Sestokas AK, Wiggins C, Samuels P, Kabalin T, McAuliffe J. Susceptibility of transcranial electric motor-evoked potentials to varying targeted blood levels of dexmedetomidine during spine surgery. Anesthesiology. 2010 Jun;112(6):1364-73. Vuletin JF, Lim FY, Cnota J, Kline-Fath B, Salisbury S, Haberman B, Kingma P, Frischer J, Crombleholme T. Prenatal pulmonary hypertension index: novel prenatal predictor of severe postnatal pulmonary artery hypertension in antenatally diagnosed congenital diaphragmatic hernia. J Pediatr Surg. 2010 Apr;45(4):703-8.
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Heidi J. Sucharew, PhD
is a biostatistician with research interests in structural equation modeling, latent profile analysis, and latent variable modeling. Her recent areas of application include infant neurobehavior, stroke severity, adolescent menstrual symptoms and depression, and glucose control during pregnancy.
513-803-1920
Heidi.Sucharew@cchmc.org
Heidi J. Sucharew, PhD
Academic Information
Instructor, UC Department of Pediatrics
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Specialties
structural equation modeling, latent profile analysis, and latent variable modeling
Biography
Dr. Sucharew's areas of applied research include infant neurobehavioral outcomes, stroke severity, adolescent menstrual symptoms and depression, and glucose control during pregnancy. Her research has been funded by the NINDS, NIH/NIEHS, and NIMH. To date, she has authored 12 publications and has presented her research at numerous national and international conferences. Part of Dr. Sucharew’s dissertation work on Item Response Theory and skin prick testing has been selected to be highlighted as Editor’s Choice in the March 2012 edition of Pediatric Allergy and Immunology. Dr. Sucharew has been very active as a teacher. She contributes to the Biostatistics and Epidemiology modules of the Pediatrics Fellowship Core curriculum. She has also developed and is the primary instructor of "Introduction to Biostatistics" online course and has served as an invited lecturer in "Design and Management of Field Studies in Epidemiology" in the graduate program in Biostatistics and Epidemiology in the Department of Environmental Health.
Education and Training
BA: Statistics, The College of New Jersey, Ewing, NJ, 2000 MS: Biostatistics, University of Washington, Seattle, WA, 2002 PhD: Biostatistics, University of Cincinnati, Cincinnati, OH, 2009
Publications
Sucharew H, Khoury JC, Rao MB, Succop P, Bernstein D, Ryan PH, LeMasters G. Predicting allergic disease at age four using an atopy predisposition score at age two: the application of Item Response Theory. Pediatr Allergy Immunol. 2012. VanDyke R, Ren Y, Sucharew H, Miodovnik M, Rosenn B, Khoury JC. Characterizing maternal glycemic control: a more informative approach using semiparametric regression. J Matern Fetal Neonatal Med, 25(1): 15-9. 2012 Flaherty ML, Kissela B, Sucharew H, Alwell K, Moomaw CJ, Woo D, Khatri P, Ferioli S, Adeoye O, Mackey J, Broderick JP, Kleindorfer D. The practice of carotid revascularization within a large metropolitan population. J Stroke Cerebrovasc Dis. 2011. Mackey J, Kleindorfer DO, Sucharew H, Moomaw CJ, Kissela BM, Alwell K, Flaherty ML, Woo D, Khatri P, Adeoye O, Ferioli S, Khoury JC, Hornung R, Broderick JP. Population-based study of wake-up strokes. Neurology, 76(19), 1662-7. 2011. Sucharew H, Ryan PH, Bernstein D, Succop P, Khurana Hershey GK, Lockey J, Villareal M, Reponen T, Grinshpun S, LeMasters G. Exposure to traffic exhaust and night cough during early childhood: the CCAAPS birth cohort. Pediatr Allergy Immunol, 21(2), 253-9. 2010. Lerner S, Tangen C, Sucharew H, Wood D, Crawford ED. Failure to achieve a complete response to induction BCG therapy is associated with increased risk of disease worsening and death in patients with high risk non-muscle invasive bladder cancer. Urol Oncol, 27(2), 155-159. 2009. Iossifova Y, Reponen T, Sucharew H, Succop P, Vesper S. Use of (1-3)-beta-d-glucan concentrations in dust as a surrogate method for estimating specific fungal exposures. Indoor Air, 18(3), 225-232. 2008. Lerner S, Tangen C, Sucharew H, Wood D, Crawford ED. Patterns of recurrence and outcomes following bacillus calmette-guerin for high risk TA, T1 bladder cancer. J Urol, 177(5), 1727-1731. 2007. Sucharew H, Goss CH, Millard SP, Ramsey B. Respiratory adverse event profiles in placebo subjects in short and long-term inhaled therapy trials. Contemp Clin Trials, 27(6), 561-70. 2006. Brody AS, Sucharew H, Campbell JD, Millard SP, Molina PL, Klein JS, Quan J. Computed tomography correlates with pulmonary exacerbations in children with cystic fibrosis. Am J Respir Crit Care Med, 172(9), 1128-32. 2005
Grants
Hemorrhagic and Ischemic Stroke Among Blacks and Whites. Biostatistician. National Institute of Health / National Institute of Neurological Disorders and Stroke. July 2009 – June 2014. Recanalization Therapies and Markers of Stroke Outcome. Co-Investigator. National Institute of Neurological Disorders and Stroke. July 2008 – April 2013. Medication Continuity in Children Treated for ADHD. Biostatistician. National Institute of Mental Health. Jan 2010 – Nov 2014. Neurobehavioral Effects of Insecticide Exposure in Pregnancy and Early Childhood. Biostatistician. National Institute of Health / National Institute of Environmental Health Sciences. Sept 2009 – Aug 2012.
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Rhonda D. VanDyke, PhD
is currently interested in statistical and epidemiological research, including functional data analysis applications, classification methods, self-modeling regressions, instrumental variables regression, and outcomes research for children with Cystic Fibrosis and obstructive sleep apnea. She was recently awarded a statistical methods development grant to further her research on ambulatory blood pressure monitoring and cardiac outcomes in children with obstructive sleep apnea.
513-803-0563
rhonda.vandyke@cchmc.org
Rhonda D. VanDyke, PhD
Academic Information
Assistant Professor, UC Department of Pediatrics
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Specialties
Self-modeling regressions; bayesian adaptive regression splines; time series analysis; spectral analysis
Education and Training
PhD: Statistics, University of Kentucky, Lexington, KY, 2007. MS: Statistics, University of Kentucky, Lexington, KY, 2005. BS: Mathematics, Radford University, Radford, VA, 2003.
Publications
View PubMed Publications
McPhail GL, Weiland J, Acton JD, Ednick M, Chima A, VanDyke R, Fenchel MC, Amin RS, Seid M. Improving evidence-based care in cystic fibrosis through quality improvement. Arch Pediatr Adolesc Med. 2010 Oct;164(10):957-60.
McPhail GL, Ednick MD, Fenchel MC, VanDyke R, Chima A, Amin RS, Seid M. Improving follow-up in hospitalised children. Qual Saf Health Care. 2010 Oct;19(5):e35.
Young LR, VanDyke R, Gulleman P, Yoshikazu I, Brown KK, Schmidt L, Hajjar F, Trapnell B, Franz D, & McCormack FX. Vascular Endothelial Growth Factor D for the Serodiagnosis of Lymphangioleiomyomatosis. CHEST. 2010 Sep;138(3):674-81. McConnell K, Somers VK, Kimball T, Daniels S, VanDyke R, Fenchel M, Cohen A, Willging P, Shamsuzzaman A & Amin R. Baroreflex Gain in Children with Obstructive Sleep Apnea. Am J Respir Crit Care Med. 2009 Jul 1;180(1):42-8. Gavotte L, Mercer DR, Vandyke R, Mains JW, Dobson SL. Wolbachia infection and resource competition effects on immature Aedes albopictus (Diptera: Culicidae). J Med Entomol. 2009 May;46(3):451-9. Stefaniak TR, Phillips TD, Rodgers CA, VanDyke R & Williams D. The Inheritance of Cold Tolerance and Turf Traits in a Seeded Bermuda Grass Population. J Crop Science. 2009;49(4). Khadra MA, McConnell K, VanDyke R, Somers V, Fenchel M, Quadri S, Jefferies J, Cohen AP, Rutter M, Amin R. Determinants of regional cerebral oxygenation in children with sleep-disordered breathing. Am J Respir Crit Care Med. 2008 Oct 15;178(8):870-5. Mercer DR, Schoergendorfer A, Vandyke R. Sexual differences in larval molting rates in a protandrous mosquito (Diptera: Culicidae) species, Aedes sierrensis. J Med Entomol. 2008 Sep;45(5):861-6. Grossoehme DH, VanDyke R, Seid M. Spirituality's role in chronic disease self-management: sanctification of the body in families dealing with cystic fibrosis. J Health Care Chaplain. 2008;15(2):149-58.
Grants
Blood pressure, cardiovascular function and sleep apnea: Developing statistical models that fit (not force) the data. Principal Investigator. Center for Clinical and Translational Science and Training. 2010 - 2011. Development and Validation of Serum VEGF-D as a Clinical Diagnostic Test in Lymphangioleiomyomatosis. Biostatistician. Center for Clinical and Translational Science and Training. 2010 - 2011.
Vascular Functions in Children with Sleep-Disordered Breathing. Biostatistician. National Heart, Lung and Blood Institute. 2006 -2011. # R01HL080670.
Late Preterm Birth, Ureaplasma Species and Childhood Lung Disease. Biostatistician. National Institutes of Health. 2009 - 2013. #R01 HL097064.
Cardiac Structure and Function in Early Familial Cardiomyopathy. Mentoring Biostatistician. National Institutes of Health. 2010 - 2015. #K25 HL102244-01.
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Bin Zhang, PhD
conducts research on statistical methods in clinical trials, survival analysis, longitudinal data analysis and optimal designs. Areas of interest: cancer, infectious diseases, asthma, cardiovascular diseases, health behavior, cohort studies, case-control studies, and clinical trials.
513-803-8050
bin.zhang@cchmc.org
Bin Zhang, PhD
Academic Information
Assistant Professor, UC Department of Pediatrics
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Biography
Dr. Zhang joined Cincinnati Children’s in January 2012. Dr. Zhang has served as co-investigator and lead statistician in clinical trials including both adult and pediatric patients. He served as the biostatistician for the Collaborative Antiviral Study Group (CASG), providing statistical support regarding study design, protocol development, study monitoring, quality assurance, data management, report generation and statistical analyses for CASG trials. In addition, he was the deputy director of the Statistical and Data Management Center of Mycoses Study Group (MSG), and served on the Steering Committee (Design and Analysis Committee) for the Consortium of Hospitals to Advance Research on Tobacco (CHART) trials. He has published theoretical as well as collaborative articles in peer-reviewed journals. His recent paper “Evaluation of lymph node numbers for adequate staging of Stage II and III colon cancers” published in the Journal of Hematology and Oncology, May 2011, has been accessed 2023 times in the past 8 months.
Education and Training
BS: University of Science and Technology of China, Hefei, Anhui, China. PhD: University of Missouri, Columbia, Missouri.
Publications
Acelajado MC, Pisoni R, Dudenbostel T, Dell’Italia LJ, Cartmill F, Zhang B, Cofield SS, Oparil S, Calhoun DA. Refractory hypertension: definition, prevalence and patient characteristics. J Clin Hyperten. 2012;14(1):7-12. Katkoori VR, Shanmugam C, Jia X, Salih C, Sthanam M, Chen D, Zhang B, Bumpers HL, Callens T, Messiaen LM, Grizzle WE, Manne U. Prognostic significance and gene expression profiles of p53 mutations in microsatellite-stable stage III colorectal adenocarcinomas. PloS One. 2012;7(1):1-10. Bovell L, Shanmugam C, Katkoori VR,; Zhang B, Vogtmann E, Grizzle WE, Manne U. microRNAs are Stable in Colorectal Cancers Archival Tissue Blocks. Frontiers in Bioscience. 2012 Jan 1;4:1937-40. PMID: 22202009. Gerald LB, McClure LA, Gerald JK, Zhang B, Harrington K, Bailey WC. Seasonal Influenza and H1N1 vaccine prevalence among children with asthma. Am J Respiratory Critical Care Medicine. 2011 May;183:A4153. Shanmugam C, Hines RB, Jhala NC, Katkoori VR, Zhang B, Posey JA, Bumpers HL, Grizzle WE, Eltoum IE, Siegal GP, Manne U. Evaluation of lymph node numbers for adequate staging of Stage II and III colon cancers. J Hematol and Oncolo. 2011 May;4(1):25. PMID: 21619690. Gerald JK, McClure LA, Zhang B, Harrington K, Bailey WC, Gerald LB. Predictors of hand sanitizer use at home among children with asthma. Am J Respiratory Critical Care Medicine. 2011 May;183:A3792. Yang M, Zhang B, Huang SG. Optimal designs for generalized linear models with multiple design variables. Statistica Sinica. 2011;21:1415-1430 Subramaniam A, Kim KH, Bryant SA, Zhang B, Sikes C, Kimball KJ, Kilgore LC, Huh WK, Straughn JM Jr., Alvarez RD. A cohort study evaluating robotic versus laparotomy surgical outcomes of obese women with endometrial carcinoma. Gynecology Oncology. 2011;122(3):604-7. PMID: 21658752.. Fauci J, Whitworth J, Subramanian A, Zhang B, Frederick PJ, Schneider K, Straughn JM, Kilgore LC. Prognostic significance of the relative dose intensity of chemotherapy in primary treatment of epithelial ovarian cancer. Gynecology Oncology. 2011;122(3):532-5. PMID: 21658751. Zhang B, Tong XW, Sun JG. Efficient estimation for the proportional odds model with bivariate current status data. Far East J Theorteical Statistics. 2009;(1):113-132.
Grants
Mycoses Study Group. Deputy Director. Statistical and Data Management Center. Feb 2010-Dec 2013. Clinical Trials for Antiviral Therapies. Investigator. National Institutes of Health / National Institute of Allergy and Infectious Diseases. Aug 2003-Jan 2012.
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