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Maurizio Macaluso, MD, DPH Director, Biostatistics and Epidemiology
has researched topics including epidemiologic research methods; cancer epidemiology; occupational epidemiology; health effects of sexual, reproductive and contraceptive behavior; acceptability, efficacy and safety of contraceptive technology; efficacy and safety of assisted reproductive technology; infectious disease epidemiology; surveillance systems; and immunology.
Director, Biostatistics and Epidemiology
Professor, UC Department of Pediatrics
Research methods; cancer; infectious disease; occupational health; sexual and reproductive health; contraception; assisted reproductive technology; surveillance systems
MD: University of Palermo, Italy, 1979. Fellowship: Experimental Oncology, Istituto Nazionale Tumori, Milano, Italy, 1981.
Residency: Hygiene and Preventive Medicine, University of Palermo, Italy, 1982. DrPH: Epidemiology, University of Alabama at Birmingham, 1991.
Tepper NK, Farr SL, Cohen BB, Nannini A, Zhang Z, Anderson JE, Jamieson DJ, Macaluso M. Singleton preterm birth: risk factors and association with assisted reproductive technology. Matern Child Health J. 2011 Apr 23.
Piyathilake CJ, Macaluso M, Alvarez RD, Chen M, Badiga S, Edberg JC, Partridge EE, Johanning GL. A higher degree of methylation of the HPV 16 E6 gene is associated with a lower likelihood of being diagnosed with cervical intraepithelial neoplasia. Cancer. 2011 Mar 1;117(5):957-63. Macaluso M, Wright-Schnapp TJ, Chandra A, Johnson R, Satterwhite CL, Pulver A, Berman SM, Wang RY, Farr SL, Pollack LA. A public health focus on infertility prevention, detection, and management. Fertil Steril. 2010 Jan; 93(1):16.e1-10. Macaluso M, Blackwell R, Jamieson DJ, Kulczycki A, Chen MP, Akers R, Kim D-j, Duerr A. Efficacy of the male latex condom and of the female polyurethane condom as barriers to semen during intercourse: a randomized clinical trial. Am J Epidemiol. 2007; 166(1):88-96.
Macaluso M, Larson R, Lynch J, Lipton S, Delzell E. Historical estimation of exposure to 1,3-butadiene, styrene, and dimethyldithiocarbamate among synthetic rubber workers. J Occup Environ Hyg. 2004 Jun;1(6):371-90 Macaluso M, Lawson L, Akers R, Valappil T, Hammond K, Blackwell R, Hortin G. Prostate-specific antigen in vaginal fluid as a biologic marker of condom failure. Contraception. 1999 Mar;59(3):195-201.Macaluso M, Demand MJ, Artz LM, Hook EW 3rd. Partner type and condom use. AIDS. 2000 Mar 31;14(5):537-46.Macaluso M, Larson R, Delzell E, Sathiakumar N, Hovinga M, Julian J, Muir D, Cole P. Leukemia and cumulative exposure to butadiene, styrene and benzene among workers in the synthetic rubber industry. Toxicology. 1996 Oct 28;113(1-3):190-202.Macaluso M. Exact stratification of person-years. Epidemiology. 1992 Sep;3(5):441-8.Butterworth CE Jr, Hatch KD, Macaluso M, Cole P, Sauberlich HE, Soong SJ, Borst M, Baker VV. Folate deficiency and cervical dysplasia. JAMA. 1992 Jan 22-29; 267(4):528-33.
Center for Clinical and Translational Science and Training. Director/Co-/Director of Biostatistics Epidemiology and Research Design Core. National Center for Research Resources. April 2009 – March 2014.
Mekibib Altaye, PhD
is a biostatistician interested in the design and analysis of correlated data, including developing inference procedures for intraclass correlation, and kappa statistic for binary and polynomial outcomes. Current research interest focused in modeling issues associated with high dimensional data that arise from fMRI, MRI and microbiome studies. He also mentors junior faculty, staff and students.
Associate Professor, UC Department of Pediatrics
Design and analysis of correlated data. This includes developing inference procedures for intraclass correlation, and kappa statistic for binary and polynomial outcomes. Recent research interest includes modeling issues associated with high dimensional data that arise from fMRI, MRI and microbiome studies.
Dr. Altaye has published more than 60 peer-reviewed articles, more than 70 abstracts/posters, invited to present his work in national meetings and co-author a book chapter. He has been a co-investigator, collaborator or biostatistician in more than 20 NIH funded projects. Dr. Altaye provides support for researchers in multiple divisions as well as for the Center for Clinical and Translational Sciences and Training (CCTST). He taught biostatistics courses for the Master of Science Clinical and Translational Research program. He has obtained travel awards to attend workshops from NSF and NIH. One of his articles received a Caffey award for best clinical science or education paper from the Pediatric Radiology Society.
PhD: The University of Western Ontario, London, Canada, 1998.
MSc: Oklahoma State University, Stillwater, OK, 1991.
BSc: Addis Ababa Universtiy, Addis Ababa, Ethiopia, 1983.
Szaflarski JP, Rajagopal A, Altay M, Byars AW, Jacola L, Schmithorst VJ, Schaprio MB, Plante E, Holland SK. Left-handedness and language lateralization in children. Brain Research. 1433: 85-97. 2012.
Cecil KM, Dietrich KN, Altaye M, Egelhoff JC, Lindquist DM, Brubaker CJ, Lanphear BP. Proton magnetic resonance spectroscopy in adults with childhood lead exposure. Environmental Health Perspective. Mar;119(3):403-8. 2011.
Yuan W, Altaye M, Ret J, Schmithorst VJ Byars AW, Plante E, Holland SK. Quantification of children’s head motion in various fMRI language tasks. Human Brain Mapping. 30(5): 1481-9. 2009.
Langberg, JM., Epstein, JN., Altaye M., Molina, B., Arnold, E., Vitiello, B. The transition to middle school is associated with changes in the developmental trajectory of ADHD symptomatology in young adolescents with ADHD. Journal of Clinical Child and Adolescent Psychology. 37(3): 651-63. 2008.
Eaton KP, Szaflarski JP, Altaye M, Ball AL, Kissela BM, Banks C, Holland SK. Reliability of fMRI for studies of language in post-stroke aphasia subjects. NeuroImage. 41(2): 311-22. 2008.
Wilke M, Holland SK, Altaye M, Gaser C. Template-o-matic: a toolbox for creating customized pediatric templates. NeuroImage. 41(3): 903-13. 2008.
Altaye M, Holland SK, Wilke M, Gaser C. Infant brain probability templates for MRI segmentation and normalization. NeuroImage. 43(4): 721-30. 2008.
Szaflarski JP, Schmithorst VJ, Altaye M, Byars AW, Rett J, Plante E, Holland SK. A longitudinal fMRI study of language development in children age 5-11. Annals of Neurology. 59(5): 796-807. 2006.
Altaye M, Donner A, Eliasziw M. A general goodness of fit approach for inference procedures concerning the kappa statistic. Statistics in Medicine. 16: 2479-2488. 2001.
Altaye M, Donner A, Klar N. Inference procedures for assessing interobserver agreement among multiple raters. Biometrics. 57: 584-588. 2001.
Pediatric Functional Neuroimaging Research Network. Biostatistician. NIH/NICHD. 09/2009-09/2014.
Neurobehavioral Effects of Insecticide Exposure in Pregnancy and Early Childhood. Biostatistician. NIH. 09/2009-06/2012.
Role of Human Milk in Infant Nutrition and Health. Co-Investigator. NIH/NICHD. 08/2009-06/2013.
Longitudinal DTI Study in Children Treated for congenital Hydrocephalus. Biostatistician. NIH. 09/2009-06/2013.
Center for Clinical and Translational Science and Training. Biostatistician NIH/NCRR. 04/2009-03/2014.
Treatment of maternal depression in home visitation: Mother and Child impacts. Co-investigator. NIH/NIMH. 12/2009-11/2014.
Imaging the effect of centrotemporal spikes and seizures. Biostatistician. NIH/NIND. 09/2011-06/2016.
Multisite Study of School Based Treatment Approaches for ADHD Adolescents. Biostatistician. NIH/NIMH. 08/2009-03/2014.
Katherine A. Bowers, PhD, MPH
is a perinatal epidemiologist interested in pre-conceptual and prenatal exposures in combination with genetic effects in relation to metabolic and neurodevelopmental consequences for the offspring.
Assistant Professor, UC Department of Pediatrics
Perinatal and genetic epidemiology; autism spectrum disorders; prenatal exposures; pregnancy complications
Bowers K, Tobias DK, Yeung E, Hu FB, Zhang C. A prospective study of pre-pregnancy dietary fat intake and risk for gestational diabetes. Am J of Clin Nutr. 2012; 95: 446-53.
Tobias DK, Zhang C, Chavarro J, Bowers K, Rich-Edwards J, Rosner B, Mozaffarian D, Hu FB. Pre-pregnancy adherence to dietary patterns and decreased risk of gestational diabetes mellitus. Am J Clin Nutr. 2012 Aug; 96 (2): 289-95.
Bowers K, Zhang C. The association between obesity and diabetes in pregnancy and neurodevelopmental outcomes in the offspring. North American Journal of Medicine and Science. 20114(4): 217-22.
Bowers K, Yeung E, Williams MA, Qi L, Tobias DK, Hu FB, Zhang C. A prospective study of prepregnancy dietary iron intake and risk for gestational diabetes mellitus. Diabetes Care. 2011 Jul; 34(7):1557-63.
Bowers K, Li Q, Bressler J, Avramopoulos D, Newschaffer C, Fallin MD. Glutathione pathway gene variation and risk of autism spectrum disorders. J Neurodev Disord. 2011 Jun; 3(2):132-43.
Bowers K, Liu G, Wang P, Ye T, Tian Z, Liu E, Yu Z, Yang X, Klebanoff M, Yeung E, Hu G, Zhang C. Birth weight, postnatal weight change, and risk for high blood pressure among Chinese children. Pediatrics. 2011 May; 127(5):e1272-9.
Schwender H, Bowers K, Fallin MD, Ruczinski I. Importance measures for epistatic interactions in case-parent trios. Ann Hum Genet. 2011 Jan;75(1):122-32.
Tobias DK, Zhang C, van Dam RM, Bowers K, Hu FB. Physical activity before and during pregnancy and risk of gestational diabetes mellitus: a meta-analysis. Diabetes Care. 2011 Jan;34(1): 223-9.
Schisterman E, Whitcomb B, Bowers K. Invited commentary: causation or “noitasuac”? Am J Epidemiol. 2011 May 1;173(9):984-7.
Bowers K, Albanes D, Limburg P, Pietinen P, Taylor PR, Virtamo J, Stolzenberg-Solomon R. A prospective study of anthropometric and clinical measurements associated with insulin resistance syndrome and colorectal cancer in male smokers. Am J Epidemiol. 2006 Oct;164(7):652-64.
Melinda S. Butsch Kovacic, MPH, PhD
is an epidemiologist who has clinical, translational and community-based participatory research projects. Her research group studies the genetic/epigenetic, environmental and socioeconomic basis of chronic diseases such as cancer, asthma and obesity, with specific interest in understanding how environmental exposures modify risk in vulnerable families. Her research is highly interdisciplinary with collaborators across the academic health center and in the community.
Visit the Butsch Kovacic Lab.
Clinical and molecular epidemiology; gene-environment interactions; biomarkers; community-based participatory research
One of Dr. Butsch Kovacic’s long-term goals is to improve the understanding of how the environment modifies chronic disease risk in genetically and/or economically vulnerable children. To this end, she is the PI of an ongoing study that is evaluating associations between environmental exposures and biomarkers of oxidative stress and whether or not these biomarkers will better predict risk of severe/uncontrolled childhood asthma compared to parental report of exposure alone (previous NIEHS R21 and CCTST KL2). As part of this study, her team is evaluating diesel exhaust particle and second hand tobacco smoke exposures, as well as obesity levels, markers of inflammation and antioxidant status, genetic and socioeconomic factors, and DNA methylation patterns. As her preliminary data revealed strong associations between her outcomes and socioeconomic factors, over the last year, she has partnered with Cincinnati’s CoreChange, a grassroots advocacy group, and Seven Hills Neighborhood Houses (SHNH; http://7hillsnh.org/), a full service social service agency and community center in the West End of Cincinnati, to expand her research into the community using a community-based participatory research (CBPR) approach. To this end, she has implemented a community-based research registry and begun needs assessments using a child-centered PhotoVoice approach and adult focus groups. A peer family health COACH (Coaching On Achieving Community Health) program will begin soon. To inform these community-based studies, she is collaborating on a project seeking to develop unique multimedia educational materials targeting low-income and low-literacy caregivers with asthmatic children.
In addition to these studies, she is also the PI of an ongoing longitudinal epidemiological study seeking to evaluate environmental and sexual exposure to human papillomavirus (HPV) in families with children diagnosed with Fanconi anemia (current NHLBI R01). Individuals with Fanconi anemia are genetically vulnerable to squamous head and neck cancers previously shown to be positively associated with HPV. Her team is testing for oral HPV DNA, HPV serological markers as well as markers of immune response. As part of this study, Dr. Butsch Kovacic regularly interacts with a community of families associated with the Fanconi Anemia Research Fund, a strong parent led advocacy group focused on the improving the lives of children with Fanconi anemia, to design, optimize and disseminate the findings from her study.
Brandt EB, Kovacic MB, Lee GB, Gibson AM, Acciani TH, Le Cras TD, Ryan PH, Budelsky AL, Khurana Hershey GK. Diesel exhaust particle induction of IL-17A contributes to severe asthma. J Allergy Clin Immunol. 2013 Nov:132(5): 1194-1204.
Epstein TG, LeMasters GK, Bernstein DI, Ericksen MB, Martin LJ, Ryan PH, Biagini Myers JM, Butsch Kovacic MS, Lindsey MA, He H, Reponen T, Villareal MS, Lockey JE, Bernstein CK, Khurana Hershey GK. Genetic variation in small proline rich protein 2B as a predictor for asthma among children with eczema. Ann Allergy Asthma Immunol. 2012 Mar;108(3):145-50.
Martin LJ, Gupta J, Butsch Kovacic M, Biagini Myers JM, Patterson TL, Ericksen MB, He H, Gibson AM, Baye TM, Heeman AM, Sha S, Eissa T, Khurana Hershey GK. Functional variants in the autophagy-related 5gene promotor associated with childhood asthma. PLoS One. 2012;7(4):e33454.
Hoskins EE, Morreale RJ, Werner SP, Higginbotham JM, Brown DR, Laimins LA, Lambert PF, Gillison ML, Nuovo GJ, Wikenheiser-Brokamp KA, Witte DP, Kim MO, Davies SM, Mehta PA, Butsch Kovacic M*, Wells SI* (*Co-corresponding authors). The Fanconi Anemia Pathway Limits Human Papillomavirus Replication. J Virol. 2012 Aug;86(15):8131-8.
Butsch Kovacic M, Biagini Myers JM, Martin LJ, Lindsey M, Patterson TL, Sauter S, Ericksen MB, Ryan PH, Assa’ad A, Lierl M, Fischer T, Kercsmar C, McDowell K, Lucky AW, Sheth, AP, Hershey AD, Ruddy RM, Rothenberg M, Khurana Hershey GK. The Greater Cincinnati Pediatric Clinic Repository (GCPCR): A Novel Framework for Asthma and Allergy Research. Pediatr Allergy Immunol Pulmonol. 2012 Jun;25(2):104-113.
Butsch Kovacic M, Biagini Myers JM, Patterson TL, Lindsey M, Ericksen MB, He H, Gupta J, Sivaprasad U, Gibson AM, Tsoras AM, Chen W, Musaad S, Baye TM, Khurana Hershey GK. Identification of KIF3A as a Novel Candidate Gene for Childhood Asthma Using RNA Expression and Population Allelic Frequencies Differences. PLoS One. 2011;6(8):e23714.
Myers KC, Bleesing JJ, Davies SM, Zhang X, Martin LJ, Mueller R, Harris RE, Filipovich AH, Butsch Kovacic M, Wells SI, Mehta PA. Impaired Immune Function in Children with Fanconi Anemia. Br J Haematol. 2011 Jul;154(2):234-40.
Cortina S, Drotar D, Ericksen M, Lindsey M, Patterson TL, Biagini Myers JM, Butsch Kovacic M, Khurana Hershey GK. Genetic Biomarkers of Health-Related Quality of Life in Pediatric Asthma. J Pediatr. 2011 Jul;159(1):21-26.
Baye TM, Butsch Kovacic M, Biagini Myers JM, Martin LJ, Lindsey M, Patterson TL, He H, Ericksen MB, Gupta J, Tsoras AM, Lindsley A, Rothenberg ME, Wills-Karp M, Eissa NT, Borish L, Khurana Hershey GK. Differences in candidate gene association between European ancestry and African American asthmatic children. PLoS One. 2011 Feb 28;6(2):e16522.
Reszka, KJ, Sallans L, Brown K, McGraw DW, Butsch Kovacic M, Britigan BE. Airway peroxidases catalyze nitration of the β2-agonist salbutamol and decrease its pharmacological activity. J Pharmacol Exp Ther. 2011 Feb;336(2):440-9.
Fanconi Anemia as a Model for Susceptibility to Human Papillomavirus Infection. Principal Investigator. NIH/NHLBI. July 2011-Jun 2016.
Epithelial Genes in Allergic Inflammation. Co- Investigator. NIH/NIAID Asthma and Allergic Diseases Cooperative Research Center. July 2011-June 2016.
Lili Ding, PhD
is a biostatistician with research interest in Bayesian modeling and inference, and its applications in various fields of biomedical research, including statistical genetics, population pharmacokinetics and pharmacodynamics, multivariate survival analysis, and multilevel latent variable modeling. Dr. Ding mentors junior faculty, fellows and students in DBE and several other divisions within the hospital.
Biostatistics, Bayesian statistics, statistical genetics, population PK/PD study design and modeling
Mullins TLK, Zimet GD, Rosenthal SL, Morrow C, Ding LL, Shew, M, Kahn, JA. Adolescent Perceptions of Risk and Need for Safer Sexual Behaviors After First Human Papillomavirus Vaccination. [Article]. Archives of Pediatrics & Adolescent Medicine, 166(1), 82-88. 2012.
Baye TM, He H, Ding L, Kurowski BG, Zhang X, Martin LJ. Population structure analysis using rare and common functional variants. BMC Proc, 5 Suppl 9, S8. doi: 10.1186/1753-6561-5-s9-s8. 2011.
Ding L, Baye TM, He H, Zhang X, Kurowski BG, Martin LJ. Detection of associations with rare and common SNPs for quantitative traits: a nonparametric Bayes-based approach. BMC Proc, 5 Suppl 9, S10. doi: 10.1186/1753-6561-5-s9-s10. 2011.
Ding L, Wiener H, Abebe T, Altaye M, Go RC, Kercsmar C, Baye TM. Comparison of measures of marker informativeness for ancestry and admixture mapping. BMC genomics, 12, 622. 2011.
He H, Zhang X, Ding L, Baye TM, Kurowski BG, Martin LJ. Effect of population stratification analysis on false-positive rates for common and rare variants. BMC Proc, 5 Suppl 9, S116. doi: 10.1186/1753-6561-5-s9-s116.2011.
Kahn JA, Huang B, Ding LL, Geller A, Frazier AL. Impact of Maternal Communication About Skin, Cervical, and Lung Cancer Prevention on Adolescent Prevention Behaviors. [Article]. Journal of Adolescent Health, 49(1), 93-96. doi: 10.1016/j.jadohealth.2010.11.247. 2011.
Sherwin C, Ding L, Kaplan J, Vinks A. Optimal design for a single dose pharmacokinetic study of Pioglitazone in septic pediatric patients. Journal of Pharmacokinetics and Pharmacodynamics, 38(4), 433-447. 2011.
Zhang X, He H, Ding L, Baye TM, Kurowski BG, Martin LJ. Family- and population-based designs identify different rare causal variants. BMC Proc, 5 Suppl 9, S36. doi: 10.1186/1753-6561-5-s9-s36. 2011.
Kahn JA, Ding LL, Huang B, Zimet GD, Rosenthal SL, Frazier AL. Mothers' Intention for Their Daughters and Themselves to Receive the Human Papillomavirus Vaccine: A National Study of Nurses. [Article; Proceedings Paper]. Pediatrics, 123(6), 1439-1445. doi: 10.1542/peds.2008-1536. 2009.
Pattullo L, Griffeth S, Ding LL, Mortensen J, Reed J, Kahn J, Huppert J. Stepwise Diagnosis of Trichomonas vaginalis Infection in Adolescent Women. [Article]. Journal of Clinical Microbiology, 47(1), 59-63. doi: 10.1128/jcm.01656-08. 2009.
Lin Fei, PhD
Mathematical statistics; clinical trial design and analysis; statistical and probability models
BS, MS: Shanghai Jiaotong University, Shanghai, China, 1984.
MS: The Ohio State University, Columbus, OH, 1988.
PhD: The Ohio State University, Columbus, OH, 1992.
Jessica Graus Woo, MHSA, PhD
is a molecular epidemiologist with particular research interest in the developmental pathways leading to pediatric obesity. She is specifically interested in how genetics and early life influences, especially early diet, may impact a child’s likelihood of developing obesity and specific metabolic complications of obesity, such as insulin resistance and dyslipidemia.
Genetic and Environmental Risk Factors in Hemorrhagic Stroke. Principal Investigator of Subcontract. National Institute of Health. 2008 - 2013
Charlotte M. Schmidlapp Women’s Scholars Award. 2011 – 2012.
David M. Hartley, PhD, MPH
investigates the factors governing the emergence and transmission of infectious diseases by applying mathematical modeling and computer simulation methods. He is also interested in data analytic and information technology approaches for understanding and improving communications in healthcare settings and improving patient safety.
Infectious disease epidemiology; public health surveillance; mathematical and computer modeling
PhD: University of Maryland Baltimore County, Baltimore, MD, 1996.
MPH: George Washington University, Washington, DC, 2006.
Smith DL, Perkins TA, Reiner Jr RC, Barker CM, Niu T, Chaves LF, Ellis AM, George DB, Le Menach A, Pulliam J, Bisanzio D, Buckee C, Chiyaka C, Cummings DAT, Garcia AJ, Gatton ML, Gething PW, Hartley DM, Johnston G, Klein EY, Michael E, Lindsay SW, Lloyd AL, Pigott DM, Reisen WK, Ruktanonchai N, Singh B, Stoller J, Tatem AJ, Kitron U, Hay SI, Scott TW. Recasting the Theory of Mosquito-Borne Pathogen Transmission Dynamics and Control. Trans R Soc Trop Med Hyg. 2014 Apr;108(4):185-87.
Hartley DM. Using social media and other Internet data for public health surveillance: The importance of talking. Milbank Q. 2014 Mar;92(1):34-9.
Barboza P, Vaillant L, Le Strat Y, Hartley DM, Nelson NP, Mawudeku A, Madoff LC, Linge JP, Collier N, Brownstein JS, Astagneau P. Factors influencing performance of Internet-based biosurveillance systems used in epidemic intelligence for early detection of infectious diseases outbreaks. PLoS One. 2014 Mar 5;9(3):e90536.
Hartley DM, Nelson NP, Arthur RR, Barboza P, Collier N, Lightfoot N, Linge JP, van der Goot E, Mawudeku A, Madoff LC, Vaillant L, Walters R, Yangarber R, Mantero J, Corley CD, Brownstein JS. An overview of Internet biosurveillance. Clin Microbiol Infect. 2013 Nov;19(11):1006-13.
Barker CM, Niu T, Reisen WK, Hartley DM. Data-driven modeling to assess receptivity for Rift Valley fever virus. PLoS Negl Trop Dis. 2013 Nov 14;7(11): e2515.
Nelson NP, Brownstein J, Hartley DM. Event-based biosurveillance of respiratory disease in Mexico, 2007-2009: Connection to influenza A(H1N1)v? Euro Surveill. 2010 Jul 29;15(30).
Nelson NP, Yang L, Reilly AR, Hardin JE, Hartley DM. Event-based Internet Biosurveillance: Relation to Epidemiological Observation. Emerg Themes Epidemiol. 2012 Jun 18;9(1):4.
Hartley DM, Barker CM, Le Menach A, Niu T, Gaff HD, Reisen WK. The effects of temperature on the emergence and seasonality of West Nile virus in California. Am J Trop Med Hyg. 2012 May;86(5):884-94.
Hartley DM, Morris JG Jr, Smith DL. Epidemiological Implications of Hyperinfectivity: A critical element in the ability of V. Cholerae to cause epidemics? PloS Med. 2006 Jan;3(1):e7.
Niu T, Gaff HD, Papelis YE, Hartley DM. An epidemiological model of Rift Valley fever with spatial dynamics. Comput Math Methods Med. 2012;2012:138757.
Md Monir Hossain, PhD, MSc
is a biostatistician whose methodologic research interests include the development of statistical methods for modeling spatial-temporal disease clusters; spatial structure equation modeling; mixture models; inter-rater reliability; multi-level modeling; health services and patient outcomes; and clinical trials. Areas of application include perinatal health; access to primary health care; and childhood cancer incidences.
PhD: Statistics, Institute of Statistical Mathematics, Japan.
MSc: Statistics, University of Dhaka, Bangladesh.
Hossain MM, Lawson AB, Cai B, Jungsoon C, Liu J, Kirby RS. Space-Time mixture models for small area disease risk and cluster estimation: model selection and optimum allocation. Environmetrics. 2014 25:84-96.
Eberth JM, Eschbach K, Morris J, Nguyen H, Hossain MM, Elting L. Geographic disparities in mammography capacity in the South: a longitudinal assessment of supply and demand. Health Serv Res. 2014 Feb;49(1):171-85.
Cai B, Lawson AB, Hossain MM, Choi J, Kirby RS, Liu J. Bayesian semiparametric model with with spatially-temporally varying coefficients selection. Stat Med. 2013 Sep 30;32(21):3670-85.
Hasbun R, Khoury N, Hadi C, Wootton S, Hossain MM, Beilke M. Risk score for identifying adults with CSF pleocytosis and negative CSF gram stain at low risk for an urgent treatable cause. J Infect. 2013 Aug;67(2):102-10.
Mirza S, Hossain MM, Mathews C, Martinez PJ, Gay J, Pino P, Rentfro A, McCormick JB, Fisher-Hoch SP. Type 2-Diabetes is Associated with Elevated Levels of TNF-alpha, IL-6 and Adiponectin and Low Levels of Leptin in a Population of Mexican American: A Cross-Sectional Study. Cytokine. 2012 Jan;57(1)136-42.
Kirby RS, Liu J, Lawson AB, Jungsoon C, Cai B, Hossain MM. Spatio-temporal Patterning of Small Area Low Birth Weight Incidence and Its Correlates: A Latent Spatial Structure Approach. Spat Spatiotemporal Epidemiol. 2011 Dec;2(4):265-71.
Jungsoon C, Lawson AB, Cai B, Hossain MM. Evaluation of Bayesian spatial-temporal latent models in small area health data. Environmetrics. 2011 Dec;22(8):1008-1022.
Lawson AB, Song HR, Cai B, Hossain MM, Huang K. Space-Time latent component modeling for Geo-referenced health data. Stat Med. 2010 Aug 30;29(19):2012-27.
Hossain MM, Lawson AB. Space-time Bayesian small area disease risk models: Development and evaluation with a focus on cluster detection. Environ Ecol Stat. 2010 Mar 1;17(1):73-95.
Hossain MM, Laditka J. Using hospitalization for ambulatory care sensitive conditions to measure access to primary health care: an application of spatial structural equation modeling. IntJ Health Geogr. 2009 Aug 28;8:51.
Bin Huang, PhD Biostatistician, Division of Biostatistics and Epidemiology
is an experienced biostatistician with research interests in mediation analysis, statistical causal inference, observational/epidemiological analyses, item response modeling, and spatially correlated data. Areas of application include: pubertal development, bio-behavior, health disparity, health related quality of life (HRQoL), patient-reported outcomes (PRO), substance use risk, STI, asthma and JIA research.
Biostatistician, Division of Biostatistics and Epidemiology
Associate Professor, Affiliated Assistant Professor, Department of Mathematical Sciences, University of Cincinnati A&S College
Biostatistics; puberty; substance use/abuse; STI; GE interaction; quality of life
Statistics mediation analyses, causal inference, clinical effectiveness research, and statistics modeling of electronic medical records and clinical registry data
Dr. Huang earned a Bachelor of Science degree in civil engineering from Shanghai Jiao Tong University (1991), a Master of Science degree in mathematical statistics (1995) and a PhD in biostatistics (2001) both from the University of Cincinnati. Dr. Huang joined Cincinnati Children’s in 1999 as a biostatistician and was promoted to a research associate in 2002. She started faculty appointment in 2003 at the rank of research assistant professor of pediatrics. In 2008 she received an affiliated assistant professor appointment with the University of Cincinnati Department of Mathematical Sciences, and in 2009 she was promoted to the rank of research associate professor of pediatrics and mathematical sciences. Dr. Huang actively collaborates with researchers in adolescent health, juvenile rheumatoid arthritis, health disparity, health related quality of life (HRQoL), patient-reported outcomes (PRO), injury prevention and sports medicine.
Seid M, Huang B, Niehaus S, Brunner HI, Lovell DJ. Determinants of health-related quality of life in children newly diagnosed with juvenile idiopathic arthritis. Arthritis Care Res (Hoboken). 2014 Feb;66(2):263-9.
Huang B, Giannini EH, Lovell DJ, Ding L, Liu Y, Hashkes PJ. Enhancing crossover trial design for rare disease: limiting ineffective exposure and increasing study power by enabling patient choice to escape early. Contemporary Clinical Trials. 2014 Jul;38(2): 204-212.
Beck AF, Huang B, Simmons JM, … and Kahn RS. Role of Financial and social hardships in asthma racial disparities. Pediatrics. 2014;133(3): 431-9.
Beck AF, Moncrief T, Simmons JM, Huang B, … and Kahn RS. Inequalities in neighborhood child asthma admission rates and underlying community characteristics in one US County. J Pediatr. 2013;163(2): 574-80.
Hashkes PJ, Spalding SJ, Giannini EH, Huang B, et al. Rilonacept for Colchicine Resistant for Intolerant Familial Mediterranean Fever: A Randomized Controlled Trial. Annals of Internal Medicine. 2012;157:533-41.
Beck AF, Simmons JM, Huang B, Kahn RS. Geomedicine: Using area-based socioeconomic measures to assess risk of reutilization among children admitted for asthma. AJPH. 2012;102(12):2308-14.
Huang B, Hillman J, Ding, L, Biro FM, Dorn LD, Susman EJ. Correspondence Between Gonadal Steroid Hormone Concentrations and Secondary Sexual Characteristics Assessed by Clinicians, Adolescents, and Parents. Journal of Research on Adolescence. 2012;22(2), 381-391.
Huang J, Huang B*. Proportion of Treatment Effects Explained by a Continuous Surrogate Marker in Randomized Clinical Trial. Statistics in Pharmaceutical Research. 2010;2(2): 229-238. (*corresponding author).
Huang B, Biro FM, Dorn LD. Determination of Relative Timing of Pubertal Maturation through Ordinal Logistic Modeling: Evaluation of Growth and Timing Parameters. Journal of Adolescent Health. 2009;45(4): 383-8.
Huang B, Sivaganasen S, Succop P, Goodman E. Statistical assessment of mediational effects for logistic mediational models. Statistics in Medicine. 2004;23(17):2713-28.
Explaining Racial Disparities in Child Asthma Morbidity. Co-investigator (PI, R. Kahn). National Institutes of Health / National Institute of Child Health and Human Development. May 2010–April 2015.
Continued Studies of Environment on Puberty: GUF2. Co-investigator (PI, F. Biro). National Institutes of Health / National Institute of Environmental Health Sciences U01. Sep 2010–April 2015.
Epidemiologic Impact of HPV Vaccination. Co-investigator (PI, J Kahn). Jan 2013–Dec 2017.
The Cincinnati Home Injury Prevention (CHIP) Trial. Biostatistician (PI, Phelan). National Institutes of Health / National Institute of Child Health and Human Development. Sep 2010–July 2015.
Enhancing PROMIS in Pediatric Pain, Rheumatology and Rehabilitation Research. Co-investigator (PI, DeWitt). National Institutes of Health / National Institute of Arthritis and Musculoskeletal and Skin Diseases. Sep 2009–July 2014.
Inpatient Asthma Care for Children: Adding a Place-Based Community-Focused Approach. Statistics Advisor (PI, Beck). National Institutes of Health. July 2014–June 2019.
Prospective Study of Biomechanics and Early Degeneration after ACL Reconstruction. Co-investigator (PI, Paterno/Schemit). National Institutes of Health / National Institute of Arthritis and Musculoskeletal and Skin Diseases. April 2014-March 2016.
Richard F. Ittenbach, PhD
is a biostatistician who specializes in the development, validation and analysis of scales for measurement of biomedical and biobehavioral factors. He mentors junior faculty, staff and students in DBE, cardiology, cardiac surgery, biomedical informatics, and psychology. He has contributed extensively to the training curricula of the Fellows Core Curriculum in biostatistics and data management.
Visit the Ittenbach Lab.
Scale development; statistical consulting; study design.
Dr. Ittenbach has authored or co-authored more than 90 peer-reviewed publications in the behavioral and biomedical sciences. He has been funded as a co-investigator and biostatistician on a number of NIH / CDC grants. He currently serves on the editorial board of four journals and reviews for several others. Dr. Ittenbach is a certified professional statistician (PStat) through the American Statistical Association and remains active in the American Statistical Association’s Section on Statistical Consulting. Areas of current professional interest include measure and scale development, mixed methods designs, as well as empirical bioethics.
PhD: University of Alabama, 1989.
Postdoctoral Fellowship: University of Minnesota, Minneapolis, MN 1989-1991MHS: Johns Hopkins University, 2001.MED: Auburn University, 1984.BS: Butler University, 1980.
Standridge S, Faist R, Pestian J, Glauser T, Ittenbach RF. The reliability of an epilepsy treatment clinical decision support system. J Med Syst. 2014 Oct;38(10):119.
Maglo KN, Rubinstein J, Huang B, Ittenbach RF. BiDil in the clinic: An interdisciplinary investigation of physicians’ prescription patterns of a genomics-free race-based therapy. AJOB Empir Bioeth. 2014 Oct 2;5(4):37-52.
Ittenbach RF, Baker CL, Corsmo JJ. A tiered quality assurance review process for clinical data management standard operating procedures in an academic health center. Acad Med. 2014 May;89(5):745-48.
Gaynor JW, Ittenbach RF, Gerdes M, Bernbaum J, Clancy RR, McDonald-McGinn DM, Zackai EJ, Wernovsky G, Nicolson SC, Spray TL. Neurodevelopmental outcomes in preschool survivors of the Fontan procedures. J Thorac Cardiovasc Surg. 2014 Apr;147(4):1276-82.
Drotar D, Ittenbach R, Rohan JM, Gupta R, Pendley JS, Delameter A. Diabetes management and glycemic control in youth with type 1 diabetes: Test of a predictive model. J Behav Med. 2013 Jun;36(3): 234-45.
Ittenbach RF, Cassedy AE, Rohan JM, Hood KK, Harris MA, Delamater A, Pendley J, Drotar D. Diabetes Self-Management Profile Short Form: A Preliminary report. J Clin Psychol Med Settings. 2013 Mar;20(1):107-13.
Gupta R, Marino BS, Cnota JF, Ittenbach RF. Finding the right distribution for highly skewed zero-inflated data. Biomedical Statistics and Clinical epidemiology. Epidemiol, Biostatistics and Pub Health. 2013;10(1): e87321-e8732-10.
Quatman-Yates CC, Gupta R, Paterno MV, Schmitt LC, Quatman CE, Ittenbach RF. Internal consistency and validity of the QuickDASH instrument for upper extremity injuries in older children. J Pediatr Orthop. 2013 Dec;33(8):838-42.
Ittenbach RF, DeAngelis FD, Altaye M. Communicating with investigators about financial compensation in statistical collaboration. Res Management Rev. 2013;19(2),1-9.
Ittenbach RF, DeAngelis F. Percent effort vs. Fee-for-service: A Comparison of models for statistical collaboration. Res Management Rev. 2012;19(1):24-41.
Jane C. Khoury, PhD
is the senior biostatistician for the study of the epidemiology of stroke in Cincinnati, and is principal investigator for the biostatistical core of a Special Program Of Translational Research In Acute Stroke. She holds a joint appointment in the Division of Endocrinology and works with many of the faculty and fellows on study design and statistical methods in development of their research studies. Her personal research interests involve the effect of intra-uterine exposure to type 1 diabetes on childhood growth, metabolism and cardiac function.
Stroke, diabetes in pregnancy; research design and analysis.
Mahabee-Gittens EM, Xiao Y, Gordon JS, Khoury JC. Continued Importance of Family Factors in Youth Smoking Behavior. Nicotine & Tobacco Research.
Khoury JC, Dolan LM, VanDyke R, Rosenn B, Feghali M, Miodovnik M. Fetal development in women with diabetes: imprinting for a life-time? Journal of Maternal-Fetal & Neonatal Medicine. 2012; 25(1), 11-14.
VanDyke R, Ren Y, Sucharew HJ, Miodovnik M, Rosenn B, Khoury JC. Characterizing maternal glycemic control: a more informative approach using semiparametric regression. Journal of Maternal-Fetal & Neonatal Medicine. 2012; 25(1), 15-19.
Yolton K, Xu YY, Strauss D, Altaye M, Calafat AM, Khoury J. Prenatal exposure to bisphenol A and phthalates and infant neurobehavior. Neurotoxicology and Teratology. 2011; 33(5), 558-566.
Phelan KJ, Khoury J, Xu YY, Liddy S, Hornung R, Lanphear BP. A Randomized Controlled Trial of Home Injury Hazard Reduction The HOME Injury Study. Archives of Pediatrics & Adolescent Medicine. 2011;165(4), 339-345.
Xu YY, Yolton K, Khoury J. Earliest Appropriate Time for Administering Neurobehavioral Assessment in Newborn Infants. Pediatrics. 2011;127(1), E69-E75.
Armour AD, Khoury JC, Kagan RJ, Gottschlich MM. Clinical Assessment of Sleep Among Pediatric Burn Patients Does Not Correlate With Polysomnography. Journal of Burn Care & Research. 32(5), 529-534.
Mahabee-Gittens EM, Xiao Y, Gordon JS, Khoury JC. The Role of Family Influences on Adolescent Smoking in Different Racial/Ethnic Groups. Nicotine & Tobacco Research. 2011.
Bollepalli S, Dolan LM, Miodovnik M, Feghali M, Khoury JC. Asymmetric large-for-gestational-age infants of type 1 diabetic women: Morbidity and abdominal growth. Am J Perinatol. 2010; 27(8), 603-610. 2010.
Kleindorfer D, Khoury J, Moomaw CJ, Alwell K, Woo D, Flaherty ML, Khatri P, Adeoye O, Ferioli S, Broderick JP, Kissela BM. Stroke Incidence is Decreasing in Whites, but Not in Blacks: A Population-Based Estimate of Temporal Trends in Stroke Incidence from the Greater Cincinnati/Northern Kentucky Stroke Study. Stroke. 2010;41(7):1326-31.
Mi-Ok Kim, PhD Biostatistician, Biostatistics and Epidemiology
is a biostatistician with interest in optimizing clinical trial designs to maximize patient benefits and incorporating genomic/genetic data to better predict survival times, and quantile regression analysis of clustered data. Dr. Kim mentors junior faculty, staff and students in DBE, and the Cancer and Blood Disorders Institute. She organizes a webinar series for the Biopharmaceutical section of the American Statistical Association.
Biostatistician, Biostatistics and Epidemiology
Fax: 513- 636-7509
Causal inference; comparative effectiveness research; longitudinal and survival data analysis; adaptive clinical trial designs
Kim MO, Liu C, Hu F, Lee JJ. Outcome-Adaptive Randomization for a Delayed Outcome with a Short-Term Predictor: Imputation Based Designs. Statistics in Medicine. 2014 May 29.
Minar P, Haberman Y, Jurickova I, Wen T, Rothenberg ME, Kim MO, Saeed SA, Baldassano RN, Stephens M, Markowitz J, Rosh J, Crandall WV, Heyman MB, Mack DR, Griffiths AM, Baker SS, Hyams JS, Kugathasan S, Denson LA. Utility of Neutrophil Fcγ Receptor I (CD64) Index as a Biomarker for Mucosal Inflammation in Pediatric Crohn's Disease. Inflamm Bowel Dis. 2014 Jun;20(6):1037-48.
Walters TD, Kim MO*, Denson LA, Griffiths AM, Dubinsky M, Markowitz J, Baldassano R, Crandall W, Rosh J, Pfefferkorn M, Otley A, Heyman MB, LeLeiko N, Baker S, Guthery SL, Evans J, Ziring D, Kellermayer R, Stephens M, Mack D, Oliva-Hemker M, Patel AS, Kirschner B, Moulton D, Cohen S, Kim S, Liu C, Essers J, Kugathasan S, Hyams JS; PRO-KIIDS Research Group. Increased effectiveness of early therapy with anti-tumor necrosis factor-α vs an immunomodulator in children with Crohn's disease. Gastroenterology. 2014 Feb;146(2):383-91. (*co-primary authors)
Dykes DM, Towbin AJ, Bonkowski E, Chalk C, Bezold R, Lake K, Kim MO, Heubi JE, Trapnell BC, Podberesky DJ, Denson LA. Increased Prevalence of Luminal Narrowing and Stricturing Identified by Enterography in Pediatric Crohn's Disease Patients With Elevated Granulocyte-Macrophage Colony Stimulating Factor Autoantibodies. Inflammatory Bowel Diseases. 2013 Sep;19(10):2146-54.
Gathungu G, Kim MO, Ferguson JP, Sharma Y, Zhang W, Ng SM, Bonkowski E, Ning K, Simms LA, Croft AR, Stempak JM, Walker N, Huang N, Xiao Y, Silverberg MS, Trapnell B, Cho JH, Radford-Smith GL, Denson LA. Granulocyte-Macrophage Colony-Stimulating Factor Autoantibodies: A Marker of Aggressive Crohn's Disease. Inflammatory Bowel Diseases. 2013 Jul;19(8):1671-1680.
Choi D, Hoffman KA, Kim MO, McCarty D. A High Resolution Evaluation of Process Improvement:Use of Quantile Regression for Wait Time. Health Services Research. 2013 Feb;48(1):333-47.
Kim MO, Yang Y. Semiparametric Approach to a Random Effects Quantile Regression Model. Journal of the American Statistical Association. 2011, Dec 1: 106(496): 1405-1417.
Denson LA, Kim MO, Bezold R, Carey R, Osuntokun B, Nylund C, Willson T, Bonkowski E, Li D, Ballard E, Collins M, Moyer MS, Klein DJ. A Randomized Controlled Trial of Growth Hormone in Active Pediatric Crohn's Disease. Journal of Pediatric Gastroenterology and Nutrition. 2010; Aug;51(2):130-9.
Han X, Uchida K, Jurickova I, Koch D, Willson T, Samson C, Bonkowski E, Trauernicht A, Kim MO, Tomer G, Dubinsky M, Plevy S, Kugathsan S, Trapnell BC, Denson LA. Granulocyte-macrophage colony-stimulating factor autoantibodies in murine ileitis and progressive ileal Crohn's disease. Gastroenterology. 2009 Apr;136(4):1261-71, e1-3.
Kim M-O. Quantile Regression with Varying Coefficients. Annals of Statistics. 2007;35(1): 92-108.
Cincinnati Center for Excellence in Molecular Hematology. Biostatistician. National Institutes of Health. Sep 2010–June 2015. P30DK090971-01 (Zheng).
Lineage Determination and Tissue HomeOstasis in the aged Hematopoietic System. Biostatistician. National Institutes of Health. Aug 2011–July 2016. R01 AG040118 (Zheng).
Risk Stratification & Identification of immunogenic and microbial markers of rapid disease progression in children with Crohn’s disease. Co-Investigator. Crohn's & Colitis Foundation of America. July 2008-June 2017. R01 (Denson/Kugathasan).
Causes and Consequences of Neutrophil Dysfunction in Pediatric Crohns Disease. Director (Biostatistics Core). National Institutes of Health. Sep 2013–July 2018. R01DK098231 (Denson).
Neurofibroma Preclinical Therapeutics. Co-Investigator. The Children’s Tumor Foundation. July 2013–July 2016. CTF (Ratner).
Macrophage Based Gene Therapy for Hereditary Pulmonary Alveolar Proteinosis. Co-Investigator. National Institutes of Health. April 2014–March 2018. R01 (Trapnell).
Rigor of Multi-Registry CER Studies: Towards Patient-Centered Treatment Planning. Principal Investigator. National Institutes of Health / Agency for Healthcare Research and Quality. July 2014–June 2016. K18 (Kim).
Eileen C. King, PhD
has 24 years of experience in the design and analysis of clinical trials for health care and pharmaceutical research studies. She enjoys collaborative research and has research interests in nonparametric regression using smoothers, comparative effectiveness research using clinical data from large multi-site registries, and statistical quality control approaches for clustered data for quality improvement initiatives in health outcomes.
Clinical trials, statistical process control, data management, nonparametric regression using linear smoothers.
Dr. King has provided biostatistical leadership in the design, analysis, and interpretation of results from animal and human clinical research studies supporting drug discovery, early and late stage drug development, commercialization, and market support. She provided statistical expertise and oversight for the development, review, and defense of 10 new drug application submissions in the areas of gastrointestinal, cardiac, bone diseases and female sexual health. She is currently leading the growing Data Management Center to assure appropriate data management processes for data collection, data cleaning and validation, and data finalization, documentation and archival are used which lead to high quality data that can be shared with the research community at large.
Dr. King is active in the American Statistical Association and is currently chair of the Council of Sections Governing Board. She is an associate editor for the Journal of Statistical Education. Dr. King mentors junior faculty, staff and students in DBE and Gastroenterology and the Anderson Center. She is the primary instructor of “Statistical Principles for Clinical Research Studies” in the UC College of Pharmacy.
Crandall WV, Margolis PA, Kappelman MD, King EC, Pratt JM, Boyle BM,Colletti RB. Improved Outcomes in a Quality Improvement Collaborative for Pediatric Inflammatory Bowel Disease. Pediatrics. 2012.
Presicce P, Orsborn K, King E, Pratt J, Fichtenbaum CJ, et al. Frequency of Circulating Regulatory T Cells Increases during Chronic HIV Infection and Is Largely Controlled by Highly Active Antiretroviral Therapy. PLoS ONE. 2011; 6(12): e28118.
Seid M, D’Amico EJ, Varni JW, Munafo JK, Britto MT, Kercsmar CM, Drotar D, King EC, Darbie L. The In Vivo Adherence Intervention For at Risk Adolescents with Asthma: Report of a Randomized Pilot Trial. J Pediatr Psychol. 2012 May;37(4):390-403.
Setchell K, Brown N, Zhao X, Lindley S, Heubi J, King E, Messina J. Soy isoflavone phase II metabolism differs between rodents and humans: implications for the effect on breast cancer risk. Am J Clin Nutr. 2011; 94:1284-94.
Debrosse CW, Franciosi JP, King EC, Buckmeier Butz BK, Greenberg AB, Collins MH, Abonia JP, Assa'ad A, Putnam PE, Rothenberg ME. Long-term outcomes in pediatric-onset esophageal eosinophilia. J Allergy Clin Immunol. 2011.
DeBrosse CW, Collins MH, Butz BK Allen CL, King EC, Assa’ad AH, Abonia JP, Putnam PE, Rothenberg ME, Franciosi JP. Identification, epidemiology and chronicity of pediatric esophageal eosinophilia, 1982-1999. Journal of Allergy and Clinical Immunology. 2010; 126 (1), pp. 112-119.
Corey AE, Agnew JR, King EC, Parekh NJ, Powell JH, Thompson GA. Effect of Mild and Moderate Hepatic Impairment on Azimilide Pharmacokinetics Following Single Dose Oral Administration. Journal of Pharmaceutical Sciences. 2004; 93 (5), pp. 1279-1286.
Sorof JM, Cargo P, Graepel J, Humphrey D, King E, Rolf C, Cunningham R. b-Blocker/thiazide combination for treatment of hypertensive children: a randomized double-blind, placebo-controlled trial. Pediatric Nephrology. 2002; 17, pp. 345-350.
Chen KS, Bharaj SS, King EC. Induction and relief of nasal congestion in ferrets infected with influenza virus. International Journal of Experimental Pathology. 1995; 76, pp. 55-64.
King EC, Hart JD, Wehrly TE. Testing the Equality of Two Regression Curves Using Linear Smoothers. Statistics and Probability Letters. 1991; 12, pp. 239-247.
Adam Lane, PhD
has methodological research interests in designs for phase I/II clinical trials, survival analysis and structural equation modeling. Dr. Lane is also a dedicated collaborator with both clinical and basic science researchers in bone marrow transplantation, hematology, oncology and cancer biology.
Instructor, UC Department of Pediatrics
Clinical trials; survival analysis; structural equation modeling
Dr. Lane joined Cincinnati Children's in July 2013. He has published novel statistical methods in the areas of adaptive and optimal experimental designs with applications to phase I and phase II clinical trials. As a graduate student he received funding from the NIH to spend the fall semester of 2011 at the University of Cambridge in the Isaac Newton Institute for Mathematical Sciences. He has also received NSF travel awards to present his research at national and international conferences.
Lane A, Segura-Cabrera A, Komurov K. A comparative survey of functional footprints of EGFR pathway mutations in human cancers. Oncogene. 2013 Oct 28. Epub ahead of print.
Lane A, Ping Y, Flournoy N. Information in a two-stage adaptive optimal design. J Statist Plan Inference. 2013 In press.
Lane A, Flournoy N. Two-stage adaptive optimal design with fixed first stage sample size. Journal of Probability and Statistics. 2012.
Ping-I (Daniel) Lin, MD, PhD
is a genetic epidemiologist and psychiatrist. His research interests have been focused on identifying genetic variants associated with neuropsychiatric diseases. Dr. Lin has discovered variants linked to clinical heterogeneity in bipolar disorder, Alzheimer’s disease and autism. He is also interested in paradoxical association findings and selection sweeps for candidate loci for schizophrenia and autism.
Genetic epidemiology; pharmacogenomics; clinical psychiatry
Dr. Lin earned his PhD from Johns Hopkins University and MD from National Taiwan University. He has published 16 peer-review research articles and one book chapter in the field of neuropsychiatric genetics. His publications in the past 7 years have been cited by more than 350 publications. One of his research articles, entitled “No Gene Is an Island: The Flip-Flop Phenomenon,” published on American Journal of Human Genetics, alone has obtained nearly 260 citations within 5 years. He received a Travel Award (only 10 recipients were selected) from 11th International Congress of Human Genetics in 2006. In 2007, Dr. Lin was invited to the press debriefing at American Society of Human Genetics Meeting. Additionally, he received an award for his genetic research of autism by Taiwan Society of Child and Adolescent Psychiatry in 2010. His current research interests are focused on pharmacogenomics research related to neuropsychiatric diseases.
PhD: Johns Hopkins University, Baltimore, MD, 2005.
MD: National Taiwan University, Taiwan.
Residency: Psychiatry, National Taiwan University Hospital, Taiwan.
Certification: Psychiatry, 2012.
Lin PI, Chien YL, Wu YY, Chen CH, Gau SS, Huang YS, Liu SK, Tsai WC, Chiu YN. The WNT2 gene polymorphism associated with speech delay inherent to autism. Research in Developmental Disabilities. 2012;33(5):1533-40.
Lin PI, Shuldiner AR. Rethinking the genetic basis of diabetes and schizophrenia. Schizophr Res. 2010;123(2-3):234-43.
Tarasov KV, Sanna S, Scuteri A, Strait JB, Orrù M, Parsa A, Lin PI, Maschio A, et al. COL4A1 is associated with arterial stiffness by genome-wide association scan. Circulation Cardiovasc Genet. 2009;2(2):151-8.
Lin PI, Mitchell BM. Approaches for deciphering joint genetic determinants for schizophrenia and bipolar disorder. Schizophr Bull. 2008;34(4):791-7.
Lin PI, Vance JM, Pericak-Vance MA, Martin ER. No gene is an island: the flip-flop phenomenon. American Journal Human Genetics. 2007;80(3):531-8.
Lin PI, Martin ER, Bronson PG, Browning-Large CA, Small GW, Schmechel DE, Welsh-Bohmer KA, Haines JL, Gilbert JR, Pericak-Vance MA. Exploring the association of GAPD genes and late-onset Alzheimer disease. Neurology. 2006;67(1):64-8.
Chong RY, Uhart M, Yang X, Lin PI, Wand GS. The A118G Mu opioid receptor polymorphism is associated with heightened HPA axis response to opioid receptor blockade but not psychosocial stress. Neuropsychopharmacology. 2006;31(1):204-11.
Li YJ, Scott WS, Zhang L, Lin PI, Oliveira SA, Skelly T, Schmechel DE, Martin ER, Haines JL, Pericak-Vance MA, Vance JM. Revealing the role of Glutathione S-Transferace Omega-1 in age-of-onset data of Alzheimer disease. Neurobiology Aging. 2006;27(8):1087-93.
Lin PI, McInnis MG, Potash JB, MacKinnon DF, Willour V, DePaulo JR Jr, Zandi PP. Clinical correlates and familial aggregation of age at onset in bipolar disorder. American Journal of Psychiatry. 2006;163(2):240-6.
Lin PI, McInnis MG, Potash JB, MacKinnon DF, Willour V, Miao K DePaulo JR Jr, Zandi, PP. Assessment of the effect of age at onset on linkage to bipolar disorder: evidence on chromosomes 18p and 21q. American Journal of Human Genetics. 2005;77(4):545-55.
Lisa J. Martin, PhD
is a statistical geneticist. Dr. Martin’s goal is to advance
knowledge of disease processes by integrating statistical genetics with biology
and epidemiology. Through independent and collaborative research, she expects
to translate genetic findings to clinical utility by developing of innovative
methods and aiding researchers in designing appropriate studies to address the
questions at hand.
Statistical genetics; allergic conditions; pediatric heart conditions; obesity
As a statistical geneticist, Dr. Martin’s goal is to advance
knowledge of underlying disease processes by improving our understanding of
genetic variation in human populations through the integration of statistical
genetics with biology and epidemiology. Since joining Cincinnati Children’s in
2002, Dr. Martin has become a leader in quantitative genetics through independent
and collaborative research, leadership, and teaching/mentoring. Her independent
research focuses on development of novel statistical methods and the evaluation
of methods for next generation data.
Recently, Dr. Martin published a novel statistical method
(Variant Impact On Linkage Effect Test; VIOLET), which overcomes a
methodological barrier to gene discovery.
Her collaborative research focuses on allergic conditions (asthma,
eosinophilic esophagitis), pediatric heart conditions, and obesity. In addition, Dr. Martin assists researchers
with an interest in incorporating genetics into their research. At the end of 2013, Dr. Martin had published
116 peer-reviewed publications (journals include Nature Genetics, PNAS, Journal
of Clinical Endocrinology and Metabolism) and 2 book chapters.
She has a strong commitment to teaching and mentorship.
Beyond teaching, she has mentored over 30 individuals. Additionally, Dr. Martin
is the co-director of the Cincinnati Genomic Control Cohort, an institutional resource
of 1,020 population representative children with phenotypic and genetic
information. Under Dr. Martin’s
leadership, utilization of this cohort has increased.
In summary, Dr. Martin’s work has resulted in the
development of an exciting research program as well as fruitful collaborations
while balancing mentoring and service.
She expects that this research will enable the translation of genetic
findings to clinical utility through the development of innovative methods and
greater capacity to perform complex genetic analyses particularly given the
rapid evolution of technologies.
PhD: (with Honors) University of Kansas, Lawrence KS, 1999
Post-doctoral fellow: Southwest Foundation for Biomedical Research, San Antonio TX, 2002
Martin LJ, Ding L, Zhang X, Kissebah AH, Olivier M, Benson
novel method, the Variant Impact On Linkage Effect Test (VIOLET), leads to
improved identification of causal variants in linkage regions. Eur J
Hum Genet. 2014 Feb;22(2):243-7.
Martin LJ, Gupta J, Jyothula SSSK, Butsch Kovacic M, Biagini
Myers JM, Patterson TL, Ericksen MB, He H, Gibson AM, Baye TM, Amirisetty S,
Tsoras AM, Sha Y, Eissa NT, Hershey GK. Functional variant in the autophagy-related
5 gene promoter is associated with childhood asthma. PLoS One. 2012;7(4):e33454.
Kottyan LC, Woo JG, Keddache M, Banach W, Crimmins NA, Dolan
LM, Martin LJ. Novel variations in the
adiponectin gene (ADIPOQ) may affect distribution of oligomeric complexes. SpringerPlus.
Chidambaran C, Ngamprasertwong P, Esslinger HR, Prows C, Zhang X, Martin
LJ, McAuliffe J. Race and unequal burden
of perioperative pain and opioid related adverse effects in children. Pediatrics.
Martin LJ, Lee SY, Couch SC, Morrison J, Woo JG. Shared
genetic contributions of fruit and vegetable consumption with body mass index
in families 20 years after sharing a household. Am J Clin
Nutr. 2011 Oct;94(4):1138-43.
Martin LJ, Hinton RB, Zhang Z, Cripe LH, Benson DW. Aorta
measurements are heritable and influenced by bicuspid aortic valve. Front Genet.
2011 Sep 5;2:61.
Martin LJ, Woo JG, Morrison JA. Evidence Of Shared Genetic Effects Between Pre And Post Obesity Epidemic
BMI Levels. Obesity. 2010 Jul;18(7):1378-82.
Rothenberg ME, Spergel JM, Sherrill JD, Annaiah K, Martin
LJ, Cianferoni A, Gober L, Kim C, Glessner J, Frackelton E, Thomas K, Blanchard
C, Liacouras C, Verma R, Aceves S, Collins MH, Brown-Whitehorn T, Putnam PE,
Franciosi JP, Chiavacci RM, Grant SF, Abonia JP, Sleiman PM, Hakonarson H. Common variants at 5q22 associate with
pediatric eosinophilic esophagitis. Nat
Genet. 2010 Apr;42(4):289-91.
Martin LJ, Ramachandran V, Cripe LH, Hinton RB, Andelfinger
G, Tabangin M, Shooner K, Keddache M, Benson DW. Evidence in Favor of Linkage to Human Chromosomal Regions 18q, 5q and
13q for Bicuspid Aortic Valve and Associated Cardiovascular Malformations. Hum Gen.
Martin LJ, Woo JG, Daniels SR, Goodman E, Dolan
LM. The Relationships of Adiponectin
with Insulin and Lipids Are Strengthened with Increasing Adiposity. J Clin Endocrinol
Metab. 2005 Jul;90(7):4255-9.
Jareen K. Meinzen-Derr, PhD
Associate Professor, UC Department of Otolaryngology, Head & Neck Surgery, UC Department of Environmental Health
Pediatric hearing impairment; cochlear implant research; neonatal outcomes
Visit the More Than Hearing Loss web page.
Dr. Meinzen-Derr has a prolific publication background in the areas of health outcomes and clinical care for children who are deaf / hard of hearing and developmental disabilities. She is focused specifically on understanding the mechanisms behind language and functional outcomes in the subset of children with hearing loss who also have an additional developmental disability. In addition to hearing and deafness research, Dr. Meinzen-Derr collaborates on clinical research regarding premature infants. She currently teaches courses as part of the Clinical Research Training Program at the University of Cincinnati, Department of Environmental Health and supports the educational curricula for fellow research education within the Divisions of Neonatology, Developmental and Behavioral Pediatrics, and Pediatric Otolaryngology. She contributes to the biostatistics and epidemiology modules of the Pediatrics Fellowship Core curriculum and leads the experimental design lectures in neonatology and developmental and behavioral pediatrics. She has developed an online curriculum for the graduate program in biostatistics and epidemiology in the Department of Environmental Health and for the Center for Clinical and Translational Science and Training.
South AP, Jones DE, Hall ES, Huo S, Meinzen-Derr J, Liu L, Greenberg JM. Spatial Analysis of Preterm Birth Demonstrates Opportunities for Targeted Intervention. Matern Child Health J. 2011 Feb 3.
Binder S, Hill K, Meinzen-Derr J, Greenberg JM, Narendran V. Increasing VLBW Deliveries at Subspecialty Perinatal Centers via Perinatal Outreach. Pediatrics. 2011 Mar;127(3):487-93.
Morrow AL, Meinzen-Derr J, Huang P, Schibler KR, Cahill T, Keddache M, Kallapur SG, Newburg DS, Tabangin M, Warner BB, Jiang X. Fucosyltransferase 2 Non-Secretor and Low Secretor Status Predicts Severe Outcomes in Premature Infants. J Pediatr. 2011 May;158(5):745-51.
Meinzen-Derr J, Wiley S, Grether S, Choo DI. Children with cochlear implants and developmental disabilities: A language skills study with developmentally matched hearing peers. Res Dev Disabil. 2011 Mar-Apr;32(2):757-67.
Slaughter JL, Meinzen-Derr J, Rose SR, Leslie ND, Chandrasekar R, Linard SM, Akinbi HT. The effects of gestational age and birth weight on false-positive newborn-screening rates. Pediatrics. 2010 Nov;126(5):910-6.
Choo D, Meinzen-Derr J. Universal newborn hearing screening in 2010. Curr Opin Otolaryngol Head Neck Surg. 2010 Oct;18(5):399-404. Review.
Akinbi H, Meinzen-Derr J, Auer C, Ma Y, Pullum D, Kusano R, Reszka KJ, Zimmerly K. Alterations in the host defense properties of human milk following prolonged storage or pasteurization. J Pediatr Gastroenterol Nutr. 2010 Sep;51(3):347-52.
Kaplan HC, Tabangin ME, McClendon D, Meinzen-Derr J, Margolis PA, Donovan EF. Understanding variation in vitamin A supplementation among NICUs. Pediatrics. 2010 Aug;126(2):e367-73.
Isemann B, Meinzen-Derr J, Akinbi H. Maternal and neonatal factors impacting response to methadone therapy in infants treated for neonatal abstinence syndrome. J Perinatol. 2011 Jan;31(1):25-9.
Giambra BK, Meinzen-Derr J. Exploration of the relationships among medical health history variables and aspiration. Int J Pediatr Otorhinolaryngol. 2010 Apr;74(4):387-92.
Early Language and Independent Functional Expectations (LIFE) of children who are deaf or hard of hearing. Principal Investigator. March of Dimes 2014-2017.
Impact of cognition on language in pediatric hearing loss and cognitive disabilities. Principal Investigator. Health Resources and Service Administration/Maternal and Child Health Research. 2011-2014.
Patterned experience for preterm infants. Co-Investigator. National Institutes of Health. 2011-2016.
Wideband clinical diagnosis and monitoring of middle-ear and cochlear function. Co-Investigator. National Institute on Deafness and Other Communication Disorders/National Institutes of Health. 2009-2014.
Nicholas J. Ollberding, PhD
is a nutritional epidemiologist with research interests focused on the role of diet in the etiology and the survival of cancer, dietary assessment and analysis methodology, and the molecular epidemiology of cancer. His research incorporates the use of observational and experimental research designs, as well as innovative molecular-based technologies to examine diet-disease associations.
Nutritional epidemiology; cancer epidemiology; dietary assessment and analysis methodology; molecular epidemiology
Dr. Ollberding earned his PhD in behavioral nutrition with a specialization in nutritional epidemiology from Columbia University and completed postdoctoral fellowships in cancer epidemiology and prevention at the University of Hawaii Cancer Center and the University of Chicago. To date, he has published more than 20 peer-reviewed research articles in prestigious journals including the Journal of the National Cancer Institute, Blood, and Cancer Prevention Research. In addition, his research has been presented at national conferences and he has authored a book chapter in the area of nutritional epidemiology. Dr. Ollberding was the recipient of the Zerkowski Habas Foundation and Grace McLeod Scholarships while at Columbia University and received a National Cancer Institute funded postdoctoral fellowship.
Dr. Ollberding’s research is motivated by the fact that while diet and obesity are major contributors to morbidity and mortality in the U.S., few Americans consume diets in accordance with recommendations for optimal health or disease prevention. Specifically, his work aims to better understand the role of diet in the etiology and progression of cancer and other chronic diseases, as well as the impact of environmental- and policy-level factors on dietary behaviors including obesity. At Cincinnati Children’s, Dr. Ollberding conducts and provides support for nutritional and cancer epidemiology studies.
PhD: Columbia University, New York, 2009.
MPhil: Columbia University, New York, 2009.
MS: University of Cincinnati, Cincinnati, OH, 2008.
BS: Miami University, Oxford, OH, 2004.
Ollberding NJ, Kim Y, Wilkens LR, Shvetsov YB, Henderson BE, Le Marchand L, Kolonel LN, Goodman MT. Prediagnostic adiponectin, leptin, and C-reactive protein and breast cancer risk among postmenopausal women in the Multiethnic Cohort Study. Cancer Prev Res (Phila). 2013 Mar;6(3):188-95.
Ollberding NJ, Aschebrook-Kilfoy B, Caces DB, Smith SM, Wright ME, Weisenburger DD, Chiu B C-H. Phytanic acid and the risk of non-Hodgkin lymphoma. Carcinogenesis. 2013 Jan;34(1):170-5.
Ollberding NJ, Maskarinec G, Conroy SM, Morimoto Y, Franke AA, Cooney RV, Wilkens LR, Le Marchand L, Goodman MT, Hernandez BY, Henderson BE, Kolonel LN. Prediagnostic Carotenoid Levels and the Risk of Non-Hodgkin Lymphoma: The Multiethnic Cohort. Blood. 2012 Jun 14;119(24):5817-23.
Ollberding NJ, Wilkens LR, Henderson BE, Kolonel LN, Le Marchand L. Meat consumption, heterocyclic amines and colorectal cancer risk: The Multiethnic Cohort Study. Int J Cancer. 2012 Oct 1;131(7):E1125-33.
Ollberding NJ, Cheng I, Wilkens LR, Henderson BE, Kolonel LN, Le Marchand L. Genetic variants, prediagnostic circulating levels of insulin-like growth factors, insulin, and glucose and the risk of colorectal cancer: The Multiethnic Cohort Study. Cancer Epidemiol Biomarkers Prev. 2012 May;21(5):810-20.
Ollberding NJ, Lim U, Wilkens LR, Setiawan VW, Shvetsov YB, Henderson BE, Kolonel LN, Goodman MT. Legume, Soy, and Isoflavone Intake and Endometrial Cancer Risk: The Multiethnic Cohort Study. J Natl Cancer Inst. 2012 Jan 4;104(1):67-76.
Ollberding NJ, Nigg CR, Geller KS, Horwath CC, Motl RW, Dishman RK. Food outlet accessibility and fruit and vegetable consumption. Am J Health Promot. 2012 Jul;26(6):366-70.
Ollberding NJ, Maskarinec G, Wilkens LR, Henderson BE, Kolonel LN. Comparison of modifiable health behaviors between persons with and without cancer: The Multiethnic Cohort. Public Health Nutr. 2011 Oct;14(10):1796-804.
Ollberding NJ, Nomura AY, Wilkens LR, Henderson BE, Kolonel LN. Racial/Ethnic Differences in Colorectal Cancer Risk: The Multiethnic Cohort Study. Int J Cancer. 2011 Oct 15;129(8):1899-906.
Ollberding NJ, Wolf RL, Contento I. Food label use and its relation to dietary intake among US adults. J Am Diet Assoc. 2010 Aug;110(8):1233-7.
Joseph R. Rausch, PhD Quantitative Psychologist, Behavioral Medicine and Clinical Psychology
Quantitative Psychologist, Behavioral Medicine and Clinical Psychology
Longitudinal data analysis; longitudinal RCTs; design and analysis of behavioral interventions; adherence to treatment regimens
Modi AC, Rausch JR, Glauser TA. Early pediatric antiepileptic drug non-adherence is related to lower long term seizure freedom. Neurology. 2013. In press.
Shenk CE, Putnam FW, Rausch JR, Peugh JL, Noll JG. A longitudinal study of several potential mediators of the relationship between child maltreatment and PTSD symptoms. Dev Psychopathol. 2013. In press.
Modi AC, Ingerski LM, Rausch JR, Glauser TA, Drotar D. White coat adherence over the first year of therapy in pediatric epilepsy. J Pediatr. 2012 Oct:161(4): 695-9.
Beebe DW, Rausch J, Byars KC, Lanphear B, Yolton K. Persistent snoring in preschool children: Predictors and behavioral and developmental correlates. Pediatrics. 2012 Sep;130(3):382-89.
Rausch JR, Hood KK, Delamater A, Shroff Pendley J, Rohan JM, Reeves G, Dolan L, Drotar D. Changes in treatment adherence and glycemic control during the transition to adolescence in type 1 diabetes. Diabetes Care. 2012 Jun;35(6):1219-24.
Kelley K, Rausch JR. Sample size planning for longitudinal models: Accuracy in parameter estimation for polynomial change models. Psychol Methods. 2011 Dec;16(4):391-405.
Modi AC, Rausch JR, Glauser TA. Patterns of Nonadherence to Antiepileptic Drug Therapy in Children With Newly Diagnosed Epilepsy. JAMA. 2011 Apr 27;305(16):1669-76.
Stark LJ, Spear S, Boles R, Kuhl E, Ratcliff M, Scharf C, Bolling C, Rausch JR. A Pilot Randomized Controlled Trial of a Clinic and Home Based Behavioral Intervention to Decrease Obesity in Preschoolers. Obesity (Silver Spring). 2011 Jan;19(1):134-41.
Rausch JR. Measures of glycemic variability and links with psychological functioning. Curr Diab Rep. 2010 Dec;10(6):415-21.
Rausch JR, Kelley K. A comparison of linear and mixture models for discriminant analysis under nonnormality. Behav Res Methods. 2009 Feb;41(1):85-98.
Promoting Treatment Adherence in Adolescent Leukemia. Co-Investigator. National Institutes of Health, National Cancer Institute. 2012 - 2014.
Effects of Adolescent Sleep Restriction on Neural and Neurobehavioral Functioning. Statistician. National Institutes of Health, National Heart, Lung and Blood Institute. 2012 - 2014.
Clinic and Home Family Based Behavioral Treatment for Obese Preschoolers: LAUNCH. Co-Investigator. National Institute of Health, National Institute of Diabetes and Digestive and Kidney Diseases. 2011 - 2016.
Nonadherence: Undermining Health Outcomes in Pediatric HSCT. Co-Investigator. National Institutes of Health, National Cancer Institute. 2012 - 2017.
Supporting Treatment Adherence Regimens in Pediatric Epilepsy: The STAR Trial. Co-Investigator, National Institutes of Health, National Institute of Child Health and Human Development. 2013 - 2018.
Self-management of type 1 diabetes during adolescence. Co-Investigator. National Institutes of Health, National Institute of Diabetes and Digestive and Kidney Diseases. 2011 - 2018.
Patrick H. Ryan, PhD, MS
is an environmental epidemiologist with research interests in the fields of air pollution epidemiology and exposure assessment.
Assistant Professor, Department of Environmental Health
Epidemiology; air pollution; exposure assessment
To date, Dr. Ryan has authored more than 30 publications and has presented his research at numerous national and international conferences. He has received research funding from the National Institute of Environmental Health Sciences, the U.S. Environmental Protection Agency, the U.S. Department of Housing and Urban Development, the Centers for Disease Control and Prevention, as well as industry and private foundations. Dr. Ryan has also been an invited speaker at numerous national conferences and universities, a guest lecturer for environmental epidemiology courses at the University of Cincinnati, and has advised masters and doctoral students in epidemiology, biostatistics, and industrial hygiene in the Department of Environmental Health at the University of Cincinnati. In 2006 Dr. Ryan received a STAR award from the American Academy of Allergy, Asthma, and Immunology and in 2010 he was selected as one of ten Science Communication Fellows by Environmental Health Sciences.
Dr. Ryan is the principal investigator of the Cincinnati Anti-Idling Campaign Study, an academic-community partnership to examine and reduce the impact of traffic-related air pollution at schools on children with asthma. He is also co-PI of a collaborative study to develop and field test, in a cohort of asthmatic children, a personal sensor to measure exposure to ultrafine particles. Dr. Ryan also serves as co-investigator of the Cincinnati Childhood Allergy and Air Pollution Study (CCAAPS), a longitudinal birth cohort study of the effects of diesel exhaust particles on the development of allergies and asthma. His research with the CCAAPS study includes the development of land-use regression models for air pollution exposure assessment and the association between air pollution and neurobehavioral development. Additional research includes studies of indoor pollutants and mold, environmental exposure to asbestos in Libby, MT, and the elemental composition of PM2.5.
PhD: Epidemiology, University of Cincinnati, Cincinnati, OH.
MS: Epidemiology, University of Cincinnati, OH.
Sebastian KJ, Ryan PH, Lockey JE, Bernstein DI, McKay RT, Hershey GKK, Villareal M, Biagini Myers JM, Levin L, Burkle J, Evans S, LeMasters GK. Unraveling the relationship between aeroallergen sensitization, gender, second hand smoke exposure and impaired lung function. Pediat Allergy and Immunol. In press.
Hochstetler HA, Yermakov M, Reponen T, Ryan PH, Grinshpun SA. Aerosol Particles Generated by Diesel-Powered School Buses at Urban Schools as a Source of Children’s Exposure. Atmospheric Environment. 2011;45:1444-1453.
Ryan PH, Dihle M, Griffin S, Taylor R, Hilbert T, Adjei S, Lockey JE. Radiographic Changes Associated with Exposure to Erionite in Road Gravel in North Dakota. J Occup Environ Med. 2011;53(8):893-899.
Sucharew H, Ryan PH, Bernstein D, Succop D, Khurana Hershey GK, Lockey J, Villareal M, Reponen T, Grinshpun S, LeMasters G. Exposure to Traffic Exhaust and Night Cough During Early Childhood: the CCAAPS Cohort. Pediatr Allergy Immunol. 2010;21(2 Pt 1):253-9.
Li C, Nguyen Q, Ryan PH, LeMasters GK, Spitz H, Lobaugh M, Glover S, Grinshpun SA. School bus pollution and changes in the air quality at schools: a case study. J Environ Monit. 2009;11:1037.
Ryan PH, Bernstein D, Reponen T, Levin L, Grinshpun S, Villareal M, Lockey J, Hershey GK, Burkle J, LeMasters GK. Exposure to traffic related-particles and endotoxin during infancy is associated with wheezing at age three. Am J Respir Criti Care. 2009;180:1068-1075
Appatova AS, Ryan PH, LeMasters GK, Grinshpun SA. Proximal Exposure of Public Schools and Students to Major Roadways: A Nationwide US Survey. Journal of Environmental Planning and Management. 2008; 51(5):631-646.
Ryan PH, LeMasters GK, Levin L, Burkle J, Biswas P, Hu S, Grinshpun S, Reponen T. A Land-Use Regression Model for Estimating Microenvironmental Diesel Exposure Given Multiple Addresses From Birth Through Childhood. Sci Total Environ. 2008;404:139-147.
Ryan PH, LeMasters GK, Biswas P, Levin L, Hu S, Lindsey M, Bernstein DI, Lockey J, Villareal M, Hershey GKK, Grinshpun SA. A comparison of proximity and land use regression traffic exposure models and wheezing in infants. Environ Health Perspect. 2007;115(2):278-284.
Ryan PH and LeMasters GK. A review of land-use regression models for characterizing intraurban air pollution exposure. Inhal Toxicol. 2007;19(Suppl 1):127-133.
Ryan PH, LeMasters G, Biagini J, Bernstein D, Grinshpun SA, Shukla R, Wilson K, Villareal M, Burkle J, Lockey J. Is it traffic type, volume, or distance? Wheezing in infants living near truck and bus traffic. J Allergy Clin Immunol. 2005;116:279-284.(Editor’s Choice article)
Impact of Traffic-Related Particles on Asthma for Students in an Urban School District. Principal Investigator. National Institute of Health (NIH) National Institute of Environmental Health Sciences (NIEHS). Oct 2009 – Sept 2012.
Analysis of Personal and Home Characteristics Associated with the Elemental Composition of PM2.5 in Indoor, Outdoor, and Personal Air in the RIOPA Study. Principal Investigator. Health Effects Institute (HEI). Aug 2010 – July 2012.
Field Validation of a Personal Sensor for Ultrafine PM in Asthmatic Children. Co-Principal Investigator. NIEHS. July 2011 – June 2013.
Diesel, Allergens, and Gene-Environment Interactions. Co-Investigator. NIEHS. July 2007 – June 2012.
The Libby Community Childhood Health Investigation and Exposure Follow-Up Study. Co-Investigator. Co-Investigator. NIEHS. October 2009 – Sept 2013.
Synergistic Effect of Home Exposure to Aeroallergens and Traffic-Related Air Pollution. Department of Housing and Urban Development (HUD). Co-Investigator. Apr 2011 – March 2013.
Shelia Salisbury, PhD
(513) 636-2947 email@example.com
Phone: (513) 636-2947
PhD: University of Cincinnati, 2008.
MS: Applied Statistics, Wright State University, 1992.
BS: Mathematics/Statistics, Wright State University, 1990.
Talbert RJ, Michaud LJ, Mehlman CT, Kinnett DG, Laor T, Foad SL, Schnell B, Salisbury S. EMG and MRI are Independently Related to Shoulder External Rotation Function in Neonatal Brachial Plexus Palsy. J Pediatr Orthop. 2011 Mar;31(2):194-204.
Larson DB, Johnson LW, Schnell BM, Salisbury SR, Forman HP. National trends in CT use in the emergency department: 1995-2007. Radiology. 2011 Jan;258(1):164-73.
Kim HK, Gottliebson W, Hor K, Backeljauw P, Gutmark-Little I, Salisbury SR, Racadio JM, Helton-Skally K, Fleck R. Cardiovascular anomalies in Turner syndrome: spectrum, prevalence, and cardiac MRI findings in a pediatric and young adult population. AJR Am J Roentgenol. 2011 Feb;196(2):454-60.
Staat MA, Rice MA, Donauer S, Payne DC, Bresee JS, Mast TC, Curns AT, Cortese MM, Connelly B, McNeal M, Ward RL, Bernstein DI, Parashar UD, Salisbury S. Estimating the rotavirus hospitalization disease burden and trends, using capture-recapture methods. Pediatr Infect Dis J. 2010 Dec;29(12):1083-6. Staat MA, Stadler LP, Donauer S, Trehan I, Rice M, Salisbury S. Serologic testing to verify the immune status of internationally adopted children against vaccine preventable diseases. Vaccine. 2010 Nov 23;28(50):7947-55. Kim HK, Laor T, Graham TB, Anton CG, Salisbury SR, Racadio JM, Dardzinski BJ. T2 relaxation time changes in distal femoral articular cartilage in children with juvenile idiopathic arthritis: a 3-year longitudinal study. AJR Am J Roentgenol. 2010 Oct;195(4):1021-5. Parikh SN, Grice SS, Schnell BM, Salisbury SR. Operating room traffic: is there any role of monitoring it?J Pediatr Orthop. 2010 Sep;30(6):617-23. Habli M, Cnota J, Michelfelder E, Salisbury S, Schnell B, Polzin W, Lim FY, Crombleholme TM. The relationship between amniotic fluid levels of brain-type natriuretic peptide and recipient cardiomyopathy in twin-twin transfusion syndrome. Am J Obstet Gynecol. 2010 Oct;203(4):404.e1-7.
Mahmoud M, Sadhasivam S, Salisbury S, Nick TG, Schnell B, Sestokas AK, Wiggins C, Samuels P, Kabalin T, McAuliffe J. Susceptibility of transcranial electric motor-evoked potentials to varying targeted blood levels of dexmedetomidine during spine surgery. Anesthesiology. 2010 Jun;112(6):1364-73.
Vuletin JF, Lim FY, Cnota J, Kline-Fath B, Salisbury S, Haberman B, Kingma P, Frischer J, Crombleholme T. Prenatal pulmonary hypertension index: novel prenatal predictor of severe postnatal pulmonary artery hypertension in antenatally diagnosed congenital diaphragmatic hernia. J Pediatr Surg. 2010 Apr;45(4):703-8.
Heidi J. Sucharew, PhD
is a biostatistician with research interests in structural equation modeling, latent profile analysis, and latent variable modeling. Her recent areas of application include infant neurobehavior, stroke severity, adolescent menstrual symptoms and depression, and glucose control during pregnancy.
structural equation modeling, latent profile analysis, and latent variable modeling
BA: Statistics, The College of New Jersey, Ewing, NJ, 2000
MS: Biostatistics, University of Washington, Seattle, WA, 2002
PhD: Biostatistics, University of Cincinnati, Cincinnati, OH, 2009
Sucharew H, Khoury JC, Rao MB, Succop P, Bernstein D, Ryan PH, LeMasters G. Predicting allergic disease at age four using an atopy predisposition score at age two: the application of Item Response Theory. Pediatr Allergy Immunol. 2012.
VanDyke R, Ren Y, Sucharew H, Miodovnik M, Rosenn B, Khoury JC. Characterizing maternal glycemic control: a more informative approach using semiparametric regression. J Matern Fetal Neonatal Med, 25(1): 15-9. 2012
Flaherty ML, Kissela B, Sucharew H, Alwell K, Moomaw CJ, Woo D, Khatri P, Ferioli S, Adeoye O, Mackey J, Broderick JP, Kleindorfer D. The practice of carotid revascularization within a large metropolitan population. J Stroke Cerebrovasc Dis. 2011.
Mackey J, Kleindorfer DO, Sucharew H, Moomaw CJ, Kissela BM, Alwell K, Flaherty ML, Woo D, Khatri P, Adeoye O, Ferioli S, Khoury JC, Hornung R, Broderick JP. Population-based study of wake-up strokes. Neurology, 76(19), 1662-7. 2011.
Sucharew H, Ryan PH, Bernstein D, Succop P, Khurana Hershey GK, Lockey J, Villareal M, Reponen T, Grinshpun S, LeMasters G. Exposure to traffic exhaust and night cough during early childhood: the CCAAPS birth cohort. Pediatr Allergy Immunol, 21(2), 253-9. 2010.
Lerner S, Tangen C, Sucharew H, Wood D, Crawford ED. Failure to achieve a complete response to induction BCG therapy is associated with increased risk of disease worsening and death in patients with high risk non-muscle invasive bladder cancer. Urol Oncol, 27(2), 155-159. 2009.
Iossifova Y, Reponen T, Sucharew H, Succop P, Vesper S. Use of (1-3)-beta-d-glucan concentrations in dust as a surrogate method for estimating specific fungal exposures. Indoor Air, 18(3), 225-232. 2008.
Lerner S, Tangen C, Sucharew H, Wood D, Crawford ED. Patterns of recurrence and outcomes following bacillus calmette-guerin for high risk TA, T1 bladder cancer. J Urol, 177(5), 1727-1731. 2007.
Sucharew H, Goss CH, Millard SP, Ramsey B. Respiratory adverse event profiles in placebo subjects in short and long-term inhaled therapy trials. Contemp Clin Trials, 27(6), 561-70. 2006.
Brody AS, Sucharew H, Campbell JD, Millard SP, Molina PL, Klein JS, Quan J. Computed tomography correlates with pulmonary exacerbations in children with cystic fibrosis. Am J Respir Crit Care Med, 172(9), 1128-32. 2005
Hemorrhagic and Ischemic Stroke Among Blacks and Whites. Biostatistician. National Institute of Health / National Institute of Neurological Disorders and Stroke. July 2009 – June 2014.
Recanalization Therapies and Markers of Stroke Outcome. Co-Investigator. National Institute of Neurological Disorders and Stroke. July 2008 – April 2013.
Medication Continuity in Children Treated for ADHD. Biostatistician. National Institute of Mental Health. Jan 2010 – Nov 2014.
Neurobehavioral Effects of Insecticide Exposure in Pregnancy and Early Childhood. Biostatistician. National Institute of Health / National Institute of Environmental Health Sciences. Sept 2009 – Aug 2012.
Rhonda D. Szczesniak, PhD
is currently interested in statistical and epidemiological research, including functional data analysis applications, classification methods, self-modeling regressions, instrumental variables regression, and outcomes research for children with cystic fibrosis and obstructive sleep apnea. She was recently awarded a statistical methods development grant to further her research on ambulatory blood pressure monitoring and cardiac outcomes in children with obstructive sleep apnea.
PhD: Statistics, University of Kentucky, Lexington, KY, 2007.
MS: Statistics, University of Kentucky, Lexington, KY, 2005.
BS: Mathematics, Radford University, Radford, VA, 2003.
McPhail GL, Weiland J, Acton JD, Ednick M, Chima A, VanDyke R, Fenchel MC, Amin RS, Seid M. Improving evidence-based care in cystic fibrosis through quality improvement. Arch Pediatr Adolesc Med. 2010 Oct;164(10):957-60. McPhail GL, Ednick MD, Fenchel MC, VanDyke R, Chima A, Amin RS, Seid M. Improving follow-up in hospitalised children. Qual Saf Health Care. 2010 Oct;19(5):e35. Young LR, VanDyke R, Gulleman P, Yoshikazu I, Brown KK, Schmidt L, Hajjar F, Trapnell B, Franz D, & McCormack FX. Vascular Endothelial Growth Factor D for the Serodiagnosis of Lymphangioleiomyomatosis. CHEST. 2010 Sep;138(3):674-81.
McConnell K, Somers VK, Kimball T, Daniels S, VanDyke R, Fenchel M, Cohen A, Willging P, Shamsuzzaman A & Amin R. Baroreflex Gain in Children with Obstructive Sleep Apnea. Am J Respir Crit Care Med. 2009 Jul 1;180(1):42-8.
Gavotte L, Mercer DR, Vandyke R, Mains JW, Dobson SL. Wolbachia infection and resource competition effects on immature Aedes albopictus (Diptera: Culicidae). J Med Entomol. 2009 May;46(3):451-9.
Stefaniak TR, Phillips TD, Rodgers CA, VanDyke R & Williams D. The Inheritance of Cold Tolerance and Turf Traits in a Seeded Bermuda Grass Population. J Crop Science. 2009;49(4).
Khadra MA, McConnell K, VanDyke R, Somers V, Fenchel M, Quadri S, Jefferies J, Cohen AP, Rutter M, Amin R. Determinants of regional cerebral oxygenation in children with sleep-disordered breathing. Am J Respir Crit Care Med. 2008 Oct 15;178(8):870-5.
Mercer DR, Schoergendorfer A, Vandyke R. Sexual differences in larval molting rates in a protandrous mosquito (Diptera: Culicidae) species, Aedes sierrensis. J Med Entomol. 2008 Sep;45(5):861-6.
Grossoehme DH, VanDyke R, Seid M. Spirituality's role in chronic disease self-management: sanctification of the body in families dealing with cystic fibrosis. J Health Care Chaplain. 2008;15(2):149-58.
Blood pressure, cardiovascular function and sleep apnea: Developing statistical models that fit (not force) the data. Principal Investigator. Center for Clinical and Translational Science and Training. 2010 - 2011.
Development and Validation of Serum VEGF-D as a Clinical Diagnostic Test in Lymphangioleiomyomatosis. Biostatistician. Center for Clinical and Translational Science and Training. 2010 - 2011. Vascular Functions in Children with Sleep-Disordered Breathing. Biostatistician. National Heart, Lung and Blood Institute. 2006 -2011. # R01HL080670.Late Preterm Birth, Ureaplasma Species and Childhood Lung Disease. Biostatistician. National Institutes of Health. 2009 - 2013. #R01 HL097064. Cardiac Structure and Function in Early Familial Cardiomyopathy. Mentoring Biostatistician. National Institutes of Health. 2010 - 2015. #K25 HL102244-01.
Bin Zhang, PhD
conducts research on statistical methods in clinical trials, survival analysis, longitudinal data analysis and optimal designs. Areas of interest: cancer, infectious diseases, asthma, cardiovascular diseases, health behavior, cohort studies, case-control studies, and clinical trials.
Dr. Zhang joined Cincinnati Children’s in January 2012. Dr. Zhang has served as co-investigator and lead statistician in clinical trials including both adult and pediatric patients. He served as the biostatistician for the Collaborative Antiviral Study Group (CASG), providing statistical support regarding study design, protocol development, study monitoring, quality assurance, data management, report generation and statistical analyses for CASG trials. In addition, he was the deputy director of the Statistical and Data Management Center of Mycoses Study Group (MSG), and served on the Steering Committee (Design and Analysis Committee) for the Consortium of Hospitals to Advance Research on Tobacco (CHART) trials. He has published theoretical as well as collaborative articles in peer-reviewed journals. His recent paper “Evaluation of lymph node numbers for adequate staging of Stage II and III colon cancers” published in the Journal of Hematology and Oncology, May 2011, has been accessed 2023 times in the past 8 months.
BS: University of Science and Technology of China, Hefei, Anhui, China.
PhD: University of Missouri, Columbia, Missouri.
Acelajado MC, Pisoni R, Dudenbostel T, Dell’Italia LJ, Cartmill F, Zhang B, Cofield SS, Oparil S, Calhoun DA. Refractory hypertension: definition, prevalence and patient characteristics. J Clin Hyperten. 2012;14(1):7-12.
Katkoori VR, Shanmugam C, Jia X, Salih C, Sthanam M, Chen D, Zhang B, Bumpers HL, Callens T, Messiaen LM, Grizzle WE, Manne U. Prognostic significance and gene expression profiles of p53 mutations in microsatellite-stable stage III colorectal adenocarcinomas. PloS One. 2012;7(1):1-10.
Bovell L, Shanmugam C, Katkoori VR,; Zhang B, Vogtmann E, Grizzle WE, Manne U. microRNAs are Stable in Colorectal Cancers Archival Tissue Blocks. Frontiers in Bioscience. 2012 Jan 1;4:1937-40.
Gerald LB, McClure LA, Gerald JK, Zhang B, Harrington K, Bailey WC. Seasonal Influenza and H1N1 vaccine prevalence among children with asthma. Am J Respiratory Critical Care Medicine. 2011 May;183:A4153.
Shanmugam C, Hines RB, Jhala NC, Katkoori VR, Zhang B, Posey JA, Bumpers HL, Grizzle WE, Eltoum IE, Siegal GP, Manne U. Evaluation of lymph node numbers for adequate staging of Stage II and III colon cancers. J Hematol and Oncolo. 2011 May;4(1):25.
Gerald JK, McClure LA, Zhang B, Harrington K, Bailey WC, Gerald LB. Predictors of hand sanitizer use at home among children with asthma. Am J Respiratory Critical Care Medicine. 2011 May;183:A3792.
Yang M, Zhang B, Huang SG. Optimal designs for generalized linear models with multiple design variables. Statistica Sinica. 2011;21:1415-1430
Subramaniam A, Kim KH, Bryant SA, Zhang B, Sikes C, Kimball KJ, Kilgore LC, Huh WK, Straughn JM Jr., Alvarez RD. A cohort study evaluating robotic versus laparotomy surgical outcomes of obese women with endometrial carcinoma. Gynecology Oncology. 2011;122(3):604-7.
Fauci J, Whitworth J, Subramanian A, Zhang B, Frederick PJ, Schneider K, Straughn JM, Kilgore LC. Prognostic significance of the relative dose intensity of chemotherapy in primary treatment of epithelial ovarian cancer. Gynecology Oncology. 2011;122(3):532-5.
Zhang B, Tong XW, Sun JG. Efficient estimation for the proportional odds model with bivariate current status data. Far East J Theoretical Statistics. 2009;(1):113-132.
Mycoses Study Group. Deputy Director. Statistical and Data Management Center. Feb 2010-Dec 2013.
Clinical Trials for Antiviral Therapies. Investigator. National Institutes of Health / National Institute of Allergy and Infectious Diseases. Aug 2003-Jan 2012.
Nanhua Zhang, PhD
is a faculty biostatistician with research interests in developing new methods for handling missing data, comparative effectiveness research, clinical trial design, meta-analysis, scale development, and joint modeling. His applied interests include environmental health, community-based intervention, health disparity, behavioral intervention and health psychology.
Missing data; comparative effectiveness; clinical trial design; meta-analysis; scale development; joint modeling; environmental health; community-based intervention; health disparity; behavioral intervention; health psychology
Dr. Zhang earned his PhD in biostatistics from the University of Michigan in Ann Arbor. Prior to joining Cincinnati Children’s Hospital Medical Center, he was a faculty member at the University of South Florida in Tampa. His statistical methodology research has covered missing data, causal inference, clinical trial design, joint modeling and meta-analysis. His applied research interests include environmental health, community-based intervention, health disparity, behavioral intervention and health psychology. His research “early childhood lead exposure on academic achievement” received media coverage on TV, radio, newspapers, magazines, and various online media such as Time.com and Yahoo.com.
Dr. Zhang has authored 20 published papers and made numerous presentations at national and international conferences. He has served as a reviewer for 15 different journals including: Biometrika, Statistics in Medicine, Statistics Sinica, Annals of Applied Statistics, American Journal of Public Health, Annals of Epidemiology, Health Education Research. He has taught graduate and advanced doctoral courses in linear models, survival analysis and statistical computing.
BS: Shanghai University of Finance and Economics, Shanghai, China.
MS: Bowling Green State University, Bowling Green, OH.
PhD: University of Michigan, Ann Arbor, MI.
Zhang N, Little RJA. Subsample ignorable likelihood for accelerated failure time models with missing predictors. Lifetime Data Anal. 2014 Aug 5. Epub ahead of print.
Huang Y, Xing D, Zhang N, Chen H. Jointly Modeling Event Time and Skewed-Longitudinal Data with Missing Response and Mismeasured Covariate. J Biopharm Stat. 2014 Jun 6. Epub ahead of print.
Zhang N, Chen H, Zou Y. A joint model of binary and longitudinal data with non-ignorable missingness, with application to marital stress and late life depression. J Applied Statistics. 2014;41(5);1028-39.
Brannick MT, Zhang N. Bayesian Meta-analysis of Coefficient Alpha. Res Synthesis Methods. 2013;4(2):198-207.
Chen H, Zhang N, Lu X, Chen S. Caution regarding the choice of standard deviations to guide sample size calculations in clinical trials. Clin Trials. 2013 Aug;10(4)522-9.
Zhang N, Baker HW, Tufts M, Raymond RE, Salihu H, Elliott MR. Early childhood lead exposure and academic achievement: evidence from Detroit Public Schools (2008-2010). Am J Public Health. 2013 Mar;103(3):e72-7.
Zhang N, Little RJA. A pseudo-Bayesian approach to regression with missing covariates. Biometrics. 2012 Sep;68(3):933-42.
Little RJA, Zhang N. Subsample ignorable likelihood for regression with missing data. J R Stat Soc Ser C Appl Stat. 2011;60, 591-605.
Resnicow K, Zhang N, Vaughan R, Reddy SP, James S, Murry DM. When intraclass correlation coefficients go awry: a case study from a school-based smoking prevention study in South Africa. Am J Public Health. 2010 Sep;100(9):1714-48.
Resnicow K, Davis RE, Zhang N, Strecher VJ, Tolsma D, Calvi J, Alexander G, Anderson JP, Wiese C. Tailoring a fruit and vegetable intervention on ethnic identity: results of a randomized study. Health Psychol. 2009 Jul;28(4):394–403.
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