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Our lab is focused on using quantitative approaches, from disciplines such as computer science and applied mathematics, to address fundamental questions in molecular biology.
In particular, we are interested in deciphering the human genetic blueprint, modeling complex biological systems such as biomolecular networks and pathways, and facilitating drug discovery and development. We have a special focus on developing computational tools to unravel the molecular mechanism of human diseases, especially pediatric cancer, cardiovascular and pulmonary diseases. We would welcome any suggestions on initiating collaborations.
Our research emphasizes the structural and functional aspects of biomolecules through modeling and simulation. We exploit diverse sources of genomic databases by integration and comparison.
For additional information visit Dr. Lu's externally hosted lab website.
Zhang M, Lu LJ. Investigating the validity of current network analysis on static conglomerate networks by protein network stratification. BMC Bioinformatics. 11:466. 2010.
Deng J, Deng L, Su S, Zhang M, Lin X, Wei L, Minai A, Hassett DJ, Lu LJ. Investigating the predictability of essential genes across distantly related organisms using an integrative approach. Nucleic Acids Research. 1-13. 2010.
Gordon SM, Deng J, Lu LJ, Davidson SW. Proteomic characterization of human plasma high density lipoprotein fractionated by gel filtration chromatography. Journal of Proteome Research. 9(10): 5239-5249. 2010.
He F, Wen Y, Cheung D, Deng J, Lu LJ, Jiao R, Ma J. Distance measurements via the morphogen gradient of Bicoid in Drosophila embryos. BMC Developmental Biology. 10:80. 2010.
Xu Y, Zhang M, Wang Y, Dave V, Kadambi P, Lu LJ, Whitsett J. A systems approach to mapping transcriptional networks controlling surfactant homeostasis. BMC Genomics. 11:451. 2010.
Zhang M, Deng J, Fang C, Zhang X, Lu LJ. Biomolecular Network Analysis and Applications. Knowledge-Based Bioinformatics. 11:253-288. 2010.
Deng J, Wang W, Lu LJ, Ma J. A two-dimensional simulation model of the bicoid gradient in drosophila. PLoS One. 5(4): e10275. 2010.
Gordon S, Durairaj A, Lu LJ, Davidson WS.HDL Proteomics: Identifying New Drug Targets and Biomarkers by Understanding Functionality. Current Cardiovascular Risk Report. 4:1-8. 2010.
He F, Wen Y, Deng J, Lin X, Lu LJ, Jiao R, Ma J. Probing intrinsic properties of a robust morphogen gradient in Drosophila. Developmental Cell. 15(4):558-67. 2008.
Huang YJ, Hang D, Lu LJ, Gerstein MB, Montelione GT. Targeting the human cancer pathway protein interaction network by structural genomics. Molecular & Cellular Proteomics. 7(10):2048-60. 2008.
Lu LJ, Sboner A, Huang YJ, Lu HX et al. Comparing classical pathways and modern networks: towards the development of an edge ontology. Trends in Biochemical Science. 32(7): 320-331. 2007.
Wu L, Hwang S, Rezaul K, Lu LJ, Mayya V, Gerstein M, Eng JK, Lundgren DH, Han DK. Global survey of human T leukemic cells by integrating proteomics and transcriptomics profiling. Molecular & Cellular Proteomics. 6(8): 1343-53. 2007.
Flores SC, Lu LJ, Yang J, Carriero N, Gerstein MB. Hinge Atlas: relating protein sequence to sites of structural flexibility. BMC Bioinformatics. 8:167. 2007.
Kim PM, Lu LJ, Xia Y, Gerstein M. Relating three-dimensional structures to protein networks provides evolutionary insights. Science. 314(5807): 1938-41. 2006.
Xia Y, Lu LJ, Gerstein M. Integrated prediction of membrane helical protein interactions in yeast. Journal of Molecular Biology. 357(1): 339-349. 2006.
Lu LJ, Xia Y, Paccanaro A, Yu H, Gerstein M. Assessing the limits of genomic integration for predicting protein networks. Genome Research. 15: 945-53. 2005.
Lu L, Arakaki AK, Lu H, Skolnick J. Multimeric Threading-Based Prediction of Protein-Protein Interactions on a Genomic Scale: Application to the Saccharomyces cerevisiae. Genome Research. 13:1146-1154. 2003.
Lu L, Lu H, Skolnick J. MULTIPROSPECTOR: An Algorithm for the Prediction of Protein-Protein Interactions by Multimeric Threading. Proteins: Structure, Functions, Genetics. 49:350-364. 2002.
Long “Jason” Lu, PhDDivision of Biomedical Informatics3333 Burnet Ave.MLC 7024Cincinnati, OH 45229-3039Phone: 513-636-8720Fax: 513-636-2056E-mail: email@example.com
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