• Research Faculty

  • A photo of Peter White.

    Peter S. White, PhD Director, Division of Biomedical Informatics

    has an active laboratory that is developing genomic analysis, natural language processing, data integration, and knowledge representation methods to help determine the molecular etiologies of particular pediatric diseases, including childhood cancer, ADHD, mitochondrial disorders, and congenital cardiac defects.


    A photo of Bruce Aronow.

    Bruce J. Aronow, PhD Co-director, Computational Medicine Center

    focuses his research on unraveling the role and mechanism by which the functional capabilities of the human genome shape human health and the body’s ability to adapt to stressful challenges. With the co-leadership of Anil Jegga, DVM, his lab is using a variety of available data on structural and functional genomics and biological systems to form models of how biological systems assemble, adapt and become impaired in disease.
    Visit the Aronow/Jegga Lab.


    A photo of Anil Jegga.

    Anil Goud Jegga, DVM, MRes

    is a medically oriented computational biologist. His work with Bruce Aronow, PhD, uses a variety of bioinformatics approaches to explore gene regulatory networks and the interaction between genotype and phenotype. He has extensive experience in transcription factor and micro-RNA based gene regulatory mechanisms, gene polymorphism functional analysis, candidate disease gene identification and prioritization.
    Visit the Aronow/Jegga Lab.


    A photo of Michal Kouril.

    Michal Kouril, PhD Director, Research IT Services

    leads the team that provides IT resources and support to the research community at Cincinnati Children’s. He also specializes in high performance computing applications in biomedical informatics and combinatorics.


    A photo of Jason Lu.

    Long (Jason) Lu, PhD

    works in bioinformatics and systems biology. He focuses on using quantitative approaches from disciplines such as computer science and applied mathematics to address fundamental questions in molecular biology. In particular, he is interested in deciphering the human genetic blueprint, modeling complex biological systems (such as biomolecular networks and pathways), and facilitating drug discovery and development.
    Visit the Lu Lab.


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    Jun Ma, PhD

    investigates fundamental mechanisms of development through a combination of quantitative experimental approaches and theoretical and simulation approaches. One major focus of Ma’s lab concerns the questions of how morphogen gradients are established, and how precise positional information is encoded by these gradients and interpreted by cells in developing tissues.


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    Keith Marsolo, PhD

    leads the team that supports Cincinnati Children's i2b2 research data warehouse. His team participates in a number of large clinical data sharing networks, and also has a focus on developing tools to support multi-center quality improvement and research networks.


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    Jarek Meller, PhD

    researches the development and application of computational methods for learning from biological data, including applications to protein structure prediction, mapping protein interactions, functional annotation and genotype-phenotype associations. State-of-the-art modeling and annotation tools developed by his group are publicly available.
    Visit the Meller Lab.


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    John P. Pestian, PhD, MBA Director, Computational Medicine Center

    advances the science of natural language processing and understanding in biomedical settings. Along with a growing list of collaborators, his lab has developed neuro-cognitive algorithms that enable computers to understand concepts and semantic relationships within clinical text. Pestian also directs the Computational Medicine Center, established in 2003 by a $28 million grant from Ohio's Third Frontier Project.
    Visit the Pestian Lab.


    A photo of Nathan Salomonis.

    Nathan Salomonis, PhD

    is a genomics and bioinformatics research scientist focusing on understanding human development and genetic networks underlying disease. His lab develops computational approaches to evaluate distinct modes of gene regulation and define molecular networks that govern mammalian progenitor cell specification and human disease pathology (e.g., Sudden Infant Death Syndrome) from genome-wide experimental datasets.


    A photo of Stephen A. Spooner

    Stephen A. Spooner, MD, MS, FAAP Chief Medical Information Officer, Biomedical Informatics

    practices general academic pediatrics and serves as the Chief Medical Information Officer for Cincinnati Children’s. He is active in the area of data standards in support of child health, and is currently the co-chair of the HL 7 child health work group. He is also co-chair of the Certification Commission for Health Information Technology inpatient work group. 


    A photo of Michael Wagner.

    Michael Wagner, PhD Faculty Liaison, Biomedical Informatics Core

    works on applications of machine learning techniques to bioinformatics problems such as protein structure prediction, disease classification and protein identification. His lab is investigating machine-learning-based scoring algorithms for peptide mass fingerprinting to better understand how to optimally mine mass spectrometry data and make high-confidence predictions of protein identities.
    Visit the Wagner Lab. 



    Judith W. Dexheimer, PhD

    is a biomedical informatics researcher with an interest in clinical decision support systems with a goal of improving clinical care and patient outcomes. Her research focuses on decision support in the emergency department with an interest in the effectiveness and efficacy of alerts and reminders throughout the hospital.


    A photo of Eric Hall.

    Eric S. Hall, PhD

    participates in a number of interdisciplinary teams investigating prematurity and neonatal disease. Along with coordinating data collection and exchange efforts, his work involves the application of knowledge discovery techniques to clinical data sets, as well as the development of software tools to assist in the summarization of clinical data and the modeling of clinical processes.


    Kenneth M. Kaufman, PhD

    Kenneth M. Kaufman, PhD

    investigates the genetics of complex and rare disorders using genotyping and next-generation DNA technologies. The goal of his research is to identify the underling mechanisms and genetics that lead to complex diseases such as systemic lupus erythematosus.


    A photo of Eric Kirkendall.

    Eric S. Kirkendall, MD, MBI, FAAP Associate Chief Medical Information Officer

    is interested in using health information technology to maximize patient safety and quality in clinical care delivery.


    A photo of Kakajan Komurov.

    Kakajan Komurov, PhD Member, Cancer Biology and Neural Tumors Program

    focuses on computational systems biology. His specific research interests include: 1) the development of novel computational methodology and software for efficient network-based data analyses and 2) computational analyses of dynamic organizational principles in intracellular molecular networks and their specific alterations that contribute to disease phenotypes.
    Visit the Komurov Lab.


    A photo of Alexey Porollo.

    Alexey Porollo, PhD Member, Center for Autoimmune Genomics and Etiology

    is computational biologist with research focused on the development of new prediction methods in structural bioinformatics. He is particularly interested in prediction and analysis of protein structure, protein-protein and protein-ligand interactions. Applications of the computational approaches include structural and functional characterization of proteins and their mutations, analysis of biological pathways, identification of alternative drug targets, and virtual drug screening.
    Visit the Porollo Lab.


    A photo of Alexander J. Towbin.

    Alexander J. Towbin, MD Radiologist, Department of Radiology and Medical Imaging

    is interested in radiology informatics; cancer imaging and abdominal imaging.


    A photo of Matthew Weirauch.

    Matthew T. Weirauch, PhD

    is a computational biologist. His lab seeks to understand the mechanisms of gene transcriptional regulation. Current projects focus on characterizing transcription factor binding specificities, and developing methods for modeling their interactions with DNA, both in vitro and in vivo. His lab applies insights from basic research on transcription factor-DNA interactions to study the mechanisms underlying complex diseases.


    A photo of Yan Xu.

    Yan Xu, PhD Director, Bioinformatics Microarray Core

    focuses on bioinformatics applications and systems biology. Her research interests are the identification of gene signatures, regulatory networks and biological pathways controlling 1) surfactant homeostasis, 2) lung maturation, 3) lung cell type specific signaling and 4) asthma associated pathology. The goal is to gain better understanding of molecular mechanisms underlying lung development and pathogenesis.