Bone Marrow Transplantation and Immune Deficiency

  • Research Faculty

  • Show All

    Division Head

    A photo of Stella Davies.

    Stella M. Davies, MBBS, PhD, MRCP Director, Bone Marrow Transplantation and Immune Deficiency

    Visit the Davies Lab.

    513-636-1371
    stella.davies@cchmc.org

    Stella M. Davies, MBBS, PhD, MRCP

    Director, Bone Marrow Transplantation and Immune Deficiency

    Jacob G. Schmidlapp Endowed Chair

    Academic Information

    Professor, UC Department of Pediatrics

    Phone: 513-636-1371

    Fax: 513-803-1969

    Email: stella.davies@cchmc.org

    Show All

    Specialties

    Education and Training

    MBBS: University of Newcastle-Upon-Tyne, England, 1981.

    Clinical and Fellowship Training: The Royal Victoria Infirmary, Newcastle General Hospital and Great Ormond St. Hospital, 1981 to 1985.

    PhD: University of Newcastle-Upon-Tyne, England, 1989.

    Pediatric Fellowship: University of Minnesota, Minneapolis, MN, 1989 to 1993.

    Publications

    View PubMed Publications

    Faculty

    A photo of Lisa Filipovich.

    Alexandra (Lisa) H. Filipovich, MD Ralph J. Stolle Chair, Clinical Immunology

    is a clinical immunologist who studies the genetics and pathogenesis of congenital immunodeficiencies including HLH (hemophagocytic lymphohistiocytosis). Translational research involves developing safer approaches to hematopoietic cell transplantation for such diseases, as well as the application of gene therapy.

    513-803-3218
    lisa.filipovich@cchmc.org

    Alexandra (Lisa) H. Filipovich, MD

    Ralph J. Stolle Chair, Clinical Immunology

    Director, Immune Deficiency and Histiocytosis Program

    Medical Director, Diagnostic Immunology Laboratory

    Academic Information

    Professor, UC Department of Pediatrics

    Phone: 513-803-3218

    Fax: 513-803-1969

    Email: lisa.filipovich@cchmc.org

    Show All

    Specialties

    Clinical Interests

    Primary immunodeficiencies; BMT for primary immunodeficiencies; hemophagocytic lymphocytosis; post-BMT immune reconstruction

    Research Interests

    Biology and genetics of hemophagocytic lymphohistiocytosis; investigation of hematopoietic cell transplantation for genetic immunodeficiencies; immunoreconstitution following pediatric stem cell transplantation

    Biography

    Lisa Filipovich, MD, began her career at the University of Minnesota where she received her medical degree in 1974 and completed fellowships in both immunopathology and pediatric immunology. She became a professor of pediatrics and served for 10 years as the head of the Division of Immunology at the University of Minnesota Medical School. Dr. Filipovich came to Cincinnati Children’s in 1996. She is currently the Ralph J. Stolle Chair in Clinical Immunology and the director of the Immune Deficiency and Histiocytosis program. She also serves as the medical director of the Diagnostic Immunology Laboratory at Cincinnati Children’s.

    Dr. Filipovich has a special interest in histiocytic disorders, especially hemophagocytic lymphohistiocytosis (HLH). Other interests include bone marrow transplant for primary immune deficiencies and post-BMT immune reconstitution. She serves as president of the Histiocyte Society, an international group of more than 200 physicians and scientists who are committed to improving the lives of patients with histiocytosis through research.

    Education and Training

    MD: University of Minnesota, Minneapolis, MN, 1974.

    Residency: University of Minnesota Hospitals, Minneapolis, MN 1975-1978.

    Fellowship: Immunopathology, Departments of Pediatrics, Laboratory Medicine and Pathology, University of Minnesota 1978-1979.

    Fellowship: Pediatric Immunology, Department of Pediatrics, University of Minnesota 1979-1980.

    Certification: Pediatrics, 1980.

    Publications

    View PubMed Publications

    Grants

    Gene Therapy for SCID-X1 Using Self-Inactivating Gamma. Principal Investigator. National Institutes of Health. Sep 2010-Aug 2015. #U01 AI 087628.

    Rare Diseases Clinical Consortia for the Rare Diseases. Principal Investigator. National Institutes of Health. Sep 2009-Aug 2014. #U54 AI 082973.

    Hypoxia and potassium channel activity in T Lymphocytes. Principal Investigator. National Institutes of Health. Jun 2009-Jun 2014. #R01 CA 095286.

    A photo of Michael Grimley.

    Michael S. Grimley, MD

    has clinical research interests in the treatment of Graft versus Host Disease (GVHD) after transplant and the use of umbilical cord blood as a stem cell source.

    513-636-5917
    michael.grimley@cchmc.org

    Michael S. Grimley, MD

    Academic Information

    Associate Professor, UC Department of Pediatrics

    Phone: 513-636-5917

    Fax: 513-803-1969

    Email: michael.grimley@cchmc.org

    Show All

    Specialties

    Bone marrow transplantation for primary immunodeficiencies; cord blood transplants; leukemia

    Education and Training

    MD: Emory University School of Medicine, Atlanta, GA, 1992.

    Residency: Wilford Hall Medical Center, Lackland, AFB, TX, 1995.

    Fellowship: Cincinnati Children’s Hospital Medical Center, 1999.

    Certification: General Pediatrics, Pediatric Hematology/Oncology.

    Licenses: Ohio, Texas.

    Publications

    View PubMed Publications
    A photo of Michael Jordan.

    Michael B. Jordan, MD

    specializes in caring for children with histiocytic disorders, primary immune deficiencies, or who are undergoing bone marrow transplantation. His laboratory focuses on understanding effector T cell function, immune regulation, and the pathogenesis of hemophagocytic lymphohistiocytosis. He is also conducting preclinical scientific studies in addition to a translational clinical trial.

    513-636-7287
    michael.jordan@cchmc.org

    Michael B. Jordan, MD

    Academic Information

    Associate Professor, UC Department of Pediatrics

    Phone: 513-636-7287

    Fax: 513-803-1969

    Email: michael.jordan@cchmc.org

    Show All

    Specialties

    Clinical Interests

    Histiocytic disorders: HLH and LCH

    Research Interests

    Better understanding histiocytic disorders and developing novel therapies for them; regulation of the immune response; immunotherapy of cancer

    Education and Training

    MD: UT Southwestern, Dallas, TX, 1993.

    Residency: Children's Hospital of Dallas, 1996.

    Fellowship: The Children's Hospital (Denver), 2002.

    Certification: American Board of Pediatrics, 1996; Sub-board of Pediatric Heme/Onc, 2002.

    Publications

    View PubMed Publications
    A photo of Ashish Kumar.

    Ashish R. Kumar, MD, PhD

    is a pediatric hematologist-oncologist who has a research program investigating the biology of leukemia caused by MLL-fusion genes. These leukemias are most common in infants and frequently fatal. The research in Dr. Kumar's lab is focused at identifying downstream targets of MLL-fusion proteins that could be exploited to develop novel therapies. Currently, the Kumar lab is investigating the role of MEIS1 in MLL-leukemia.
    Visit the Kumar Lab.

    513-803-1631
    ashish.kumar@cchmc.org

    Ashish R. Kumar, MD, PhD

    Academic Information

    Associate Professor, UC Department of Pediatrics

    Phone: 513-803-1631

    Fax: 513-636-3549

    Email: ashish.kumar@cchmc.org

    Show All

    Specialties

    Clinical Interests

    Childhood cancer and blood disorders; immune deficiency

    Research Interests

    Leukemia biology; cancer biology

    Visit the Kumar Lab.

    Biography

    Dr. Kumar received his medical degree from L.T.M. Medical College, Mumbai, India, his PhD in anatomy and cell biology from the University of Iowa, pediatric residency training at the Mayo Clinic and fellowship in pediatric hematology / oncology / BMT at the University of Minnesota. He was appointed to the faculty of the University of Minnesota in the Department of Pediatrics where he was a member of the programs in pediatric leukemia and global pediatrics. As a faculty of the Masonic Cancer Center, he was also part of the Genetic Mechanisms of Cancer research program. Dr. Kumar’s laboratory is engaged in researching the biology of infant leukemia. Discoveries made in his laboratory have significantly enhanced the current understanding of leukemia.

    Education and Training

    MD: LTM Medical College, Mumbai, India.

    Residency: Mayo Clinic, Rochester, MN.

    Fellowship: University of Minnesota, Minneapolis, MN.

    PhD: University of Iowa, Iowa City, IA.

    Certification: General Pediatrics; Pediatric Hematology/Oncology Subspecialty.

    Licenses: State of Ohio; State of Minnesota.

    Publications

    View PubMed Publications
    A photo of Rebecca Marsh.

    Rebecca A. Marsh, MD

    is an immunologist and bone marrow transplant physician. Her research focuses on understanding the pathogenesis of HLH in patients with XIAP deficiency, developing new diagnostic laboratory assays, and improving the outcomes of allogeneic bone marrow transplantation in patients with primary immune deficiencies.

    513-803-9063
    hlh@cchmc.org

    Rebecca A. Marsh, MD

    Academic Information

    Assistant Professor, UC Department of Pediatrics

    Phone: 513-803-9063

    Fax: 513-636-3549

    Email: hlh@cchmc.org

    Show All

    Education and Training

    Fellowship: Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, 2008.

    Residency: Rush University Medical Center, Chicago, Illinois, 2006.

    MD: Rush Medical College 2003.

    BS: University of Tennessee, Knoxville, Tennessee, 1998.

    Publications

    View PubMed Publications

    Grants

    Studies to Determine why XIAP Deficiency leads to HLH. Clinical Immunology Society. Jul 2010 - Jun 2012,
    A photo of Kasiani Myers.

    Kasiani C. Myers, MD

    is a bone marrow transplant physician focused on translational research in bone marrow failure and Fanconi anemia (FA), specifically the longitudinal evaluation of hematopoiesis in FA as a model for de novo leukemogenesis. These studies will lead to development and clinical trials of targeted therapies to preserve stem cell function through the elucidation of the steps in the pathway towards marrow failure and malignant transformation.

    513-636-7287
    kasiani.myers@cchmc.org

    Kasiani C. Myers, MD

    Academic Information

    Assistant Professor, UC Department of Pediatrics

    Phone: 513-636-7287

    Email: kasiani.myers@cchmc.org

    Show All

    Biography

    Dr. Myers received her medical degree from Case Western Reserve University and pursued training in pediatrics and hematology/oncology at Cincinnati Children’s Hospital Medical Center. After completion of her postdoctoral training, she joined the faculty at Cincinnati Children’s in the Division of Bone Marrow Transplantation and Immune Deficiency. She is a recipient of the Procter Scholar Award to support her translational research in the field of Fanconi anemia.

    Education and Training

    BS: University of Michigan, 2000.

    MD: Case Western Reserve University, 2004.

    Post-Doctoral: Cincinnati Children’s Hospital Medical Center, 2010.

    Certification: Pediatrics, 2007.

    Publications

    View PubMed Publications
    A photo of Kimberly Risma.

    Kimberly A. Risma, MD, PhD Director, Allergy and Immunology Fellowship Program

    is focused on the molecular and cellular bases of primary disorders of immune deficiency and dysregulation, especially as it relates to lymphocyte cytotoxicity. She studies the pathologic consequences of missense mutations in perforin identified in patients with hemophagocytic lymphohistiocytosis (HLH) and strives to develop novel therapies through gene therapy or small molecule chaperones.
    Visit the Risma Lab website.

    513-636-6771
    kimberly.risma@cchmc.org

    Kimberly A. Risma, MD, PhD

    Director, Allergy and Immunology Fellowship Program

    Academic Information

    Assistant Professor, UC Department of Pediatrics

    Phone: 513-636-6771

    Fax: 513-636-4615

    Email: kimberly.risma@cchmc.org

    Show All

    Specialties

    Clinical Interests

    Immune deficiency; immune dysregulation

    Research Interests

    Pathophysiology of perforin missense mutations identified in individuals with hemophagocytic lymphohistiocytosis; molecular mechanisms of primary immune deficiency and dysregulation; natural killer cell and cytotoxic T lymphocyte cytotoxicity

    Visit the Risma Lab website.

    Biography

    Kimberly Risma, MD, PhD, is an assistant professor in the Division of Allergy and Immunology at Cincinnati Children’s and the University of Cincinnati College of Medicine.

    Dr. Risma graduated magna cum laude with a Bachelor of Arts in Chemistry from Duke University in 1990 and was elected into The Phi Beta Kappa Society. She then matriculated at Case Western Reserve University (CWRU) School of Medicine in the Medical Scientist Training Program (MSTP). In 1996, she completed a PhD in pharmacology. She was selected by the leadership of the CWRU MSTP as the recipient of the 1997 Martin Wahl Memorial Fund Award, given annually to recognize the graduating MD, PhD student who has demonstrated the highest level of independence in research and excellence in research and clinical skills. She was also elected to Alpha Omega Alpha Society in 1997.

    In 1997, she enrolled in a Pediatrics residency at Cincinnati Children’s Hospital Medical Center/University of Cincinnati.  During the residency program, Dr. Risma was awarded the pediatric resident teaching award by the medical students. She also engaged in translational research studies related to the genetics of asthma under the mentorship of Dr. Gurjit Hershey, resulting in a first author publication as a pediatric resident.

    In 2000, Dr. Risma was accepted to the Allergy and Immunology Fellowship Program at Cincinnati Children’s.  In addition to her clinical training, she pursued an innovative research project under the mentorship of Dr. Janos Sumegi and Dr. Alexandra Filipovich. She proposed a mechanism to study the structural and functional impact of perforin missense mutations identified in patients with hemophagocytic lymphohistiocytosis. In 2004 she was awarded the Nezelof Prize for best scientific presentation at the international meeting of the Histiocyte Society. The culmination of her fellowship research project was published in the Journal of Clinical Investigation, 2006.  

    Upon completion of her fellowship in 2005, Dr. Risma was appointed as an Assistant Professor in the Division of Allergy and Immunology at Cincinnati Children’s Hospital Medical Center. In 2006 Dr. Risma received a Clinical Scientist Development Award from the Doris Duke Charitable Foundation. Dr. Risma is the director of the Allergy and Immunology Fellowship Program at Cincinnati Children's, having served in this leadership position since August of 2012.

    Dr. Risma's research program focuses on understanding the molecular mechanisms of immunodeficiency and immune dysregulation in children, especially as it relates to disorders of lymphocyte cytotoxicity. In addition to her research, she sees patients from all around the country in consultation for primary immune deficiency, immune dysregulation, and allergic disorders.   

    Education and Training

    MD: Case Western Reserve University School of Medicine, Cleveland, OH, 1997.

    PhD: Case Western Reserve University School of Medicine, Cleveland, OH, 1996.

    Residency: Pediatrics, Cincinnati Children's Hospital Medical Center, 1997-2000.

    Fellowship: Allergy / Immunology, Cincinnati Children's Hospital Medical Center.

    Certification: Pediatrics, 2007; Allergy and Immunology, 2005.

    Publications

    View PubMed Publications
    A photo of Janos Sumegi.

    Janos Sumegi, MD, PhD

    is a molecular geneticist who has an interest in the molecular mechanisms involved in Familial Hemophagocytic Lymphohistiocytosis and X-linked Lymphoproliferative Syndrome. A second focus of his lab is to study the genes and regulatory pathways involved in the tumorigenesis of alveolar rhabdomyosarcoma.

    513-636-5976
    janos.sumegi@cchmc.org

    Janos Sumegi, MD, PhD

    Academic Information

    Professor, UC Department of Pediatrics

    Phone: 513-636-5976

    Fax: 513-636-3549

    Email: janos.sumegi@cchmc.org

    Show All

    Specialties

    Lymphoproliferative disease; hemophagocytic lymphohistiocytosis; usher syndrome

    Education and Training

    MD: University Medical School of Debrecen, Hungary, 1968.

    PhD: Research Center of the Hungarian Academy of Science, Budapest, Hungary, 1974.

    Docent (DMSc): Karolinska Institute Stockhom, Sweden, 1982.

    Publications

    View PubMed Publications

    Grants

    Gene-Expression Profiling of Peripheral Blood Mononuclear Cells in Hemophagocytic Lymphohistiocytosis. Histiocytosis Association of America. Dec 2010 - Nov 2011.