Research Support
Financial support for Beebe's research has come through the Cincinnati Children's Research Foundation, the National Institutes of Health, the American Sleep Medicine Foundation, and the State of Ohio Emergency Medical Services fund.
Collaborators have also received funding from the Department of Defense, Institute of Educational Sciences, American Diabetes Association, Canadian Institutes of Health Research, and University of Otago (NZ).
Current Funding
Impact of Well-Timed vs. Mis-timed Sleep Extension on Adolescents’ Dietary Intake
NIH/NHLBI
1R01HL147915-01A1 (pending) PI: Beebe04/01/20 – 03/31/24
This experimental sleep manipulation study will assess the effects of sleep timing on the dietary intake of adolescents with early or late chronotypes. It will test a causal model in which sleep timing plays an important role in promoting or negating the benefits of sleep extension.
Role: Principal Investigator.
Antioxidant Therapy with N-Acetylcysteine for Motor Behavior and Learning in Children with Neurofibromatosis Type 1
Department of Defense
W81XWH-19-NFRP-CTA (pending) PI: Prada04/01/20 – 03/31/24
This is a single center randomized double-blind placebo controlled, prospective, Phase II study to explore safety, tolerability, and efficacy of N-Acetylcysteine on motor behavior and/or attention deficit in children with Neurofibromatosis Type 1 aged 8 through 16 years old.
Role: Co-Investigator.
Cognitive Outcome Measures in School-Age Children with Down Syndrome (DS)
NIH/NICHD
R01HD093754PI: Esbensen7/20/18 - 6/30/23
The objective of this study is to establish the psychometric properties of clinical outcome measures in children with DS across the cognitive domains of executive functioning (inhibition, working memory, set-shifting), learning and memory, and processing speed. It aims: 1) To examine the psychometric properties of measures in the assessment battery with children with DS. 2) To evaluate differences in the psychometric properties of the measures as a function of variations in demographics and medical comorbidities. 3) To characterize the developmental trajectories of cognition and executive functioning.
Role: Co-Investigator
Delayed Sleep Phase and Risk for Adolescent Substance Use
NIH/NIDA
R01 DA044143PI: Hasler7/1/18 - 6/30/23
Mounting evidence indicates that delayed sleep timing may confer risk for adolescent substance use disorders. A mismatch between late sleep hours and early school start times may lead to disturbed sleep and circadian rhythms, as well as increased impulsivity and sensitivity to rewards, and increased substance use in turn. The aims of this research are (1) to examine associations between sleep timing, impulsivity, reward sensitivity, and substance use, and (2) to determine whether stabilizing sleep/circadian timing in adolescents with delayed sleep timing reduces impulsivity and reward sensitivity.
Role: Consultant
Research Training in Child Behavior and Nutrition
NIH/NIDDK
T32DK063929PIs: Powers, Zeller7/1/03 – 6/30/23
This multidisciplinary grant supports postdoctoral fellows seeking specialized training in the relationship between child and family behaviors, nutrition, and nutrition-related health conditions.
Role: Mentor.
Impact of Sleep Extension on Insulin Sensitivity and Dietary Intake in Adolescents
NIH/NIDDK
K23 DK117021PI: Simon9/17/18 - 8/31/22
This career development award includes formal research and training. The research aims to examine the effect of extending sleep on 1) insulin sensitivity/secretion and 2) circadian timing of dietary intake among adolescents with habitually insufficient sleep, and 3) identify key perceptions, barriers, and facilitators to obtaining sufficient sleep in adolescents with obesity and T2D, to inform the refinement of a sleep extension manipulation in this at-risk population. Complementary training aims include: 1) IVGTT performance and modelling; 2) circadian rhythms; 3) advanced energy intake/expenditure assessment; and 4) qualitative methodology.
Role: Mentor
Extending Sleep to Improve Glycemic Control in Pediatric Type 1 Diabetes
NIH/NIDDK
R01 DK110528PI: Perfect9/12/16 - 6/30/21
Primary study aims are to (1) Test if lengthening sleep improves glycemic control and in youth with T1DM; (2) Assess if “booster” sessions can contribute to sustained sleep length; and (3) Assess if “booster” sessions can lead to statistically and clinically meaningful changes in HbA1c, the gold standard of glucose control.
Role: Consultant
Driving Skills of Adolescents with Obstructive Sleep Apnea (OSA)
NIH/NHLBI
R21HD096014PI: Beebe4/1/19 - 3/30/21
This study aims to test (1) whether adolescent OSA increases driving risk and (2) whether inattention and daytime sleepiness are mechanisms in OSA-linked driving risk. This small-scale study using a driving simulator will provide proof-of concept findings to prepare for anticipated larger on-road research work.
Role: Principal Investigator.
Sleep and Pain in Childhood Arthritis: A crossover randomized control trial comparing adequate and restricted sleep duration, and its impact on pain in adolescents with arthritis.
Canadian Institutes of Health Research
390137PI: Feldman1/22/18 – 1/21/21
This study tests the hypothesis that changes in sleep duration will cause differences in disease activity, physical activity/sedentary behavior, and health-related quality of life, among youth aged 12-18 years with juvenile idiopathic arthritis.
Role: Co-Investigator
Administrative Coordinating Center: Cardiovascular Development and Pediatric Cardiac Genomics Consortia.
NIH/NHLBI/NICHD
1U01HL131003PI: King1/1/16 – 12/31/20
The Bench to Bassinet Program accelerates pediatric cardiovascular translational research from discovery to early translational testing to clinical testing. The ACC supports this mission via a unique, integrated combination of world-leading pediatric cardiovascular and neurocognitive clinical/translational research expertise, advanced infrastructure, outstanding institutional support, and state-of- the-art technology.
Role: Internal Advisory Committee Member.
A Multi-Method Investigation to Distinguish Sluggish Cognitive Tempo from ADHD
NIH/NIMH
K23 MH108603 PI: S Becker 9/18/15 – 8/31/2020
In the context of the PI’s career development proposal, this research will identify the daily life, neuropsychological, and neurophysiological correlates that distinguish children with well-defined sluggish-cognitive tempo (with or without ADHD) from typically developing children and children with ADHD-only. Findings from this research will contribute to an improved understanding of the underlying dysfunctions and impairments that distinguish sluggish cognitive tempo from ADHD.
Role: Mentor
Longitudinal Evaluation of the Impact of Sleep Problems on the Academic and Social Functioning of Adolescents with and without ADHD
Institute of Educational Sciences (IES)
R305 A160126PI: Langberg 7/1/16 – 6/30/20
This is a prospective longitudinal study of adolescents with ADHD and a comparison group that includes a comprehensive assessment of sleep, academic, and social functioning, and factors that may differentially predict the presence of sleep problems. Findings will lead to best-practice recommendations for how and when schools can include the assessment of sleep as part of psychoeducational evaluations and may inform policy decisions about school contextual factors that can impact sleep.
Role: Subcontract Co-Investigator
