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Zeller Lab

Zeller Lab

 
 

  • Adolescent Bariatric Surgery

    Meg Zeller, PhD was a recipient of internal funding from the Children’s Hospital Research Foundation (CREFF: Grant #M01 RR 08084 from the General Clinical Research Centers Program, National Center for Research Resources/NIH) and subsequently, external funding from NIH (R03 DK0788901). Zeller has worked in collaboration with pediatric surgeon and researcher, Thomas Inge, MD, PhD to identify psychosocial benefits of bariatric surgery in the treatment of severely obese adolescents and the psychosocial predictors of successful surgical outcomes. These pilot data served to inform the psychosocial aims of the five-center adolescent bariatric research consortium, developed in cooperation with NIDDK staff executing a prospective longitudinal observational study to document the safety and post-operative health outcomes of bariatric surgery when performed during adolescence.
     
    Visit the Teen-LABS or the Teen Longitudinal Assessment in Bariatric Surgery page.
     

    Zeller obtained additional funding (R01DK080020-01) for an ancillary study (TeenView) to enhance the aims of Teen-LABS by examining the impact of adolescent bariatric surgery on long-term improvements in psychosocial functioning, quality of life and developmental adaptation as well as factors that may negatively impact weight loss and psychosocial outcomes. Zeller recently obtained additional ARRA supplemental funding to convert this study to a web-based format.  Zeller and Inge recently received supplemental funding to Teen-LABS from the National Institute on Drug Abuse (NIDA) for a more thorough examination of the development of substance abuse and other high-risk / addictive behaviors in adolescents who undergo bariatric surgery.
     

    Additionally, in collaboration with David Sarwer, PhD (University of Pennsylvania, principal investigator), the Zeller lab (co-investigator) is a site executing his ancillary study to Teen-LABS (R01DK080738-01), which examines dietary intake and eating behaviors in adolescents who undergo bariatric surgery (TeenIntake).

     

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    TeenView

    Adolescent Bariatrics: Controlled Longitudinal Study of Psychosocial Development

    Adolescents with extreme obesity (BMI > 40 kg / m2) are a growing subpopulation at considerable health risk. Bariatric surgery is an established treatment for extreme obesity in adulthood resulting in impressive weight loss and the resolution of most obesity-related comorbidities, including significant improvements in quality of life.


    Unfortunately, the pediatric obesity literature is severely lacking in prospective longitudinal psychosocial studies in general, and specifically, studies that characterize adolescents with extreme obesity as they transition to adulthood. Their psychosocial future can only be assumed when based on the adult experience.

    The TeenView study (R01DK080020-01), an ancillary study to Teen-LABS, will address these gaps by utilizing a prospective, controlled, longitudinal design and follow two parallel cohorts of adolescents over the same time: Teen-LABS participants (ages 13-18) and demographically matched non-operative extremely obese adolescents recruited from the Teen-LABS sites.


    Both cohorts complete a series of measures at baseline / pre-surgery and at various times within the first two years postoperatively. TeenView will provide the first comprehensive evidence of whether there are pre-surgical psychosocial factors (e.g., depression, binge eating behavior, social support) that are predictive of poorer adolescent weight loss outcomes.

    Alternately, if adolescents with poorer parent / family functioning show less relative improvement in psychosocial status post-surgery, clinical programs could include adjunctive interventions to target these parent / family factors, which may improve both health and psychosocial outcomes long term. Findings from TeenView therefore have the potential to markedly influence clinical practice, bariatric surgery patient selection and management decisions and nonsurgical interventions to prevent, limit and reverse the effects of extreme obesity at all ages. Data collection is ongoing.

     

    TeenIntake

    Dietary Intake and Eating Behavior in Adolescents who undergo Bariatric Surgery

    TeenIntake, an ancillary to TeenLABS, proposes to investigate changes in dietary intake and eating behavior in Teen-LABS participants as compared to adolescents treated within a lifestyle modification program. TeenIntake will examine the relationship of these outcomes to percent of weight loss following surgery as well as postoperative reports of nausea, vomiting and gastric dumping. In addition, TeenIntake will examine the relationship of these variables of interest to demographic, educational, health-related quality of life, and physical health outcomes following intervention.


 
  • TeenView logo.
    TeenView logo.
 
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