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Scientific evidence suggests that many adolescents with acute lymphoblastic leukemia (ALL) or lymphoblastic lymphoma (LBL) do not adhere to their prescribed medication regimens. Such nonadherence may have undesirable clinical and scientific consequences; not only can it increase the risk of relapse, but it can also reduce the validity of data for clinical trials of medication treatment.
To address the need for studies of efficacy of adherence promotion in pediatric cancer, we are conducting a randomized clinical trial (RCT) with children and adolescents diagnosed with ALL / LBL to evaluate a family-centered, problem-solving intervention (FPST) plan to promote adherence to oral medication treatment. This intervention plan will be compared with current psychological care. We anticipate that the proposed study will identify effective strategies to promote adherence among children and adolescents with ALL / LBL, and that our findings may potentially lead to improved medical outcomes for these children and adolescents.
The proposed intervention model is novel in that it integrates three key components derived from theory and research on pediatric illness and treatment adherence. The components are:
The study is currently in the fifth year of data collection and data collection across all sites will end in June 2013. Recruitment for the study closed in January 2012 -- 139 patients and their families participated in the baseline data collection visit. We are currently in the process of summarizing and describing the baseline data. Presently, 101 patients and families have finished the study. We will begin analyzing the full data set soon after June 2013.
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