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Our lab examines factors that influence treatment adherence, develops interventions to improve adherence and quantifies the impact of treatment adherence on medical and psychological outcomes. We focus specifically on pediatric solid organ transplant, hematopoietic stem cell transplant and oncology populations. We are interested in the ways that families and medical teams support adherence in pediatric patients, and how children and adolescents learn to effectively manage their own treatment regimens as they progress to adulthood.
Read more about the Pai Lab’s research in kidney transplant and stem cell transplant patients.
McGrady, M. E., Ryan, J. L., Gutierrez-Colina, A. M., Fredericks, E. M., Towner, E. K., & Pai, A. L. H. (In Press). The impact of effective pediatric adherence promotion interventions: Systematic review and meta-analysis. Child: Care, Health and Development.
Pai, A. L. H., & McGrady, M. E. (2015). Assessing mediation adherence as a standard of care in pediatric oncology. Pediatric Blood and Cancer, 62, S818-S828.
Hummel, T. R., Salloum, R., Drissi, R., Kumar, S., Sobo, M., Goldman, S., Pai, A., Leach, J., Lane, A., Pruitt, D., Sutton, M., Chow, L. M., Grimme, L., Doughman, R., Backus, L., Miles, L., Stevenson, C., Fouladi, M., & DeWire, M. (2015). A pilot study of bevacizumab-based therapy in patients with newly diagnosed high-grade gliomas and diffuse intrinsic pontine gliomas. Journal of Neuro-Oncology, pp1-9. DOI: 10.1007/s11060-015-2008-6.
Crosby LE, Joffe NE, Reynolds N, Peugh JL, Manegold E, Pai AL. Psychometric Properties of the Psychosocial Assessment Tool-General in Adolescents and Young Adults With Sickle Cell Disease. J Pediatr Psychol. 2015 Aug 13. pii: jsv073. [Epub ahead of print]
Kazak AE, Schneider S, Didonato S, Pai AL. Family psychosocial risk screening guided by the Pediatric Psychosocial Preventative Health Model (PPPHM) using the Psychosocial Assessment Tool (PAT). Acta Oncol. 2015 May;54(5):574-80.
Gass D, Dewire M, Chow L, Rose SR, Lawson S, Stevenson C, Pai AL, Jones B, Sutton M, Lane A, Pruitt D, Fouladi M, Hummel TR. Pediatric tectal plate gliomas: a review of clinical outcomes, endocrinopathies, and neuropsychological sequelae. J Neurooncol. 2015 Mar;122(1):169-77.
Drotar D, Cortina S, Crosby LE, Hommel KA, Modi AC, Pai ALH. Competency-based postdoctoral research for clinical psychologists: An example and implications. Training and Education in Professional Psychology. 2015;9(2).
Tackett AP, Peugh J, Wu Y, Pai ALH. Parent Medication Barriers Scale (PMBS): A Preliminary Investigation of Factor Structures with Hematopoietic Stem Cell Transplant Recipients. Children’s Health Care. 2014.
Foster BJ, Pai ALH. Adherence in adolescent and young adult kidney transplant recipients. The Open Urology & Nephrology Journal. 2014.
Gray WN, Szulczewski LJ, Regan SM, Williams JA, Pai AL. Cultural influences in pediatric cancer from diagnosis to cure/end of life. J Pediatr Oncol Nurs. 2014 Sep-Oct;31(5):252-71.
Ryan JL, Arnett AD, Pai AL, Modi AC. An examination of the Allocation of Treatment Responsibility scale in adolescents with epilepsy. Epilepsy Behav. 2014 Dec;41:1-5.
Foster BJ, Pai A, Zhao H, Furth S; TAKE-IT Study Group. The TAKE-IT study: aims, design, and methods. BMC Nephrol. 2014 Aug 30;15:139.
Pai AL, McGrady M. Systematic review and meta-analysis of psychological interventions to promote treatment adherence in children, adolescents, and young adults with chronic illness. J Pediatr Psychol. 2014 Sep;39(8):918-31.
Brosig C, Pai A, Fairey E, Krempien J, McBride M, Lefkowitz DS. Child and family adjustment following pediatric solid organ transplantation: factors to consider during the early years post-transplant. Pediatr Transplant. 2014 Sep;18(6):559-67.
Wu YP, Pai AL. Health care provider-delivered adherence promotion interventions: a meta-analysis. Pediatrics. 2014 Jun;133(6):e1698-707.
McGrady ME, Williams SN, Davies SM, Pai AL. Adherence to outpatient oral medication regimens in adolescent hematopoietic stem cell transplant recipients. Eur J Oncol Nurs. 2014 Apr;18(2):140-4.
Pai AL, Tackett A, Hente EA, Ernst MM, Denson LA, Hommel KA. Assessing psychosocial risk in pediatric inflammatory bowel disease: validation of the Psychosocial Assessment Tool 2.0_General. J Pediatr Gastroenterol Nutr. 2014 Jan;58(1):51-6.
Wu YP, Pai AL, Gray WN, Denson LA, Hommel KA. Development and reliability of a correction factor for family-reported medication adherence: pediatric inflammatory bowel disease as an exemplar. J Pediatr Psychol. 2013 Sep;38(8):893-901.
Morrison CF, Flesch L, Pai ALH, Longo A, Duane C, Donnelly M. Therapeutic relationship education on a pediatric bone marrow transplant and immunology unit. Biology of Blood and Marrow Transplantation. 2013.
Goebel J, Pai A. Creating a monster: non-adherence underlying late transplant rejection. Pediatr Transplant. 2012 Jun;16(4):312-4
Pai AL, Rausch J, Tackett A, Marsolo K, Drotar D, Goebel J. System for integrated adherence monitoring: real-time non-adherence risk assessment in pediatric kidney transplantation. Pediatr Transplant. 2012 Jun;16(4):329-34.
Modi AC, Pai AL, Hommel KA, Hood KK, Cortina S, Hilliard ME, Guilfoyle SM, Gray WN, Drotar D. Pediatric self-management: a framework for research, practice, and policy. Pediatrics. 2012 Feb;129(2):e473-85.
Pai AL, Tackett A, Ittenbach RF, Goebel J. Psychosocial Assessment Tool 2.0_General: validity of a psychosocial risk screener in a pediatric kidney transplant sample. Pediatr Transplant. 2012 Feb;16(1):92-8.
Page MC, Fedele DA, Pai AL, Anderson J, Wolfe-Christensen C, Ryan JL, Mullins LL. The relationship of maternal and child illness uncertainty to child depressive symptomotology: a mediational model. J Pediatr Psychol. 2012 Jan-Feb;37(1):97-105.
Pai ALH, Ingerski LM. Psychosocial adjustment and adherence of children and adolescents on dialysis. Pediatric Dialysis. 2012.
Mullins LL, Molzon ES, Suorsa KI, Tackett AP, Pai ALH, Chaney JM. Models of resilience: Developing psychosocial interventions for parents of children with chronic health conditions. Family Relations. 64. Page 176-189.
Guilfoyle SM, Goebel JW, Pai ALH. Efficacy and flexibility impact perceived adherence barriers in pediatric kidney post-transplantation. Fam Syst Health. 2011 Mar;29(1):44-54.
Ingerski L, Perrazo L, Goebel J, Pai ALH. Family strategies for achieving medication adherence in pediatric kidney transplantation. Nurs Res. 2011 May-Jun;60(3):190-6.
Pai ALH, Ingerski LM, Perazzo L, Ramey C, Bonner M, Goebel J. Preparing for transition? The allocation of oral medication regimen tasks in adolescents with renal transplants. Pediatr Transplant. 2011 Feb;15(1):9-16.
Pai ALH, Ostendorf HM. Treatment Adherence in Adolescents and Young Adults Affected by Chronic Illness during the Health Care Transition from Pediatric to Adult Health Care: A Literature Review. Children’s Health Care. 2011;40, 16-33.
Pai ALH, Gray E, Kurvival K, Ross J, Schoborg D, Goebel J. The Allocation of Treatment Responsibility scale: a novel tool for assessing patient and caregiver management of pediatric medical treatment regimens. Pediatr Transplant. 2010 Dec;14(8):993-9.
Pai ALH, Drotar D. Treatment adherence impact: the systematic assessment and quantification of the impact of treatment adherence on pediatric medical and psychological outcomes. J Pediatr Psychol. 2010 May;35(4):383-93.
Ingerski LM, Modi AC, Hood KK, Pai ALH,Zeller M, Piazza-Waggoner C, Driscoll KA, Rothenberg ME, Franciosi J, Hommel KA. Health-related quality of life across pediatric chronic conditions. J Pediatr. 2010 Apr;156(4):639-44.
Butow P, Palmer S, Pai ALH, Goodenough B, Luckett T, King M. Review of adherence-related issues in adolescents and young adults with cancer. J Clin Oncol. 2010 Nov 10;28(32):4800-9.
Stehl ML, Kazak AE, Alderfer MA, Rodriguez A, Hwang W, Pai ALH, Boeving A, Reilly A. Conducting a randomized clinical trial of an psychological intervention for parents/caregivers of children with cancer shortly after diagnosis. J Pediatr Psychol. 2009 Sep;34(8):803-16.
Patino-Fernandez AM, Pai ALH, Alderfer M, Hwang W, Reilly A, Kazak AE. Acute stress in parents of children newly diagnosed with cancer. Pediatr Blood Cancer. 2008 Feb;50(2):289-92.
Peterson CC, Johnson CE, Ramirez LY, Huestis S, Pai ALH, Demaree HA, Drotar D. A meta-analysis of the neuropsychological sequelae of chemotherapy-only treatment for pediatric acute lymphoblastic leukemia. Pediatr Blood Cancer. 2008 Jul;51(1):99-104.
Pai ALH, Patino-Fernandez AM, McSherry M, Beele D, Alderfer MA, Reilly AT, Hwang W, Kazak AE. The Psychosocial Assessment Tool (PAT2.0): psychometric properties of a screener for psychosocial distress in families of children newly diagnosed with cancer. J Pediatr Psychol. 2008 Jan-Feb;33(1):50-62.
Pai ALH, Drotar D, Kodish E. Correspondence between objective and subjective reports of adherence among adolescents with acute lymphoblastic leukemia. Children’s Health Care. 2008;37,225-235.
Stehl ML, Kazak AE, Hwang WT, Pai ALH, Reilly AF, Douglas SD. Innate immune markers in mothers and fathers of children newly diagnosed with cancer. Neuroimmunomodulation. 2008;15(2):102-7.
Mullins LL, Wolfe-Christensen C, Pai ALH, Carpentier MY, Gillaspy S, Cheek JA. The relationship of parental overprotection, perceived child vulnerability, and parenting stress to uncertainty in youth with chronic illness. J Pediatr Psychol. 2007 Sep;32(8):973-82.
Kazak AE, Rourke MT, Alderfer MA, Pai ALH, Reilly AF, Meadows AT. Evidence-based assessment, intervention and psychosocial care in pediatric oncology: A blueprint for comprehensive services across treatment. Journal of Pediatric Psychology. 2007;32, 1099-1110.
Pai ALH, Neff-Greenly R, Lewandowski A, Drotar D, Youngstrom E, Peterson CC. A meta-analytic review of the influence of pediatric cancer on parent and family functioning. J Fam Psychol. 2007 Sep;21(3):407-15.
Pai ALH, Mullins LL,Drotar D, Burant C, Wagner J, Chaney JM. Exploratory and confirmatory factor analysis of the Child Uncertainty in Illness Scale among children with chronic illness. J Pediatr Psychol. 2007 Apr;32(3):288-96.
Pai, A. L. H. & Drotar, D (2014). Medication Adherence in Pediatric Oncology. In L. S. Wiener, M. Pao, A. E. Kazak, M. Kupst, A. F. Patenaude, & J. C. Holland (Eds.). Quick Reference for Pediatric Oncology Clinicians: The Psychiatric and Psychological Dimensions of Pediatric Cancer Symptom Management, 2nd Edition Charlottesville, VA. IPOS Press.
Pai ALH, Ingerski L. Psychological Adjustment and Treatment Adherence. In Warady BA, Schaefer F, Alexander SR, eds. Pediatric Dialysis, 2nd Edition. New York. Springer Press [in press].
Pai ALH, Drotar D. Medication Adherence in Pediatric Oncology. In Wiener, LS, Pao, M, Kazak, AE, Kupst, M, Patenaude, AF, Holland, JC, eds. Quick Reference for Pediatric Oncology Clinicians: The Psychiatric and Psychological Dimensions of Pediatric Cancer Symptom Management. Charlottesville, VA. IPOS Press, 2009.
Ahna L.H. Pai, PhDMember, Center for Treatment Adherence and the Promotion of Self-Management
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