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Our lab examines factors that influence treatment adherence, develops interventions to improve adherence and quantifies the impact of treatment adherence on medical and psychological outcomes. We focus specifically on pediatric solid organ transplant, hematopoietic stem cell transplant and oncology populations. We are interested in the ways that families and medical teams support adherence in pediatric patients, and how children and adolescents learn to effectively manage their own treatment regimens as they progress to adulthood.
Read more about the Pai lab’s research in kidney transplant and stem cell transplant patients.
Goebel, J. & Pai, A.L. H. Creating a Monster: Non-Adherence Underlying Late Transplant Rejection. Pediatric Transplantation, 16: 312–314. 2012.
Pai, A.L.H, Rausch, J., Tackett, A., Marsolo, K., Drotar, D., & Goebel, J.W. System for Integrated Adherence Monitoring (SIAM): Real-Time Non-Adherence Risk Assessment in Pediatric Kidney Transplantation. Pediatric Transplantation, 16, 329–334. 2012.
Modi, A.C., Pai, A.L.H., Hommel, K.A., Hood, K.K., Cortina, S., Hilliard, M.E., Guilfoyle, S.M., Gray,W.N., & Drotar, D. Pediatric self-management: A framework for research, practice, and policy. Pediatrics, 129, e473-485. 2012.
Pai, A.L.H, Tackett, A., Ittenbach, R. & Goebel, J.W. Psychosocial Assessment Tool 2.0_General: Validity of a Psychosocial Risk Screener in a Pediatric Kidney Transplant Sample. Pediatric Transplantation, 16. 92-98. 2012.
Page, M.C., Fedele, D.A., Pai, A.L.H., Anderson, J., Wolfe-Christensen, C., Ryan, J.L., Mullins, L.L. The Relationship of Maternal and Child Illness Uncertainty to Child Depressive Symptomotology: A Mediational Model. Journal of Pediatric Psychology, 37, 97-105. 2012.
Guilfoyle, SM, Goebel, JW, Pai, ALH. Efficacy and flexibility impact perceived adherence barriers in pediatric kidney post-transplantation. Family Systems & Health, 29, 44-54. 2011.
Ingerski, L, Perrazo, L, Goebel, J, & Pai, ALH. Family Strategies for Achieving Medication Adherence in Pediatric Kidney Transplantation. Nursing Research, 60, 190-196. 2011.
Pai ALH, Ingerski LM, Perazzo L, Ramey C, Bonner M, Goebel J. Preparing for transition? The allocation of oral medication regimen tasks in adolescents with renal transplants. Pediatric Transplantation.15, 9-16. 2011.
Pai ALH, Ostendorf HM. Treatment Adherence in Adolescents and Young Adults Affected by Chronic Illness during the Health Care Transition from Pediatric to Adult Health Care: A Literature Review. Children’s Health Care, 40, 16-33. 2011.
Pai, ALH, Gray, E, Kurvival, K, Ross, J, Schoborg, D, & Goebel, J. The Allocation of Treatment Responsibility scale: a novel tool for assessing patient and caregiver management of pediatric medical treatment regimens. Pediatric Transplantation, 14 , 993-999. 2010.
Pai ALH, Drotar D. Treatment adherence impact: the systematic assessment and quantification of the impact of treatment adherence on pediatric medical and psychological outcomes. Journal of Pediatric Psycholog. 35, 383-393. 2010.
Ingerski, L.M., Modi, A.C., Hood, K.K., Pai, A.L.H., Zeller, M., Piazza-Waggoner, C., Driscoll, K.A., Rothenberg, M.E., Franciosi, J., & Hommel, K.A. (2010). Health-related quality of life across pediatric chronic conditions. Journal of Pediatrics,156: 639-644, 2010.
Butow P, Palmer S, Pai ALH, Goodenough B, Luckett T, King M. Review Series Adolescent: A review of adherence-related issues in adolescents and young adults with cancer. Journal of Clinical Oncology. 28, 4800-4809. 2010.
Patino-Fernandez AM, Pai ALH, Alderfer M, Hwang W, Reilly A, Kazak AE. Acute stress in parents of children newly diagnosed with cancer. Pediatric Blood and Cancer. 50, 289-292. 2008.
Peterson CC, Johnson CE, Ramirez LY, Huestis S, Pai ALH, Demaree HA, Drotar D. A meta-analysis of the neuropsychological sequelae of chemotherapy-only treatment for pediatric acute lymphoblastic leukemia. Pediatric Blood and Cancer.51, 99-104. 2008.
Pai ALH, Patino-Fernandez AM, McSherry M, Beele D, Alderfer MA, Reilly AT, Hwang W, Kazak AE. The Psychosocial Assessment Tool (PAT2.0): psychometric properties of a screener for psychosocial distress in families of children newly diagnosed with cancer. Journal of Pediatric Psychology. 33, 50-62. 2008.
Pai ALH, Drotar D, Kodish E. Correspondence between objective and subjective reports of adherence among adolescents with acute lymphoblastic leukemia. Children’s Health Care. 37,225-235. 2008.
Stehl ML, Kazak AE, Hwang WT, Pai ALH, Reilly AF, Douglas SD. Innate immune markers in mothers and fathers of children newly diagnosed with cancer. Neuro Immuno Modulation. 15 (2) 102-107. 2008.
Mullins LL, Wolfe-Christensen C, Pai ALH, Carpentier MY, Gillaspy S, Cheek JA. The relationship of parental overprotection, perceived child vulnerability, and parenting stress to uncertainty in youth with chronic illness. Journal of Pediatric Psychology. 32,937-982. 2007.
Kazak AE, Rourke MT, Alderfer MA, Pai ALH, Reilly AF, Meadows AT. Evidence-based assessment, intervention and psychosocial care in pediatric oncology: A blueprint for comprehensive services across treatment. Journal of Pediatric Psychology. 32, 1099-1110. 2007.
Pai ALH, Neff-Greenly R, Lewandowski A, Drotar D, Youngstrom E, Peterson CC. A meta-analytic review of the influence of pediatric cancer on parent and family functioning. Journal of Family Psychology. 21,407-415. 2007.
Pai ALH, Mullins LL,Drotar D, Burant C, Wagner J, Chaney JM. Exploratory and confirmatory factor analysis of the Child Uncertainty in Illness Scale among children with chronic illness. Journal of Pediatric Psychology. 32,288-296. 2007.
Pai ALH, Ingerski L. Psychological Adjustment and Treatment Adherence. In Warady BA, Schaefer F, Alexander SR, eds. Pediatric Dialysis, 2nd Edition. New York. Springer Press [in press].
Pai ALH, Drotar D. Medication Adherence in Pediatric Oncology. In Wiener, LS, Pao, M, Kazak, AE, Kupst, M, Patenaude, AF, Holland, JC, eds. Quick Reference for Pediatric Oncology Clinicians: The Psychiatric and Psychological Dimensions of Pediatric Cancer Symptom Management. Charlottesville, VA. IPOS Press, 2009.
Ahna L.H. Pai, PhDCenter for Treatment Adherence and the Promotion of Self-Management
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