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Andrew Redington, MD Executive Co-Director, Heart Institute; Chief, Pediatric Cardiology
Executive Co-Director, Heart Institute; Chief, Pediatric Cardiology
Professor, UC Department of Pediatrics
Dr. Redington comes to Cincinnati Children’s from The Hospital for Sick Children in Toronto, Ontario. His research interests include ventricular function, integrated physiology of congenital heart disease, and ischemic preconditioning. Dr. Redington has written more than 300 peer-reviewed publications, more than 30 book chapters, and has co-edited seven textbooks. He currently holds over 15 US and international patents.
Working with colleagues throughout the Heart Institute, his plans include building on the remarkable developments achieved in the recent past to establish a world-leading multidisciplinary team providing the highest quality clinical care and practice-changing research for children and adults with congenital heart disease.
Medical School: University of London.
Research Training: Doctorate of Medicine, University of London.
Fellowship: Adult cardiology, pediatric cardiology, The Royal Brompton Hospital, London, England.
Li J, Rohaila S, Gelber N, Rutka J, Sabah N, Gladstone R, Wei C, Kharbanda R, Redington AN. MicroRNA-144 is a circulating effector of remote ischemic preconditioning. Basic Research in Cardiology 2014: 109 (5): pp 423. (Sept)
Burns KM, Byrne BJ, Gelb BD, Kuhn B, Leinwand LA, Mital S, Pearson GD, Rodefeld M, Rossano JW, Stauffer BL, Taylor MD, Towbin JA, Redington AN. New mechanistic and therapeutic targets for pediatric heart failure: report from a national heart, lung, and blood institute working group. Circulation 2014: 130 (1): pp 79-86. (July)
Friedberg MK, Redington AN. Right versus left ventricular failure: differences, similarities, and interactions. Circulation 2014: 129 (9): pp 1033-1044. (Mar)
Friedberg MK, Cho MY, Li J, Assad RS, Sun M, Rohailla S, Honjo O, Apitz C, Redington AN. Adverse biventricular remodeling in isolated right ventricular hypertension is mediated by increased TGFβ1 signaling and is abrogated by angiotensin receptor blockade. American Journal of Respirology Cell Molecular Biology 2013: 49 (6): pp 1019-1028. (Dec)
Roche SL, Redington AN. Right ventricle: wrong targets? Another blow for pharmacotherapy in congenital heart diseases. Circulation 2013: 127 (3): pp 314-316. (Jan)
Hahn CD, Manlhiot C, Schmidt MR, Nielsen TT, Redington AN. Remote ischemic per-conditioning: A novel therapy for evolving stroke? Stroke 2011: 42 (10) pp 2960-2962.
Jean-St-Michel E, Manlhiot C, Li J, Tropak M, Michelsen MM, Schmidt MR, McCrindle BW, Slievert G, Wells GD, Redington AN. Remote Ischemic Preconditioning improves maximal performance in elite athletes. Medicine & Science of Sports & Exercise 2011: 43 (7): pp 1280-1286.
Wei M, Xin P, Li Y, Li J, Ma S, Wang L, Liu M, Li J, Zhu W, Redington AN. Repeated remote ischemic postconditioning protects against adverse left ventricular remodeling and improves survival in a rat model of myocardial infarction. Circulation Research 2011: 108 (10): pp 1220-1225.
Roche SL, Vogel M, Pitkanen O, Grant B, Slorach C, Fackoury C, Stephens D, Smallhorn J, Benson LN, Kantor PF, Redington AN. Isovolumic acceleration at rest and during exercise in children normal values for the left ventricle and first non-invasive demonstration of exercise-induced force-frequency relationships. Journal of American College of Cardiology 2011: 57 (9): pp 1100-1107.
Botker HE, Kharbanda R, Schmidt MR, Bottcher M, Kaltoft AK, Terkelsen CJ, Munk K, Anderson NH, Hansen TM, Trautner S, Lassen JF, Christiansen EH, Krusell LR, Kristensen SD, Thuesen L, Nielsen SS, Rehling M, Sorensen HT, Redington AN, Neilseu TT: Remote ischaemic conditioning before hospital admission, as a complement to angioplasty, and effect on myocardial salvage in patients with acute myocardial infarction: a randomized trial. Lancet 2010: 375 (9716): pp 727-734.
Jeffrey B. Anderson, MD, MPH, MBA Chief Quality Officer, Heart Institute
has research interests that include nutrition in congenital heart disease, syncope in the pediatric population and application of quality improvement methodology to improve outcomes and value in congenital heart disease.
Chief Quality Officer, Heart Institute
Associate Professor, UC Department of Pediatrics
Pediatric electrophysiology; syncope; quality improvement and outcomes
Following his cardiology fellowship, Dr. Anderson helped establish the Syncope Clinic in the Heart Institute at Cincinnati Children’s Hospital Medical Center, and he continues to direct the work in this clinic.
Dr. Anderson helped develop the Safety, Quality, Value program within the Heart Institute at Cincinnati Children's Hospital Medical Center. The Heart Institute’s Safety, Quality, and Value team provides a platform of core data management, analytic, quality improvement, and project management expertise focused specifically on the Heart Institute’s strategic priority areas related to safety, quality, and value. This team serves a supporting role to further the Heart Institute’s ability to achieve its mission of being the leader in clinical outcomes, experience, and value for patients and families who receive diagnostic and interventional services for congenital and acquired heart disease.
MD: University of Utah School of Medicine, Salt Lake City, UT, 2002.
Masters of Public Health: University of Utah School of Medicine, Salt Lake City, UT, 2002.
Residency: Pediatrics, University of North Carolina,Chapel Hill, NC, 2002-2006.
Fellowship: Pediatric Cardiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 2006-2009.
Fellowship: Pediatric Electrophysiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 2009-2010.
Masters of Business Administration: Ross School of Business, University of Michigan, Ann Arbor, MI, 2013.
Anderson J, Grenier M, Edwards N, Madsen N, Czosek R, Spar D, Barnes A, Pratt J, King E, Knilans T.Usefulness of Combined History, Physical Examination, Electrocardiogram and Limited Echocardiogram in Screening Adolescent Athletes for Risk for Sudden Cardiac Death. Am J Cardiol. 2014 Dec 1;114(11):1763-7.
Anderson JB, Beekman RH 3rd, Kugler JD, Rosenthal GL, Jenkins KJ, Klitzner TS, Martin GR, Neish SR, Darbie L, King E, Lannon C. Improvement in growth in infants with single ventricle using a learning collaborative. National Pediatric Cardiology Quality Improvement Collaborative. Congenit Heart Dis. 2014 Nov;9(6):512-20.
Burch PT, Gerstenberger E, Ravishankar C, Hehir DA, Davies RR, Colan SD, Sleeper LA, Newburger JW, Clabby ML, Williams IA, Li JS, Uzark K, Cooper DS, Lambert LM, Pemberton VL, Pike NA, Anderson JB, Dunbar-Masterson C, Khaikin S, Zyblewski SC, Minich LL. Longitudinal assessment of growth in hypoplastic left heart syndrome: results from the single ventricle reconstruction trial. J Am Heart Assoc. 2014 Jun 27;3(3).
Slicker J, Hehir DA, Horsley M, Monczka J, Stern KW, Roman B, Ocampo EC, Flanagan L, Keenan E, Lambert LM, Davis D, Lamonica M, Rollison N, Heydarian H, Anderson JB. Nutrition Algorithms for Infants with Hypoplastic Left Heart Syndrome; Birth Through the First Interstage Period. Congenital Heart Disease. 2013 Mar-April;8(2)89-102.
Anderson JB, Czosek RJ, Knilans TK, Marino BS.The Effect of Paediatric Syncope on Health-Related Quality of Life. Cardiol Young. 2012 Oct;22(5):583-588.
Anderson J, Czosek R, Cnota J, Meganathan K, Knilans T, Heaton P. Pediatric syncope: National Hospital Ambulatory Medical Care Survey results. J Emerg Med. 2012 Oct;43(4):575-83.
Anderson J, Iyer S, Schidlow D, Williams R, Varadarajan K, Horsley M, Slicker J, Pratt J, King E, Lannon C. Variation in growth of infants with a single ventricle. J Pediatr. 2012 Jul;161(1):16-21.
Anderson J, Eghtesady P, Kalkwarf HJ, Kehl JE, Marino BS. Low weight-for-age z-score and infection risk following Fontan procedure. Ann Thorac Surg. 2011 May;91(5):1460-6.
Anderson J, Beekman RH, Eghtesady P, Uzark K, Kalkwarf HJ, Kehl JE, Marino BS.Predictors of poor weight gain in infants with a single ventricle. J Pediatr. 2010 Sep;157(3):407-13, 413.e1.
Anderson JB, Beekman RH, 3rd, Border WL, Kalkwarf HJ, Khoury PR, Uzark K, Eghtesady P, Marino BS. Lower weight-for-age z score adversely affects hospital length of stay after the bidirectional Glenn procedure in 100 infants with a single ventricle. J Thorac Cardiovasc Surg. 2009;138(2):397-404.
Robert H. Beekman III, MD
is a recognized leader in pediatric cardiology and interventional cardiology. He’s currently researching participation in multicenter trials of stent therapy for coarctation (COAST), covered stents for coarctation and aortic aneurysms, and the C3PO Registry. Dr. Beekman is also chair of the JCCHD National Pediatric Cardiology Quality Improvement Collaborative (NPC-QIC) and a member of the Steering Committee of the ACC/NCDR IMPACT Registry.
Cardiac catheterization; intervention for congenital heart disease; quality improvement
Robert H. Beekman, III, MD, is currently professor of pediatric cardiology at Children's Hospital Medical Center of Cincinnati within the University of Cincinnati College of Medicine. Dr. Beekman's subspecialty interests involve cardiovascular physiology, interventional pediatric cardiology and clinical quality improvement.
A native of California, Dr. Beekman graduated from Occidental College in Los Angeles, and earned his MD from Duke University in Durham, NC. Dr. Beekman completed his pediatric internship and residency at UCLA Medical Center, and his pediatric cardiology fellowship at the University of Michigan Medical Center, Ann Arbor, Mich. Dr. Beekman also obtained a master's degree in statistical analysis and research design from the University of Michigan. From 1985-1996, Dr. Beekman was a member of the Division of Pediatric Cardiology at the University of Michigan School of Medicine. From 1996-2009 he was director of Cardiology at Children's Hospital Medical Center of Cincinnati, and professor of pediatrics at the University of Cincinnati School of Medicine.
Dr. Beekman is passionate about improving care for patients born with congenital heart disease, and throughout his career has been an active clinician and educator. Dr. Beekman's academic interests relate to cardiovascular physiology, cardiac catheterization and quality improvement. He has published more than 200 manuscripts in cardiology and pediatric journals. Dr. Beekman is the chair of the JCCHD National Pediatric Cardiology Quality Improvement Collaborative and chair of the ACC Adult Congenital and Pediatric Cardiology Section. He has been chair of the Section on Cardiology and Cardiac Surgery of the American Academy of Pediatrics and president of the Society of Pediatric Cardiology Training Program Directors.
MD: Duke University School of Medicine, Durham, NC, 1976.
MS: Clinical Research Design and Statistics, University of Michigan, Ann Arbor, MI, 1986.Residency: Pediatrics, UCLA Medical Center, Los Angeles, CA, 1976 to 1979.Fellowship: Pediatric Cardiology, CS Mott Children's Hospital, University of Michigan, Ann Arbor, MI, 1979 to 1982.Certification: Pediatrics, 1981; Pediatric Cardiology, 1983.
Seckeler MD, Hirsch R, Beekman RH, Goldstein BH. A new predictive equation for oxygen consumption in children and adults with congenital and acquired heart disease. Heart. 2015;101(7):517-524.
Brown DW, Cohen KE, O’Brien P, Gauvreau K, Klitzner TS, Beekman RH, Kugler JD, Martin GR, Neish SR, Rosenthal GL, Lannon C, Jenkins KJ. Impact of prenatal diagnosis in survivors of initial palliation of single ventricle heart disease: Analysis of the National Pediatric Cardiology Quality Improvement Collaborative database. Pediatr Cardiol. 2015;36(2):314-321.
Anderson JB, Beekman RH, Kugler JD, Rosenthal GL, Jenkins KJ, Klitzner TS, Martin GR, Neish SR, Darbie L, King E, Lannon C. Use of a learning network to improve variation in interstage weight gain after the Norwood operation. Congenital Heart Disease. 2014;9(6):512-520.
Moore J, Vincent R, Beekman R, Benson L, Bergersen L, Holzer R, Jayaram N, Jenkins K, Li Y, Ringel R, Rome J, Martin G. Procedural results and safety of common interventional procedures in congenital heart disease: Initial report from the National Cardiovascular Data Registry. J Am Coll Cardiol. 2014;64:2439-2451.
Zussman M, Hirsch R, Beekman RH, Goldstein BH. Impact of percutaneous interventions for pulmonary artery stenosis in Alagille syndrome. Congenital Heart Disease. 2014.
Villafane J, Lantin-Hermoso MR, Bhatt AB, Tweddell JS, Geva T, Nathan M, Elliott MJ, Vetter VL, Paridon SM, Kochilas L, Jenkins KJ, Beekman RH, Wernovsky G, Towbin JA. D-Transposition of the great arteries: The current era of the arterial switch operation. J Am Coll Cardiol. 2014;64:498-511.
Armsby L, Beekman RH, Benson L, Fagan T, Hagler D, Hijazi ZM, Holzer R, Ing F, Kreutzer J, Lang P, Levi D, Latson L, Moore P, Mullins C, Ruiz C, Vincent R.SCAI expert consensus statement for advanced training programs in pediatric and congenital interventional cardiac catheterization. Cath and Cardiovasc Intervent. 2014.
Villafane J, Baker GH, Austin E, Miller S, Peng L, Beekman R. Melody pulmonary valve bacterial endocarditis: Experience in four pediatric patients and a review of the literature. Cath and Cardiovasc Intervent. 2014;84:212-218.
Lin CH, Hegde S, Marshall AC, Porras D, Gauvreau K, Beekman RH, Torres A, Vincent JA, Moore JW, Holzer R, Armsby L, Bergersen L. Incidence and management of life threatening adverse events during cardiac catheterization for congenital heart disease. Pediatric Cardiology. 2014;35:140-148.
Baker-Smith CM, Wilhelm CM, Neish SR, Klitzner TS, Beekman RH, Kugler JD, Martin GR, Lannon C, Jenkins KJ, Rosenthal GL. Predictors of prolonged length of intensive care unit stay after Stage I palliation: A report from the National Pediatric Cardiology Quality Improvement Collaborative. Pediatric Cardiol. 2014;25(3):431-440.
Burns C. Blaxall, PhD, FAHA Director of Translational Science, Heart Institute
is interested in understanding the molecular mechanisms associated with the development and progression of heart failure. We are particularly interested in developing novel heart failure therapeutics targeting myocardial function and fibrosis. To this end, we also seek to understand the pathologic role of cardiac myocyte and non-myocyte (i.e.. fibroblast) intercellular communication.
Director of Translational Science, Heart Institute
Molecular and signaling mechanisms of heart failure; cardiac fibrosis; drug and therapeutic discovery
Visit the Blaxall lab.
Dr. Burns C. Blaxall has focused his entire career on understanding the molecular mechanisms of heart failure. He received his PhD in pharmacology from the University of Colorado Health Sciences Center, and postdoctoral training at Duke University Medical Center. He then rose through the faculty ranks at the University of Rochester Medical Center and the Aab Cardiovascular Research Institute, where he also directed the Howard Hughes Medical Institute Med-into-Grad Fellowship in Cardiovascular Science.
In 2012, he was recruited to the Heart Institute of Cincinnati Children’s Hospital Medical Center, where he is director of Translational Science. Dr. Blaxall has received many academic honors, including the Early Career Investigator Award from the American Heart Association (AHA), the Outstanding Achievement Award from the Founder’s AHA Affiliate, the Merit Award for Research Achievement from Mended Hearts, and election as fellow of the AHA.
PhD: University of Colorado HSC, Denver, CO, 1999.
Fellowship: Duke University Medical Center, Durham, NC.
Martin ML, Blaxall BC. Cardiac intercellular communication: are myocytes and fibroblasts fair-weather friends? J Cardiovasc Transl Res. 2012.
Jaffré F, Friedman AE, Hu Z-Y, Mackman N and Blaxall BC. Beta-adrenergic receptor stimulation transactivates Protease-Activated Receptor 1 via MMP-13 in heart. Circulation. 2012;125(24):2993-3003.
Kamal FA, Smrcka AV, Blaxall BC. Taking the heart failure battle inside the cell: Small molecule targeting of Gβγ subunits. J Mol Cell Cardiol. 2011;51(4):462-7.
Ram R, Mickelsen DM, Theodoropoulos C, Blaxall BC. New approaches in small animal echocardiography: imaging the sounds of silence. Amer J Pathol Heart Circ Physiol. 2011;301(5):H1765-80.
Belmonte S, Blaxall BC. G-protein coupled receptor kinases as therapeutic targets in cardiovascular disease. Circ Res. 2011;109(3):309-19.
Aguilar F, Casey LM, Belmonte S, Noujaim SF, Maekawa N, Dunaevsky O, Protak TL, Noujaim S, Jalife J, Berk BC, Gertler FB, Blaxall BC. Cardiac dysfunction in Mena knockout mice. Amer J Pathol Heart Circ Phys. 2011;300(5):H1841-52.
Casey LM, Pistner AR, Belmonte S, Jaffre F, Migdalovic D, Stolpnik O, Nwakanma F, Vorobiof G, Dunaevsky O, Smrcka AV, Blaxall BC. Small molecule targeting of G beta gamma prevents heart failure progression. Circ Res. 2010;107(4):532-9.
Jaffré F, Bonnin P, Callebert J, Debbabi H, Setola V, Doly S, Monassier L, Mettauer, Blaxall BC, Launay JM, Maroteaux L. Serotonin and angiotensin receptors in cardiac fibroblasts coregulate adrenergic-dependent cardiac hypertrophy. Circ Res. 2009;104;113-123.
Bullard TA, Protack TL, Aguilar F, Bagwe S, Massey HT, Blaxall BC. Identification of Nogo as a novel indicator of heart failure. Physiolog Genom. 2008;32(2):182-9.
R, Hampton CR, Casey LM, Bullard TA, Tencati M, Pedersen B, Andrade-Gordon P, Sayen MR, Gottlieb RA, Pohlman TH, Verrier ED, Blaxall BC, Mackman N. Par-1 in Cardiac Remodeling and Heart Failure. Circulation. 2007;116(20):2298-306.
Jonathan W. Byrnes, MD Attending Cardiac Intensivist, Cardiac Intensive Care Unit
is a cardiac intensivist who is active in clinical and translational research involving extracorporeal life support. This research is focused on the biocompatibility of the patient/device interface and the associated interaction of coagulation and inflammatory pathways. The aim of these endeavors is to decrease the incidence of end organ dysfunction and stroke associated with these therapies.
Attending Cardiac Intensivist, Cardiac Intensive Care Unit
Assistant Professor, UC Department of Pediatrics
Jonathan Byrnes, MD, is an assistant professor of pediatrics with the University of Cincinnati College of Medicine and an attending cardiac intensivist in Cincinnati Children’s Hospital Medical Center’s Cardiac Intensive Care Unit. He joined the faculty in July 2013.
A native of Mississippi, Dr. Byrnes graduated with honors from University of Mississippi and earned his medical degree from University of Mississippi Medical Center in 2005. He completed his pediatric residency at Blair Batson Children's Hospital in Jackson, MS and a combined fellowship in cardiology and critical care medicine at Arkansas Children's Hospital. Dr. Byrnes’s clinical interests are providing superb, cost-effective care and delivering cohesive management amongst all specialties in the cardiac intensive care unit.
Dr. Byrnes is active in clinical and translational research involving extracorporeal life support that would benefit critically ill children. This research is primarily focused on the biocompatibility of the patient / device interface and the associated interaction of the coagulation and inflammatory pathways. The aim of these endeavors is to ultimately decrease the incidence of end organ dysfunction and stroke associated with these therapies.
MD: University of Mississippi Medical Center, Jackson, MS, 2005.
Residency: Pediatrics, University of Mississippi Medical Center, Jackson, MS, 2008.
Fellowships: Combined Pediatric Cardiology and Pediatric Critical Care Medicine, Arkansas Children's Hospital, University of Arkansas Medical Sciences, Little Rock, AR, 2013.
Certification: American Board of Pediatrics, 2008.
Prodhan P, Imamura M, Garcia X, Byrnes J, Bhutta A, Dyamenahalli U. Abdominal Compartment Syndrome in Newborns and Children supported on Extracorporeal Membrane Oxygenation. ASAIO J. 2012;58(2): 143-147.
Byrnes J, Williams B, Prodhan P, Erdem E, Williamson R, Gautam N, James C, Jaquiss R, Imamura M, Bhutta A. Successful intra-arterial thrombolytic therapy for a right middle cerebral artery stroke in a 2-year old supported by a ventricular assist device. Transpl Int. 2012;25(3): e31-33.
Byrnes J, W McKamie, C Swearingen, Gossett J, Prodhan P, Bhutta A, Jaquiss R, Imamura M, Fiser R. Hemolysis during Cardiac Extracorporeal Membrane Oxygenation: A Case-Control Comparison of a Roller Pump and a Centrifugal Pump in a Pediatric Population. ASAIO J. 2011 Sep-Oct;57(5):456-61.
Byrnes J, Prodhan P, Imamura M, Frazier E. Accidental Azygos Vein Extracorporeal Membrane Oxygenation Cannulation in a Neonate with Premature Closure of the Ductus Arteriosus. ASAIO J. 2011 Jul-Aug; 57(4): 344-5.
James F. Cnota, MD
is a pediatric cardiologist with clinical focus in echocardiography and fetal cardiology. His research activities are in two areas: 1) fetal cardiology and perinatal risk factors in congenital heart disease and 2) multicenter clinical trials in pediatric cardiovascular disease.
Congenital heart disease; echocardiography; fetal cardiology
Dr. Cnota is an associate professor of pediatrics at the University of Cincinnati College of Medicine and Cincinnati Children's Hospital. His patient care activities focus on echocardiography and fetal cardiology. He is currently director of the Neonatal Cardiology service.
His clinical research focuses on two areas. He is the site principal investigator of the Prairieland Consortium within the NHLBI sponsored Pediatric Heart Network. He also studies growth and development in the fetus with congenital heart disease.
BS: Molecular and Cellular Biology, University of Arizona, Tucson, Arizona, 1991.
MD: Tulane University School of Medicine, New Orleans, Louisiana, 1995.
Residency: University of Arizona Health Sciences Center, Tucson, Arizona, 1998.
Fellowship: Cardiology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, 2001.
MS: Clinical Epidemiology and Health Services Research, Wake Forest University School of Medicine, Winston-Salem, North Carolina, 2005.
Votava-Smith JK, Habli M, Cnota JF, Divanovic A, Polzin W, Lim FY, Michelfelder EC. Diastolic Dysfunction and Cerebrovascular Redistribution Precede Overt Recipient Twin Cardiomyopathy in Early-Stage Twin-Twin Transfusion Syndrome. J Am Soc Echocardiogr. 2015 Jan 7.
Frommelt PC, Gerstenberger E, Cnota JF, Cohen MS, Gorentz J, Hill KD, John JB, Levine JC, Lu J, Mahle WT, McCandless RT, Mertens L, Pearson GD, Spencer C, Thacker D, Williams IA, Wong PC, Newburger JW, Pediatric Heart Network Investigators. Impact of initial shunt type on cardiac size and function in children with single right ventricle anomalies before the Fontan procedure: the single ventricle reconstruction extension trial. J Am Coll Cardiol. 2014 Nov 11;64(19):2026-35.
Weaver KN, Wang D, Cnota J, Gardner N, Stabley D, Sol-Church K, Gripp KW, Witte DP, Bove KE, Hopkin RJ. Early-lethal Costello syndrome due to rare HRAS Tandem Base substitution (c.35_36GC>AA; p.G12E)-associated pulmonary vascular disease. Pediatr Dev Pathol. 2014 Nov-Dec;17(6):421-30.
Czosek RJ, Cnota JF, Knilans TK, Pratt J, Guerrier K, Anderson JB. Relationship between echocardiographic LV mass and ECG based left ventricular voltages in an adolescent population: related or random? Pacing Clin Electrophysiol. 2014 Sep;37(9):1133-40.
Butts RJ, Zak V, Hsu D, Cnota J, Colan SD, Hehir D, Kantor P, Levine JC, Margossian R, Richmond M, Szwast A, Williams D, Williams R, Atz AM. Factors associated with serum B-type natriuretic peptide in infants with single ventricles. Pediatr Cardiol. 2014 Jun;35(5):879-87.
Villa CR, Habli M, Votava-Smith JK, Cnota JF, Lim FY, Divanovic AA, Wang Y, Michelfelder EC. Assessment of fetal cardiomyopathy in early-stage twin-twin transfusion syndrome: comparison between commonly reported cardiovascular assessment scores. Ultrasound Obstet Gynecol. 2014 Jun;43(6):646-51.
Sekar P, Heydarian HC, Cnota JF, Hornberger LK, Michelfelder EC. Diagnosis of congenital heart disease in an era of universal prenatal ultrasound screening in southwest Ohio. Cardiol Young. 2015 Jan;25(1):35-41.
Marx GR, Shirali G, Levine JC, Guey LT, Cnota JF, Baffa JM, Border WL, Colan S, Ensing G, Friedberg MK, Goldberg DJ, Idriss SF, John JB, Lai WW, Lu M, Menon SC, Ohye RG, Saudek D, Wong PC, Pearson GD, Pediatric Heart Network Investigators. Multicenter study comparing shunt type in the norwood procedure for single-ventricle lesions: three-dimensional echocardiographic analysis. Circ Cardiovasc Imaging. 2013 Nov;6(6):934-42.
Michelfelder E, Tan X, Cnota J, Divanovic A, Statile C, Lim FY, Crombleholme T. Prevalence, Spectrum, and Outcome of Right Ventricular Outflow Tract Abnormalities in Twin-twin Transfusion Syndrome: A Large, Single-center Experience. Congenit Heart Dis. 2014 Aug 25.
Cnota JF, Hangge PT, Wang Y, Woo JG, Hinton AC, Divanovic AA, Michelfelder EC, Hinton RB. Somatic growth trajectory in the fetus with hypoplastic left heart syndrome. Pediatr Res. 2013 Sep;74(3):284-9.
David S. Cooper, MD, MPH Chief Safety Officer, Heart Institute
has several research interests including acute/chronic kidney injury in patients with heart disease, anticoagulation on extracorporeal support and tracking/improving outcomes in cardiac intensive care.
Chief Safety Officer, Heart Institute
Associate Medical Director, Cardiovascular Intensive Care Unit
Co-Director, Center for Acute Care Nephrology
Medical Director, Cardiac Extracorporeal Life Support Program
Pediatric cardiac critical care; patient safety; extracorporeal life support
Dr. Cooper is board certified in Pediatrics, Pediatric Cardiology and Pediatric Critical Care. He is currently the Heart Institute Safety Officer, Co-Director of the Center for Acute Care Nephrology, Director of the Cardiac ECMO Program and Associate Medical Director of the CICU at Cincinnati Children’s Hospital Medical Center.
Dr. Cooper's career over the past 10 years has focused on the care of critically ill neonates, infants, children, adolescents and adults with complex congenital heart disease (CHD). He has a particular interest in how care in the intensive care unit can impact morbidity with a specific interest in hematologic, infectious and renal morbidities. Additionally, Dr. Cooper has had extensive involvement with the Pediatric Cardiac Critical Care Consortium (PC4), including the development of the PC4 CICU database that will be used to track outcomes and improve outcomes for patients with critical cardiac disease.
MD: University of South Florida College of Medicine, Tampa, Florida, 1996.
MPH: University of South Florida College of Public Health, Tampa, Florida, 1999.
Residency: All Children’s Hospital, University of South Florida, St. Petersburg, FL.
Fellowships: Cardiology, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH; Critical Care, Children’s Medical Center Dallas, UT Southwestern, Dallas, Texas.
Certifications: American Board of Pediatrics; American Board of Pediatrics, Sub-board of Pediatric Cardiology; American Board of Pediatrics, Sub-board of Pediatric Critical Care.
DeSena HC, Nelson DP, Cooper DS. Cardiac Intensive Care for the Neonate and Child After Cardiac Surgery. Current Opinion in Cardiology. 2015 Jan;30(1):81-8.
Kwiatkowski DM, Menon S, Krawczeski CD, Goldstein SL, Morales DL, Philips A, Manning PB, Eghtesady P, Wang Y, Nelson DP, Cooper DS. Improved Outcomes with Peritoneal Dialysis Catheter Placement after Cardiopulmonary Bypass in Infants. Journal of Thoracic and Cardiovascular Surgery. 2015 Jan;149(1):230-6.
Gaies M, Cooper DS, Tabbutt S, Schwartz SM, Ghanayem N, Chanani NK, Costello JM, Thiagarajan RR, Laussen PC, Shekerdemian LS, Donohue JE, Willis GM, Gaynor JW, Jacobs JP, Ohye RG, Charpie JR, Pasquali SK, Scheurer MA. Collaborative quality improvement in the cardiac intensive care unit: development of the Paediatric Cardiac Critical Care Consortium (PC4). Cardiol Young. 2014 Aug;28:1-7.
Jolley M, Thiagarajan R, Salvin J, Barrett C, Cooper DS, Teele S. ECMO in Patients with Superior Cavopulmonary Anastomosis (Glenn). Journal of Thoracic and Cardiovascular Surgery. 2014;148(4):1512-8.
Costello JM, Pasquali SK, He X, Jacobs JP, Hill KD, Cooper DS, Baker CL, Jacobs ML. Gestational Age at Birth and Outcomes after Neonatal Cardiac Surgery: An Analysis of the Society of Thoracic Surgeons (STS) Congenital Heart Surgery Database. Circulation. 2014;129:2511-2517.
Tabbutt S, Ghanayem N, Ravishankar C, Sleeper LA, Cooper DS, Frank DU, Lu M, Pizarro C, Frommelt P, Goldberg CS, Graham EM, Krawczeski CD, Lai WW, Lewis A, Kirsh JA, Mahony L, Ohye RG, Simsic J, Lodge AJ, Spurrier E, Stylianou M, Laussen P, Pediatric Heart Network Investigators. Risk factors for hospital morbidity and mortality after the Norwood procedure: A report from the Pediatric Heart Network Single Ventricle Reconstruction trial. J Thorac Cardiovasc Surg. 2012 Oct;144(4):882-95.
Ghanayem NS, Allen KR, Tabbutt S, Atz AM, Clabby ML, Cooper DS, Eghtesady P, Frommelt PC, Gruber PJ, Hill KD, Kaltman JR, Laussen PC, Lewis AB, Lurito KJ, Minich LL, Ohye RG, Schonbeck JV, Schwartz SM, Singh RK, Goldberg CS, Pediatric Heart Network Investigators. Interstage mortality after the Norwood procedure: Results of the multicenter Single Ventricle Reconstruction trial. J Thorac Cardiovasc Surg. 2012 Oct;144(4):896-906.
Cooper DS, Charpie JR, Flores FX, Gaynor JW, Salvin JW, Devarajan P, Krawczeski CD. Acute kidney injury and critical cardiac disease. World J Ped Congen Heart Surg. 2011;2:411-423.
Jacobs JP, Asante-Korang A, O'Brien SM, Chai PJ, Dadlani GH, Rodriguez-Fazzi GL, Vu D, McCormack J, McKenna DE, Boucek RJ Jr, Cooper DS, Saltiel A, Carapellucci J, van Gelder HM, Daicoff GR, Quintessenza JA. Lessons learned from 119 consecutive cardiac transplants for pediatric and congenital heart disease. Ann Thorac Surg. 2011 Apr;91(4):1248-54.
Pilchard J, Dadlani G, Andropoulos D, Jacobs JP and Cooper DS. Intensive care and perioperative management of patients with complete atrioventricular septal defect. World J Ped Congen Heart Surg. 2010 Apr;1:105-111.
Evaluation of the Pharmacokinetics of ATIII in Neonates and Infants Undergoing CPB and ECMO Support. Principal Investigator. Grifols. 2014-present.
A Randomized, Placebo Controlled, Multi-Center Study of the Efficacy, Pharmacokinetics (PK) and Pharmacodynamics (PD) of Intravenous (IV) Acetaminophen for the Treatment of Acute Pain in Pediatric Patients. Site Principal Investigator. Cadence. 2014-present.
Use of acute kidney injury biomarkers to predict impaired milrinone pharmacokinetics in children. Mentor. Thrasher grant. 2013-present.
Extracorporeal Life Support Organization (ELSO) Research Grant. Principal Investigator. Extracorporeal Life Support Organization. 2012-present.
Allison A. Divanovic, MD Co-Director, Medical Student/Resident Education, Heart Institute
is interested in improving the pre- and postnatal outcomes of infants with congenital heart disease. Her research has evaluated factors that increase risk of intrauterine fetal demise in fetuses with congenital heart disease. She has also conducted research to improve prenatal diagnosis of coarctation and HLHS with restrictive atrial septum. Analyzing cost effectiveness of murmur evaluations in kids is also an ongoing interest.
Co-Director, Medical Student/Resident Education, Heart Institute
Pediatric cardiology; fetal and neonatal cardiology; echocardiography
Allison A. Divanovic, MD, is an assistant professor of pediatrics with the University of Cincinnati College of Medicine and is currently the co-director of Medical Student and Resident Education in the Heart Institute.
A native of Cincinnati, Dr. Divanovic has completed all of her medical training locally, starting with medical school at the University of Cincinnati. She completed both her pediatric residency and cardiology fellowship at Cincinnati Children’s Hospital Medical Center. In addition to her three year cardiology fellowship, she completed a fourth year of training in order to gain further expertise in fetal echocardiography, transthoracic and transesophageal echocardiography, and neonatal cardiology.
Dr. Divanovic has been an attending staff member in the Heart Institute at Cincinnati Children’s Hospital Medical Center since 2009. Her academic interests include identifying factors that affect outcome in the setting of fetal congenital heart disease, improving the diagnosis of coarctation and hypoplastic left heart syndrome with restrictive atrial septum prior to birth and the cost effectiveness of referrals for murmur evaluations in children. In addition, Dr. Divanovic worked with the Ohio State Legislature to help pass into law the bill which led to the requirement for pulse oximetry screening in all Ohio newborns.
Dr. Divanovic has been active in the pediatric and cardiology communities as a member of the American Heart Association, American Society of Echocardiography and the American Academy of Pediatrics.
MD: Univeristy of Cincinnati, Cincinnati, OH.
Residency: Cincinnati Children's Hospital Medical Center, Cincinnati, OH.
Fellowship: Pediatric Cardiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH.
Michelfelder E, Tan X, Cnota J, Divanovic A, Statile C, Lim FY, Crombleholme T. Prevalence, Spectrum and Outcome of Right Ventricular Outflow Tract Abnormalities in Twin-Twin Transfusion Syndrome: A Large, Single-Center Experience. Congenit Heart Dis. 2014 Aug 25.
Villa CR, Habli M, Votava-Smith JK, Cnota JF, Lim FY, Divanovic AA, Wang Y, Michelfelder EC. Assessment of Fetal Cardiomyopathy in Early Stage Twin-Twin Transfusion Syndrome: Comparison between Commonly Reported Cardiovascular Assessment Scores. Ultrasound Obstet Gynecol. 2014 Jun;43(6):646:51.
Cnota JF, Hangge PT, Wang Y, Woo JG, Hinton AC, Divanovic AA, Michelfelder EC, Hinton RB. Somatic Growth Trajectory in the Fetus with Hypoplastic Left Heart Syndrome. Pediatr Res. 2013 Sep;74(3):284-9.
Hangge P, Cnota JF, Woo JG, Hinton AC, Divanovic AA, Manning PB, Ittenbach RF, Hinton RB. Microcephaly is Associated with Early Adverse Neurologic Outcomes in Hypoplastic Left Heart Syndrome. Pediatr Res. 2013 Jul;74(1):61-7.
Statile CJ, Cnota JF, Gomien S, Divanović A, Crombleholme T,
Michelfelder E. The Relationship between Estimated Cardiac Output and
Cardiovascular Profile Score in High Output Lesions in the Fetus.
Ultrasound Obstet Gynecol. 2013 Jan:41(1):54-8.
Divanović A, Witte D, Michelfelder E. A Fetus with Hypoplastic Left Heart Syndrome and Tricuspid Stenosis with Evolving Hydrops Fetalis. Pediatr Cardiol. 2012 Oct;33(7):1210-12.
Sheridan RM, Michelfelder EC, Choe KA, Divanovic A, Ware S, Liu C, Stanek JW. Ductus Arteriosus Aneurysm with Massive Thrombosis of Pulmonary Artery. Pediatr Dev Pathol. 2012 Jan-Feb;15(1):79-85.
Divanović A, Cnota J, Ittenbach R, Tan X, Border W, Crombleholme T, Michelfelder E. Characterization of Diastolic Dysfunction in Twin-Twin Transfusion Syndrome: Association between Doppler Findings and Ventricular Hypertrophy. J Am Soc Echocardiogr. 2011 Aug;24(8):834-40.
Divanović A, Hor K, Cnota J, Hirsch R, Kinsel-Ziter M, Michelfelder E. Prediction and Perinatal Management of Severely Restrictive Atrial Septum in Fetuses with Critical Left Heart Obstruction: Clinical Experience Using Pulmonary Venous Doppler Analysis. J Thorac Cardiovasc Surg. 2011 Apr;141(4):988-94.
Stuart L. Goldstein, MD, FAAP, FNKF Director, Center for Acute Care Nephrology
focuses on all aspects of acute kidney injury (AKI) spanning from translational work in AKI biomarker validation to long-term AKI epidemiology and outcomes. He is specifically interested in improving outcomes in the critically ill child with or at risk for AKI.
Director, Center for Acute Care Nephrology
Medical Director, Pheresis Service
Co-Medical Director, Heart Institute Research Core
Medical Director, Dialysis Unit
Acute kidney injury; continuous renal replacement therapy; cardio-renal syndrome; nephrotoxic medication associated morbidity
Stuart L. Goldstein, MD, has been an active investigator in the field of pediatric acute kidney injury (AKI) since 2000. Dr. Goldstein’s main research foci include: AKI epidemiology and outcomes, acute renal replacement therapy provision and investigation of novel urinary AKI biomarkers in the pediatric population. Dr. Goldstein has established a strong record of interdisciplinary and inter-institutional collaboration with cardiologists, intensivists and emergency center physicians, which is evidenced by his establishment and directing of the Prospective Pediatric Continuous Renal Replacement Therapy Registry from 2001 to 2012, and the Prospective Pediatric AKI Research Group (ppAKI-RG) in 2012. The ppAKI-RG is comprised of 39 centers from around the world with the goal of improving outcomes for the child with or at-risk for, AKI.
Dr. Goldstein has led initial efforts to develop a standardized definition for pediatric AKI, assess novel AKI biomarkers in heterogeneous populations, and conceiving and validating stratification tools to identify patients at risk for AKI. Building up these findings, Dr. Goldstein embarked on establishing the ppAKI-RG consortium to focus on multi-centered research studies that are dedicated to understanding and treating AKI in pediatric patients. Currently, the ppAKI-RG has initiated three major, and unprecedented, national and international studies (AWARE, NINJA and DIRECT) to reduce AKI and improve patient outcomes. Dr. Goldstein is also a recognized educator; he has developed the only pediatric specific acute care nephrology sub-specialty fellowship with graduates who are now leaders in the field of pediatric AKI.
MD: Columbia College of Physicians and Surgeons, New York, NY, 1990.
Residency: Baylor College of Medicine, Houston, TX.
Fellowship: Pediatric Nephrology, Children's Hospital, Boston, MA.
Inflammation, malnutrition and cardiac calcification in pediatric ESRD patients receiving dialysis. Principal Investigator. Casey Lee Ball Foundation. Jan 2010–Dec 2020.
Use of NGAL to Optimize Fluid Dosing, CRRT Initiation and Discontinuation in Critically Ill Children with Acute Kidney Injury. Principal Investigator. Gambro Renal Products. Nov 2011-Jan 2017.
Clinical Evaluation of the Prismaflex™ HF20 Set and Prismaflex™Control Unit Version 5.10 Software for Acute Continuous Renal Replacement Therapy (CRRT) in Children. Principal Investigator. Gambro Renal Products, Inc. Mar 2014–Mar 2016.
An Observational, Genomic Study of Patients with Drug Induced Kidney Injury. Principal Investigator. International SAE Consortium, LTD. May 2013-Dec 2015.
Pharmacokinetics of Understudied Drugs Administered to Children per Standard of Care. Principal Investigator. NICHD Pediatric Trials Network-POPS. Feb 2013–Feb 2017.
Antibiotic Safety in Infants with Complicated Intra-Abdominal Infections (SCAMP Trial). Principal Investigator. NICHD-2013-ABS01 Pediatric Trials Network. May 2014–Sep 2017.
Recombinant Erythropoietin Protects Against Kidney Disease. Principal Investigator. National Institutes of Health. Sep 2014–Aug 2019.
Reduction of Nephrotoxic Medication Associated Acute Kidney Injury in Children: Dissemination of a Successful Quality Improvement Project. Principal Investigator. Agency for Healthcare Research and Quality. Apr 2015–Mar 2018.
Bryan H. Goldstein, MD Attending Cardiologist, Cardiac Catherization Laboratory
is an interventional pediatric cardiologist with a clinical focus on minimally invasive and hybrid transcatheter therapies for complex congenital and structural heart disease. His research interests include novel transcatheter interventions (including fetal therapy), long-term outcomes following interventions for congenital heart disease, long-term functional outcomes following Fontan palliation for single ventricle physiology, and investigations of vascular function in repaired or palliated CHD patients.
Attending Cardiologist, Cardiac Catherization Laboratory
Bryan H. Goldstein, MD, joined the Heart Institute in 2011 in the section of Cardiac Catheterization and Intervention. A native of Boston, Mass., Dr. Goldstein graduated with honors from Amherst College, where he was a goalie on the men's lacrosse team. He earned his medical degree with honors from Boston University School of Medicine. He completed his pediatric residency at Children's Hospital Boston (BCRP) and his pediatric and interventional cardiology fellowships at the University of Michigan (C.S. Mott Children's Hospital) in Ann Arbor.
Dr. Goldstein’s clinical expertise is in congenital cardiac catheterization. He is interested in invasive physiologic assessment of complex congenital heart disease (CHD), including single ventricle physiology, as well as minimally invasive transcatheter therapies. Dr. Goldstein has particular clinical interests in transcatheter valve therapy and innovative hybrid therapies
Dr. Goldstein’s research interests include novel transcatheter interventions and long-term outcomes following interventions for CHD. An additional research focus includes long-term functional outcomes in Fontan survivors, including investigations of vascular function and ventricular diastolic function in the Fontan population. Dr. Goldstein receives grant funding from the American Heart Association and NHLBI. He is a co-investigator for the Nit-Occlud® PDA Post-Approval Study and previously served as a co-investigator for the Melody™ Transcatheter Pulmonary Valve Post-Approval Study.
Dr. Goldstein is a fellow of the American College of Cardiology (FACC), the Society of Cardiovascular Angiography and Interventions (FSCAI), and the American Academy of Pediatrics (FAAP) and an active member of the American Heart Association (AHA). He received the Pediatric Interventional Cardiology Symposium Young Leadership Award in 2013 and was recently honored with election to the Emerging Leader Mentorship program 2015-2017 through SCAI, ACC and CRF.
MD: Boston University School of Medicine, Boston, MA, 2004.
Residency: Pediatrics, Children’s Hospital Boston, Boston, MA, 2007.
Fellowship: Pediatric Cardiology, C.S. Mott Children’s Hospital, Ann Arbor, MI, 2010.
Advanced Fellowship: Interventional Cardiology, C.S. Mott Children’s Hospital, Ann Arbor, MI, 2011.
Certifications: Pediatrics, 2007; Pediatric Cardiology, 2010.
Lin H, Desai S, Nicolas R, Guavreau K, Foerster S, Sharma A, Armsby L, Odegard K DiNardo J, Vincent J, El-Said H, Goldstein BH, Holzer R, Balzer D, Bergersen L. Sedation and Anesthesia Related Adverse Events in Pediatric and Congenital Cardiac Catheterization. Pediatr Cardiol. 2015.
Seckeler M, Hirsch R, Beekman RH III, Goldstein BH. A New Predictive Equation for Oxygen Consumption in Children and Adults with Congenital and Acquired Heart Disease. Heart. 2015 Apr 1;101(7)517-24.
Karani KB, Zafar F, Morales DLS, Goldstein BH. Hybrid Stage I Palliation in a 1.1 Kilogram 28 Week Preterm Neonate with Posterior Malalignment Ventricular Septal Defect, Left Ventricular Outflow Tract Obstruction and Coarctation of the Aorta. World J Pediatr Congenit Heart Surg. 2014 Oct;5(4):603-7.
Zampi JD, Hirsch-Romano JC, Goldstein BH, Shaya JA, Armstrong AK. Hybrid Approach for Pulmonary Atresia with Intact Ventricular Septum: Early Single Center Results and Comparison to the Standard Surgical Approach. Catheter Cardiovasc Inter. 2014 Apr 1;83(5):753-61.
Zampi JD, Hirsch JC, Goldstein BH, Armstrong AK. Use of a Pressure Guidewire to Assess Pulmonary Artery Band Adequacy in the Hybrid Stage I Procedure for High Risk Neonates with Hypoplastic Left Heart Syndrome and Variants. Congenit Heart Dis. 2013 Mar-Apr;8(2):149-58.
Goldstein BH, Hirsch R, Zussman M, Vincent JA, Torres A, Coulson J, Ringel RE, Beekman RH III. Percutaneous Balloon-Expandable Covered Stent Implantation for Treatment of Traumatic Aortic Injury in Children and Adolescents. Am J Cardiol. 2012 Nov 15;110(10):1541-5.
Goldstein BH, Golbus JR, Sandelin AM, Warnke N, Gooding L, King KK, Donohue JE, Yu S, Gurney JG, Goldberg CS, Rocchini AP, Charpie JR. Impact of Vitamin C on Endothelial Function and Exercise Capacity in Patients with a Fontan Circulation. Congenit Heart Dis. 2011.
Goldstein BH, Fifer CG, Armstrong AK, Gelehrter SK, Treadwell MC, van de Ven C, Rocchini AP. Use of a Pressure Guidewire in Fetal Cardiac Intervention for Critical Aortic Stenosis. Pediatrics. 2011 Aug 15.
Goldstein BH, Golbus JR, Sandelin AM, Warnke N, Gooding L, King KK, Donohue JE, Gurney JG, Goldberg CS, Rocchini AP, Charpie JR. Usefulness of Peripheral Vascular Function to Predict Functional Health Status in Patients with a Fontan Circulation. Am J Cardiol. 2011 Aug 1;108(3):428-34.
Goldstein BH, Connor C, Gooding L, Rocchini AP. Relation of Systemic Venous Return, Diastolic Dysfunction and Pulmonary Vascular Resistance to Exercise Capacity in Patients with Single Ventricle Receiving Fontan Palliation. Am J Cardiol. 2010 Apr 15;105(8):1169-75.
Utilizing Vascular Function to Predict Functional Outcomes in Fontan Survivors. Principal Investigator. American Heart Association. Jan 2014-Dec 2015.
PFM NitOcclud Post Approval Study. Co-Investigator. PFM Medical. Jun 2015-Jun 2017.
A Phase I/II Dose Escalation Trial of Udenafil in Adolescents with Single Ventricle Physiology after Fontan Palliation. Co-Investigator. National Heart, Lung, and Blood Institute. Jul 2014-Jul 2015.
Off-label Use of the Melody Valve in the “Native” Right Ventricular Outflow Tract. Co-Investigator. National Heart, Lung, and Blood Institute. Jul 2014-Dec 2015.
John Lynn Jefferies, MD, MPH, FAAP, FACC Director, Advanced Heart Failure and Cardiomyopathy
is a clinical cardiologist who has translational and clinical research programs. His research involves cardiomyopathy and cardiovascular genetics with specific interest in dystrophinopathies and aortopathies in children and adults. He also has clinical research projects investigating novel biomarkers of heart failure, chemotherapy induced cardiotoxicity, and the cardiorenal syndrome.
Director, Advanced Heart Failure and Cardiomyopathy
Dr. Jefferies, an associate professor of pediatric cardiology and adult cardiovascular diseases within the University of Cincinnati College of Medicine, is the director of Advanced Heart Failure / Cardiomyopathy in the Heart Institute at Cincinnati Children's Hospital Medical Center.
He completed his combined pediatric and adult cardiology training at the Baylor College of Medicine in Houston, Texas at the Texas Children's Hospital and the Texas Heart Institute. He has authored or co-authored over 120 peer-reviewed manuscripts and book chapters on cardiomyopathy, cardiovascular genetics, and adults with congenital heart disease.
His current research interests include heritable causes of cardiovascular disease, novel drug therapies for advanced heart failure, novel gene discovery in cardiomyopathy, characterization and management of left ventricular noncompaction (LVNC), and early diagnosis and management of chemotherapy induced cardiotoxicity.
He is on the editorial board of the Texas Heart Institute Journal and is an active member of numerous professional organizations, including the Heart Failure Society of America, the American College of Cardiology and the American Heart Association. He is the lead editor for two textbooks that focus on the management of heart disease in children and young adults entitled “Heart Failure in the Child and Young Adult: From Bench to Bedside” and “Cardioskeletal Myopathies in Children and Young Adults.”
BS: University of Tennessee, Knoxville, TN, 1992.
MD: University of Tennessee, Knoxville, TN, 1996.
Residency: University of Kentucky, Lexington, KY, 2000.
MPH: University of Kentucky, Lexington, KY, 2001.
Fellowship: Baylor College of Medicine, Houston, TX, 2006.
Certification: Pediatrics, Internal Medicine, Cardiology, Advanced Heart Failure, Cardiac Transplant.
Towbin JA, Lorts A, Jefferies JL. Left ventricular noncompaction cardiomyopathy. Lancet. 2015;Apr 9. Epub ahead of print.
McCullough PA, Jefferies JL. Novel Markers And Therapies For Patients With Acute Heart Failure And Renal Dysfunction. Am J Med. 2015 Mar;128(3):312.e1-22.
Villa CR, Ryan TD, Collins JJ, Taylor MD, Lucky AW, Jefferies JL. Left ventricular non-compaction cardiomyopathy associated with epidermolysis bullosa simplex with muscular dystrophy and PLEC1 mutation. Neuromuscul Disord. 2015 Feb;25(2):165-8.
Raman SV, Hor KN, Halnon NJ, Kissel JT, He X, Tran T, Smart S, McCarthy B, Taylor MD, Jefferies JL, Rafael-Fortney JA, Lowe J, Roble SL, Cripe LH. Eplerenone for early cardiomyopathy in Duchenne muscular dystrophy: a randomised, double-blind, placebo-controlled trial. Lancet Neurol. 2015 Feb;14(2):153-61.
Jefferies JL. Barth syndrome. Am J Med Genet C Semin Med Genet. 2013 Aug;163C(3):198-205.
Breinholt JP, Moulik M, Dreyer WJ, Denfield SW, Kim JJ, Jefferies JL, Rossano JW, Gates CM, Clunie SK, Bowles KR, Kearney DL, Bowles NE, Towbin JA. Viral epidemiologic shift in inflammatory heart disease: the increasing involvement of parvovirus B19 in the myocardium of pediatric cardiac transplant patients. J Heart Lung Transplant. 2010 Jul;29(7):739-46.
Carlson P, Jefferies JL, Kearney D, Russell H. Refractory dilated cardiomyopathy associated with metastatic neuroblastoma. Pediatr Blood Cancer. 2010 Jun 29.
Shah AM, Jefferies JL, Rossano JW, Decker JA, Cannon BC, Kim JJ. Electrocardiographic abnormalities and arrhythmias are strongly associated with the development of cardiomyopathy in muscular dystrophy. Heart Rhythm. 2010 Jun 18.
Rossano JW, Morales DL, Zafar F, Denfield SW, Kim JJ, Jefferies JL, Dreyer WJ. Impact of antibodies against human leukocyte antigens on long-term outcome in pediatric heart transplant patients: An analysis of the United Network for Organ Sharing database. J Thorac Cardiovasc Surg. 2010 May 26.
Thomas R. Kimball, MD Medical Director, Heart Institute
is a clinical cardiologist who has clinical research interests in the impact of systemic diseases (including renal, pulmonary and hematologic) on cardiovascular structure and function. He has studied the impact of pediatric obesity on both cardiac and arterial anatomy and physiology and directs the Cardiovascular Imaging Core Research Laboratory which is active in using echocardiography to cardiac phenotype transgenic mice models.
Medical Director, Heart Institute
Congential heart disease; echocardiography; cardiac imaging
Thomas R. Kimball, MD, is a professor of pediatrics with the University of Cincinnati College of Medicine and is currently the medical director of the Heart Institute at Cincinnati Children's Hospital Medical Center.
A native of California, Dr. Kimball graduated with distinction and honors from Stanford University. He earned his medical degree from New York University, New York, NY. He completed his pediatric internship and residency at Children's Hospital of Los Angeles and his pediatric cardiology fellowship at Cincinnati Children's Hospital Medical Center.
Dr. Kimball has been an attending staff member of the Division of Cardiology at Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine since 1988.
Dr. Kimball's academic interests relate to echocardiography and he has made numerous scholarly contributions in the field of ventricular function utilizing echocardiography, particularly in the field of hypertension and obesity.
He has established collaborative relationships with basic scientists at the University of Cincinnati College of Medicine using echocardiography to evaluate phenotypes of transgenic mice, including embryonic mice.
Dr. Kimball has been active in the cardiology community. He is a member of the American Society of Echocardiography, American Heart Association, American Academy of Pediatrics, American College of Cardiology and an investigator in the NIH Pediatric Heart Network.
He was also a member of the first Family Advisory Council at Cincinnati Children's and received the 2006 Family Advisory Council Award of Excellence.
In 2010, he was made the medical director of the Heart Institute at Cincinnati Children's.
BS: Stanford University with Honors and Distinction, Stanford, CA, 1978.
MD: New York University School of Medicine, New York City, NY, 1982.
Residency: Children's Hospital of Los Angeles, Los Angeles, CA, 1985.
Fellowship: Children's Hospital Medical Center, Cincinnati, OH, 1988.
Certification: Pediatrics, 1986; Pediatric Cardiology, 1991 (recertification, 1997, 2004).
Shah AS, Gao Z, Urbina EM, Kimball TR, Dolan LM. The effects of arterial thickness and stiffness in obese youth. Journal of Clinical Endocrinology Metabolism. 2014 Mar;99(3):1037-43.
Alghamdi M, De Souza AM, White CT, Potts MT, Warady BA, Furth SL, Kimball TR, Potts JE, Sandor GG. Response to: echocardiography assessment of the aorta in children with chronic kidney disease. Pediatric Cardiology. 2014 Jan;35(1):183-4.
Uzark K, King E, Spicer R, Beekman R, Kimball T, Varni J. The clinical utility of health-related quality of life assessment in pediatric cardiology outpatient practice. Congenital Heart Disease. 2013 May;8(3):211-8.
Madueme PC, Khoury PR, Urbina EM, Kimball TR. Predictors of exaggerated exercise-induced systolic blood pressures in young patients after coarctation repair. Cardiology In The Young. 2013 Jun;23(3):416-22.
Alghamdi M, De Souza A, White CT, Potts MT, Warady BA, Furth SL, Kimball T, Potts JE, Sandor GG. Echo-Doppler assessment of the biophysical properties of the aorta in children with chronic kidney disease. Pediatric Cardiology. 2013 Jun;34(5):1218-25.
Urbina EM, Khoury PR, McCoy CE, Dolan LM, Daniels SR, Kimball TR. Triglyceride to HDL-C ratio and increased arterial stiffness in children, adolescents and young adults. Pediatrics. 2013 Apr;131(4):E1082-90.
Shah AS, Urbina EM, Khoury PR, Kimball TR, Dolan LM. Lipids and lipoprotein ratios: Contribution to carotid intima media thickness in adolescents and young adults with type 2 diabetes mellitus. Journal of Clinical Lipidology. 2013 Sept-Oct;7(5):441-445.
Kimball TR. Echocardiography in the Assessment of Cardiovascular Disease Risk. In: Eduardo M. da Cruz, Dunbar Ivy, James Jaggers, editors, Pediatric and Congenital Cardiology, Cardiac Surgery and Intensive Care. Springer-Verlag London 2013. ISBN:978-1-4471-4618-6.
Kimball TR, Michelfelder EC. Echocardiography: Basic Principles and Imaging. In: Allen HD, Driscoll DJ, Shaddy RE, Feltes TF, editors. Moss & Adams' Heart Disease in Infants, Children and Adolescents: Including the Fetus and Young Adult. 1. Philadelphia, PA: Lippincott Williams & Wilkins; 2012. p. 134-71.
Shah AS, Dolan LM, Gao Z, Kimball TR, Urbina EM. Racial differences in arterial stiffness among adolescents and young adults with type 2 diabetes. Pediatric Diabetes. 2012 Mar;13(2):170-5.
Shelley Kirk, PhD, RD, LD Director, HealthWorks!, Center for Better Health and Nutrition, Heart Institute
is a clinical dietitian specializing in the assessment and treatment of obese youth and their families. With her doctorate in epidemiology, her research interests are focused on evaluating the effectiveness and efficacy of the dietary component as part of a comprehensive pediatric weight management intervention offered in a clinical setting.
Director, HealthWorks!, Center for Better Health and Nutrition, Heart Institute
BS: Rutgers University, New Brunswick, NJ, 1976.
MS: University of Minnesota, St. Paul, MN, 1978; University of Southern California, Los Angeles, CA, 1988.
PhD: University of Cincinnati, Cincinnati, OH, 2003.
Hoelscher DM, Kirk S, Cunningham-Sabo L, Ritchie L. Position of the Academy of Nutrition and Dietetics: Interventions for the prevention and treatment of pediatric overweight and obesity. J Acad Nutri. 2013 Oct;113(10):1375-94.
Hampl S, Demeule M, Eneli I, Frank M, Hawkins MJ, Kirk S, Sallinen B, Santos M, Schmidt A, Ward W, Rhodes S. Parent perspectives on attrition from tertiary care pediatric weight management programs. Clin Pediatr (Phila). 2013; 52(6):509-515.
Kirk S, Brehm B, Saelens BE, Woo JG, Kissel E, D’Alessio D, Bolling C, Daniels SR. Role of carbohydrate modification in weight management among obese children: A randomized clinical trial. J Pediatr. 2012; 161(2): 320-327.
Beebe DW, Miller N, Kirk S, Daniels SR, Amin R. The association between obstructive sleep apnea and dietary choices among obese individuals during middle to late childhood. Sleep Medicine. 2011; 12(8):797-799.
Sung V, Beebe DW, Vandyke R, Fenchel MC, Crimmins NA, Kirk S, Amin R, Hiscock H, Wake M. Does sleep duration predict metabolic risk in obese adolescents attending tertiary services? A cross- sectional study. Sleep. 2011; 34(7):891-898.
Siegel RM, Neidhard MS, Kirk S. A comparison of low glycemic index and staged portion-controlled diets in improving BMI of obese children in a pediatric weight management program. Clinical Pediatrics. 2011; 50(5):459-461.
Kirk S, Bolling C. Practical Strategies in a Clinical Setting for Promoting Lifestyle Changes in Overweight Youth. Obesity Management. December 2007; 3(6):272-282.
Lawson ML, Kirk S, Mitchell T, Chen MK, Loux TJ, Daniels SR, Harmon CM, Clements RH. One-year outcomes of Roux-en-Y gastric bypass for morbidly obese adolescents: a multi-center study from the Pediatric Bariatric Study Group. Journal of Pediatric Surgery. 2006; 41(1):137-43.
Kirk S, Scott B, Daniels SR. Supplement to the Journal: Pediatric obesity epidemic: Treatment options. Journal of the American Dietetic Association. 2005; 105(5 Suppl 1):S44-51.
Kirk S, Zeller MH, Claytor R, Santangelo M, Khoury PR, Daniels SR. The relationship of health outcomes to improvement in body mass index in children and adolescents. Obes Res. 2005; 13:876-882.
Timothy K. Knilans, MD Director, Clinical Cardiac Electrophysiology and Pacing
is a clinical cardiac electrophysiologist with a large clinical practice in management of arrhythmia and syncope. He has extensive experience in non-invasive electrocardiographic methods and invasive therapeutic modalities including catheter and surgical ablation and implanted electrical device therapy. His research interests center on evaluation and treatment of syncope and prevention of sudden cardiac death.
Director, Clinical Cardiac Electrophysiology and Pacing
Cardiac electrophysiology and pacing; radio frequency ablation; tilt table testing
MD: University of Cincinnati, Cincinnati, OH, 1983.
Residency: Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 1983-1986.
Fellowship (Pediatric Cardiology): Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 1986-1989.
Fellowship (Cardiac Electrophysiology): St. Vincent Hospital, Indianapolis, IN, 1990-1991.
Fellowship (Pediatric cardiac Electrophysiology): Texas Children's Hospital, Houston, TX, 1991.
Certification: Pediatrics, 1989 (Recertified 1999); Pediatric Cardiology, 1992 (Recertified 1998).
Czosek RJ, Anderson JB, Marino BS, Mellion K, Knilans TK. Noninvasive risk stratification techniques in pediatric patients with ventricular preexcitation. Pacing Clin Electrophysiol. 2011 May;34(5):555-62.
Eghtesady P, Michelfelder EC, Knilans TK, Witte DP, Manning PB, Crombleholme TM. Fetal surgical management of congenital heart block in a hydropic fetus: Lessons learned from a clinical experience. J Thorac Cardiovasc Surg. 2011 Mar;141(3):835-7.
Czosek RJ, Anderson J, Marino BS, Connor C, Knilans TK. Linear lesion cryoablation for the treatment of atrioventricular nodal re-entry tachycardia in pediatrics and young adults. Pacing Clin Electrophysiol. 2010 Nov;33(11):1304-11.
Czosek RJ, Anderson JB, Cao J, Knilans TK. Assessment of T-wave oversensing in an infant with an implanted defibrillator. Heart Rhythm. 2010 Oct;7(10):1516-7.
Mays WA, Border WL, Knecht SK, Gerdes YM, Pfriem H, Claytor RP, Knilans TK, Hirsch R, Mone SM, Beekman RH 3rd. Exercise capacity improves after transcatheter closure of the Fontan fenestration in children. Congenit Heart Dis. 2008 Jul;3(4):254-61.
Knecht SK, Mays WA, Gerdes YM, Claytor RP, Knilans TK. Exercise evaluation of upper- versus lower-extremity blood pressure gradients in pediatric and young-adult participants. Pediatr Exerc Sci. 2007 Aug;19(3):344-8.
Wright KN, Knilans TK, Irvin HM. When, why, and how to perform cardiac radiofrequency catheter ablation. J Vet Cardiol. 2006 Nov;8(2):95-107.
Knilans TK. Multielectrode coronary artery catheterization: still an effective tool in ablation of right free-wall accessory pathways. J Cardiovasc Electrophysiol. 2004 Nov;15(11):1244-5.
Markham LW, Knecht SK, Daniels SR, Mays WA, Khoury PR, Knilans TK. Development of exercise-induced arm-leg blood pressure gradient and abnormal arterial compliance in patients with repaired coarctation of the aorta. Am J Cardiol. 2004 Nov 1;94(9):1200-2.
Beery TA, Dyment M, Shooner K, Knilans TK, Benson DW. A candidate locus approach identifies a long QT syndrome gene mutation. Biol Res Nurs. 2003 Oct;5(2):97-104.
Andreas W. Loepke, MD, PhD Staff Anesthesiologist, Division of Cardiac Anesthesia
Staff Anesthesiologist, Division of Cardiac Anesthesia
Professor, UC Department of Anesthesiology
UC Department of Pediatrics
Anesthesia for neonates; congenital heart surgery; single-ventricle physiology
Visit the Loepke Lab.
Andreas W. Loepke, MD, PhD, has been practicing pediatric cardiac anesthesiology since 2000, first at the Children's Hospital of Philadelphia, and since 2003 at Cincinnati Children's Hospital Medical Center.
Dr. Loepke’s research laboratory investigates the potential use of anesthetics for neurological protection during brain ischemia as well as their possible adverse effects on brain development. His research group discovered in animals that anesthetics differentially affect brain regions, dependent on the age during exposure. Related to these findings, his lab made the discovery that neurons are susceptible to the anesthetics’ toxic effects during a specifically vulnerable stage of their development.
MD: University of Dusseldorf, Germany, 1993.
PhD: University of Dusseldorf, Germany, 1995.
Internship: General Surgery, Pennsylvania Hospital, Philadelphia, PA, 1996.
Residency: Anesthesiology, Thomas Jefferson Medical College, Philadelphia, PA, 1999.
Fellowship: Pediatric Anesthesia and Pediatric Cardiac Anesthesia, Children's Hospital of Philadelphia, Philadelphia, PA, 2000.
Certification: Anesthesiology, 2000.
Maintenance of Certification: Anesthesiology, 2010.
Hofacer RD, Deng M, Ward CG, Joseph B, Hughes EA, Jiang C, Danzer SC, Loepke AW. Cell-age specific vulnerability of neurons to anesthetic toxicity. Ann Neurol. 2013.
Istaphanous GK, Ward CG, Nan X, Hughes EA, McCann JC, McAuliffe JJ, Danzer, SC, Loepke AW. Characterization and Quantification of Isoflurane-Induced Developmental Apoptotic Cell Death In Mouse Cerebral Cortex. Anes Analg. 2013; 116(4): 845-54.
Mintz CD, Wagner M, Loepke AW. Preclinical research into the effects of anesthetics on the developing brain: promises and pitfalls. J Neurosurg Anesthesiol. 2012; 24(4): 362-7.
Istaphanous GK, Howard J, Nan X, Hughes EA, McCann JC, McAuliffe JJ, Danzer SC, Loepke AW. Comparison of the Neuroapoptotic Properties of Equipotent Anesthetic Concentrations of Desflurane, Isoflurane, or Sevoflurane in Neonatal Mice. Anesthesiology. 2011; 114(3): 578-87.
Loepke AW. Developmental Neurotoxicity of Sedatives and Anesthetics – A Concern For Neonatal and Pediatric Critical Care Medicine? Pediatr Crit Care Med. 2010; 11(2): 217-226.
McAuliffe JJ, Loepke AW, Miles L, Joseph B, Hughes E, Vorhees CV. Desflurane, Isoflurane and Sevoflurane Provide Limited Neuroprotection Against Neonatal Hypoxia-Ischemia in a Delayed-Preconditioning Paradigm. Anesthesiology. 2009; 111(3): 533-46.
Loepke AW, Istaphanous GK, McAuliffe JJ, Miles L, Hughes EA, McCann JC, Harlow KE, Kurth CD, Williams MT, Vorhees CV, Danzer SC. The Effects of Neonatal Isoflurane Exposure in Mice on Brain Cell Viability, Adult Behavior, Learning, and Memory. Anesth Analg. 2009; 108(1): 90-104.
Loepke AW, Soriano SG. An Assessment of the Effects Of General Anesthetics on Developing Brain Structure and Neurocognitive Function. Anesth Analg. 2008; 106: 1681-1707.
Loepke AW, McCann JC, Kurth CD, McAuliffe JJ. Physiologic Effects of Isoflurane Anesthesia in Neonatal Mice. Anesth Analg. 2006; 102: 75-80.
Loepke AW, Priestley MA, Schultz SE, McCann JC, Kurth CD. Desflurane Improves Outcome After Low-Flow Cardiopulmonary Bypass in Newborn Pigs. Anesthesiology. 2002; 97: 1521-7.
Erik C. Michelfelder, MD Co-Director, Cardiac Imaging Services, Heart Institute
is a clinical cardiologist who has clinical research programs in fetal cardiology and echocardiography. Within the Fetal Heart Program, the fetal echocardiography lab studies anatomic and physiologic predictors of cardiac function, perinatal physiology, and clinical outcomes in fetuses with both structural and function cardiovascular abnormalities. General echocardiographic research conducted by Dr. Michelfelder also included echocardiographic assessment of cardiac systolic and diastolic function in infants, children, and young adults with a variety of structural and function cardiac abnormalities.
Co-Director, Cardiac Imaging Services, Heart Institute
Director, Fetal Heart Program, Heart Institute
Erik C. Michelfelder Sr., MD, is a professor of pediatrics with the University of Cincinnati College of Medicine. He is currently director of the Fetal Heart Program, and co-director of Cardiac Imaging Services for the Heart Institute at Cincinnati Children’s Hospital Medical Center.
Dr. Michelfelder graduated with a degree in biology from Bucknell University and earned his MD from the Penn State University College of Medicine. He completed his residency in pediatrics at St. Christopher’s Hospital for Children in Philadelphia, and his cardiology fellowship at C.S. Mott Children’s Hospital at the University of Michigan in Ann Arbor.
Dr. Michelfelder has been a member of the Division of Cardiology at Cincinnati Children’s Hospital Medical Center since 1998. His clinical and academic focus relate to fetal cardiology and echocardiography.
He is a member of the American Society of Echocardiography, The American Heart Association, The American College of Cardiology, The American Academy of Pediatrics, and the Society for Pediatric Research.
BS: Bucknell University, Lewisburg, PA, 1986.
MD: Penn State University College of Medicine, Hershey, PA, 1990.
Residency: St. Christopher's Hospital for Children, Temple University School of Medicine, Philadelphia, PA, 1990-1993.
Fellowship: C.S. Mott Children's Hospital, University of Michigan Medical Center, Ann Arbor, MI, 1993-1996.
Certification: Pediatrics, 1991; Pediatric Cardiology, 1998.
Ngamprasertwong P, Michelfelder EC, Arbabi S, Choi YS, Statile C, Ding L, Boat A, Eghtesady P, Holland K, Sadhasivam S. Anesthetic Techniques for Fetal Surgery: Effects of Maternal Anesthesia on Intraoperative Fetal Outcomes in Sheep Model. Anesthesiology. 2013 Apr;118(4):796-808.
Statile C, Cnota J, Gomien S, Divanovic A, Crombleholme T, Michelfelder EC. Estimated Cardiac Output and Cardiovascular Profile Score in Fetuses with High Cardiac Output Lesions. Ultrasound Obstet Gynecol. 2013 Jan;41(1):54-8.
Williams IA, Fifer C, Jaeggi E, Levine J, Michelfelder EC, Garfinkel R, Szwast AL. The Association of Fetal Cerebrovascular Resistance with Early Neurodevelopment in Single Ventricle Congenital Heart Disease. Am Heart J. 2013;165(4):544-50.
Habli M, Michelfelder EC, Cnota J, Wall D, Polzin W, Lewis D, Lim FY, Crombleholme TM. Prevalence and Progression of Recipient-twin Cardiomyopathy in Early-stage Twin-twin Transfusion Syndrome. Ultrasound Obstet Gynecol. 2012 Jan;39(1):63-8.
Divanovic A, Cnota JF, Ittenbach R, Tan X, Border WL, Crombleholme T, Michelfelder E. Characterization of Diastolic Dysfunction in Twin-Twin Transfusion Syndrome: Association between Doppler Findings and Ventricular Hypertrophy. J Am Soc Echocardiogr. 2011 Aug;24(8):834-40.
Divanovic A, Hor K, Cnota JF, Hirsch R, Kinsel-Ziter M, Michelfelder EC. Prediction and Perinatal Management of Severely Restrictive Atrial Septum in Fetuses With Critical Left Heart Obstruction: Clinical Experience Using Pulmonary Venous Doppler Analysis. J Thorac Cardiovasc Surg. 2011 Apr;141(4):988-94.
Kinsel-Ziter ML, Cnota JF, Crombleholme TM, Michelfelder EC. Twin-Reversed Arterial Perfusion Sequence: Pre- and Post- Operative Cardiovascular Findings in the Pump Twin. Ultrasound Obstet Gynecol. 2009 Nov;34(5):550-5.
Shah AD, Border WL, Crombleholme TM, Michelfelder EC. Initial Fetal Cardiovascular Profile Score Predicts Recipient Twin Outcome in Twin-Twin Transfusion Syndrome. J Am Soc Echocardiogr. 2008 Oct; 21(10):1105-8.
Michelfelder EC, Gottliebson WM, Border WL, Kinsel ML, Polzin WJ, Livingston JC, Khoury P, Crombleholme TM. Early Manifestations and Spectrum of Recipient Twin Cardiomyopathy in Twin-Twin Transfusion Syndrome: Relation to Quintero Stage. Ultrasound Obstet Gynecol. 2007 Dec;30(7):965-71.
Michelfelder EC, Gomez CA, Border W, Gottliebson W, Franklin C. Predictive Value of Fetal Pulmonary Venous Flow Patterns in Identifying the Need for Atrial Septoplasty in the Newborn With Hypoplastic Left Ventricle. Circulation. 2005 Nov 8;112(19):2974-79.
Robert M. Siegel, MD, FAAP Medical Director, Center for Better Health and Nutrition
is a general pediatrician whose clinical work is focused on pediatric weight management. His research interests are dietary interventions in overweight children, exercise in obese children and training community practitioners in obesity prevention and obesity treatment.
Medical Director, Center for Better Health and Nutrition
Pediatric obesity prevention and treatment
Robert M. Siegel is a professor of clinical pediatrics at the University of Cincinnati and medical director of the Center for Better Health and Nutrition of the Heart Institute. He graduated magna cum laude from Hunter College of the City University of New York and earned his MD from New York University. Dr. Siegel did his pediatric residency at Cincinnati Children’s Hospital Medical Center. He was a general pediatrician for more than twenty years before joining the Heart Institute and was president of the Medical Staff at Cincinnati Children’s from 2008 to 2010. Dr. Siegel’s research interests include dietary and physical activity interventions in obese children.
MD: New York University, School of Medicine, New York, NY, 1984.
Residency: Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 1984-87.
Fellowship: Infectious Diseases, Cincinnati Children’s Hospital Medical Center, 1992. American Board of Pediatrics, 1988.
Certification: Pediatrics, 1988.
Kirk S, Woo J, Jone M, Siegel R. Increased Frequency of Dietitian Visits is Associated with Improved BMI Outcomes in Obese Youth Participating in a Comprehensive Pediatric Weight Management Program. Childhood Obesity. 2015;11:202-207.
Murphy A, Kist C, Gier A, Edwards NM, Gao Z, Siegel RM. The Feasibility of High Intensity Interval Exercise in Obese Adolescents. Clin Ped. 2015;54:87-90.
Inge T, Siegel R, Xanthakos S. Weight loss maintenance: A hard nut to crack. JAMA Pediatr. 2014;168:796-7.
Siegel RM, Pitnar HE, Kist C, Woo JG, Gier A, Sewell M, Lattin B, Rooney A, Kirk S. Obese Children in a Community YMCA “Fun 2B Fit” Program have a reduction in BMI Z-scores. Clin Ped. 2014;53:694-696.
Siegel RM, Kist C, Ingram L, Kirk S. An after hours rapid access pediatric weight management clinic increases show rate. Clin Ped. 2014;53:490-492.
Garbutt JM, Mandrell KM, Allen M, Sterkel R, Epstein J, Stahl K, Kreusser K, Sitrin H, Ariza A, Cohen Reis E, Siegel R, Strunk RC. Pediatric providers experience with retail-based clinics. Journal of Pediatrics. 2013;163:1384-1388.e6.
Berger KA, Lynch J, Prows CA, Siegel RM, Myers MF. Mother’s perceptions of family health history and an online parent-generated family health history tool. Clin Ped. 2012;52:70-77.
Kanetzke EE, Lynch J, Prows CA, Siegel RM, Myers MF. Perceived Utility of Parent-Generated Family Health History as a Health Promotion Tool in Pediatric Practice. Clinical Pediatrics. 2011;50:720-8.
Siegel RM, Neidhard MS, Kirk S. A Comparison of Reduced Glycemic Load and Staged Portion-Controlled Diets in Improving BMI and Other Health Outcomes of Obese Children in a Pediatric Weight Management Program. Clinical Pediatrics. 2011;50:459-461.
Siegel RM, Rich W, Khoury J. An Office-Based Low Carbohydrate Intervention in Teens: One Year Follow-up of a Six-Month Intervention. Clinical Pediatrics. 2011;50:459-461.
James P. Spaeth, MD Director, Cardiac Anesthesia
is a pediatric cardiac anesthesiologist and the director of Cardiac Anesthesia. His clinical research interests include the effect of congenital cardiac disease and cardiac surgery on neurodevelopmental outcomes, and the use of cerebral monitoring during the perioperative period. He is also involved in quality improvement work focused on improving the safety of pediatric anesthesia.
Director, Cardiac Anesthesia
Staff Anesthesiologist, Department of Anesthesia
Associate Professor, UC Department of Anesthesiology
Cardiac anesthesia; neurologic injury in children with congenital heart disease; improving perioperative safety
MD: University of Virginia School of Medicine, Charlottesville, VA, 1993.
Internship: Internal Medicine, University of Virginia Medical Center, Charlottesville, VA, 1994.
Residency: Anesthesiology, University of California, San Diego Medical Center, San Diego, CA, 1997.
Fellowship: Pediatric Anesthesiology, Children's Hospital of Philadelphia, Philadelphia, PA, 1998.
Certification: Anesthesiology, 1998.
Gunter JB, McAuliffe JJ, Beckman EC, Wittkugel EP, Spaeth JP, Varughese AM. A factorial study of ondansetron, metoclopramide, and dexamethasone for emesis prophylaxis after adenotonsillectomy in children. Paediatr Anaesth. 2006 Nov;16(11):1153-65.
Dent CL, Spaeth JP, Jones BV, Schwartz SM, Glauser TA, Hallinan B, Pearl JM, Khoury PR, Kurth CD. Brain magnetic resonance imaging abnormalities after the Norwood procedure using regional cerebral perfusion. J Thorac Cardiovasc Surg. 2006 Jan;131(1):190-7.
Aronson LA, Spaeth JP. Frontiers in pediatric anesthesia: cardiac anesthesia. Int Anesthesiol Clin. 2006 Winter;44(1):33-49.
Dent CL, Spaeth JP, Jones BV, Schwartz SM, Glauser TA, Hallinan B, Pearl JM, Khoury PR, Kurth CD. Brain magnetic resonance imaging abnormalities after the Norwood procedure using regional cerebral perfusion. J Thorac Cardiovasc Surg. 2005 Dec;130(6):1523-30.
Loepke AW, Spaeth JP. Glucose and Heart Surgery: Neonates Are Not Just Small Adults. Anesthesiology. 2004 Jun;100(6):1345-52.
Baker RC, Schubert CJ, Kirwan KA, Lenkauskas SM, Spaeth JT. After-hours telephone triage and advice in private and nonprivate pediatric populations. Arch Pediatr Adolesc Med. 1999 Mar;153(3):292-6.
Michael D. Taylor, MD Director, Advanced Imaging Innovation
is a non-invasive cardiologist interested in applications of imaging to problems of congenital and acquired heart disease. His primary research interest is cardiac MRI and its application in evaluating myocardial function and disease. He has a translational program that uses multi-modality imaging to characterize mouse models of inherited and acquired cardiomyopathies.
Director, Advanced Imaging Innovation
Cardiac MRI; cardiac CT; and echocardiography
Michael Taylor, MD, joined the Heart Institute in July, 2010 as the director of Advanced Imaging Innovation. He was previously the director of cardiac magnetic resonance at Texas Children’s Hospital in Houston.
Dr. Taylor has expertise in cardiac magnetic resonance imaging, positron emission tomography and computed tomography. He has a dual appointment in the Cincinnati Children's Hospital Medical Center Imaging Research Center, an interdisciplinary facility of advanced imaging faculty with dedicated clinical and pre-clinical imaging equipment.
Dr. Taylor's primary interests include myocardial metabolism in heart failure, animal models of cardiac pathology, and cardiac magnetic resonance imaging of congenital and acquired heart disease.
MD: University of Wisconsin, Madison, WI, 2001.
PhD: Medical Physics, University of Wisconsin, Madison, WI, 2001.
Residency: Pediatrics, Baylor College of Medicine, Houston, TX, 2003.
Fellowship: Pediatric Cardiology, Baylor College of Medicine, Houston, TX, 2006.
Certification: Pediatrics, 2005.
Certification: Pediatric Cardiology, 2006.
Mazur W, Hor KN, Germann JT, Fleck RJ, Al-Khalidi HR, Wansapura JP, Chung ES, Taylor MD, Jefferies JL, Woodrow Benson D, Gottliebson WM. Patterns of left ventricular remodeling in patients with Duchenne Muscular Dystrophy: a cardiac MRI study of ventricular geometry, global function, and strain. Int J Cardiovasc Imaging. 2011 Jan 8.
Purevjav E, Varela J, Morgado M, Kearney DL, Li H, Taylor MD, Arimura T, Moncman CL, McKenna W, Murphy RT, Labeit S, Vatta M, Bowles NE, Kimura A, Boriek AM, Towbin JA. Nebulette mutations are associated with dilated cardiomyopathy and endocardial fibroelastosis. J Am Coll Cardiol. 2010 Oct 26;56(18):1493-502.
LP Browne, D Kearney, MD Taylor, T Chung, TC Slesnick, AC Nutting, R Krishnamurthy. ALCAPA: the role of myocardial viability studies in determining prognosis. Pediatr Radiol. 2010;40(2):163-167.
JL Jefferies, MD Taylor, J Rossano, JW Belmont, WJ Craigen. Novel cardiac findings in periventricular nodular heterotopia. Am J Med Genet. 2009; 152A(1): 165-8.
JW Rossano, MD Taylor, EO Smith, CD Fraser, ED McKenzie, JF Price, HA Dickerson, DP Nelson, AR Mott. Glycemic profile in infants who have undergone the arterial switch operation: hyperglycemia is not associated with adverse events. J Thorac Cardiovasc Surg. 2008; 135(4): 739-745.
Elaine M. Urbina, MD, MS Director, Preventive Cardiology
is a pediatric preventive cardiologist who is interested in how CV risk factors affect vascular function. Her lab uses a variety of non-invasive techniques to measure how vascular structure (carotid intima-media thickness), arterial stiffness (pulse wave velocity) and endothelial function (brachial flow mediated dilation) are affected by a variety of pediatric diseases.
Director, Preventive Cardiology
Elaine M. Urbina, MD, graduated from the Medical College of Georgia in 1988. She subsequently trained in pediatrics at the University of California at San Francisco. She completed her pediatric cardiology fellowship at Tulane University in New Orleans, Louisiana, in 1994 where she accepted an assistant professor position.
In addition to practicing clinical pediatric cardiology at Tulane, she was also director of preventive cardiology and the Pediatric Echocardiography Laboratory. Her research interests led her to join the world-renowned Bogalusa Heart Study, one of the longest running epidemiologic studies of CV risk factors in children. As co-investigator under the tutelage of Dr. Gerald S. Berenson, she initiated the non-invasive imaging program and supervised collection of CV data for over a decade.
Dr. Urbina joined Cincinnati Children's Hospital Medical Center as associate professor within the UC Department of Pediatrics in October of 2003 and became director of preventive cardiology in 2006. This new opportunity allowed her to concentrate her clinical practice on the diagnosis and treatment of high blood pressure and cholesterol. She continues her research studies concentrating on non-invasive imaging methods to measure atherosclerosis with a focus on vascular function abnormalities using the modalities of:
Her current research includes the application of these new techniques to study the roles that pre- and post-natal nutrition, overweight, high blood pressure, cholesterol and diabetes play in the development of hardening of the arteries.
MD: Medical College of Georgia, Augusta, GA, 1988.
Residency: University of California, San Francisco, CA, 1990; Tulane University, New Orleans, LA, 1991 (Pediatrics).
Fellowship: Tulane University, New Orleans, LA, 1994 (Pediatric Cardiology).
Certification: Pediatrics, 1991; Pediatric Cardiology, 1994.
Urbina EM, Khoury PR, McCoy C, Daniels SR, Kimball TR, Dolan LM. Cardiac and vascular consequences of pre-hypertension in youth. J Clin Hypertens (Greenwich). May 2011;13(5):332-342.
Urbina EM, Dolan LM, McCoy CE, Khoury PR, Daniels SR, Kimball TR. Relationship between elevated arterial stiffness and increased left ventricle mass in adolescents and young adults. J Pediatr. May 2011;158(5):715-721.
Urbina EM, Kimball TR, Khoury PR, Daniels SR, Dolan LM. Increased arterial stiffness is found in adolescents with obesity or obesity-related type 2 diabetes mellitus. J Hypertens. Aug 2010;28(8):1692-1698.
Urbina EM, Wadwa RP, Davis C, Snively BM, Dolan LM, Daniels SR, Hamman RF, Dabelea D. Prevalence of increased arterial stiffness in children with type 1 diabetes mellitus differs by measurement site and sex. J Pediatr. May 2010;156(5):731-737.
Urbina EM, Kimball TR, McCoy CE, Khoury PR, Daniels SR, Dolan LM. Youth with obesity and obesity-related type 2 diabetes mellitus demonstrate abnormalities in carotid structure and function. Circulation. Jun 2009;119(22):2913-2919.
Urbina EM, Bean JA, Daniels SR, D’Alessio D, Dolan LM. Overweight and hyperinsulinemia provide individual contributions to comprises in brachial artery distensibility in healthy adolescents and young adults: brachial distensibility in children. J Am Soc Hypertens. Jun 2007;1(3):200-207.
Urbina EM, Kieltkya L, Tsai J, Srinivasan SR, Berenson GS. Impact of multiple cardiovascular risk factors on brachial artery distensibility in young adults: The Bogalusa Heart Study. Am J Hypertens. Jun 2005;18:767-771.
Urbina EM, Srinivasan SR, Kieltyka RL, Tang R, Bond MG, Chen W, Berenson GS. Correlates of carotid artery stiffness in young adults: The Bogalusa Heart Study. Atherosclerosis. Sep 2004;176(1):157-164.
Urbina EM, Srinivasan SR, Tang R, Bond MG, Kieltyka L, Berenson GS. Impact of multiple coronary risk factors on the intima-media thickness of different segments of carotid artery in healthy young adults: The Bogalusa Heart Study. Am J Cardiol. Nov 2002;90(9):953-958.
Urbina EM, Gidding SS, Bao W, Pickoff AS, Berdusis K, Berenson GS. Effect of body size, ponderosity and blood pressure of the left ventricular growth in children and young adults in Bogalusa Heart Study. Circulation. May 1995;91(9):2400-2406.
Accelerated CV Aging in Youth Related to CV Risk Factor Clusters. Principal Investigator. National Heart, Lung and Blood Institute. Jan 2011-Dec 2016.
SEARCH 3: Cohort Study - Ohio site. Co-Investigator. Centers for Disease Control & National Institutes of Health. Sept 2010-Oct 2015.
Gruschen R. Veldtman, FRCP, MBChB Director of Inpatient ACHD Services, Heart Institute
is a clinician scientist who conducts research in the areas of single ventricle and Fontan physiology and pathophysiology; Eisenmenger syndrome and arrhythmia; contractile reserve in tetralogy of Fallot; and hepatopathy in the Fontan circulation and heart failure.
Director of Inpatient ACHD Services, Heart Institute
Spectrum of adult congenital heart disease: the Fontan circulation; interventional cardiology; pregnancy cardiology; pulmonary hypertension in congenital heart disease
Gruschen R. Veldtman, FRCP, MBChB, is appointed in the Heart Institute at Cincinnati Children's Hospital Medical Center. His major achievement has been the establishment of patient and science centered clinical programs that serve adult patients with various complexity of congenital heart conditions. His major academic contributions have been in the field of liver disease as it relates to the Fontan circulation.
General Paediatrics and Neonates, Royal Hospital for Sick Children, Glasgow, 1995.
Paediatric Cardiology, Leeds General Infirmary, 1999.
Fellowship: Adult Congenital Heart Disease, Toronto, 2000.
Research Fellowship: Hospital For Sick Children Toronto, 2001.
Fellowship: Adult Congenital Heart Disease, Mayo Clinic, 2002.
Fellowship: Paediatric Interventional Cardiology, 2003.
Ivan Wilmot, MD Heart Failure, Transplant, Ventricular Assist Device Physician
focuses on care of children with advanced heart failure requiring mechanical circulatory support bridge to transplant; quality of life in children with heart failure, transplant, and mechanical circulatory support (MCS); and advanced strain imaging in evaluation of ventricular function in pediatric heart transplant patients.
Heart Failure, Transplant, Ventricular Assist Device Physician
Heart failure; transplantation; mechanical circulatory support.
Ivan Wilmot, MD, graduated summa cum laude from Louisiana State University with a Bachelor of Science in zoology.
In 1998 he began medical school at Emory University. His general pediatrics residency training took place at the Emory Affiliated Hospitals from 2002 to 2006. He completed his pediatric cardiology fellowship training from 2006 to 2009, and advanced fellowship in heart failure and transplant from 2009 to 2010.
His clinical and research interests focus on heart failure, cardiac transplantation and mechanical circulatory support (MCS).
BS: Louisiana State University, Baton Rouge, LA, 1998.
MD: Emory University School of Medicine, Atlanta, GA, 2002.
Residency: Emory Affiliated Hospitals, Atlanta, GA, 2005; Chief Resident: Emory Affiliated Hospitals, Atlanta, GA, 2006.
Fellowship: Baylor College of Medicine, Texas Children’s Hospital, Houston, TX, 2009.
Advanced Fellowship: Heart Failure and Transplant, Baylor College of Medicine, Texas Children’s Hospital, Houston, TX, 2010.
Certification: American Board of Pediatrics; American Board of Pediatrics Sub-board of Pediatric Cardiology.
Ryan T, Jefferies J, Wilmot I. Managing Heart Failure in Adults with Congenital Heart Disease. 2014. Curr Treat Options Cardiovasc Med. 2015 Feb;17(2):376.
Czosek R, Wilmot I, Jefferies J, Spar D, Anderson J, Khoury P, Knilans T. Outcomes, Arrhythmic Burden and Ambulatory Monitoring of Pediatric Patients with Left Ventricular Non-Compaction and Preserved Left Ventricular Function. AJC. 2015 April;115(7);962-6.
Fries M, Marino B, Cassedy A, Wilmot I, Jefferies J, Lorts A. Health-Related Quality of Life Assessment in Children Followed in a Cardiomyopathy Clinic. Pediatric Cardiol. 2014 Oct 7.
Stapleton GE, Wilmot I, Suh EJ. Cardiac catheterisation of patients with common arterial trunk and transposition of the great arteries. Cardiol Young. 2012 Dec:22(6), 687–690.
Dadlani GH, Braley K, Perez-Colon E, Stapleton G, Crawford M, Turpin D, Wilmot I, Freire G, Decker J, Martinez R. Long-term management of patients with hypoplastic left heart syndrome: the diagnostic approach at All Children's Hospital. Cardiol Young. 2011 Dec:21 Suppl 2, 80–87.
Asante-Korang A, Jacobs JP, Ringewald J, Carapellucci J, Rosenberg K, McKenna D, McCormack J, Wilmot I, Gjeldum A, Lopez-Cepero M, Sleasman J. Management of children undergoing cardiac transplantation with high Panel Reactive Antibodies. Cardiol Young. 2011 Dec:21 Suppl 2, 124–132.
Wilmot I, Morales DL, Price JF, Rossano JW, Kim JJ, Decker JA, McGarry MC, Denfield SW, Dreyer, WJ, Towbin JA, Jeffries JL. Effectiveness of mechanical circulatory support in children with acute fulminant and persistent myocarditis. J Card Fail. 2011 June:17(6), 487–494.
Perez-Colon E, Dadlani GH, Wilmot I, Miller M. Mesalamine-induced myocarditis and coronary vasculitis in a pediatric ulcerative colitis patient: a case report. Case Rep Peditr. 2011; 524364.
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