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James S. Tweddell, MD Executive Co-Director, Heart Institute
concentrates his clinical and research efforts on the care of the neonate before, during and after complex congenital heart surgery. Together with his colleagues, Dr. Tweddell has established a multi-institutional, multi-disciplinary group studying bleeding and antithrombotic strategies among pediatric cardiac surgical patients with a special focus on neonates and patients requiring mechanical circulatory support.
Executive Co-Director, Heart Institute
Surgical Director, Heart Institute
Professor, UC Department of Surgery
Surgical emphases include congenital heart surgery in neonates, infants, children, teenagers and adults. Heart transplantation and mechanical circulatory support.
Dr. Tweddell leads the Heart Institute’s surgical team providing unparalleled surgical care and innovation for our patients and their families. Over the last 20 years, he built the pediatric cardiothoracic surgery program at the Medical College of Wisconsin, where he held the S. Bert Litwin Chair for Cardiothoracic Surgery position, served as medical director of pediatric cardiothoracic surgery at Children’s Hospital of Wisconsin and professor and chief for the Division of Cardiothoracic Surgery. Dr. Tweddell has an extensive list of vital research contributions, having authored more than 125 peer reviewed articles, published numerous books, chapters, invited reviews and editorials, and serving on multiple editorial boards and national committees.
Dr. Tweddell is the elite surgeon of his generation and has earned a worldwide reputation for outstanding clinical results based on team contributions to his outcomes. He decreased mortality following the Norwood procedure through the use of venous saturation monitoring and afterload reduction. In addition, Dr. Tweddell reduced interstage mortality of a single ventricle patient through the development of a home monitoring program.
MD: University of Cincinnati, Cincinnati, OH, 1985.
Residency: Intern and Second Year Resident in General Surgery, New York Medical Center, New York, NY, 1987.
Residency: Research Fellow in Cardiothoracic Surgery, Washington University Medical Center, St. Louis, MO, 1989.
Residency: Senior Resident and Chief Resident in General Surgery, Washington University Medical Center, St. Louis, MO, 1991.
Residency: Resident in Cardiothoracic Surgery, Washington University Medical Center, St. Louis, MO, 1993.
Fellowship: Fellow in Pediatric Cardiothoracic Surgery, Washington University Medical Center, St. Louis, MO, 1993.
Jacobs JP, O'Brien SM, Pasquali SK, Gaynor JW, Mayer JE Jr, Karamlou T, Welke KF, Filardo G, Han JM, Kim S, Quintessenza JA, Pizarro C, Tchervenkov CI, Lacour-Gayet F, Mavroudis C, Backer CL, Austin EH 3rd, Fraser CD, Tweddell JS, Jonas RA, Edwards FH, Grover FL, Prager RL, Shahian DM, Jacobs ML. The Society of Thoracic Surgeons Congenital Heart Surgery Database Mortality Risk Model: Part 2-Clinical Application. Ann Thorac Surg. 2015 Aug 3.
Tweddell JS. The Atrial Level Switch Operation: Lessons Old and New. Circulation. 2015 Jul 16.
Niebler RA, Shah TK, Mitchell ME, Woods RK, Zangwill SD, Tweddell JS, Berger S, Ghanayem NS. Ventricular Assist Device in Single-Ventricle Heart Disease and a Superior Cavopulmonary Anastomosis. Artif Organs. 2015 Jul 6.
Jacobsen RM, Earing MG, Hill GD, Barnes M, Mitchell ME, Woods RK, Tweddell JS. The Externally Supported Ross Operation: Early Outcomes and Intermediate Follow-Up. Ann Thorac Surg. 2015 Aug;100(2):631-8.
Ginde S, Lam J, Hill GD, Cohen S, Woods RK, Mitchell ME, Tweddell JS, Earing MG. Long-term outcomes after surgical repair of complete atrioventricular septal defect. J Thorac Cardiovasc Surg. 2015 Aug;150(2):369-74.
Buelow MW, Earing MG, Hill GD, Cohen SB, Bartz PJ, Tweddell JS, Ginde S. Tricuspid repair at pulmonary valve replacement does not alter outcomes in tetralogy of Fallot. Ann Thorac Surg. 2015 Mar;99(3):899-904.
Cox DA, Ginde S, Tweddell JS, Earing MG. Outcomes of a hepatitis C screening protocol in at-risk adults with prior cardiac surgery. World J Pediatr Congenit Heart Surg. 2014 Oct;5(4):503-6.
Samyn MM, Plymale JM, Cousineau AJ, Tweddell JS. TAPVR in a kindergartner presenting with fatigue. BMJ Case Rep. 2014 Oct 9;2014.
McCrindle BW, Li JS, Manlhiot C, Tweddell JS, Giglia TM, Massicotte MP, Monagle P, Krishnamurthy R, Mahaffey KW, Michelson AD, Verdun N, Almond CS, Newburger JW, Brandão LR, Esmon CT, Manco-Johnson MJ, Ichord R, Ortel TL, Chan AK, Portman R, Rose M, Strony J, Kaltman JR. Challenges and priorities for research: a report from the National Heart, Lung, and Blood Institute (NHLBI)/National Institutes of Health (NIH) Working Group on thrombosis in pediatric cardiology and congenital heart disease. Circulation. 2014 Sep 30;130(14):1192-203.
Mitchell ME, Rumman N, Chun RH, Rao A, Martin T, Beste DJ, Berens RJ, Parakininkas DE, Ghanayem NS, Hubert MJ, Uhing M, Simpson P, Sato TT, Tweddell JS, Kerschner JE. Anterior tracheal suspension for tracheobronchomalacia in infants and children. Ann Thorac Surg. 2014 Oct;98(4):1246-53.
PumpKIN Trial. Principle Surgical Investigator. National Institutes of Health. 2013-ongoing.
Targeted, Highly Sensitive, Non-Invasive Cardiac Transplant Rejection Monitoring. Co-Principal Investigator. National Institutes of Health. 2013-2018.
Berlin Heart Post Approval Study. Co-Principal Investigator. Berlin Heart Inc. Aug 2013-ongoing.
Roosevelt Bryant III, MD
Assistant Professor, UC Department of Pediatrics
UC Department of Surgery
Neonatal and congenital heart surgery and pediatric heart transplantation with specialty certification in Berlin Heart Surgical implantation and training.
BA: Biology, Dillard University, New Orleans, LA, 1990.
MS: Boston University, Boston, BA, 1999.
MD: Boston University, School of Medicine, Boston, MA.
Internship and Residency: General Surgery, University of Kansas, Kansas City, KS, 2004.
Residency: Cardiovascular and Thoracic Surgery, Cleveland Clinic, Cleveland, OH, 2007.
Fellowship: Congenital Heart Surgery, Texas Children's Hospital, Houston, TX, 2009.
Arain N, Braunlin E, St. Louis J, Bryant R 3rd. Delayed Arterial Switch Operation in a Patient with Complete Transposition of the Great Arteries and Glucocorticoid Remediable Aldosteronism. World Journal for Pediatric and Congenital Heart Surgery. 2011 Apr; 2(2):316-17.
Bryant R 3rd, Steiner M, St. Louis JD. Current Use of the EXCOR Pediatric Ventricular Assist Device. J Cardiovasc Transl Res. 2010 Dec;3(6):612-7.
Shepard CW, Kochilas LK, Rosengart RM, Bryant R 3rd, Moller JH, St. Louis JD. Repair of Major Cardiac Defects in Low Birth Weight Infants; Is Delay Warranted? J Thorac Cardiovasc Surg. 2010 Nov;140(5):1104-9.
Arain N, Bryant R 3rd, Ameduri R, Gruenstein D, Braunlin E, Joyce L, St. Louis J. Successful Coil Embolization of a Large Ascending Aortic Pseudoaneurysm Following Explanation of the EXCOR Pediatric Ventricular Assist Device in a Patient with Acute Fulminant Myocarditis. World Journal for Pediatric and Congenital Heart Surgery. 2010;1(2): 259-26.
Owens WR, Bryant R 3rd,Dreyer WJ, Price JF, Morales D. Initial Experience with the Heart Mate II Ventricular Assist System in a Pediatric Institution. Artif Organs. 2010 Jul;34(7):600-3.
Booth JH, Bryant R 3rd, Powers SC, Ge S, McKenzie ED, Heinle JS, Fraser CD, Morales D. Transthoracic Echocardiography Does Not Reliably Predict Involvement of the Aortic Valve in Patients with Discrete Subaortic Shelf. Cardiol Young. 2010 Jun;20(3):284-9.
Zhi D, Bryant R 3rd, Heinle J, Nihill M. Isolated Cleft of the Mitral Valve: Clinical Spectrum and Course. Tex Heart Inst J. 2009;36(6):553-6.
Bryant R 3rd, Morales D. Corkscrew Trachea: A Novel Type of Distal Congenital Tracheal Stenosis. Ann Thorac Surg. 2009 Jun;87(6):1923-5.
Booth JH, Bryant R 3rd, Vaporciyan A, Morales D. Complete Lung Parenchyma Sparing Resection of the Right Main Stem Bronchus and Bronchus Intermedius. J Thorac Cardiovasc Surg. 2009 Mar 6.
Bryant R 3rd, Phalak K, Morales D. Multimodality Therapy for Primary Sternal Osteomyelitis. Pediatr Infect Dis J. 2009 Jan;28(1):73-4.
David L. S. Morales, MD Chief of Cardiovascular Surgery, Heart Institute, Cardiothoracic Surgery
Chief of Cardiovascular Surgery, Heart Institute, Cardiothoracic Surgery
Clark-Helmsworth Chair of Cardiovascular Surgery
Professor, UC Department of Pediatrics
UC Division of Surgery
Congenital heart surgery; heterotaxy syndrome; pediatric heart and lung transplantation; mechanical circulatory support
MD: Yale University School of Medicine, New Haven, CT.
Residency: General and cardiothoracic surgery, New York-Presbyterian Medical Center, Columbia University, New York, NY.
Fellowships: Congenital heart surgery, Texas Children’s Hospital, Baylor University, Waco, TX.
Board certifications: Surgery, thoracic surgery, congenital heart surgery.
Farhan Zafar, MD
Instructor, UC Department of Surgery
Pediatric heart and lung transplant; congenital heart surgery
MD: Dow Medical College, Karachi, Pakistan, 2005.
Residency: Surgery, Baylor College of Medicine, Houston, TX, 2010-2012.
Zafar F, Hinton RB, Moore RA, Baker RS, Bryant III R, Narmoneva DA, Taylor MD, Morales DL. Physiological Growth, Remodeling Potential, and Preserved Function of a Novel Bioprosthetic Tricuspid Valve: Tubular Bioprosthesis Made of Small Intestinal Submucosa-Derived Extracellular Matrix. J Am Coll Cardiol. 2015 Aug 25;66(8):877-88.
Zafar F, Jefferies JL, Tjossem C, Bryant R, Jaquiss RDB, Wearden PD, Rosenthal DN, Cabrera AG, Rossano JW, Humpl T, Morales DLS. Biventricular Berlin Heart EXCOR Pediatric use across the US. Ann Thorac Surg. 2015;99(4):1328-34.
Khan MS, Zafar F, Morales DL. High risk congenital heart surgery and mechanical circulatory support as an alternative to heart transplantation in patients with end-stage adult congenital heart disease. Prog Pediatr Cardiol. 2014;38(1-2):33-35.
Zafar F, Khan MS, Bryant III R, Castleberry C, Lorts A, Wilmot I, Jeffries JL, Clifford C, Morales DL. Pediatric heart transplant waitlist mortality in the era of ventricular assist devices. Journal of Heart Lung Transplantation. 2015;34(1):82-8.
Karani KB, Zafar F, Morales DL, Goldstein BH. Hybrid stage I palliation in a 1.1 kg 28-wk preterm neonate with posterior malalignment ventricular septal defect, left ventricular outflow tract obstruction, and coarctation of the aorta. World J Pediatr Congenit Heart Surg. 2014;5(4):603-7.
Ryan TD, Jefferies JL, Zafar F, Lorts A, Morales DL. The evolving role of Total Artificial Heart in the management of end-stage congenital heart disease and adolescents. ASAIO J. 2015;61(1):8-14.
Lorts A, Zafar F, Morales DLS. Mechanical Assist Devices in neonates and infants. Semin Thorac Cardiovasc Surg Pediatr Card Surg Annu. 2014;17(1):91-5.
Rodriguez FH, Moodie DS, Parekh DR, Franklin WJ, Morales DL, Zafar F, Graves DE, Friedman RA, Rossano JW. Outcomes of heart failure-related hospitalization in adults with congenital heart disease in the United States. Congenital Heart Disease. Congenit Heart Dis. 2013 Nov-Dec;8(6):513-9.
Khan MS, Mery CM, Zafar F, Adachi I, Heinle JS, Cabrera AG, Fraser CD Jr, Morales DL. Is mechanically bridging patients with a failing cardiac graft to retransplantation an effective therapy? Analysis of the United Network of Organ Sharing database. J Heart Lung Transplant. 2012 Nov;31(11):1192-8.
Rossano JW, Kim JJ, Decker JA, Price JF, Zafar F, Graves DE, Morales DL, Heinle JS, Bozkurt B, Towbin JA, Denfield SW, Dreyer WJ, Jefferies JL. Prevalence, morbidity, and mortality of heart failure-related hospitalizations in children in the United States: a population-based study. J Card Fail. 2012 Jun;18(6):459-70.
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