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Multiple pathologies during
pregnancy are associated with inappropriate placental development and/or
function. A transient organ, usually disposed of after birth, the placenta is
the ideal target organ for gene therapy. Development of non-viral tissue-specific
transgene delivery systems is essential for the safe application of gene
therapy in the developing human placenta. In this project we are designing and
investigating the effects of gene transfer and cell-specific expression of
biodegradable placenta-specific polymer-DNA nanoparticles on placental function
in a model of placental insufficiency in mice.
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