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Menon, K., J.D. McNally, K. Choong, R.E. Ward, M. Lawson, T. Ramsay, and H.R. Wong. A survey of physician practices and beliefs on the use of steroids in pediatric fluid and/or vasoactive infusion dependent shock. Pediatr Crit Care Med. 2013 (in press).
Wong H.R., N.Z. Cvijanovich, M. Hall, G.L. Allen, N.J. Thomas, R.J. Freishtat, N. Anas, K. Meyer, P.A. Checchia, R. Lin, M.T. Bigham, A. Sen, J. Nowak, M. Quasney, J.W. Henricksen, A. Chopra, S. Banschbach, E. Beckman, K. Harmon, P. Lahni, and T.P. Shanley. Interleukin-27 is a novel candidate diagnostic biomarker for bacterial infection in critically ill children. Crit Care. 16:R213, 2012.
Wong, H.R., S. Salisbury, Q. Xiao, N.Z. Cvijanovich, M. Hall, G.L. Allen, N.J. Thomas, R.J. Freishtat, N. Anas, K. Meyer, P.A. Checchia, R. Lin, T.P. Shanley, M.T. Bigham, A. Sen, J. Nowak, M. Quasney, J.W. Hendricksen, A. Chopra, S. Banschbach, E. Beckman, K. Harmon, P. Lahni, and C.J. Lindsell. The pediatric sepsis biomarker risk model. Crit Care. 16:R174, 2012.
Nowak, J.E., K. Harmon, C.C. Caldwell, and H.R. Wong. Prophylactic zinc supplementation reduces bacterial load and improves survival in a murine model of sepsis. Pediatr Crit Care Med. 13:e323-329, 2012.
Standage, S.W., C.C. Caldwell, B. Zingarelli, and H.R. Wong. Reduced PPARα expression is associated with decreased survival and increased tissue bacterial load in sepsis. Shock. 37:164-169, 2012.
Standage, S.W., Caldwell, C.C., Zingarelli, B. and Wong, H.R. Reduced PPARα expression is associated with decreased survival and increased tissue bacterial load in sepsis. Shock. 37:164-169, 2012.
Wheeler, D.S., Dunsmore, K.E., Denenberg, A.G., Muething, L. , Poynter, S.E. and Wong, H.R. Biological activity of truncated C-terminus human heat shock protein 72. Immunol Lett. 135:173-179, 2011.
Wheeler, D.S., Guiliano, J., Lahni, P., Denenberg, A., Wong, H.R. and Zingarelli, B. The immunomodulatory effects of albumin in vitro and in vivo. Adv Pharmacol Sci. Volume 2011 (2011), Article ID 691928, 7 pages.
Mahabeleshwar, G.H., Kawanami, D., Sharma, N., Takami, Y., Zhou, G., Shi, H., Nayak, L., Jeyaraj, D., Grealy, R., White, M., McManus, R., Ryan, T., Leahy, P., Lin, Z., Haldar, S.M., Atkins, G.B., Wong, H.R., Lingrel, J.B. and Jain, M.K. Myeloid KLF2 regulates the host response to polymicrobial infection and endotoxic shock. Immunity. 34:715-728, 2011.
Basu, R.K., Donaworth, E., Wheeler, D.S, Devarajan, P. and Wong, H.R. Antecedent acute kidney injury worsens subsequent endotoxin-induced lung inflammation in a 2-hit mouse model. Am J Physiol Renal Physiol. 301:F597-604, 2011.
Wong, H.R., Cvijanovich, N.Z., Allen, G.L., Thomas, N.J., Freishtat, R.J., Anas, N., Meyer, K., Checchia, P.A., Lin, R., Shanley, T.P., Bigham, M.T., Wheeler, D.S., Doughty, L.A., Tegtmeyer, K., Poynter, S.E., Kaplan, J.M., Chima, R.S., Stalets, E., Basu, R.K., Varisco, B.M. and Barr, F.E. Validation of a gene expression-based subclassification strategy for pediatric septic shock. Crit Care Med. 39:2511-2517, 2011.
Basu, R.K., Standage, S.W., Cvijanovich, N.Z., Allen, G.L., Thomas, N.J., Freishtat, R.J., Anas, N., Meyer, K., Checchia, P.A., Lin, R., Shanley, T.P., Bigham, M.T., Wheeler, D.S., Devarajan, P., Goldstein, S.L. and Wong, H.R. Identification of candidate serum biomarkers for severe septic shock-associated kidney injury via microarray. Crit Care. 15:R273, 2011.
Wynn, J.L., Cvijanovich, N.Z., Allen, G.L., Thomas, N.J., Freishtat, R.J., Anas, N., Meyer, K., Checchia, P.A., Lin, R., Shanley, T.P., Bigham, M.T., Banschbach, S., Beckman, E. and Wong, H.R. The influence of developmental age on the early transcriptomic response of children with septic shock. Mol Med. 2011 (in press).
Solan, P.D., Dunsmore, K.E., Denenberg, A.G., Odoms, K., Zingarelli, B. and Wong, H.R. A novel role for matrix metalloproeinase-8 in sepsis. Crit Care Med. 2011 (in press).
Kaplan, J.M., Denenberg, A., Monaco, M., Nowell, M., Wong, H.R. and Zingarelli, B. Changes in peroxisome proliferator-activated receptor-gamma activity in children with septic shock. Intensive Care Med. 36:123-130, 2010.
Nowak, J.E., Wheeler, D.S., Harmon, K.K. and Wong, H.R.Admission chemokine (C-C motif) ligand 4 levels predict survival in pediatric septic shock. Ped Crit Care Med. 11:213-216, 2010.
Wong, H.R., Freishtat, R.J., Monaco, M., Odoms, K. and Shanley, T.P. Leukocyte subset-specific genome-wide expression profiles in pediatric septic shock. Ped Crit Care Med. 11:349-355, 2010.
Calfee, C.S., Thompson, B.T., Parsons, P.E., Ware, L.B., Matthay, M.A. and Wong, H.R. Plasma IL-8 is not an effective risk stratification tool for adults with vasopressor-dependent septic shock. Crit Care Med. 38:1436-1441, 2010.
Wong, H.R., Wheeler, D.S., Tegtmeyer, K., Poynter, S.E., Kaplan, J.M., Chima, R.S., Stalets, E., Basu, R.K. and Doughty, L.A. Toward a clinically feasible gene expression-based sub-classification strategy for septic shock: proof of concept. Crit Care Med. 38:1955-1961, 2010.
Cvijanovich, N.Z., King, J.C., Flori, H.R., Gildengorin, G. and Wong, H.R. Zinc homeostasis in pediatric critical illness. Ped Crit Care Med. 10:29-34, 2009.
Wong, H.R., Shanley, T.P., Cvijanovich, N., Allen, G.L., Lin, R., Anas, N., Meyer, K., Freishtat, R.J., Monaco, M., Odoms, K. and Sakthivel, B. Genome-wide expression profiling across the pediatric SIRS, sepsis, and septic shock spectrum. Crit Care Med. 37:1558-1566, 2009.
Huber, N., Sakai, N., Eismann, T., Shin, T., Kuboki, S., Blanchard, J., Schuster, R., Edwards, M.J., Wong, H.R. and Lentsch, A.B. Age-related decrease in proteasome expression contributes to defective NF-kB activation during hepatic ischemia/reperfusion. Hepatology. 49:1718-1728, 2009.
Zingarelli, B., Hake, P.W., O’Connor, M., Burroughs, T.J., Wong, H.R., Solomkin, J.S. and Lentsch, A.B. Lung injury after hemorrhage is age dependent: Role of peroxisome proliferator-activated receptor gamma. Crit Care Med. 37:1978-1987, 2009.
Wong, H.R., Cvijanovich, N., Lin, R., Allen, G.L., Thomas, N.J., Willson, D.F., Freishtat, R.J., Anas, N., Meyer, K., Checchia, P.A., Monaco, M., Odoms, K. and Shanley, T.P.Identification of pediatric septic shock classes based on genome-wide expression profiling. BMC Medicine. 7:34, 2009.
Cobb, J.P., Cairns, C.B., Bulger, E., Wong, H.R., Parsons, P.E., Angus, D.C., Gentile, N.T., Hoyt, D.B., Schwinn, D.A., Wiener-Kronish, J.P. and Upperman, J.S. The United States critical illness and injury trials group. J Trauma. 67:S159-S160, 2009.
Wheeler, D.S., Devarajan, P., Ma, Q., Harmon, K., Monaco, M., Cvijanovich, N. and Wong, H.R. Serum neutrophil gelatinase-associated lipocalin (NGAL) as a marker of acute kidney injury in critically ill children with septic shock. Crit Care Med. 36:1297-1303, 2008.
Wong, H.R., Odoms, K. and Sakthivel, B. Divergence of canonical danger signals: The genome-level expression patterns of human mononuclear cells subjected to heat shock or lipopolysaccharide. BMC Immunol. 9:24, 2008.
Cvijanovich, N, Shanley, T.P., Lin, R., Allen, G.L., Thomas, N.J., Checchia, P., Anas, N., Freishtat, R.J., Monaco, M., Odoms, K., Sakthivel, B. and Wong, H.R., for the Genomics of Pediatric SIRS Investigators. Validating the genomic signature of pediatric septic shock. Physiol Genomics. 34:127-134, 2008.
Wong, H.R., Cvijanovich, N., Wheeler, D.S., Bigham, M.T., Monaco, M., Odoms, K., Macias, W.L. and Williams, M.D. Interleukin-8 as a stratification tool for interventional trials involving pediatric septic shock. Am J Respir Crit Care Med. 178:276-282, 2008.
Wong, H.R., Shanley, T.P., Sakthivel, B., Cvijanovich, N., Lin, R., Allen, G.L., Thomas, N.J., Doctor, A., Kalyanaraman, M., Tofil, N.M., Penfil, S., Monaco, M., Tagavilla, M.A., Odoms, K., Dunsmore, K., Barnes, M. and Aronow, B.J., for the Genomics of Pediatric SIRS Investigators. Genome level expression profiles in pediatric septic shock indicate a role for altered zinc homeostasis in poor outcome. Physiol Genomics. 30:146-155, 2007.
Shanley, T.P., Cvijanovich, N., Lin, R., Allen, G.L., Thomas, N.J., Doctor, A., Kalyanaraman, M., Tofil, N.M., Penfil, S., Monaco, M., Odoms, K., Barnes, M., Sakthivel, B., Aronow, B.J. and Wong, H.R. Genome-level longitudinal expression of signaling pathways and gene networks in pediatric septic shock. Mol Med. 13:496-508, 2007.
