Critical Care

  • Research Faculty

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    Division Head

    A photo of Hector Wong.

    Hector R. Wong, MD Director, Critical Care Medicine

    is a clinician with a translational research program focused on sepsis. The centerpiece of the research program involves genome wide expression analyses from blood samples of children with sepsis representing multiple institutions. These data are directing three major areas of focus: stratification of sepsis through biomarkers and gene expression signatures; the development of sepsis diagnostic biomarkers; and testing of novel sepsis targets and pathways in the laboratory.
    Visit the Wong Lab.

    513-636-4259
    hector.wong@cchmc.org

    Hector R. Wong, MD

    Director, Critical Care Medicine

    Academic Information

    Professor, UC Department of Pediatrics

    Phone: 513-636-4259

    Fax: 513-636-4267

    Email: hector.wong@cchmc.org

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    Specialties

    Critical care; sepsis
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    Education and Training

    MD: University of Medicine and Dentistry of New Jersey-Robert Wood Johnson Medical School, Piscataway, NJ, 1989.

    Residency: Department of Pediatrics, George Washington University School of Medicine, Children's National Medical Center, Washington, DC, 1990 to 1992.

    Fellowship: Clinical Fellow, Department of Anesthesiology, Division of Pediatric Critical Care Medicine, University of Pittsburgh School of Medicine, Children's Hospital of Pittsburgh, Pittsburgh, PA, 1992 to 1995; Research Fellow, Department of Pharmacology, University of Pittsburgh School of Medicine, Pittsburgh, PA, 1992 to 1995.

    Certification: National Board of Medical Examiners, 1990; Diplomate, American Board of Pediatrics, 1993; American Board of Pediatrics: Sub-Board of Pediatric Critical Care Medicine, 1996.

    Publications

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    Grants

    Point of care center for emerging neurotechnologies. Co-Investigator. National Institutes of Health. Sep 2007 - Jun 2012. #U54 EB007954.

    The pediatric sepsis biomarker risk model. Principal Investigator. National Institutes of Health. Oct 2009 - Sep 2012. #RC1 HL100474.

    Host response to trauma research training program. Co-program director. National Institutes of Health. Jul 2008 - Jun 2013. #T32 GM008478.

    The role of PPARγ and PPARγ agonists in septic shock. Co-Investigator. National Institutes of Health. Jul 2008 - Jun 2013. #RO1 GM067202.

    PPARγ in pediatric sepsis and the inflammatory response in obesity. Co-Mentor. National Institutes of Health. Jun 2010 - May 2014.

    MMP-8 as a novel therapeutic target in sepsis. Principal Investigator. National Institutes of Health. Apr 2011 - Mar 2015.

    Clinical Director

    A photo of Erika Stalets.

    Erika L. Stalets, MD Medical Director, Pediatric Intensive Care Unit

    is a clinical intensivist interested in quality improvement and patient safety. She is a Quality Scholar and working toward her MS in clinical and translational research. Her interests include decreasing and eliminating hospital acquired infections and the reliable delivery of evidenced-based care to pediatric patients with septic shock.

    513-636-4259
    erika.stalets@cchmc.org

    Erika L. Stalets, MD

    Medical Director, Pediatric Intensive Care Unit

    Academic Information

    Assistant Professor, UC Department of Pediatrics

    Phone: 513-636-4259

    Fax: 513-636-4267

    Email: erika.stalets@cchmc.org

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    Specialties

    Critically ill and injured children; sepsis; multi-organ dysfunction; Quality improvement and patient safety

    Education and Training

    MD: Southern Illinois University School of Medicine, Springfield, IL, 1997-2001.

    Residency: Internal Medicine and Pediatrics, University of Tennessee Health Science Center, Memphis, TN, 2001-2005.

    Chief Residency: Pediatrics. LeBonheur Children’s Medical Center, University of Tennessee Health Science Center, Memphis, TN, 2005-2006.

    Fellowship: Pediatric Critical Care, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, 2006-2009.

    Certification: American Board of Pediatrics, 2005; Sub-Board of Pediatric Critical Care Medicine, 2010; American Board of Internal Medicine, 2005.

    Faculty

    A photo of Raj Basu.

    Raj K. Basu, MD Co-Director, Center for Acute Care Nephrology

    Dr. Basu's primary research interest is the impact of acute kidney injury on pediatric critical illness. Combining basic and clinical research programs, his work investigates: 1) the propagation of ischemic acute kidney injury and the mechanisms vital for recovery, 2) molecular mediation of injurious crosstalk between the kidneys and lungs, and 3) risk stratified biomarker incorporation for prediction of acute kidney injury onset, severity, and duration.

    513-636-4259
    rajit.basu@cchmc.org

    Raj K. Basu, MD

    Co-Director, Center for Acute Care Nephrology

    Academic Information

    Assistant Professor, UC Department of Pediatrics

    Phone: 513-636-4259

    Fax: 513-636-4267

    Email: rajit.basu@cchmc.org

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    Specialties

    Pediatric critical care; acute kidney injury; ethics/end-of-life care

    Biography

    Dr. Basu arrived at Cincinnati Children's after completing his residency and fellowship training at Children’s Memorial Hospital in Chicago. The focus of his research efforts thus far have been in increasing the appreciation for the impact of acute kidney injury (AKI) on critical illness. In addition to his research and publication efforts, Dr. Basu has been actively involved in the fellowship program coordinating numerous lectures, an ethics curriculum, and mentoring residents/fellows. He also currently sits on the hospital action committees dedicated to improving the care of status asthmaticus and status epilepticus.

    Education and Training

    MD: Indiana University, Indianapolis, IN 2003

    Residency: Pediatrics, Northwestern University Children’s Memorial Hospital, Chicago, IL, 2003-2006

    Fellowship: Pediatric Critical Care, Northwestern University Children’s Memorial Hospital, Chicago, IL, 2006-2009

    Certifications: Pediatrics, 2006; Critical Care, 2010

    Publications

    View PubMed Publications
    A photo of Ranjit Chima.

    Ranjit S. Chima, MD

    is a clinical assistant professor with an interest in critically ill stem cell transplant recipients. His research is focused on predicting and improving outcomes for critically ill stem cell transplant recipients. This work is done in close collaboration with the Division of Bone Marrow Transplantation and Immunodeficiency.

    513-636-4259
    ranjit.chima@cchmc.org

    Ranjit S. Chima, MD

    Academic Information

    Assistant Professor, UC Department of Pediatrics

    Phone: 513-636-4259

    Fax: 513-636-4267

    Email: ranjit.chima@cchmc.org

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    Specialties

    Critical Illness following stem cell transplantation; extracorporeal life support; venous thromboembolism; critical Illness hyperglycemia

    Education and Training

    MBBS: Grant Medical College, Mumbai, India, 1996.

    MD: Pediatrics, University of Mumbai, Mumbai, India, 1999.

    Residency: Pediatrics, University of Mumbai, Mumbai, India, 1996-1999; Pediatrics, Children's Hospital of Michigan, Detroit, MI, 2001-2004.

    Fellowship: Critical Care Medicine, Cincinnati Childrens Hospital Medical Center, 2004-2007.

    Certification: Pediatrics, 2004; Pediatric Critical Care Medicine, 2008

    Publications

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    Grants

    Heart and Lung Failure-Pediatric Insulin Titration Trial. Site Principal Investigator. National Institutes of Health, National Heart, Lung and Blood Institute (NHLBI). July 2012-present.
    A photo of Lesley A. Doughty.

    Lesley A. Doughty, MD Physician, Division of Critical Care Medicine

    is a clinician scientist whose basic science research program focuses on the molecular mechanisms underlying the inflammatory synergy observed during viral and bacterial co-infection. Specific areas of focus include the impact of influenza and antiviral cytokines on TLR signaling.

    513-636-4259
    lesley.doughty@cchmc.org

    Lesley A. Doughty, MD

    Physician, Division of Critical Care Medicine

    Academic Information

    Associate Professor, UC Department of Pediatrics

    Phone: 513-636-4259

    Fax: 513-636-4267

    Email: lesley.doughty@cchmc.org

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    Specialties

    Sepsis; multiple organ failure; viral immunomodulation

    Education and Training

    MD: Dartmouth Medical School.

    Residency: Tripler Army Medical Center.

    Fellowship: Children's Hospital of Pittsburgh.

    Publications

    View PubMed Publications
    A photo of Jennifer Kaplan.

    Jennifer Kaplan, MD, MS

    is an attending physician in the PICU who has basic and translational research programs. Her laboratory focuses on understanding the inflammatory responses in sepsis, with a specific interest in the role of the nuclear receptor PPAR gamma. Dr. Kaplan is conducting a Phase 1 clinical trial to evaluate the pharmacokinetic characteristics, safety profile, and effect on inflammatory markers of pioglitazone in patients with severe sepsis and septic shock. Pioglitazone belongs to a class of drugs called thiazolidinediones (TZDs), which are commonly used in patients with type 2 diabetes and ligands for PPAR gamma. Her laboratory also focuses on the increased susceptibility of diet-induced obesity to sepsis. She focuses on the critical links between the inflammatory pathways in sepsis and obesity.
    Visit the Kaplan Lab.

    513-636-4259
    jennifer.kaplan@cchmc.org

    Jennifer Kaplan, MD, MS

    Academic Information

    Associate Professor, UC Department of Pediatrics

    Phone: 513-636-4259

    Email: jennifer.kaplan@cchmc.org

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    Specialties

    Intensive care; respiratory failure; multi-organ failure; sepsis; trauma; inflammation; obesity; PPARg

    Visit the Kaplan Lab.

    Biography

    My long-term career goal is to improve the outcomes of critically ill children. I began my research career in fellowship studying sepsis, driven by the realization that there are few clinical therapies that improve outcomes in critically ill children with severe infections. I focused on the nuclear receptor PPARg as a potential target to alter the sepsis-induced inflammatory state. PPARg is a nuclear receptor with effects on lipid and glucose metabolism, atherosclerosis and inflammation. I elected to extend my fellowship a fourth year to complete training in molecular epidemiology and the Master of Science program at the University of Cincinnati Academic Health Center. I received grant funding from the Translational Research Initiative and the NIH K12 Child Health Research Career Development Award at Cincinnati Children's to investigate the alteration of PPARg in peripheral blood cells from children with sepsis. I am a recipient of an NIH Mentored Clinical Scientist Research Career Development Award (K08).

    Education and Training

    MS: Epidemiology, University of Cincinnati College of Medicine, Cincinnati, OH.

    MD: University of Cincinnati, Cincinnati, OH, 1999.

    BA: Washington University in St. Louis, St. Louis, Missouri.

    Fellowship: Pediatric Critical Care Medicine, Cincinnati Children's Hospital Medical Center, Cincinnati, OH.

    Residency: Pediatrics, Orlando Regional Healthcare, Orlando, FL.

    Certification: Pediatric Critical Care Medicine, Pediatrics.

    Publications

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    Grants

    Pioglitazone in Adolescents with Severe Sepsis and Septic Shock. Institutional Award Recipient. CCTST Junior T1 Pilot Award. Jun 2011-May 2012.

    PPAR gamma in pediatric sepsis and the inflammatory response in obesity. Principal Investigator. NIH-K08GM093135. Apr 2010-Mar 2014.

    A photo of Sue Poynter, MD.

    Sue E. Poynter, MD, MEd Director, Pediatric Residency Program

    is an Associate Director of Pediatric Residency Training Program with an interest in medical education, curriculum development and educational research.

    513-636-4259
    sue.poynter@cchmc.org

    Sue E. Poynter, MD, MEd

    Director, Pediatric Residency Program

    Academic Information

    Assistant Professor, UC Department of Pediatrics

    Assistant Professor, Procter Scholar

    Phone: 513-636-4259

    Fax: 513-636-4267

    Email: sue.poynter@cchmc.org

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    Specialties

    Surfactant biology, lung immunity and acute lung injury

    Education and Training

    MD: Indiana University School of Medicine, Indianapolis, IN, 1997.

    Residency: Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 1997-2000.

    Chief Residency: Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 2000-2001.

    Fellowship: Cincinnati Children's Hospital Medical Center, Cincinnati, OH, Feb 2001-July 2004.

    Certification: American Board of Pediatrics, 2000, 2007; Pediatric Critical Care, 2004.

    Publications

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    A photo of Ken Tegtmeyer.

    Ken Tegtmeyer, MD

    Develops multimedia medical education tools involving video as well as 2- and 3D animations to enhance medical education. Also interested in resuscitation and is in charge of the code and MRT processes.

    513-636-4259
    ken.tegtmeyer@cchmc.org

    Ken Tegtmeyer, MD

    Academic Information

    Associate Professor, UC Department of Pediatrics

    Phone: 513-636-4259

    Fax: 513-636-4267

    Email: ken.tegtmeyer@cchmc.org

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    Specialties

    Shock; sepsis; respiratory failure; head trauma; mechanical ventilation; multimedia medical education

    Education and Training

    MD: University of Minnesota, Twin Cities, 1992.

    Residency: Pediatrics, University of Minnesota, 1995.

    Fellowship: Pediatric Critical Care, 1998.

    Certification: Pediatrics, 1996; Pediatric Critical Care, 2000, 2007.

    Publications

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    A photo of Brian Varisco.

    Brian M. Varisco, MD

    is interested in the cell-matrix interactions and matrix remodeling events during lung development and lung regeneration. Through our use of mouse models, we aim to leverage our findings to develop new therapies to reverse impaired lung development following premature birth and improve lung repair and regeneration following lung injury.
    Visit the Varisco Lab.

    513-803-2485
    brian.varisco@cchmc.org

    Brian M. Varisco, MD

    Academic Information

    Assistant Professor, UC Department of Pediatrics

    Phone: 513-803-2485

    Email: brian.varisco@cchmc.org

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    Specialties

    Lung development; lung fibroblast biology; chronic lung disease / bronchopulmonary dysplasia

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    Education and Training

    MD: Medical College of Georgia, Augusta, GA, 2004.

    Residency: Pediatrics, The Children's Hospital, Denver, CO.

    Fellowship: Pediatrics, The Children's Hospital, Denver, CO.

    Certification: Pediatrics, 2008; Pediatric Critical Care Medicine, 2011.

    Publications

    View PubMed Publications
    A photo of Derek Wheeler.

    Derek Wheeler, MD, MMM, FAAP, FCCP, FCCM Associate Chief of Staff

    is a pediatric intensivist who has translational and clinical research interests in the fields of pediatric sepsis and shock.  He is also the Associate Chief of Staff.  Additional research interests include hospital-acquired infection, quality improvement and patient safety.

    513-636-4259
    derek.wheeler@cchmc.org

    Derek Wheeler, MD, MMM, FAAP, FCCP, FCCM

    Associate Chief of Staff

    Attending Physician

    Academic Information

    Associate Professor, UC Department of Pediatrics

    Phone: 513-636-4259

    Fax: 513-636-4267

    Email: derek.wheeler@cchmc.org

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    Specialties

    Quality improvement and patient safety, high reliability organizations, sepsis and acute kidney injury.

    Education and Training

    Masters of Medical Management: Carnegie Mellon University, Pittsburgh, PA, 2013.

    MD: Indiana University School of Medicine, Indianapolis, IN, 1994.

    Intern: Department of Pediatrics, Naval Medical Center, San Diego, CA, 1994-1995.

    Residency: Department of Pediatrics, Naval Medical Center, San Diego, CA, 1995-1997.

    Fellowship: Division of Critical Care Medicine, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 2000-2003.

    Certification: Diplomate, National Board of Medical Examiners, 1995; Diplomate, American Board of Pediatrics, 1997, 2004; Diplomate, American Board of Pediatrics: Sub-Board of Pediatric Critical Care Medicine, 2004 .

    Publications

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    A photo of Basilia Zingarelli.

    Basilia Zingarelli, MD, PhD Director, Basic Science Research

    focuses on molecular mechanisms of organ injury during sepsis, trauma and hemorrhage. Her research also involves the identification of age-dependent pathological mechanisms, with special focus on anti-inflammatory nuclear receptors, whose activation may have a clinical therapeutic application in the treatment of critically ill patients.
    Visit the Zingarelli Lab.

    513-636-8704
    basilia.zingarelli@cchmc.org

    Basilia Zingarelli, MD, PhD

    Director, Basic Science Research

    Academic Information

    Professor, UC Department of Pediatrics

    Phone: 513-636-8704

    Email: basilia.zingarelli@cchmc.org

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    Specialties

    Sepsis; trauma; hemorrhagic shock and ischemia and reperfusion injury.
    Visit the Zingarelli Lab.

    Biography

    Basilia Zingarelli, MD, PhD, came to Cincinnati Children's Hospital Medical Center in 1995 as a post-doctoral research fellow in Critical Care Medicine. She joined the faculty in 1997.

    Dr. Zingarelli graduated from the Medical School of the University of Messina in Italy in 1990. She also obtained a doctorate in experimental medicine in 1997 and attended a residency in medical toxicology at the University of Messina from 1990 to 1992.

    Dr. Zingarelli now directs the basic science research in the Division of Critical Care Medicine. She directs an NIH-funded research laboratory focused on the pathogenetic mechanisms of organ injury during sepsis, trauma and hemorrhage and coordinates basic science and clinical translational research projects related to other critical care conditions.

    Dr. Zingarelli serves on the Executive Council of the Shock Society, a well-established international association of clinical and research scientists in the field of shock and trauma, and serves as associate editor for the journal Shock. She also serves as permanent and ad hoc member on a number of study sections at the National Institutes of Health.

    Education and Training

    MD: School of Medicine, University of Messina, Italy, 1990.

    PhD: Experimental Medicine, School of Medicine, University of Messina, Italy, 1997.

    Residency: Medical Toxicology, School of Medicine, University of Messina, Italy, 1990-1992.

    Certification: General Medicine (Italian), 1990.

    Publications

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    Grants

    Role of Eicosanoids In Shock. Co-Investigator. National Institutes of Health. Jul 2008 - Jun 2012. #R01 GM 027673.

    Mechanisms of Age-Related Inflammatory Response in Hemorrhagic Shock. Principal Investigator. National Institutes of Health. Sep 2007 - Aug 2012. #R01 AG 027990.

    Host response to trauma research training program. Faculty/mentor. National Institutes of Health (T32 GM08478). Jul 2003-Jun 2013.

    Interferon-mediated reprogramming of Toll-like receptor signaling. Co-Investigator. National Institutes of Health. Jul 2008 - Jun 2013. #R01 GM085063.

    Role of PPARgamma and PPARgamma Agonists in Septic Shock. Principal Investigator. National Institutes of Health. Jul 2008 - Jun 2013. #R01 GM 067202.

    MMP-8 as a novel therapeutic target in sepsis. Co-Investigator. National Institutes of Health. Jul 2011 - Jun 2015. #R01 GM096994.