• Research Faculty

  • A photo of Hector Wong.

    Hector R. Wong, MD Director, Division of Critical Care Medicine

    is a clinician with a translational research program focused on sepsis. The centerpiece of the research program involves genome wide expression analyses from blood samples of children with sepsis representing multiple institutions. These data are directing three major areas of focus: stratification of sepsis through biomarkers and gene expression signatures; the development of sepsis diagnostic biomarkers; and testing of novel sepsis targets and pathways in the laboratory.
    Visit the Wong Lab.


    A photo of Erika Stalets.

    Erika L. Stalets, MD Medical Director, Pediatric Intensive Care Unit

    is a clinical intensivist interested in quality improvement and patient safety. She is a Quality Scholar and working toward her MS in clinical and translational research. Her interests include decreasing and eliminating hospital acquired infections and the reliable delivery of evidenced-based care to pediatric patients with septic shock.


    A photo of Matthew N. Alder.

    Matthew N. Alder, MD, PhD

    studies the function of the immune system in patients with sepsis and septic shock. We use patient samples and animal models to better understand how we can treat patients with sepsis.


    A photo of Raj Basu.

    Raj K. Basu, MD Co-Director, Center for Acute Care Nephrology

    Dr. Basu's primary research interest is the impact of acute kidney injury on pediatric critical illness. Combining basic and clinical research programs, his work investigates: 1) the propagation of ischemic acute kidney injury and the mechanisms vital for recovery, 2) molecular mediation of injurious crosstalk between the kidneys and lungs, and 3) risk stratified biomarker incorporation for prediction of acute kidney injury onset, severity, and duration.


    A photo of Ranjit Chima.

    Ranjit S. Chima, MD

    is a clinical assistant professor within the UC Department of Pediatrics with an interest in critically ill stem cell transplant recipients. His research is focused on predicting and improving outcomes for critically ill stem cell transplant recipients. This work is done in close collaboration with the Division of Bone Marrow Transplantation and Immunodeficiency.


    A photo of Lesley Doughty.

    Lesley A. Doughty, MD Physician, Division of Critical Care Medicine

    is a clinician scientist whose basic science research program focuses on the molecular mechanisms underlying the inflammatory synergy observed during viral and bacterial co-infection. Specific areas of focus include the impact of influenza and antiviral cytokines on TLR signaling.


    A photo of Jennifer Kaplan.

    Jennifer M. Kaplan, MD, MS

    is an attending physician in the PICU who has basic and translational research programs. Her laboratory focuses on understanding the inflammatory responses in sepsis, with a specific interest in the role of the nuclear receptor PPAR gamma. Dr. Kaplan is conducting a Phase 1 clinical trial to evaluate the pharmacokinetic characteristics, safety profile, and effect on inflammatory markers of pioglitazone in patients with severe sepsis and septic shock. Pioglitazone belongs to a class of drugs called thiazolidinediones (TZDs), which are commonly used in patients with type 2 diabetes and ligands for PPAR gamma. Her laboratory also focuses on the increased susceptibility of diet-induced obesity to sepsis. She focuses on the critical links between the inflammatory pathways in sepsis and obesity.
    Visit the Kaplan Lab.


    A photo of Sue Poynter.

    Sue E. Poynter, MD, MEd Co-Director, Pediatric Residency Training Program

    is a co-director of the Pediatric Residency Training Program with an interest in medical education, curriculum development and educational research.


    A photo of Carley L. Riley.

    Carley L. Riley, MD, MPP, MHS, FAAP Attending Physician, Division of Critical Care Medicine

    aims to generate actionable knowledge to inform multi-sector interventions to foster creation of high well-being populations. She aims to encourage a paradigm shift in how health and heath creation are viewed, with research in healthcare and non-healthcare investments in health, including social determinants of health as a central feature, with projects from the PICU to the community.


    A photo of Ken Tegtmeyer.

    Ken Tegtmeyer, MD

    develops multimedia medical education tools involving video as well as 2- and 3D animations to enhance medical education. Dr. Tegtmeyer is also interested in resuscitation and is in charge of the code and MRT processes.


    A photo of Brian Varisco.

    Brian M. Varisco, MD

    is interested in the cell-matrix interactions and matrix remodeling events during lung development and lung regeneration. Through our use of mouse models, we aim to leverage our findings to develop new therapies to reverse impaired lung development following premature birth and improve lung repair and regeneration following lung injury.
    Visit the Varisco Lab.


    A photo of Derek Wheeler.

    Derek S. Wheeler, MD, MMM Chief of Staff

    is a pediatric intensivist who has translational and clinical research interests in the fields of pediatric sepsis and shock. He is also the associate chief of staff. Additional research interests include hospital-acquired infection, quality improvement and patient safety.


    A photo of Basilia Zingarelli.

    Basilia Zingarelli, MD, PhD Director, Basic Science Research

    focuses on molecular mechanisms of organ injury during sepsis, trauma and hemorrhage. Her research also involves the identification of age-dependent pathological mechanisms, with special focus on anti-inflammatory nuclear receptors, whose activation may have a clinical therapeutic application in the treatment of critically ill patients.
    Visit the Zingarelli Lab.