Raj K. Basu, MD
Co-Director, Center for Acute Care Nephrology
is a pediatric intensivist who has basic and clinical research programs investigating the impact of acute kidney injury on critical illness. His lab studies the chemical signals involved in injurious crosstalk between the kidneys and lungs. His translational studies investigate the identification of early signs of acute kidney injury.
513-636-4259
rajit.basu@cchmc.org
Raj K. Basu, MD
Co-Director, Center for Acute Care Nephrology
Academic Information
Assistant Professor, UC Department of Pediatrics
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Specialties
Pediatric Critical Care, Acute kidney injury, ethics/end-of-life care
Biography
Dr. Basu arrived at Cincinnati Children's after completing his residency and fellowship training at Children’s Memorial Hospital in Chicago. The focus of his research efforts thus far have been in increasing the appreciation for the impact of acute kidney injury (AKI) on critical illness. In addition to his research and publication efforts, Dr. Basu has been actively involved in the fellowship program coordinating numerous lectures, an ethics curriculum, and mentoring residents/fellows. He also currently sits on the hospital action committees dedicated to improving the care of status asthmaticus and status epilepticus.
Education and Training
MD: Indiana University, Indianapolis, IN 2003
Residency: Pediatrics, Northwestern University Children’s Memorial Hospital, Chicago, IL, 2003-2006
Fellowship: Pediatric Critical Care, Northwestern University Children’s Memorial Hospital, Chicago, IL, 2006-2009
Certifications: Pediatrics, 2006; Critical Care, 2010
Publications
View PubMed Publications
HR Wong, NZ Cvijanovich, GL Allen, NJ Thomas, RJ Freishtat, N Anas, K Meyer, PA Checchia, R Lin, TP Shanley, MT Bigham, DS Wheeler, LA Doughty, K Tegtmeyer, SE Poynter, JM Kaplan, RS Chima, E Stalets, RK Basu, BM Varisco, and FE Barr. “Validation of a Gene Expression-Based Subclassification Strategy for Pediatric Septic Shock”. Critical Care Medicine, 2011 Jun 23. Rajit K. Basu, E Donaworth, DS Wheeler, P Devarajan, and HR Wong. “Antecedent acute kidney injury worsens subsequent endotoxin-induced lung inflammation in a 2-hit mouse model”. Am Journ Physio Renal Physiology, 2011 Jun 15. Rajit K. Basu and Derek Wheeler. “Effects of ischemic acute kidney injury on lung water balance: Nephrogenic pulmonary edema.” Pulmonary Med 2011; 2011. Rajit K. Basu, DS Wheeler, SL Goldstein, and LA Doughty. “Acute Renal Replacement Therapy in Pediatrics”. International Journal of Nephrology, 2011; 2011: 785392. Rajit K. Basu, Wong H, Wheeler DS, Devarajan P. “Acute Kidney Injury in Pediatrics, an Update and Review”.Pediatric Crit Care Med, 2011, May; 12(3): 339-47 Rajit K. Basu, S Hubchak, T Hayashida, CE Runyan, PT Schumacker, HW Schnaper. Interdependence of HIF-1 and TGF- signaling in normoxic and hypoxic renal epithelial cell collagen expression.Am Journ Physio Renal Physiology, Jan 2011, 300: F898-905. Rajit K. Basu and Derek Wheeler. “Approaches to the management of acute kidney injury in children.” Recent Patents on Biomarkers 2011, 1:49-59. Hector R. Wong, Derek S. Wheeler, Ken Tegtmeyer, Sue E. Poynter, Jennifer M. Kaplan, Ranjit S. Chima, Erika Stalets, Rajit K. Basu, Lesley A. Doughty. “Toward a clinically feasible gene expression-based subclassification strategy for septic shock: Proof of concept”.Critical Care Med 2010 Oct; 38(10): 1955-61.
Grants
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Ranjit S. Chima, MD
is a pediatric intensivist who studies the inflammatory response following ischemia-reperfusion as seen in hemorrhagic shock. The focus of his work is to study and modulate lung inflammation and injury in this setting.
513-636-4259
ranjit.chima@cchmc.org
Ranjit S. Chima, MD
Academic Information
Assistant Professor, UC Department of Pediatrics
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Specialties
Lung injury; lung inflammation; hemorrhagic shock
Biography
Education and Training
MBBS: Grant Medical College, Mumbai, India, 1996. MD: Pediatrics, University of Mumbai, Mumbai, India, 1999. Residency: Pediatrics, University of Mumbai, Mumbai, India, 1996-1999; Pediatrics, Children's Hospital of Michigan, Detroit, MI, 2001-2004. Fellowship: Critical Care Medicine, Cincinnati Childrens Hospital Medical Center, 2004-2007. Certification: Pediatrics, 2004.
Publications
View PubMed Publications
Chima RS, Lamontagne T, Piraino G, Hake PW, Denenberg A, Zingarelli B. C-peptide, a novel inhibitor of lung inflammation following hemorrhagic shock. Am J Physiol Lung Cell Mol Physiol. 2011 May;300(5):L730-9. Chima RS, Maltese G, Lamontagne T, Piraino G, Denenberg A, O'Connor M, Zingarelli B. C-Peptide ameliorates kidney injury following hemorrhagic shock. Shock. 2011 May;35(5):524-9. Chima RS, Zingarelli B. Toll-like receptor-2 and disturbances of the cardiac rhythm: life changes in a heartbeat. Crit Care Med. 2010 Oct;38(10):2062-3. Wong HR, Wheeler DS, Tegtmeyer K, Poynter SE, Kaplan JM, Chima RS, Stalets E, Basu RK, Doughty LA. Toward a clinically feasible gene expression-based subclassification strategy for septic shock: proof of concept. Crit Care Med. 2010 Oct;38(10):1955-61. Chima RS, Hake PW, Piraino G, Mangeshkar P, O'Connor M, Zingarelli B. Ciglitazone, a novel inhibitor of lung apoptosis following hemorrhagic shock. Int J Clin Exp Med. 2010 Jan 1;3(1):1-9. Chima RS, Hake P, Mangeshkar P, Piraino G, Denenberg A, Zingarelli B. Ciglitazone ameliorates lung inflammation by inhibiting NF-κB/IKK pathway in hemorrhagic shock. Crit Care Med. 2008 Oct;36(10):2849-57. Chima RS, Zingarelli B. Surfactant treatment of neonatal acute respiratory distress syndrome: is "fortification" the answer? Crit Care Med. 2007;35(10):2442-3.
Grants
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Lesley A. Doughty, MD
Physician, Division of Critical Care Medicine
is a clinician scientist whose basic science research program focuses on the molecular mechanisms underlying the inflammatory synergy observed during viral and bacterial co-infection. Specific areas of focus include the impact of influenza and antiviral cytokines on TLR signaling.
513-636-4259
lesley.doughty@cchmc.org
Lesley A. Doughty, MD
Physician, Division of Critical Care Medicine
Academic Information
Associate Professor, UC Department of Pediatrics
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Specialties
Sepsis; multiple organ failure; viral immunomodulation
Biography
Education and Training
MD: Dartmouth Medical School.
Residency: Tripler Army Medical Center.
Fellowship: Children's Hospital of Pittsburgh.
Publications
View PubMed Publications
Goodman DM, Winkler MK, Fiser RT, Abd-Allah S, Mathur M, Rivero N, Weiss IK, Peterson B, Cornfield DN, Mink R, Nozik Grayck E, McCabe ME, Schuette J, Nares MA, Totapally B, Petrillo-Albarano T, Wolfson RK, Moreland JG, Potter KE, Fackler J, Garber N, Burns JP, Shanley TP, Lieh-Lai MW, Steiner M, Tieves KS, Goldsmith M, Asuncion A, Ross SL, Howell JD, Biagas K, Ognibene K, Joshi P, Rubenstein JS, Kocis KC, Cheifetz IM, Turner DA, Doughty L, Hall MW, Mason K, Penfil S, Morrison W, Hoehn KS, Watson RS, Garcia RL, Storgion SA, Fleming GM, Castillo L, Tcharmtchi MH, Taylor RP, Ul Haque I, Crain N, Baden HP, Lee KJ. The Accreditation Council for Graduate Medical Education proposed work hour regulations. Pediatr Crit Care Med. 2011 Jan;12(1):120-121.
Wong HR, Wheeler DS, Tegtmeyer K, Poynter SE, Kaplan JM, Chima RS, Stalets E, Basu RK, Doughty LA. Toward a clinically feasible gene expression-based subclassification strategy for septic shock: proof of concept. Crit Care Med. 2010 Oct;38(10):1955-61.
Giuliano JS Jr, Lahni PM, Harmon K, Wong HR, Doughty LA, Carcillo JA, Zingarelli B, Sukhatme VP, Parikh SM, Wheeler DS. Admission angiopoietin levels in children with septic shock. Shock. 2007 Dec;28(6):650-654.
Wheeler DS, Lahni P, Odoms K, Jacobs BR, Carcillo JA, Doughty LA, Wong HR. Extracellular heat shock protein 60 (Hsp60) levels in children with septic shock. Inflamm Res. 2007 May;56(5):216-9.
Han YY, Doughty LA, Kofos D, Sasser H, Carcillo JA. Persistently Increased Procalcitonin Is Associated with Poor Outcome among Children with Bacterial Sepsis. Crit Care Med. 2003;4:21-25.
Ayala A, Chung CS, Lomas J, Song GY, Doughty LA, Gregory SH, Cioffi WG, LeBlanc BW, Reichner J, Simms HH, Grutkoski P. Shock Induced Neutrophil Mediated Priming for Acute Lung Injury in Mice: Divergent Effects of TLR 4 and TLR 4 / FasL Deficiency. AJP. 2003;161:2283-2294.
Lomas JL, Chung CS, Grutkoski pS, LeBlanc BW, Lavigne L, Reichner J, Gregory SH, Doughty LA, Cioffi WG, Ayala A. Differential Effects of MIP-2 and KC on Hemorrhage Induced Neutrophil Priming for Lung Inflammation: Assessment by Adoptive Cells. Shock. 2003;19(4):358-365.
Carcillo JA, Doughty L, Kofos D, Frye RF, Kaplan SS, Sasser H, Burckart GJ. Cytochrome P450 mediated-drug metabolism is reduced in children with sepsis-induced multiple organ failure. Intensive Care Medicine. 2003;29:980-984.
Durbin J, Doughty L, Nguyen K, Caliguri M, Van Deusen J, Biron C. The role of STAT1 in viral sensitization to LPS. J Endotoxin Res. 2003;9:313-316.
Doughty LA. Modulation of the immune response in critical illness / injury. Immunology and Infectious Disease. Eds. Doughty L. and Linden P. Kluwer Academic Publishers, Norwell, MA, 2003.
Grants
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Jennifer M. Kaplan, MD, MS
is an attending physician in the PICU who has basic and translational research programs. Her laboratory focuses on understanding the inflammatory responses in sepsis, with a specific interest in the role of the nuclear receptor PPAR gamma. A second focus is on the increased susceptibility of diet-induced obesity to sepsis. She focuses on the critical links between the inflammatory pathways in sepsis and obesity.
513-636-4259
jennifer.kaplan@cchmc.org
Jennifer M. Kaplan, MD, MS
Academic Information
Assistant Professor, UC Department of Pediatrics
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Specialties
Intensive care; respiratory failure; multi-organ failure; sepsis; trauma; inflammation; obesity; PPARg
Biography
My long term career goal is to improve the outcomes of critically ill children. I began my research career in fellowship studying sepsis, driven by the realization that there are few clinical therapies that improve outcomes in critically ill children with severe infections. I focused on the nuclear receptor PPARg as a potential target to alter the sepsis-induced inflammatory state. PPARg is a nuclear receptor with effects on lipid and glucose metabolism, atherosclerosis and inflammation. I elected to extend my fellowship a fourth year to complete training in molecular epidemiology and the Masters of Science program at the University of Cincinnati Academic Health Center. I received grant funding from the Translational Research Initiative and the NIH K12 Child Health Research Career Development Award at CCHMC to investigate the alteration of PPARg in peripheral blood cells from children with sepsis. I am a recipient of an NIH Mentored Clinical Scientist Research Career Development Award (K08).
Education and Training
MS: Epidemiology, University of Cincinnati College of Medicine, Cincinnati, OH. MD: University of Cincinnati, Cincinnati, OH, 1999. BA: Washington University in St. Louis, St. Louis, Missouri. Fellowship: Pediatric Critical Care Medicine, Cincinnati Children's Hospital Medical Center, Cincinnati, OH.
Residency: Pediatrics, Orlando Regional Healthcare, Orlando, FL.
Certification: Pediatric Critical Care Medicine, Pediatrics.
Publications
View PubMed Publications.
Wong HR, Cvijanovich N, Allen G, Thomas N, Freishtat R, Anas N, Meyer K, Checchia P, Lin R, Shanley T, Bigham M, Wheeler DS, Doughty LA Tegtmeyer K, Poynter SE, Kaplan JM, Chima RS, Stalets E, Basu RK, Varisco B, Barr F. Validation of a gene expression-based subclassification strategy for pediatric septic shock. Crit Care Med. 2011 Jun 23. Epub ahead of print. Kaplan JM, Zingarelli B. Novel therapeutic agents in pediatric sepsis: peroxisome proliferator receptor g (PPARg). The Open Inflammation Journal. 2011; 4: 117-121. Kaplan JM, Wong HR. Biomarker discovery and development in pediatric critical care medicine. Pediatr Crit Care Med. 2011; 12: 165-173. Sherwin CMT, Ding L, Kaplan J, Spigarelli MG, Vinks AA. Optimal design for a single dose, sparse sampling, pharmacokinetic study in pediatrics subpopulations: A proposed study of pioglitazone in septic pediatric patients. Journal of Pharmacokinetics and Pharmacodynamics. 2011; 38:433-447. Kaplan JM, Hake P, Denenberg A, Nowell M, Piraino G, Zingarelli B. Phosphorylation of Extracellular Signal-Regulated Kinase (ERK)-1/2 is Associated with the Downregulation of Peroxisome Proliferator Activated Receptor (PPAR)-g During Polymicrobial Sepsis. Mol Med. 2010 Nov-Dec; 16(11-12): 491-7. Kaplan JM, Denenberg A, Monaco M, Nowell M, Wong H, Zingarelli B. Changes in Peroxisome Proliferator Activated Receptor-gamma Activity in Children with Septic Shock. Intensive Care Med. 2010 Jan; 36(1): 123-130. Kaplan JM, O’Connor M, Zingarelli B. Peroxisome Proliferator Activated Receptor-g is Required for the Inhibitory Effect of Ciglitazone but not 15-Deoxy-Δ12,14-Prostaglandin J2 on the NF-kB Pathway in Human Endothelial Cells. Shock. 2007 Dec; 28(6): 722-726. Kaplan JM, Ancheta R, Jacobs BR. Inpatient Verbal Orders and the Impact of Computerized Provider Order Entry. J Pediatr. 2006 Oct; 149(4): 461-467. Kaplan JM, Cook JA, Hake PW, O’Connor M, Burroughs TJ, Zingarelli B. 15-Deoxy-Δ12,14-Prostaglandin J2 (15d-PGJ2), A Peroxisome Proliferator Activated Receptor-g Ligand, Reduces Tissue Leukosequestration and Mortality in Endotoxic Shock. Shock. 2005 July; 24(1): 59-65. Kaplan J, O’Connor M, Hake PW, Zingarelli B. Inhibitors of Poly (ADP-Ribose) Polymerase Ameliorate Myocardial Reperfusion Injury by Modulation of Activator Protein-1 and Neutrophil Infiltration. Shock. 2005 Mar; 23(3):233-238.
Grants
Pioglitazone in Adolescents with Severe Sepsis and Septic Shock. Institutional Award Recipient. CCTST Junior T1 Pilot Award. Jun 2011 - May 2012. PPAR gamma in pediatric sepsis and the inflammatory response in obesity.Principal Investigator. NIH-K08GM093135. Apr 2010 - Mar 2014.
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Kristen Page, PhD
is a basic researcher investigating the mechanisms of allergic airway inflammation with specific interest in protease-activated receptor (PAR)2 and pattern-recognition receptors (PAMPs). Her lab also focuses on the early response to allergens by airway epithelial cells and mucosal dendritic cells. An emerging area of interest involves the role of dendritic cells in regulating immune responses and disease severity in sepsis.
513-636-3079
kristen.page@cchmc.org
Kristen Page, PhD
Academic Information
Associate Professor, UC Department of Pediatrics
Show All
Specialties
Asthma, innate immune response, septic shock
Biography
Education and Training
PhD: Rush-Presbyterian-St. Luke's Medical Center, Chicago, IL 1997.
Fellowship: University of Chicago, Chicago, IL 1997-1999.
Publications
View PubMed Publications
Lewkowich IP, Day SB*, Ledford JR, Zhou P, Dienger K, Wills-Karp M, Page K. Protease-activated receptor activation of myeloid dendritic cells regulates allergic airway inflammation. Respir Res. 2011;12:122. Day SB*, Ledford JR, Zhou P, Lewkowich IP, Page K. German cockroach proteases and protease-activated receptor-2 regulate chemokine production and dendritic cell recruitment. Journal of Innate Immunity. 2011. Page K, Zhou P, Ledford JR, Day SB, Lutfi R, Dienger K, Lewkowich IP. Early immunological response to german cockroach frass exposure induces a th2/th17 environment. J Innate Immun. 2011;3(2):167-79. Day SB, Zhou P, Ledford JR, Page K. German cockroach frass proteases modulate the innate immune response via activation of protease-activated receptor-2. J Innate Immun. 2011;2(5):495-504. Page K, Ledford JR, Zhou P, Dienger K, Wills-Karp M. Mucosal sensitization to German cockroach involves protease-activated receptor-2. Respir Res. 2011 May;11:62. Wills-Karp M, Nathan A, Page K, Karp CL. New insights into innate immune mechanisms underlying allergenicity.Mucosal Immunol. 2010 Mar;3(2):104-10. Page K, Ledford JR, Zhou P, Wills-Karp M. A TLR2 agonist in German cockroach frass activates MMP-9 release and is protective against allergic inflammation in mice. J Immunol. 2009 Sep;183(5):3400-8. Page K, Lierl KM, Hughes VS, Zhou P, Ledford JR, Wills-Karp M. TLR2-mediated activation of neutrophils in response to German cockroach frass. J Immunol. 2008 May;180(9):6317-24. Chase MA*, Wheeler DS, Lierl KM, Hughes VS, Wong HR, Page K. Heat shock protein-72 induces inflammation and regulates cytokine production in airway epithelium through a TLR4 and NF-kappaB dependent mechanism. J Immunol. 2007;179:6318-6324. Page K, Li J, Zhou L, Iazvovskaia S, Corbit KC, Soh J-W, Weinstein IB, Brasier AR, Lin A, Hershenson MB. Regulation of airway epithelial cell NF-kappa B-dependent gene expression by protein kinase C delta. J Immunol. 2003;170:5681-5689.
Grants
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Sue E. Poynter, MD
Associate Director, Pediatric Residency Program
is an Associate Director of Pediatric Residency Training Program with an interest in medical education, curriculum development and educational research.
513-636-4259
sue.poynter@cchmc.org
Sue E. Poynter, MD
Associate Director, Pediatric Residency Program
Academic Information
Assistant Professor, UC Department of Pediatrics
Assistant Professor, Procter Scholar
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Specialties
Surfactant biology, lung immunity and acute lung injury
Biography
Education and Training
MD: Indiana University School of Medicine, Indianapolis, IN, 1997. Residency: Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 1997-2000. Chief Residency: Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 2000-2001. Fellowship: Cincinnati Children's Hospital Medical Center, Cincinnati, OH, Feb 2001-July 2004. Certification: American Board of Pediatrics, 2000, 2007; Pediatric Critical Care, 2004.
Publications
View PubMed Publications
Wheeler DS, Dunsmore KE, Denenberg AG, Muething L, Poynter SE, Wong HR. Biological activity of truncated C-terminus human heat shock protein 72.Immunol Lett. 2011 Mar 30;135(1-2):173-9. Wong HR, Wheeler DS, Tegtmeyer K, Poynter SE, Kaplan JM, Chima RS, Stalets E, Basu RK, Doughty LA. Toward a clinically feasible gene expression-based subclassification strategy for septic shock: proof of concept.Crit Care Med. 2010 Oct;38(10):1955-61. Wheeler DS, Chase MA, Senft AP, Poynter SE, Wong HR, Page K. Extracellular Hsp72, an endogenous DAMP, is released by virally infected airway epithelial cells and activates neutrophils via Toll-like receptor (TLR)-4.Respir Res. 2009 Apr 30;10:31. Wheeler DS, Lahni PM, Denenberg AG, Poynter SE, Wong HR, Cook JA, Zingarelli B. Induction of endotoxin tolerance enhances bacterial clearance and survival in murine polymicrobial sepsis.Shock. 2008 Sep;30(3):267-73. Poynter SE, LeVine AM. Surfactant biology and clinical application. Crit Care Clin. 2003 Jul;19(3):459-72. Review.
Grants
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Erika L. Stalets, MD
is a clinical intensivist interested in quality improvement and patient safety. She is a Quality Scholar and working toward her MS in clinical and translations research. Her research focus is the reliable delivery of evidenced-based care to pediatric patients with septic shock.
513-636-4259
erika.stalets@cchmc.org
Erika L. Stalets, MD
Academic Information
Assistant Professor, UC Department of Pediatrics
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Specialties
Quality Improvement; sepsis; multi-organ dysfunction
Biography
Education and Training
MD: Southern Illinois University School of Medicine, Springfield, IL, 1997-2001. Residency: Internal Medicine and Pediatrics, University of Tennessee Health Science Center, Memphis, TN, 2001-2005. Chief Residency: Pediatrics. LeBonheur Children’s Medical Center, University of Tennessee Health Science Center, Memphis, TN, 2005-2006. Fellowship: Pediatric Critical Care, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, 2006-2009. Certification: American Board of Pediatrics, 2005; Sub-Board of Pediatric Critical Care Medicine, 2010; American Board of Internal Medicine, 2005.
Grants
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Ken Tegtmeyer, MD
Academic Information
Associate Professor, UC Department of Pediatrics
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Specialties
Shock; sepsis; respiratory failure; head trauma; mechanical ventilation; multimedia medical education
Biography
Education and Training
MD: University of Minnesota, Twin Cities, 1992. Residency: Pediatrics, University of Minnesota, 1995. Fellowship: Pediatric Critical Care, 1998. Certification: Pediatrics, 1996; Pediatric Critical Care, 2000, 2007.
Publications
View PubMed Publications
Wong HR, Wheeler DS, Tegtmeyer K, Poynter SE, Kaplan JM, Chima RS, Stalets E, Basu RK, Doughty LA. Toward a clinically feasible gene expression-based subclassification strategy for septic shock: proof of concept. Crit Care Med. 2010 Oct;38(10):1955-61. Malempati S, Joshi S, Lai S, Braner DA, Tegtmeyer K. Videos in clinical medicine. Bone marrow aspiration and biopsy. N Engl J Med. 2009 Oct 8;361(15):e28. Anderson J, Leonard D, Braner DA, Lai S, Tegtmeyer K. Videos in clinical medicine. Umbilical vascular catheterization. N Engl J Med. 2008 Oct 9;359(15):e18. Braner DA, Lai S, Eman S, Tegtmeyer K. Videos in clinical medicine. Central venous catheterization--subclavian vein. N Engl J Med. 2007 Dec 13;357(24):e26. Edelman A, Anderson J, Lai S, Braner DA, Tegtmeyer K. Videos in clinical medicine: Pelvic examination. N Engl J Med. 2007 Jun 28; 356(26):e26. Graham AS, Ozment C, Tegtmeyer K, Lai S, Braner DA. Videos in clinical medicine: Central venous catheterization. N Engl J Med. 2007 May 24; 356(21):e21. Ellenby MS, Tegtmeyer K, Lai S, Braner DA. Videos in clinical medicine. Lumbar puncture.N Engl J Med. 2006 Sep 28;355(13):e12.
Tegtmeyer K, Brady G, Lai S, Hodo R, Braner D. Videos in Clinical Medicine. Placement of an arterial line. N Engl J Med. 2006 Apr 13;354(15):e13.
Cornfield DN, Tegtmeyer K, Nelson MD, Milla CE, Sweeney M. Continuous propofol infusion in 142 critically ill children. Pediatrics. 2002 Dec;110(6):1177-81. Tegtmeyer K, Ibsen L, Goldstein B. Computer-assisted learning in critical care: from ENIAC to HAL. Crit Care Med. 2001 Aug;29(8 Suppl):N177-82.
Grants
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Brian M.Varisco, MD
is interested in the cell-matrix interactions and matrix remodeling events of normal and impaired alveolar development. Through our use of mouse models, we aim to leverage our findings to develop new therapies to improve alveolarization following premature birth. Visit the Varisco Lab.
513-803-2485
brian.varisco@cchmc.org
Brian M.Varisco, MD
Academic Information
Instructor, UC Department of Pediatrics
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Specialties
Lung development; lung fibroblast biology; chronic lung disease / bronchopulmonary dysplasia Visit the Varisco Lab.
Biography
Education and Training
MD: Medical College of Georgia, Augusta, GA, 2004. Residency: Pediatrics, The Children's Hospital, Denver, CO. Fellowship: Pediatrics, The Children's Hospital, Denver, CO. Certification: Pediatrics, 2008; Pediatric Critical Care Medicine, 2011.
Publications
View PubMed Publications
Varisco BM. The pharmacology of acute lung injury in sepsis. Adv Pharmacol Sci. 2011 Jun. Epub ahead of print.
Wong HR, Cvijanovich NZ, Allen GL, Thomas NJ, Freishtat RJ, Anas N, Meyer K, Checchia PA, Lin R, Shanley TP, Bigham MT, Wheeler DS, Doughty LA, Tegtmeyer K, Poynter SE, Kaplan JM, Chima RS, Stalets E, Basu RK, Varisco BM, Barr FE. Validation of a gene expression-based subclassification strategy for pediatric septic shock. Crit Care Med. 2011 Jun 23. Epub ahead of print.
Tofil NM, Benner KW, Zinkan L, Alten JA, Varisco BM, White MW. Pediatric intensive care simulation course: a new paradigm in teaching. J Grad Med Edu. 2011 Mar;3(1):81-87.
Sanders YY, Tollefsbol TO, Varisco BM, Hagood JS. Epigenetic Regulation of Thy-1 by Histone Deacetylase Inhibitor in Rat Lung Fibroblasts. Am J Respir Cell Mol Biol. 2011 Jul; 45(1):16-23. Varisco BM, Palmitier CM, Alten JA. Reversal of Severe Hypoxemia with Calfactant and Complete Neurologic Recovery in a Hypothermic Drowning Victim. Pediatr Emerg Care. 2010 Aug;26(8):571-3. Varisco BM, Benner KW, Prabhakaran P. Neonatal peritoneal candidiasis successfully treated with anidulafungin add-on therapy. Ann Pharmacother. 2009 Nov;43(11):1907-10.
Varisco B, McAlvin B, Dias J, Franga D. Adenocarcinoid of the appendix: is right hemicolectomy necessary? A meta-analysis of retrospective chart reviews.Am Surg. 2004 Jul;70(7):593-9.
Grants
Thy-1 is Critical in Pulmonary Fibroblast PGE2 Synthesis. Principal Investigator. National Institutes of Health. Apr 2011 - Mar 2013.
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Basilia Zingarelli, MD, PhD
Director, Basic Science Research
focuses on molecular mechanisms of organ injury during sepsis, trauma and hemorrhage. Her research also involves the identification of age-dependent pathological mechanisms, with special focus on anti-inflammatory nuclear receptors, whose activation may have a clinical therapeutic application in the treatment of critically ill patients.
513-636-8704
basilia.zingarelli@cchmc.org
Basilia Zingarelli, MD, PhD
Director, Basic Science Research
Academic Information
Professor, UC Department of Pediatrics
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Specialties
Sepsis; trauma; hemorrhagic shock and ischemia and reperfusion injury.
Biography
Basilia Zingarelli, MD, PhD, came to Cincinnati Children's Hospital Medical Center in 1995 as a post-doctoral research fellow in Critical Care Medicine. She joined the faculty in 1997. Dr. Zingarelli graduated from the Medical School of the University of Messina in Italy in 1990. She also obtained a doctorate in Experimental Medicine in 1997 and attended a residency in Medical Toxicology at the University of Messina from 1990 to 1992.
Dr. Zingarelli now directs the Basic Science Research in the Division of Critical Care Medicine. She directs an NIH-funded research laboratory focused on the pathogenetic mechanisms of organ injury during sepsis, trauma and hemorrhage and coordinates basic science and clinical translational research projects related to other critical care conditions.
Dr. Zingarelli serves on the Executive Council of the Shock Society, a well-established international association of clinical and research scientists in the field of shock and trauma, and serves as Associate Editor for the journal Shock. She also serves as permanent and ad hoc member on a number of study sections at the National Institutes of Health.
Education and Training
MD: School of Medicine, University of Messina, Italy, 1990. PhD: Experimental Medicine, School of Medicine, University of Messina, Italy, 1997. Residency: Medical Toxicology, School of Medicine, University of Messina, Italy, 1990-1992. Certification: General Medicine (Italian), 1990.
Publications
View PubMed Publications
Chima RS, LaMontagne T, Piraino G, Hake PW, Denenberg A, Zingarelli B. C-peptide, a novel inhibitor of lung inflammation following hemorrhagic shock. Am J Physiol Lung Cell Mol Physiol. 2011 May;300(5):L730-9.
Solan PD, Piraino G, Hake PW, Denenberg A, O'Connor M, Lentsch A, Zingarelli B. Liver X receptor α activation with the synthetic ligand T0901317 reduces lung injury and inflammation after hemorrhage and resuscitation via inhibition of the NF-κB pathway. Shock. 2011; 35:367-374. Kaplan JM, Hake PW, Denenberg A, Nowell M, Piraino G, Zingarelli B. Phosphorylation of extracellular signal-regulated kinase (ERK)-1/2 Is associated with the downregulation of peroxisome proliferator-activated receptor (PPAR)-γ during polymicrobial sepsis. Mol Med. 2010 Nov-Dec;16(11-12):491-7. Zingarelli B, Piraino G, Hake PW, O'Connor M, Denenberg A, Fan H, Cook JA. Peroxisome proliferator-activated receptor {delta} regulates inflammation via NF-{kappa}B signaling in polymicrobial sepsis. Am J Pathol. 2010 Oct;177(4):1834-47. Zingarelli B, Chima R, O'Connor M, Piraino G, Denenberg A, Hake PW. Liver apoptosis is age dependent and is reduced by activation of peroxisome proliferator-activated receptor-gamma in hemorrhagic shock. Am J Physiol Gastrointest Liver Physiol. 2010 Jan;298(1):G133-41. Kaplan JM, Denenberg A, Monaco M, Nowell M, Wong H, Zingarelli B. Changes in peroxisome proliferator-activated receptor-gamma activity in children with septic shock. Intensive Care Med. 2010 Jan;36(1):123-30.
Zingarelli B, Hake PW, O'Connor M, Burroughs TJ, Wong HR, Solomkin JS, Lentsch AB. Lung injury after hemorrhage is age dependent: role of peroxisome proliferator-activated receptor gamma. Crit Care Med. 2009 Jun;37(6):1978-87.
Zingarelli B, Fan H, Ashton S, Piraino G, Mangeshkar P, Cook JA. Peroxisome proliferation-activated receptor (PPAR) γ is not necessary for the development of LPS-induced tolerance. Immunology. 2008;124:51-57. Chima RS, Hake PW, Piraino G, Mangeshkar P, Denenberg A, Zingarelli B. Ciglitazone ameliorates lung inflammation by modulating the inhibitor kappaB protein kinase/nuclear factor-kappaB pathway after hemorrhagic shock. Crit Care Med. 2008 Oct;36(10):2849-57. Vish MG, Mangeshkar P, Piraino G, Denenberg A, Hake PW, O'Connor M, Zingarelli B. Proinsulin c-peptide exerts beneficial effects in endotoxic shock in mice. Crit Care Med. 2007 May;35(5):1348-55.
Grants
Role of Eicosanoids In Shock. Co-Investigator. National Institutes of Health. Jul 2008 - Jun 2012. #R01 GM 027673. Mechanisms of Age-Related Inflammatory Response in Hemorrhagic Shock. Principal Investigator. National Institutes of Health. Sep 2007 - Aug 2012. #R01 AG 027990. Host response to trauma research training program. Faculty/mentor. National Institutes of Health (T32 GM08478). Jul 2003-Jun 2013. Interferon-mediated reprogramming of Toll-like receptor signaling. Co-Investigator. National Institutes of Health. Jul 2008 - Jun 2013. #R01 GM085063.
Role of PPARgamma and PPARgamma Agonists in Septic Shock. Principal Investigator. National Institutes of Health. Jul 2008 - Jun 2013. #R01 GM 067202.
MMP-8 as a novel therapeutic target in sepsis. Co-Investigator. National Institutes of Health. Jul 2011 - Jun 2015. #R01 GM096994.
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