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At Cincinnati Children’s Hospital Medical Center, the Clinical Translational Research Center’s Biochemistry Core Laboratory provides investigators the following services:
As stipulated by the Scientific Advisory Committee, the Core Laboratory functions to more efficiently serve the common needs of the investigators. The Laboratory has the expertise and facilities to execute most commercially available assays, The Core Laboratory can develop new tests with the approval of the CTRC Scientific Advisory Committee. Preference will be given to analyses used by more than one investigator and likely to be used by multiple investigators in the future.
New assays are recommended by the program director and/or Core Laboratory director. Final approval to include tests in the Core Laboratory portfolio of assays is discussed by the Scientific Advisory Committee prior to providing the tests for investigators.
The Biochemistry Core Laboratory is CAP (College of American Pathologists) and CLIA (Clinical Laboratory Improvement Amendments) certified.
The CTRC also offers a Sample Processing Lab.
The Clinical Translational Research Center Biochemistry Core Laboratory at Children’s Hospital Medical Center provides clinical and research assays for the study bone and mineral metabolism disorders:
Parathyroid hormone and vitamin D 25-OH are measured using chemiluminescence immunoassay (CLIA) methodology. 1, 25 dihydroxy vitamin D is measured by a competitive equilibrium radioimmunoassay (RIA).
Total calcium and phosphorus are measured on an automated analyzer (cobas c 311) using second generation chemistry methods.
The assorted formation and resorption markers (BALP,PICP, CICP, ICTP, NTx, PYD) are measured using ELISA methodologies.
The laboratory provides clinical and research assays for assessment of nutritional status: Carnitine (total, free, and short chain) is measured using a radio-enzymatic assay. Prealbumin levels are measured using an automated chemistry analyzer. Vitamins A and E are measured using HPLC methodology.
The laboratory provides many research assays for the assessment of endocrine health. The various hormone levels (ACTH, Cortisol, DHEAS, estradiol, FSH, LH, progesterone 17-OH, testosterone and TSH) can be measured by CLIA, ELISA, or RIA. Obesity related assays such as adiponectin, ghrelin, leptin, and PYY are measured by ELISA.
The laboratory currently uses ELISA methodologies for all human cytokine analyses.
The laboratory provides research assays for many general chemistries using a cobas c 311 automated analyzer. Assays available include lipid profiles, renal function, total bile acids, glucose, C-reactive protein as well as others listed in the Comprehensive Test Menu. Tests not listed but commercially available for the analyzers can be discussed with the laboratory supervisor.
The following assays are available to investigators through the Clinical Translational Research Center Biochemistry Core Laboratory at Cincinnati Children’s Hospital Medical Center. Details of the assay methods and measuring ranges can be obtained by contacting the laboratory supervisor.
For more information about the Clinical Translational Research Center Biochemistry Core Laboratory, contact Theresa Kenney, laboratory supervisor, at 513-636-2229 or firstname.lastname@example.org.
The Biochemistry Core Laboratory is on the Cincinnati Children’s Burnet Campus in Location R, third floor, room R3053.
3333 Burnet Avenue, Cincinnati, Ohio 45229-3026 | 1-513-636-4200 | 1-800-344-2462 | TTY:1-513-636-4900
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