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The Biochemistry Core Laboratory is CAP (College of American Pathologists) and CLIA (Clinical Laboratory Improvement Amendments) certified and functions to more efficiently serve the common needs of investigators by providing them with the expertise, facilities and services necessary to execute most commercially available clinical and research assays.
The Biochemistry Core Laboratory provides an analyte testing service for investigators in the following disciplines:
The Clinical Translational Research Center Biochemistry Core Laboratory at Children’s Hospital Medical Center provides clinical and research assays for the study bone and mineral metabolism disorders:
Parathyroid hormone and vitamin D 25-OH are measured using chemiluminescence immunoassay (CLIA) methodology. 1, 25 dihydroxy vitamin D is measured by a competitive equilibrium radioimmunoassay (RIA).
Total calcium and phosphorus are measured on an automated analyzer (cobas c 311) using second generation chemistry methods.
The assorted formation and resorption markers (BALP,PICP, CICP, ICTP, NTx, PYD) are measured using ELISA methodologies.
The laboratory provides clinical and research assays for assessment of nutritional status: Carnitine (total, free, and short chain) is measured using a radio-enzymatic assay. Prealbumin levels are measured using an automated chemistry analyzer. Vitamins A and E are measured using HPLC methodology.
The laboratory provides many research assays for the assessment of endocrine health. The various hormone levels (ACTH, Cortisol, DHEAS, estradiol, FSH, LH, progesterone 17-OH, testosterone and TSH) can be measured by CLIA, ELISA, or RIA. Obesity related assays such as adiponectin, ghrelin, leptin, and PYY are measured by ELISA.
The laboratory currently uses ELISA methodologies for all human cytokine analyses.
The laboratory provides research assays for many general chemistries using a cobas c 311 automated analyzer. Assays available include lipid profiles, renal function, total bile acids, glucose, C-reactive protein as well as others listed in the Comprehensive Test Menu. Tests not listed but commercially available for the analyzers can be discussed with the laboratory supervisor.
The following assays are available to investigators through the Clinical Translational Research Center Biochemistry Core Laboratory at Cincinnati Children’s Hospital Medical Center. Details of the assay methods and measuring ranges can be obtained by contacting the laboratory supervisor.
If you don't see the test you're looking for, you can request the development of a new test. Contact us with the requested test and the CTRC Scientific Advisory Committee will review the request. Preference will be given to analyses used by more than one investigator and likely to be used by multiple investigators in the future.
The Biochemistry Core Laboratory is CAP (College of American Pathologists) and CLIA (Clinical Laboratory Improvement Amendments) certified.
The CTRC provides a Sample Processing Laboratory to accommodate investigators’ immediate processing needs. Samples of blood, urine, stool, bile, etc. can be processed 24 hours a day and are stored according to protocol.
For questions, or to arrange a consultation, contact:
Theresa KenneyLaboratory Supervisor513firstname.lastname@example.org
3333 Burnet Avenue, Cincinnati, Ohio 45229-3026 | 1-513-636-4200 | 1-800-344-2462 | TTY:1-513-636-4900
New to Cincinnati Children’s or live outside of the Tristate area? 1-877-881-8479
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