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Tsuyoshi Fukuda, PhD
is director of the pharmacogenetics laboratory in the Division of Clinical Pharmacology. He focuses on drug metabolizing enzyme and transporter genetic variants, PK and response to medication and adverse drug events. He has developed innovative approaches in pharmacogenetic assay development, data analyses, integrated PK/PD/PG modeling of the clinical data set, and physiologically based pharmacokinetic (PBPK) analysis and model development.
Associate Professor, UC Department of Pediatrics
Clinical pharmacology (pharmacogenetics, pharmacokinetics and pharmacodynamics)
Dr. Fukuda received his pharmacy degree and PhD in pharmaceutical science from Osaka University, Japan. He received postdoctoral training in the Division of Clinical Pharmacology and Pharmacogenomics (Prof. J. Azuma, MD) and served as an assistant professor at Osaka University, Graduate School of Pharmaceutical Sciences. He joined the Division of Clinical Pharmacology (Prof. Alexander A Vinks, PharmD, PhD) at Cincinnati Children's Hospital Medical Center in 2007. He spent over 15 years in the field of clinical pharmacology while engaged in pharmacogenetic (PG) and pharmacokinetic-pharmacodynamic (PK/PD) research. His current research interests include the clinical application of integrated PK/PD/PG modeling and simulation and physiologically based pharmacokinetic (PBPK) analysis with developmental pharmacology, focusing on improving our understanding of inter-patient differences in drug response and developing individualized dosing strategies in pediatric patients.
Dr. Fukuda’s efforts have resulted in over 50 peer-reviewed publications with project members that include master's and PhD students, research fellows, clinical fellows, pharmacists, physicians, and private sector R & D staff.
Mizuno T, Fukuda T, Masuda S, Uemoto S, Matsubara K, Inui KI, Vinks AA. Developmental trajectory of intestinal MDR1/ABCB1 expression in children. Br J Clin Pharmacol. 2014 May;77(5):910-2.
Emoto C, Fukuda T, Cox S, Christians U, Vinks AA. Development of a physiologically-based pharmacokinetic model for sirolimus: predicting bioavailability based on intestinal CYP3A content. CPT Pharmacometrics Syst Pharmacol. 2013 Jul 24;2:e59.
Fukuda T, Chidambaran V, Mizuno T, Venkatasubramanian R, Ngamprasertwong P, Olbrecht V, Esslinger HR., Vinks AA, Sadhasivam S. Organic Cation Transporter 1 Genetic Variants influence the pharmacokinetics of Morphine in Children. Pharmacogenomics. 2013 Jul;14(10):1141-51.
Shimamoto Y, Fukuda T, Tanaka K, Komori K, Sadamitsu D. Systemic inflammatory response syndrome criteria and vancomycin dose requirement in patients with sepsis. Intensive Care Med. 2013 Jul;39(7):1247-52.
Shimamoto Y, Fukuda T, Tominari S, Fukumoto K, Ueno K, Dong M, Tanaka K, Shirasaka T, Komori K. Decreased vancomycin clearance in patients with congestive heart failure. Eur J Clin Pharmacol. 2013 Mar;69(3):449-57.
Fukuda T, Goebel J, Cox S, Maseck D, Zhang K, Sherbotie JR, Ellis EN, James LP, Ward RM, Vinks AA. UGT1A9, UGT2B7, and MRP2 genotypes can predict mycophenolic acid pharmacokinetic variability in pediatric kidney transplant recipients. Ther Drug Monit. 2012 Dec;34(6):671-9.
Hooper DK, Fukuda T, Gardiner R, Logan B, Roy-Chaudhury A, Kirby CL, Vinks AA, Goebel J. Risk of Tacrolimus Toxicity in CYP3A5 Non-Expressors Treated with Intravenous Nicardipine After Kidney Transplantation. Transplantation. 2012 Apr 27;93(8):806-12.
Fukuda T, Brunner HI, Sagcal-Gironella AC, Vinks AA. Non-steroidal Anti-Inflammatory Drugs may reduce Enterohepatic Recirculation of Mycophenolic Acid in Patients with Childhood-onset Systemic Lupus Erythematosus. Ther Drug Monit. 2011 Oct;33(5):658-62.
Sagcal-Gironella AC, Fukuda T, Wiers T, Cox S, Nelson S, Dina B, Sherwin CM, Klein-Gitelman MS, Vinks AA, Brunner HI. Pharmacokinetics and Pharmacodynamics of Mycophenolic Acid and Their Relation to Response to Therapy of Childhood-onset Systemic Lupus Erythematosus. Seminars in Arthritis and Rheumatism. 2011 Feb;40(4):307-13.
Fukuda T, Goebel J, Thøgersen H, Maseck D, Cox S, Logan B, Sherbotie J, Seikaly M, Vinks AA. Inosine Monophosphate Dehydrogenase (IMPDH) activity as a pharmacodynamic biomarker of Mycophenolic Acid effects in Pediatric Kidney Transplant Recipients. J Clin Pharmacol. 2011 Mar;51(3):309-20.
Alexander A. Vinks, PharmD, PhD, FCP Director, Division of Clinical Pharmacology
Director, Division of Clinical Pharmacology
Scientific Director, Pharmacy Research, Research in Patient Services
Professor, UC Department of Pediatrics
Adjunct Professor of Pharmacology
Sander Vinks, PharmD, PhD, FCP, is a professor of Pediatrics and Pharmacology at the University of Cincinnati, College of Medicine. He is the director of the Division of Clinical Pharmacology, and serves as director of the Pediatric Clinical and Developmental Pharmacology NIH T32 training program since 2011. He is co-director of Cincinnati Children’s Genetic Pharmacology Service, and Scientific Director for Pharmacy Research in the Division of Patient Services. He also directs the Laboratory of Applied Pharmacokinetics and Pharmacogenetics (LAPP) and a multidisciplinary Pharmacometrics Core. Dr. Vinks also serves as an advisor on an FDA pediatric sub-committee.
Dr. Vinks is the past president of the International Association of Therapeutic Drug Monitoring and Clinical Toxicology. He serves on the Board of Regents of the American College of Clinical Pharmacology and is chair of the Clinical Pharmacology and Translational Research committee of the American Association of Pharmaceutical Scientists. He has served as the principal investigator of the former NICHD Pediatric Research Unit at Cincinnati Children’s Hospital Medical Center.
His major research interests include personalized and precision medicine, pharmacokinetic-pharmacodynamic (PK/PD) modeling, physiologically based pharmacokinetics (PBPK), pharmacogenetics/genomics (PG) and the application of genomic, population and simulation approaches (Pharmacometrics) to pediatric trial design and Therapeutic Drug Management.
Dr. Vinks has presented his research as an invited speaker in 220 national and international conferences, has published over 140 peer reviewed manuscripts and 18 book chapters and has presented more than 150 abstracts. He is associate editor of Clinical Pharmacology & Therapeutics. Dr. Vinks is both board certified in clinical pharmacology and toxicology and is a fellow of the American College of Clinical Pharmacology.
Certification: American Board of Clinical Pharmacology, 2001.
PhD: Clinical Pharmacology, Leiden University, Leiden The Netherlands, 1996.
PharmD: Hospital Pharmacy, The Hague Central Hospital Pharmacy, The Hague, The Netherlands, 1986.
MS: Pharmacology, University of Toronto, Toronto Canada, 1983.
MS: Pharmacy, Leiden University, Leiden, The Netherlands, 1981.
Wiles JR, Isemann B, Ward LP, Vinks AA, Akinbi H. Current management of neonatal abstinence syndrome secondary to intrauterine opioid exposure. J Pediatr. 2014 Sep;165(3):440-6.
Hahn A, Frenck RW Jr, Zou Y, Vinks AA. Validation of a Pediatric Population Pharmacokinetic Model for Vancomycin. Ther Drug Monit. 2014 Nov 21.
Nehus EJ, Mouksassi S, Vinks AA, Goldstein S. Meropenem in Children Receiving Continuous Renal Replacement Therapy: Clinical Trial Simulations Using Realistic Covariates. Journal Clin Pharmacology. 2014 Dec;54(12):1421-1428.
Smits TA, Cox S, Fukuda T, Sherbotie JR, Ward RM, Goebel J, Vinks AA. Effects of unbound mycophenolic Acid on inosine monophosphate dehydrogenase inhibition in pediatric kidney transplant patients. Ther Drug Monit. 2014 Dec;36(6):716-23.
Dong M, Fukuda T, Cox S, de Vries MT, Hooper DK, Goebel J, Vinks AA. Population pharmacokinetic-pharmacodynamic modelling of mycophenolic acid in paediatric renal transplant recipients in the early post-transplant period. Br J Clin Pharmacol. 2014 Nov;78(5):1102-12.
Rasmussen-Torvik LJ, Stallings SC, Gordon AS, et al. Design and anticipated outcomes of the eMERGE-PGx project: a multicenter pilot for preemptive pharmacogenomics in electronic health record systems. Clin Pharmacol Ther. 2014 Oct;96(4):482-9.
Emoto C, Fukuda T, Mizuno T, Cox S, Schniedewind B, Christians U, Widemann BC, Fisher MJ, Weiss B, Perentesis J, Vinks AA. Age dependent changes in sirolimus metabolite formation in patients with neurofibromatosis type 1. Ther Drug Monitoring. 2014 Aug 26.
Venkatasubramanian R, Fukuda T, Niu J, Mizuno T, Chidambaran V, Vinks AA, Sadhasivam S. ABCC3 and OCT1 genotypes influence pharmacokinetics of morphine in children. Pharmacogenomics. 2014 Jul;15(10):1297-309.
Roberts JA, Abdul-Aziz MH, Lipman J, Mouton JW, Vinks AA, Felton TW, Hope WW, Farkas A, Neely MN, Schentag JJ, Drusano G, Frey OR, Theuretzbacher U, Kuti JL; on behalf of The International Society of Anti-Infective Pharmacology and the Pharmacokinetics and Pharmacodynamics Study Group of the European Society of Clinical Microbiology and Infectious Diseases. Individualized antibiotic dosing for patients who are critically ill: challenges and potential solutions. Lancet Infect Dis. 2014 Jun;14(6):498-509.
Vidya Chidambaran, MD Anesthesiologist, Department of Anesthesia
is a pediatric anesthesiologist and acute pain physician with special interests in personalization of pediatric analgesia and opioid pharmacogenomics, optimization of drug (propofol) dosing in morbidly obese children by study of pharmacokinetics/pharmacodynamics, evaluation of factors leading to persistent postoperative pain and use of capnography for early detection of opioid induced respiratory depression.
Anesthesiologist, Department of Anesthesia
Associate Professor, UC Department of Anesthesia
MBBS: Medicine,Bangalore Medical College, India, 1997
MD: Anesthesiology, Kasturba Medical College, India, 1998-2001
Internship: Anesthesiology, Jackson Memorial Hospital, Miami, Florida, 2003-2004
Residency: Anesthesiology, Brookdale University Hospital, Brooklyn, New York, 2004-2007
Fellowship: Pediatric Anesthesia, Johns Hopkins Hospital, Baltimore, Maryland, 2007-2008
Sadhasivam S, Fukuda T, Chidambaran V, Mizuno T, Venkatasubramanian R, Ngamprasertwong P, Olbrecht V, Esslinger H, Vinks AA. OCT1 Genetic Variants influence the pharmacokinetics of morphine in children. Pharmacogenomics. 2013 Jul;14(10):1141-51.
Chidambaran V, Sadhasivam S, Diepstraten J, Esslinger H, Cox S, Schnell BM, Samuels P, Inge T, Vinks AA, Knibbe CA. Evaluation of propofol anesthesia in morbidly obese children and adolescents. BMC Anesthesiology 2013, 13:8.
Chidambaran V, Gentry C, Ajuba-Iwuji C, Sponsellar PD, Ain M, Lin E, Zhang X, Klaus SA, Njoku DB. A Retrospective identification of gastroesophageal reflux disease as a new risk factor for surgical site infection in cerebral palsy patients after spine surgery. Anesth Analg. 2013 117(1):162-8.
Chidambaran V, Mahmoud M, Sadhasivam S. Risk for Peroneal Nerve Injury After Femur Osteosarcoma Resection: Is regional analgesia safe? J Clin Anesth. 2013 Feb;25(1):76-8.
Sadhasivam S and Chidambaran V. Pharmacogenomics of Opioids and Perioperative Pain Management. Pharmacogenomics. 2012 Nov;13(15):1719-40.
V Chidambaran, S Sadhasivam. Pediatric Acute and Surgical Pain Management: Recent Advances and Future Perspectives. "Contemporary Topics in Pediatric Anesthesiology" in International Anesthesiology Clinics 2012 Fall; 50(4):66-82.
Sadhasivam S, Krekels E, Chidambaran V, Esslinger H, Zhang K, Fukuda T, Vinks AA. Morphine Clearance in Children: Does Race or Genetics Matter? J Opioid Manag. 2012 Jul-Aug;8(4):217-26.
Chidambaran V, Rosing J, Soler X, Sadhasivam S. Muscle Trauma from Tourniquet (Mis)Use. Anesthesiology. 2012 Jul;117(1):179.
Diepstraten J, Chidambaran V, Sadhasivam S, Esslinger H, Cox S, Inge T, Knibbe CAJ, Vinks AA. Propofol Clearance in Morbidly Obese Children and Adolescents. Clin Pharmacokinet. 2012 Aug 1:51(8):543-51.
Sadhasivam S, Chidambaran V, Ngamprasertwong P, Esslinger H, Prows C, Zhang X, Martin LJ, McAuliffe J. Race and Unequal Burden of Perioperative Pain and Opioid Related Adverse Effects in African-American and Caucasian Children. Pediatrics. 2012 May;129(5):832-8.
Tracy A. Glauser, MD Associate Director, Cincinnati Children's Research Foundation
Associate Director, Cincinnati Children's Research Foundation
Director, Comprehensive Epilepsy Center
Co-Director, Genetic Pharmacology Service
Epilepsy; pharmacogenetics; clinical pharmacology
Modi AC, Guilfoyle SM, Morita DA, Glauser TA. Development and reliability of a correction factor for parent-reported adherence to pediatric antiepileptic drug therapy. Epilepsia. 2010 Nov 18. doi: 10.1111/j.1528-1167.2010.02789.x.
Modi AC, Monahan S, Daniels D, Glauser TA. Development and validation of the Pediatric Epilepsy Medication Self-Management Questionnaire. Epilepsy Behav. 2010 May;18(1-2):94-9
Glauser TA, Cnaan A, Shinnar S, Hirtz DG, Dlugos D, Masur D, Clark PO, Capparelli EV, Adamson PC; Childhood Absence Epilepsy Study Group. Ethosuximide, valproic acid, and lamotrigine in childhood absence epilepsy. N Engl J Med. 2010 Mar 4;362(9):790-9.
Holland KD, Monahan S, Morita D, Vartzelis G, Glauser TA. Valproate in children with newly diagnosed idiopathic generalized epilepsy. Acta Neurol Scand. 2010 Mar;121(3):149-53.
Pestian J, Spencer M, Matykiewicz P, Zhang K, Vinks AA, Glauser T. Personalizing Drug Selection Using Advanced Clinical Decision Support. Biomed Inform Insights. 2009 Jun 23;2:19-29.
Prows CA, Nick TG, Saldaña SN, Pathak S, Liu C, Zhang K, Daniels ZS, Vinks AA, Glauser TA. Drug-metabolizing enzyme genotypes and aggressive behavior treatment response in hospitalized pediatric psychiatric patients. J Child Adolesc Psychopharmacol. 2009 Aug;19(4):385-94.
Modi AC, King AS, Monahan SR, Koumoutsos JE, Morita DA, Glauser TA. Even a single seizure negatively impacts pediatric health-related quality of life. Epilepsia. 2009 Sep;50(9):2110-6.
Daniels ZS, Nick TG, Liu C, Cassedy A, Glauser TA. Obesity is a common comorbidity for pediatric patients with untreated, newly diagnosed epilepsy. Neurology. 2009 Sep 1;73(9):658-64.
Glauser TA, Sankar R; Co-chairs of the Leadership in Epilepsy, Advocacy, and Development Faculty. Core elements of epilepsy diagnosis and management: expert consensus from the Leadership in Epilepsy, Advocacy, and Development (LEAD) faculty. Curr Med Res Opin. 2008 Dec;24(12):3463-77.
Glauser T, Kluger G, Sachdeo R, Krauss G, Perdomo C, Arroyo S. Rufinamide for generalized seizures associated with Lennox-Gastaut syndrome. Neurology. 2008 May 20;70(21):1950-8.
Senthilkumar Sadhasivam, MD, MPH
MBBS: Thanjavur Medical College, India, 1993.
MD: AIIMS, New Delhi, India, 1999.
Residency: Beth Israel Deaconess Medical Center, Harvard University, Boston, MA.
Fellowship: Children's Hospital of Philadelphia, 2004.
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