• Research Faculty

  • A photo of Chie Emoto.

    Chie Emoto, PhD

    studies physiologically-based pharmacokinetics modeling. Her studies allow us to visualize the relationship between ontogeny profiles of drug-metabolizing enzymes/transporters and their pharmacogenetics. This model supports improving clinical outcomes and reducing adverse side-effects in pediatric patients. Her expertise also includes drug metabolism studies; pharmacokinetic analysis; and analytical pharmacology.


    A photo of Tsuyoshi Fukuda.

    Tsuyoshi Fukuda, PhD

    is director of the pharmacogenetics laboratory in the Division of Clinical Pharmacology. He focuses on drug metabolizing enzyme and transporter genetic variants, PK and response to medication and adverse drug events. He has developed innovative approaches in pharmacogenetic assay development, data analyses, integrated PK/PD/PG modeling of the clinical data set, and physiologically based pharmacokinetic (PBPK) analysis and model development.


    A photo of Alexander Vinks.

    Alexander (Sander) A. Vinks, PharmD, PhD, FCP Director, Division of Clinical Pharmacology

    is interested in population and physiologically based PK/PD modeling, pharmacogenetics (PG) and the application of genomic, population and simulation approaches (pharmacometrics) to pediatric clinical trial design and the development of Bayesian dosing algorithms. He is program director of the Cincinnati Training Program in Pediatric Clinical and Developmental Pharmacology and a founder and co-director of the Genetic Pharmacology Service.


    A photo of Vidya Chidambaran.

    Vidya Chidambaran, MD Anesthesiologist, Department of Anesthesia

    is a pediatric anesthesiologist and acute pain physician with special interests in personalization of pediatric analgesia and opioid pharmacogenomics, optimization of drug (propofol) dosing in morbidly obese children by study of pharmacokinetics/pharmacodynamics, evaluation of factors leading to persistent postoperative pain and use of capnography for early detection of opioid induced respiratory depression.

    A photo of Tracy Glauser.

    Tracy A. Glauser, MD Associate Director, Cincinnati Children's Research Foundation

    is director of the Comprehensive Epilepsy Center and co-director of the Genetic Pharmacology Service. His research has focused on improving the care of children with epilepsy through identifying the genetic and non-heritable factors that underlie the inter-individual variation in response to antiepileptic medications. Since 2003, he has directed the NIH-funded Childhood Absence Epilepsy trial, a 31-center, 446-patient double-blind randomized comparative trial of three commonly used antiepileptic medications focused on identifying the optimal initial therapy for children with childhood absence epilepsy and the pharmacokinetic, pharmacodynamic, and pharmacogenetic factors that impact the inter-individual response to antiepileptic therapy. Glauser and the Genetic Pharmacology Service have also developed and are testing treatment selection algorithms for epilepsy and non-epilepsy medications that incorporate genetic information and drug-drug interactions.


    A photo of Laura B. Ramsey.

    Laura B. Ramsey, PhD

    investigates how genetic variants influence a patient's response to a medication. The goal of this research is to personalize medicine using pharmacogenetics, to ensure that each patient receives an individualized dose of the optimal medication.
    Visit the Ramsey Lab.


    A photo of Sadhasivam Senthilkumar.

    Senthilkumar Sadhasivam, MD, MPH

    is director of Perioperative Pain Service, has clinical interests in regional anesthesia, fetal anesthesia and perioperative pain management. His funded clinical research aims to improve anesthetic outcomes and personalizing pain management. He mentors junior faculty with clinical research, especially pharmacogenetic and pharmacokinetic research to improve perioperative outcomes in children.