Clinical Pharmacology

  • Research Faculty

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    Faculty

    A photo of Tsuyoshi Fukuda.

    Tsuyoshi Fukuda, PhD

    is director of the pharmacogenetics laboratory in the Division of Clinical Pharmacology. He focuses on drug metabolizing enzyme and transporter genetic variants, PK and response to medication and adverse drug events. He has developed innovative approaches in pharmacogenetic assay development, data analyses, integrated PK/PD/PG modeling of the clinical data set, and physiologically based pharmacokinetic (PBPK) analysis and model development.

    513-803-0428
    tsuyoshi.fukuda@cchmc.org

    Tsuyoshi Fukuda, PhD

    Academic Information

    Associate Professor, UC Department of Pediatrics

    Phone: 513-803-0428

    Fax: 513-636-0168

    Email: tsuyoshi.fukuda@cchmc.org

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    Specialties

    Clinical pharmacology (pharmacogenetics, pharmacokinetics and pharmacodynamics)

    Biography

    Dr. Fukuda received his pharmacy degree and PhD in pharmaceutical science from Osaka University, Japan. He received postdoctoral training in the Division of Clinical Pharmacology and Pharmacogenomics (Prof. J. Azuma, MD) and served as an assistant professor at Osaka University, Graduate School of Pharmaceutical Sciences. He joined the Division of Clinical Pharmacology (Prof. Alexander A Vinks, PharmD, PhD) at Cincinnati Children's Hospital Medical Center in 2007. He spent over 15 years in the field of clinical pharmacology while engaged in pharmacogenetic (PG) and pharmacokinetic-pharmacodynamic (PK/PD) research. His current research interests include the clinical application of integrated PK/PD/PG modeling and simulation and physiologically based pharmacokinetic (PBPK) analysis with developmental pharmacology, focusing on improving our understanding of inter-patient differences in drug response and developing individualized dosing strategies in pediatric patients. 

    Dr. Fukuda’s efforts have resulted in over 50 peer-reviewed publications with project members that include master's and PhD students, research fellows, clinical fellows, pharmacists, physicians, and private sector R & D staff.

    Education and Training

    BS: Osaka University, School of Pharmacy, Osaka, Japan, 1995.

    Pharmacist: Japan, 1995.

    MS: Osaka University, Osaka, Japan,1997.

    PhD: Osaka University, Osaka, Japan, 2000.

    Certification: Clinical Pharmacology (Pharmacist), 2003 (Japanese Society of Clinical Pharmacology), 2008 renewed.

    Publications

    View PubMed Publications
    A photo of Sander Vinks.

    Alexander A. Vinks, PharmD, PhD, FCP Director, Division of Clinical Pharmacology

    is interested in population and physiologically based PK/PD modeling, pharmacogenetics (PG) and the application of genomic, population and simulation approaches (pharmacometrics) to pediatric clinical trial design and the development of Bayesian dosing algorithms. He is program director of the Cincinnati Training Program in Pediatric Clinical and Developmental Pharmacology and a founder and co-director of the Genetic Pharmacology Service.

    513-636-0159
    sander.vinks@cchmc.org

    Alexander A. Vinks, PharmD, PhD, FCP

    Director, Division of Clinical Pharmacology

    Academic Information

    Professor, UC Department of Pediatrics

    Professor, Adjunct Professor of Pharmacology

    Phone: 513-636-0159

    Fax: 513-636-0168

    Email: sander.vinks@cchmc.org

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    Biography

    Dr. Vinks received his MS in pharmacology from the University of Toronto, Canada and a pharmacy degree and PhD in pharmacology from Leiden University, The Netherlands. He was trained as a hospital pharmacist (PharmD) and clinical pharmacologist at The Hague Hospitals Central Pharmacy, The Hague, The Netherlands.

    Before joining the Division of Pharmacology Research at Cincinnati Children's Hospital Medical Center, he was director of the Clinical Pharmacology & Toxicology Laboratory at The Hague. Dr. Vinks has spent over 20 years in the field of therapeutic drug monitoring and applied pharmacokinetics, both in the research aspects of population pharmacokinetic studies, as well as in the clinical application of these approaches to clinical patient care.

    Dr. Vinks holds an academic appointment with the University of Cincinnati College of Medicine and is the principal investigator for the Pediatric Pharmacology Research Unit (PPRU). He is director of the Laboratory of Applied Pharmacokinetics and Therapeutic Drug Management (LAP/TDM) and clinical pharmacology fellowship program at Cincinnati Children's. His current research interests include pharmacokinetic-pharmacodynamic (PK-PD) modeling and the application of population and simulation methods in TDM and clinical trial design. He has authored over 50 publications in the area of TDM, pharmacokinetics and clinical pharmacology. Dr. Vinks has been actively involved with International Association of Therapeutic Drug Monitoring and Clinical Toxicology from the beginning. He is chair of the TDM cost-effectiveness committee, serves as secretary of the Executive Board of Directors, and is on the editorial board of the journal Therapeutic Drug Monitoring. Dr. Vinks is both board certified in clinical pharmacology and toxicology and is a fellow of the American College of Clinical Pharmacology.

    Education and Training

    Certification American Board of Clinical Pharmacology, 2001.

    PhD Clinical Pharmacology, Leiden University, Leiden The Netherlands, 1996.

    PharmD Hospital Pharmacy, The Hague Central Hospital Pharmacy, The Hague, The Netherlands, 1986 .

    MS Pharmacology, University of Toronto, Toronto Canada, 1983.

    MS Pharmacy, Leiden University, Leiden, The Netherlands, 1982.

    Publications

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    Affiliated Faculty

    A photo of Vidya Chidambaran.

    Vidya Chidambaran, MD Anesthesiologist, Department of Anesthesia

    is a pediatric anesthesiologist and acute pain physician with special interests in personalization of pediatric analgesia and opioid pharmacogenomics, optimization of drug (propofol) dosing in morbidly obese children by study of pharmacokinetics/pharmacodynamics, evaluation of factors leading to persistent postoperative pain and use of capnography for early detection of opioid induced respiratory depression.

    Vidya Chidambaran, MD

    Anesthesiologist, Department of Anesthesia

    Academic Information

    Associate Professor, UC Department of Anesthesia

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    Specialties

    Education and Training

    MBBS: Medicine,Bangalore Medical College, India, 1997

    MD: Anesthesiology, Kasturba Medical College, India, 1998-2001

    Internship: Anesthesiology, Jackson Memorial Hospital, Miami, Florida, 2003-2004

    Residency: Anesthesiology, Brookdale University Hospital, Brooklyn, New York,  2004-2007

    Fellowship: Pediatric Anesthesia, Johns Hopkins Hospital, Baltimore, Maryland, 2007-2008

    Publications

    A photo of Tracy Glauser.

    Tracy A. Glauser, MD Associate Director, Cincinnati Children's Research Foundation

    is the director of the Comprehensive Epilepsy Center and co-director of the Genetic Pharmacology Service. His research has focused on improving the care of children with epilepsy through identifying the genetic and non-heritable factors that underlie the inter-individual variation in response to antiepileptic medications. Since 2003, he has directed the NIH-funded Childhood Absence Epilepsy trial, a 31-center, 446-patient double-blind randomized comparative trial of three commonly used antiepileptic medications focused on identifying the optimal initial therapy for children with childhood absence epilepsy and the pharmacokinetic, pharmacodynamic, and pharmacogenetic factors that impact the inter-individual response to antiepileptic therapy. Glauser and the Genetic Pharmacology Service have also developed and are testing treatment selection algorithms for epilepsy and non-epilepsy medications that incorporate genetic information and drug-drug interactions.

    513-636-4222
    tracy.glauser@cchmc.org

    Tracy A. Glauser, MD

    Associate Director, Cincinnati Children's Research Foundation

    Director, Comprehensive Epilepsy Center

    Co-Director, Genetic Pharmacology Service

    Academic Information

    Professor, UC Department of Pediatrics

    Phone: 513-636-4222

    Fax: 513-636-3980

    Email: tracy.glauser@cchmc.org

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    Specialties

    Clinical Interests

    Epilepsy; pharmacogenetics; clinical pharmacology

    Research Interests

    Clinical pharmacology; pharmacogenetics; antiepileptic clinical trials 

    Biography

    Tracy A. Glauser, MD, is professor of pediatrics, director of the Comprehensive Epilepsy Center and co-director of the Genetic Pharmacology Service at Cincinnati Children’s Hospital Medical Center. Dr. Glauser received his medical degree, cum laude, from Jefferson Medical College in Philadelphia, PA. He completed his residency in pediatrics at the John Hopkins Hospital in Baltimore, MD, and fellowship in child neurology at The Children’s Hospital of Philadelphia, University of Pennsylvania in Philadelphia, PA. Dr. Glauser completed a National Institute of Neurological Disorders and Stroke research fellowship in pediatric neurology and was a fellow in epilepsy and electroencephalography at St. Louis Children’s Hospital, Washington University School of Medicine in St. Louis, Missouri.

    Dr. Glauser has authored and co-authored more than 130 articles and book chapters, been involved with the development of 6 evidence based guidelines about epilepsy therapy and given over 150 invited lectures throughout the world. He has been the principal investigator on multiple NIH grants. Currently, Dr. Glauser directs the NIH funded Childhood Absence Epilepsy clinical trial involving 32 pediatric centers around the United States. Dr. Glauser’s fields of expertise are pediatric neurology, pediatric epilepsy, clinical pharmacology and pharmacogenetics.

    Education and Training

    MD: Jefferson Medical College, Philadelphia, PA, 1985.

    Residency: Johns Hopkins Hospital, Baltimore, MD.

    Fellowship: St. Louis Children's Hospital, St. Louis, MO.

    Certification: Pediatrics, 1990; Neurology (with special competence in child neurology), 1991.

    Publications

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    A photo of Sadhasivam Senthilkumar.

    Senthilkumar Sadhasivam, MD, MPH

    is director of Perioperative Pain Service, has clinical interests in regional anesthesia, fetal anesthesia and perioperative pain management. His funded clinical research aims to improve anesthetic outcomes and personalizing pain management. He mentors junior faculty with clinical research, especially pharmacogenetic and pharmacokinetic research to improve perioperative outcomes in children.

    513-636-4408
    senthilkumar.sadhasivam@cchmc.org

    Senthilkumar Sadhasivam, MD, MPH

    Academic Information

    Associate Professor, UC Department of Anesthesia

    Phone: 513-636-4408

    Fax: 513-636-7337

    Email: senthilkumar.sadhasivam@cchmc.org

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    Specialties

    Pediatric pain management; regional anesthesia; clinical research on improving perioperative outcomes

    Education and Training

    MBBS: Thanjavur Medical College, India, 1993.

    MD: AIIMS, New Delhi, India, 1999.

    Residency: Beth Israel Deaconess Medical Center, Harvard University, Boston, MA.

    Fellowship: Children's Hospital of Philadelphia, 2004.