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Developmental Biology

Significant Accomplishments

Growing intestinal tissue

A recent paper in Nature documented the first example of organogenesis into intestinal tissue from human pluripotent stem cell cultures. The team of principal investigators, including Chris Mayhew, PhD, and Aaron Zorn, PhD (Developmental biology), Vladimir Kalinichenko, MD, PhD (Neonatology/Pulmonary Biology), Susanne Wells, PhD (Hematology/Oncology), and Noah Shroyer, PhD (Gastroenterology), was headed up by James Wells, PhD (Developmental biology). The paper was first-authored by postdoctoral fellow Jason Spence, PhD.

Studying neuron development

A team including including Richard Lang, PhD (Ophthalmology), Alex Kuan, MD, PhD (Developmental Biology), Yi Zheng, PhD (Experimental Hematology), and headed by Yutaka Yoshida, PhD, (Developmental Biology), published a paper in Proceedings of the National Academy of Sciences showing that disruption of the intracellular signal RhoA altered the balance between differentiation and proliferation in the progenitor cells of neurons in the central nervous system. The paper is first-authored by Kei-ichi Katayama, PhD, DVM, a trainee in the Yoshida laboratory.

Understanding abnormal hematopoiesis

In a recent issue of Current Opinion in Hematology, Noah Shroyer, PhD (Gastroenterology), Tiffany Cook, PhD (Ophthalmology), Brian Gebelein, PhD (Developmental Biology), and H. Leighton Grimes, PhD (Immunobiology), discuss the roles of a specific transcription factor (Gfi1) whose actions are conserved in evolution from fruit fly development to human hematopoiesis. In humans, Gfi1 is a component of transcriptional regulatory pathways whose disregulation leads to abnormal hematopoiesis and malignancy. Such pathways represent key targets for clinical intervention. The article is first-authored by James Phelan, a graduate student in the immunology graduate program.

Neonatal trauma and muscle growth

In a paper in the Journal of Bone and Joint Surgery, Chris Wylie, PhD (Developmental Biology), and Roger Cornwall, MD (Orthopaedic Surgery) identify a failure of normal satellite cell function and muscle growth as the primary defect in the contractures caused by neonatal trauma to the brachial plexus. The paper is first-authored by Sia Nikolaou, PhD, a postdoctoral fellow in Orthopaedic Surgery.