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Visit Dr. Chang's external lab website for additional information.
The Chang lab focuses its research on the nervous system of the C. elegans in the hope that findings will be relevant to the development and regeneration of the human nervous system. Our lab uses a genetic and optical approach. Our major goal is to test this hypothesis: that there are negative regulators of axon growth that limit the brain’s ability to grow out axon. Are there more of these negative regulators in an aging brain than in the baby’s brain? If such molecules exist, blocking their function in the aging brain might rejuvenate neurons. This project has the potential to develop a new approach for treatment of neurodegenerative diseases of aging by harnessing hidden neuronal ability to reorganize itself.
Whitehall Foundation Research Award, 2013
March of Dimes Research Program Award, March of Dimes Foundation, 2010-2013
Whitehall Foundation Research Award, 2009
Canada Foundation for Innovation, Leaders Opportunity Award, 2006
American Cancer Society Postdoctoral Fellow, 2002
Helen G. and Arthur McCallum Fellowship, Caltech, 1998-1999
Howard Hughes Medical Fellowship, Caltech, 1995-1998
Chiu H, Chang C. Rejuvenating nerve cells in adults. Aging, 5, 1-2, 2013.
Zou Y†, Chiu H†, Zinovyeva A, Ambros V, Chuang C-F*, Chang C*. Developmental decline in neuronal regeneration by the progressive change of two intrinsic timers. Science, 340, 372-376, 2013. †Equal contribution *Senior authors contributed equallyRecommended by Faculty of 1000; Featured in "Perspective" in Science.
Schumacher JA, Hsieh Y-W, Chen S, Pirri JK, Alkema MJ, Li W-H, Chang C*, Chuang C-F*. Intercellular calcium signaling in a gap junction-coupled cell network establishes asymmetric neuronal fates in C. elegans. Development, 139, 4191-4201. 2012. * Senior Authors contributed equally.
Hsieh Y-W, Chang C*, Chuang C-F*. The microRNA mir-71 inhibits calcium signaling by targeting the TIR-1/Sarm1 adaptor protein to control stochastic L/R neuronal asymmetry in C. elegans. PLoS Genetics 8(8): research article e1002864. Aug 2. 2012. *Senior Authors contributed equally.
Zou Y, Chiu H, Domenger D, Chuang C-F, Chang C. The lin-4 microRNA targets the LIN-14 transcription factor to inhibit netrin-mediated axon attraction. Full text (please click on the title first, then here) Science Signaling 5, research article ra43, 2012.
Chiu H, Alqadah A, Chuang C-F, Chang, C. C. elegans as a genetic model to identify novel cellular and molecular mechanisms underlying nervous system regeneration.Cell Adhesion & Migration. 5: 387-394. 2011.
Chang C, Hsieh Y-W, Lesch BJ, Bargmann CI, Chuang C-F. Microtubule-based localization of a synaptic calcium signaling complex is required for left-right neuronal asymmetry in C. elegans. Development. 138: 3509-3518. 2011.
For questions regarding graduate student and postdoctoral fellow openings, please contact:Chieh Chang, PhDDivision of Developmental Biology3333 Burnet AvenueCincinnati, OH 45229-3039Phone: 513-803-0945Email: email@example.com
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