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Hegde Lab

  • Hegde Lab Research

    Molecular Mechanisms in Organogenesis

    The Hegde laboratory, part of the Division of Developmental Biology at the Cincinnati Children’s Research Foundation, studies molecular mechanisms involved in organ development. Our tools include solution and cellular biochemistry, structural biology and computational methods. The current areas of research are:

    • Molecular pathways in organogenesis
    • Dysregulation of developmental pathways in cancer

     

  • Lab Publications

    Show All

    2011

    Riazuddin S, Ahmed ZM, Hegde RS, Khan SN, Nasir I, Shaukat U, Riazuddin S, Butman JA, Griffith AJ, Friedman TB, Choi BY. Variable expressivity of FGF3 mutations associated with deafness and LAMM syndrome. BMC Med Genet. 12:21. 2011.

    2010

    Pandey RN, Rani R, Yeo EJ, Spencer M, Hu S, Lang RA, Hegde RS. The Eyes Absent phosphatase-transactivator proteins promote proliferation, transformation, migration, and invasion of tumor cells. Oncogene. 29(25):3715-22. 2010.

    Miller SJ, Lan ZD, Hardiman A, Wu J, Kordich JJ, Patmore DM, Hegde RS, Cripe TP, Cancelas JA, Collins MH, Ratner N. Inhibition of Eyes Absent Homolog 4 expression induces malignant peripheral nerve sheath tumor necrosis. Oncogene. 29(3):368-79. 2010.

    2009

    Trompette A, Divanovic S, Visintin A, Madan R, Blanchard C, Hegde RS, Wills-Karp M, Gioannini TL, Weiss JP, Karp CL. Allerginictiy resulting from functional mimicry of a Toll-like receptor complex protein. Nature. 457(7229):585-8. 2009.

    Tan M, Xia M, Chen Y, Bu W, Hegde RS, Meller J, Li X, Jiang X. Conservation of carbohydrate binding interfaces: evidence of human HBGA selection in norovirus evolution. PLoS ONE. 4(4):e5058. 2009.

    Morrelae R, Fernandez-Fuentes N, Chen Z, Hegde RS, Butsch-Kovacic M, Wells SI. Insights from transcriptional profiling of human papillomavirus infection and associated carcinogenesis. Review in Molecular Biology of Tumor Virus Gene Products.169-196 (Publisher: Research Signpost, Editor: Kenichi Yoshida). 2009.

    Blakaj DM, Fernandez-Fuentes N, Chen Z, Hegde RS, Fiser A, Burk RD, Brenowitz M. Evolutionary, structural and electrostatic relationships among the papillomavirus E2 protein DNA binding domains. Frontiers in Bioscience.14:900-17. 2009.

    2008

    Bu W, Mamedova A, Xia M, Tan M, Jiang J, Hegde RS. Structural basis for the receptor binding specificity of Norwalk virus. J Virology. 82(11):5340-7. 2008.

    Hu SH, Mamedova A, Hegde RS. DNA-binding and regulation mechanisms of the SIX family of retinal determination proteins. Biochemistry. 47:3586-94. 2008.