Hegde Lab

Tadjuidje E., Wang T.S., Pandey R.N., Sumanas S., Lang, R.A., Hegde R.S.  The EYA Tyrosine Phosphatase activity is pro-angiogenic and is inhibited by Benzbromarone.PLoS One 7(4):e34806. 2012.

Korfhagen T.R., Kitzmiller J., Chen G., Sridharan A., Haitchi H.M., Hegde R.S., Divanovic S., Karp C.L., Whitsett J. SAM Pointed Domain Ets Factor mediates epithelial cell-intrinsic innate immune signaling during airway mucous metaplasia.  PNAS Sept. 24 EPub.

Tadjuidje E., Hegde R.S.  The Eyes Absent proteins in development and disease. Cell and Molecular Life Sciences. EPub. Sept. 13. 2012.

Riazuddin S, Belyantseva I.A., Giese A., Kwanghyuk L., Indzhykulian A., Nandamuri S.P., Yousaf R., Lee S., Terrell D., Hegde R.S., Morell R.J., Ali R.A., Anwar S., Rachel R.A., Andrade-Elizondo P.B., Sirmaci A., Husnain T., Khan S.N., Parise L.V., Basit S., Wali A., Ayub M., Ansar M., Swaroop A., Ahmad W., Tekin M., Riazuddin S., Cook T., Buschbeck E., Frolenkov G.I., Leal S.M., Friedman T.B., Ahmed Z.A.  Alterations of the CIB2 calcium- and integrin-binding protein cause Usher syndrome type 1J and nonsyndromic deafness DFNB48.  Nature Genetics, EPub. Sep 30. 2012.

Ponferrada V.G., Fan J., Vallance J.E., Hu S., Mamedova A., Rankin S.A., Zorn A.M., Hegde R.S.*, Lang R.A.*   CRIM1 complexes with ß-catenin and cadherins, stabilizes cell-cell junctions and is critical for neural morphogenesis.   PLoS One 7(3):e32635 . *co-corresponding authors. 2012.

Riazuddin S, Ahmed ZM, Hegde RS, Khan SN, Nasir I, Shaukat U, Riazuddin S, Butman JA, Griffith AJ, Friedman TB, Choi BY. Variable expressivity of FGF3 mutations associated with deafness and LAMM syndrome. BMC Med Genet. 12:21. 2011.

Pandey RN, Rani R, Yeo EJ, Spencer M, Hu S, Lang RA, Hegde RS. The Eyes Absent phosphatase-transactivator proteins promote proliferation, transformation, migration, and invasion of tumor cells. Oncogene. 29(25):3715-22. 2010.

Xi Z., Zhang Y., Hegde R.S., Shakked Z., Crothers D.M.  Anomalous DNA binding by E2 regulatory protein driven by spacer sequence TATA.   Nucleic Acids Research 38(11):3827-33. 2010.

Miller SJ, Lan ZD, Hardiman A, Wu J, Kordich JJ, Patmore DM, Hegde RS, Cripe TP, Cancelas JA, Collins MH, Ratner N. Inhibition of Eyes Absent Homolog 4 expression induces malignant peripheral nerve sheath tumor necrosis. Oncogene. 29(3):368-79. 2010.

Trompette A., Divanovic S., Visintin A., Madan R., Blanchard C., Hegde R.S., Wills-Karp M., Gioannini T.L., Weiss J.P., Karp C.L.  Functional mimicry between the major house dust mite allergen, Der p 2, and the TLR4 complex protein, MD-2.  Nature 457(7229):585-588. 2009.

Tan M, Xia M, Chen Y, Bu W, Hegde RS, Meller J, Li X, Jiang X. Conservation of carbohydrate binding interfaces: evidence of human HBGA selection in norovirus evolution. PLoS ONE. 4(4):e5058. 2009.

Morrelae R, Fernandez-Fuentes N, Chen Z, Hegde RS, Butsch-Kovacic M, Wells SI. Insights from transcriptional profiling of human papillomavirus infection and associated carcinogenesis. Review in Molecular Biology of Tumor Virus Gene Products.169-196 (Publisher: Research Signpost, Editor: Kenichi Yoshida). 2009.

Blakaj DM, Fernandez-Fuentes N, Chen Z, Hegde RS, Fiser A, Burk RD, Brenowitz M. Evolutionary, structural and electrostatic relationships among the papillomavirus E2 protein DNA binding domains. Frontiers in Bioscience.14:900-17. 2009.

Bu W, Mamedova A, Xia M, Tan M, Jiang J, Hegde RS. Structural basis for the receptor binding specificity of Norwalk virus. J Virology. 82(11):5340-7. 2008.

Tan M., Xia M., Cao S., Huang P., Meller J., Hegde R.S., Li X., Rao Z., Jiang X. “Elucidation of strain-specific interaction of a GII-4 norovirus with HBGA receptors by site-directed mutagenesis study” Virology 379(2):324-34. 2008.

Hu SH, Mamedova A, Hegde RS. DNA-binding and regulation mechanisms of the SIX family of retinal determination proteins. Biochemistry. 47:3586-94. 2008.

Liu, Y., Henry, G.D., Hegde, R.S., Baleja J.D. “Solution structure of the hDlg/SAP97 PDZ2 domain and its mechanism of interaction with HPV-18 papillomavirus E6 protein”. Biochemistry 46(38):10864-74. 2007.

Blakaj D.M., Kattamuri C., Khrapunov S., Hegde R.S., Brenowitz M. “Indirect readout of DNA sequence by papillomavirus E2 proteins depends upon cation uptake” Journal of Molecular Biology. 358(1):224-40. 2006. 

Liou B., Kazmierczek A., Zhang M., Scott C.R., Hegde R.S., Grabowski G. “Analyses of variant Acid -Glucosidases: Effects of Gaucher disease mutations” Journal of Biological Chemistry 281(7):4242-53. 2006.

Rayapureddi J.P. and Hegde R.S. “Branchio-oto-renal syndrome associated mutations in Eyes Absent 1 result in loss of phosphatase activity” FEBS Letters   580(16):3853-3859. 2006.

Hegde R.S. “Papillomavirus proteins and their potential as drug design targets” Future Virology, 1(6):795-810. 2006.

Rayapureddi J.P., Kattamuri C., Chan F.H., Hegde R.S.  “Characterization of a plant, tyrosine-specific phosphatase of the aspartyl class”. Biochemistry 44(2):751-8. 2005.

Seufert D.W., Hegde R.S., Nekkalapudi S., Kelly L.E., El-Hodiri H.M. “Expression of a novel Ski-like gene in Xenopus Development”. Gene Expression Patterns 6(1):22-8. 2005.

Zhang Y., Xi A., Hegde R.S., Shakked Z., Crothers D.M. "Predicting indirect readout effects in protein-DNA interactions" Proceedings of the National Academy of Sciences 101(22):8337-41. 2004.

Wilson J., Malakhova M., Zhang R.G., Joachimiak A., Hegde R.S.  "Crystal structure of the Dachshund-homology domain of human SKI". Structure 12(5):785-792. 2004.

Blakaj D.M., Khrapunov S., Kattamuri C., Hegde R.S., Brenowitz M. “Assessing the contribution of DNA structure and flexibility to DNA sequence specific recognition by papillomavirus E2 proteins”. Biophysical Journal 86(1):590A-590A Part 2, Suppl. S. 2004.

Tan M., Hegde R.S., Jiang J. "The P domain of norovirus capsid protein forms a dimer and binds to histo-blood group antigen receptor". Journal of Virology 78(12):6233-42. 2004.

Rayapureddi J.P., Kattamuri C., Steinmetz B.D., Frankfort B.J., Ostrin E.J., Mardon G., Hegde R.S.  "Eyes Absent represents a class of protein tyrosine phosphatases."  Nature 426(6964):295-298 (News and Views, Nature (2003) 426(6964):238-9).  2003.

Hegde R.S., "The papillomavirus E2 proteins: Structure, Function and Biology." Annual Reviews of Biophysics and Biomolecular Structure 31:343-360. 2002.

Kim S.S., Braunstein S.E., Zhang R.G., Joachimiak, A., Cvekl A., Hegde R.S.,  "Structure of the retinal determination protein Dachshund reveals a DNA binding motif."  Structure 10:787-795.  2002. 

Kim S.S., Tam J.K., Wang A.F., and Hegde, R.S.  "The structural basis of DNA target discrimination by papillomavirus E2 proteins." Journal of Biological Chemistry 275:31245-31254. 2000.

Hegde R.S., Androphy E.  "Crystal structure of the E2 DNA-binding domain from human papillomavirus type 16: Implications for its DNA binding-site selection mechanism" Journal of Molecular Biology 284(5):1479-1489. PMID: 9878365. 1998.

Rozenberg, H., Rabinovich, D., Frolow, F., Hegde, R.S., Shakked, Z.  “Structural code for DNA recognition in gene regulation revealed by crystal structures of papillomavirus E2-DNA targets.” Proceedings of the National Academy of Sciences 95 (26): 15194 – 15199. 1998.

Ogden A.T., Nunes I., Ko K., Wu S., Hines C.S., Wang A., Hegde R.S., and Lang R.A. "GRIFIN, a novellens-specific protein related to the galectin family." Journal of Biological Chemistry 273(4): 28889-28896. 1998.

Hegde R.S., Wang A., Kim S.S., Schapira M. “Subunit rearrangement accompanies sequence specific DNA binding by the Bovinepapillomavirus-1 E2 protein with DNA”, Journal of Molecular Biology 276(4):797-808. 1998.

Hines C.S., Meghoo C., Shetty S., Biburger M., Brenowitz M. and Hegde R.S. DNA structure and flexibility in the sequence-specific binding of papillomavirus E2 proteins.  Journal of Molecular Biology. 276(4):809-818. 1998.

Rozenberg H., Rabinovich D., Frolow F., Hegde R.S., and Shakked Z. “Crystal structures of DNA targets of the E2 Protein from Bovine papillomavirus-1." J. Biomolecular Structure and Dynamics, 14(6):859-860. 1997.

Hegde R.S. “Protein-DNA interactions: The papillomavirus E2 proteins as a model system” Advances in Biophysical Chemistry, 6: 143-171. 1997.

Hegde R.S. “Structure of the BPV-1 E2DNA-binding domain bound to its DNA target” Journal of Nuclear Medicine, 36(6):25S-27S. PMID: 7769463. 1995.

Braig K., Otwinowski Z., Hegde, R.S., Boisvert D.B., Joachimiak A., Horwich A., Sigler P.B. “The crystal structure of GroEl at 2.8Å" Nature 371: 579-586. (News and Views, Nature (1994) 371(6498):557-9. 1994.

Hegde, R.S., Grossman, S.R., Laimins, L.A., Sigler, P.B. “The 1.7 Å crystal structure of the DNA-binding domain of the E2 protein from Bovine Papillomavirus-1 bound to its specific DNA target” Nature, 359: 505-512. (News and Views, Nature (1992) 359(6395):476) 1992.