Publications

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Lan, Y., Jia, S., Jiang, R. Molecular patterning of the mammalian dentition. Seminars in Cell and Developmental Biology. 2014 Jan-Feb;25-26:61-70.

Zhou, H., Zou, S., Lan, Y., Fei, W., Jiang, R., Hu, J. Smad7 modulates TGF-beta signaling during cranial suture development to maintain suture patency. Journal of Bone and Mineral Research. 2014 Mar;29(3):716-24.

Xu, J., Liu, H., Park, J. S., Lan, Y., Jiang, R. Osr1 acts downstream of and interacts synergistically with Six2 to maintain nephron progenitor cells during kidney organogenesis. Development. 2014 Apr;141(7):1442-52.

Zhu, S., Chen, K., Lan, Y., Zhang, N., Jiang, R., Hu, J. Alendronate protects against articular cartilage erosion by inhibiting subchondral bone loss in ovariectomized rats. Bone. 2013 Apr;53(2):340-9.

Jia, S., Zhou, J., Gao, Y., Baek, J.-A, Martin, J. F., Lan, Y., Jiang, R.Roles of Bmp4 during tooth morphogenesis and sequential tooth formation. Development. 2013 Jan 15;140(2):423-32.

Zhou, J., Gao, Y., Lan, Y., Jia, S., Jiang, R. Pax9 regulates a molecular network involving Bmp4, Fgf10, Shh signaling and the Osr2 transcription factor to control palate morphogenesis. Development. 2013 Dec;140(23):4709-18.

Liu, H., Lan, Y., Xu, J., Jiang, R.Odd-skipped related-1 controls neural crest chondrogenesis during tongue development. Proceedings of the National Academy of Sciences USA. 2013 Nov 12;110(46):18555-60.

Kim, T-H., Bae, C-H., Lee, J-C., Ko, S-O., Yang, X., Jiang, R., Cho, E-S. β-catenin is required in odontoblasts for tooth root formation. Journal of Dental Research. 2013 Mar;92(3):215-21.

Bae, C.H., Lee, J.Y., Kim, T.H., Baek, J.A., Yang, X., Taketo, M.M., Jiang, R., Cho, E.S. Excessive Wnt/beta-catenin signaling disturbs tooth root formation. J. Periodontal Res. 2013 Aug;48(4):405-10.

Bush, J.O. and *Jiang, R. Palatogenesis: morphogenetic and molecular mechanisms of secondary palate development.Development. 2012 Jan;139(2):231-43.

Yu, C.-T., Tang, K., Suh, J. M., Jiang, R., Tsai, S. Y., Tsai, M.-J. COUP-TFII is essential for metanephric mesenchyme formation and kidney precursor cell survival. Development. 2012 Jul;139(13):2330-9.

Guillot, N., Kollins, D., Gilbert, V., Xavier, S., Chen, J., Gentle, M.E., Reddy, A., Bottinger, E.P., Jiang, R., Rastaldi, M., Corbelli, A., Schlondorff, D.O. BAMBI regulates angiogenesis and endothelial homeostasis through modulation of alternative TGFβ signaling. PLoS One. 2012;7(6):e39406.

Anderson, D.M., George, R., Noyes, M.B., Rowton, M., Liu, W., Jiang, R., Wolfe, S.A., Wilson-Rawls, J., Rawls, A. Characterization of the DNA-binding properties of the Mohawk homeobox transcription factor. J. Biol. Chem. 2012 Oct 12;287(42):35351-9.

Baek JA, Lan Y, Liu H, Maltby KM, Mishina Y, Jiang R.Bmpr1a signaling plays critical roles in palatal shelf growth and palatal bone formation. Developmental Biology. 2011 Feb 15;350(2):520-31.

Gao Y, Lan Y, Liu H, Jiang R.The zinc finger transcription factors Osr1 and Osr2 control synovial joint formation. Developmental Biology. 2011 Apr 1;352(1):83-91.

Kim TH, Lee JY, Baek JA, Lee JC, Yang X, Taketo MM, Jiang R, Cho ES. Constitutive stabilization of b-catenin in the dental mesenchyme leads to excessive dentin and cementum formation. Biochem Biophys Res Commun. 2011 Sep 9;412(4):549-55.

Lan Y, Liu H, Ovitt CE, Jiang R. Generation of Osr1 conditional mutant mice. Genesis. 2011 May;49(5):419-22.

Li J, Xu X, Huang X, Mayo JE, Bringas P Jr., Jiang R, Wang S, Chai Y. Smad4-mediated Wnt signaling controls the fate of cranial neural crest cells during tooth morphogenesis. Development. 2011 May;138(10):1977-89.

Xie R, Jiang R, Chen D. Generation of Axin1 conditional mutant mice. Genesis. 2011 Feb;49(2):98-102.

Zhou J, Gao Y, Zhang Z, Zhang Y, Liu Z, Maltby KM, Lan Y, Jiang R. Osr2 acts downstream of Pax9 and interacts with both Msx1 and Pax9 to pattern the tooth developmental field. Developmental Biology. 2011 May 15;353(2):344-53.

Liu W, Watson SS, Lan Y, Keene DR, Ovitt CE, Liu H, Schweitzer R, Jiang R.The atypical homeodomain transcription factor Mohawk controls tendon morphogenesis. Molecular and Cellular Biology. 2010 30:4797-4807.

Zhang Z, Lan Y, Chai Y, Jiang R.Antagonistic actions of Msx1 and Osr2 pattern mammalian teeth into a single row. Science. 2009 323:1232-1234.

Lan Y, Jiang R.Sonic hedgehog signaling regulates reciprocal epithelial-mesenchymal interactions controlling palatal outgrowth. Development. 2009 136:1387-1396.

Gao Y, Lan Y, Ovitt CE, Jiang R.Functional equivalence of the zinc finger transcription factors Osr1 and Osr2 in mouse development. Developmental Biology. 2009 328:200-209.

Richardson R, Dixon J, Jiang R, Dixon M. Integration of IRF6 and Jagged2 signalling is essential for controlling palatal adhesion and fusion competence. Human Molecular Genetics. 2009 18:2632-2642.

Xiong W, He F, Morikawa Y, Yu X, Zhang Z, Lan Y, Jiang R, Cserjesi P, Chen Y. Hand2 is required in the epithelium for palatogenesis in mice. Developmental Biology. 2009 330:130-141.

Chen J, Lan Y, Baek JA, Gao Y, Jiang R. Wnt/beta-catenin signaling plays an essential role in activation of odontogenic mesenchyme during early tooth development. Developmental Biology. 334:174-185. 2009.

Liu W, Lan Y, Pauws E, Meester-Smoor MA, Stanier P, Zwarthoff EC, Jiang R. The Mn1 transcription factor acts upstream of Tbx22 and preferentially regulates posterior palate growth in mice. Development. 135:3959-3968. 2008. 

Lan Y, Wang Q, Ovitt CE, Jiang R. A unique mouse strain expressing Cre recombinase for tissue-specific analysis of gene function in palate and kidney development. Genesis. 45:618-624. 2007.

James RG, Kamei CN, Wang Q, Jiang R, Schultheiss TM. Odd-skipped related 1 is required for development of the metanephric kidney and regulates formation and differentiation of kidney precursor cells. Development. 15:2995-3004. 2006.

Jiang R, Bush JO, Lidral AC. Development of the upper lip: morphogenetic and molecular mechanisms. Developmental Dynamics. 235:1152-1166. 2006.

Wang Q, Lan Y, Cho ES, Maltby KM, Jiang R. Odd-skipped related 1 (Odd 1) is an essential regulator of heart and urogenital development. Developmental Biology. 288:582-594. 2005.

Bush JO, Lan Y, Jiang R. The cleft lip and palate defects in Dancer mutant mice result from gain of function of the Tbx10 gene. Proceedings of the National Academy of Sciences USA. 101:7022-7027. 2004.

Lan Y, Ovitt CE, Cho ES, Maltby KM, Wang Q, Jiang R. Odd-skipped related 2 (Osr2) encodes a key intrinsic regulator of secondary palate growth and morphogenesis. Development. 131:3207-3216. 2004

Contact Us

A photo of Rulang Jiang.
Rulang Jiang, PhD
Professor, UC Department of Pediatrics

Phone: 513-636-3212
Email: rulang.jiang@cchmc.org

Graduate Student and Postdoctoral Training Opportunities

The Jiang lab welcomes graduate students and postdoctoral fellows to join our team. Each graduate student or postdoctoral fellow carries out semi-independent research projects and is expected to generate high–quality, first-author publications.

Students and postdoctoral candidates interested in mammalian development and birth defect research are encouraged to contact Rulang Jiang, PhD, (rulang.jiang@cchmc.org) to discuss opportunities.