Potter Lab

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Potter Lab

Potter Lab Research

We use the mouse model system to study the principles of organogenesis. Much of our work is focused on the kidney, which employs many of the fundamental mechanisms used throughout development, including inductive interactions, mesenchyme to epithelia transformation, segmentation and differentiation along the length of the forming nephron.
We use a combination of laser capture microdissection, microarrays, organ culture, next-generation DNA sequencing, gene-targeted mice and single-cell gene-expression profile analysis to better define the gene-expression programs driving kidney development. We are also using recombineering technology to create sets of multiple Hox mutations to better understand these functionally redundant genes in development.
Another area of study for the lab is craniofacial development. The face is constructed primarily from neural crest cells. One project examines the function of a zinc finger transcription factor gene, Sp8, which when mutated gives a “faceless” phenotype. A second project is devoted to the construction of an atlas of gene-expression programs that direct craniofacial development.
Lab Publications

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2011

Potter SS, Brunskill EW, Patterson LT. Defining the genetic blueprint of kidney development. Pediatr Nephrol. Feb. 19. 2011.
Hochheiser, H., Aronow, B.J., Artinger, K., Beaty, T.H., Brinkley, J.F., Chai, Y., Clouthier, D., Cunningham, M.L., Michael Dixon, M., Donahue, L.R., Fraser, S.E., Iwata, J., Marazita M.L., Murray, J.C., Stephen Murray, S., Postlethwait, J., Potter, S., Shapiro, L, Spritz, R., Visel, A., Weinberg, S.M., and Trainor, P.A. The FaceBase Consortium: A comprehensive program to facilitate craniofacial research. Dev. Biol. 355:175-182. 2011

Brunskill, E.W., Lai, H.L., Jamison, D.C., Potter, S.S., and Patterson, L.T. Microarrays and RNA-Seq identify molecular mechanisms driving the end of nephron formation. BMC Developmental biology 11:15. 2011

Harding, S.D., Armit, C. Armstrong, J. Brennan, J., Cheng, Y., Haggarty, B. Houghton, D., Lloyd-MacGilp, S., Pi, X., Roochun, Y., Sharghi, M., Tindal, C., McMahon, A.P., Gottesman, B., Little, M.H., Georgas, K., Aronow, B.J., Potter, S.S., Brunskill, E.W., Southard-Smith, E.M., Mendelsohn, C., Baldock, R.A., Davies, J.A., and Davidson, D. The GUDMAP database- and online resources for genitourinary research. Development 138:2845-2853. 2011

Brunskill, E.W. and Potter, S.S. Defining the molecular character of the developing and adult kidney podocyte. In Press. PlosOne. 2011

Brunskill, E.W., Sequeira-Lopez, M.L.S., Pentz, E.S. Lin, E., Aronow, B.J., Potter, S.S*. and Gomez, R.A.* (*co-senior authors) the Genes that confer the identity of the renin cell. J. of Am Soc. Of Nephrology (in press). 2011

2010

Potter SS, Brunskill EW, Patterson LT. Microdissection of the gene expression codes driving nephrogenesis. Organogenesis. 6(4):263-9. Oct-Dec, 2010.
Brunskill EW, Potter SS. Gene expression programs of mouse endothelial cells in kidney development and disease. PLoS One. 5(8):e12034. Aug, 2010.

2009

Georgas K, Rumballe B, Valerius MT, Chiu HS, Thiagarajan RD, Lesieur E, Aronow BJ, Brunskill EW, Combes AN, Tang D, Taylor D, Grimmond SM, Potter SS, McMahon AP, Little MH. Analysis of early nephron patterning reveals a role for distal RV proliferation in fusion to the ureteric tip via a cap mesenchyme-derived connecting segment. Dev Biol. 332(2):273-86. 2009.

2008

Brunskill EW, Aronow BJ, Georgas K, Rumballe B, Valerius MT, Aronow J, Kaimal V, Jegga AG, Yu J, Grimmond S, McMahon AP, Patterson LT, Little MH, Potter SS. Atlas of gene expression in the developing kidney at microanatomic resolution. Dev Cell. 15(5):781-91. 2008. Erratum in: Dev Cell 16(3):482. Yu, Jing. 2009.
McMahon AP, Aronow BJ, Davidson DR, Davies JA, Gaido KW, Grimmond S, Lessard JL, Little MH, Potter SS, Wilder EL, Zhang P; GUDMAP project. GUDMAP: the genitourinary developmental molecular anatomy project. J Am Soc Nephrol. 2008.
Adam M, Murali B, Glenn NO, Potter SS. Epigenetic inheritance based evolution of antibiotic resistance in bacteria. BMC Evol Biol. 8:52. 2008.

Other Significant Publications

Bennett MR, Czech KA, Arend LJ, Witte DP, Devarajan P, Potter SS. Laser capture microdissection-microarray analysis of focal segmental glomerulosclerosis glomeruli. Nephron Exp Nephrol. 107(1):e30-40. 2007.
Potter SS, Hartman HA, Kwan KM, Behringer RR, Patterson LT. Laser capture-microarray analysis of Lim1 mutant kidney development. Genesis. 45(7):432-9. 2007.
Song N, Schwab KR, Patterson LT, Yamaguchi T, Lin X, Potter SS, Lang RA. pygopus 2 has a crucial, Wnt pathway-independent function in lens induction. Development. 134(10):1873-85. 2007.
Schwab KR, Patterson LT, Hartman HA, Song N, Lang RA, Lin X, Potter SS. Pygo1 and Pygo2 roles in Wnt signaling in mammalian kidney development. BMC Biol. 5:15. 2007.
Schwab K, Hartman HA, Liang HC, Aronow BJ, Patterson LT, Potter SS. Comprehensive microarray analysis of Hoxa11/Hoxd11 mutant kidney development. Dev Biol. 293(2):540-54. 2006.
Waclaw RR, Allen ZJ 2nd, Bell SM, Erdélyi F, Szabó G, Potter SS, Campbell K. The zinc finger transcription factor Sp8 regulates the generation and diversity of olfactory bulb interneurons. Neuron. 49(4):503-16. 2006.

Contact Us

S. Steven Potter, PhD

Phone: 513-636-4850
Fax: 513-636-4317
Email: steve.potter@cchmc.org

3333 Burnet Avenue, Cincinnati, Ohio 45229-3026 | 1-513-636-4200 | 1-800-344-2462 | TTY:1-513-636-4900

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