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Focal segmental glomerulosclerosis (FSGS) is a heterogeneous and devastating disease that is one of the major causes of renal failure. The long-term goals of this research are to provide a deeper understanding of this disease, to identify novel therapeutic targets that might lead to more effective treatments and to define gene-expression signature-based subtypes that are useful guides for therapy.
Toward these ends, we are carrying out the following specific aims:
Public Health Relevance
For most FSGS patients, there is no effective therapy, and kidney failure is the end result. We propose to use a combination of cutting-edge technologies to study the normal glomerulus as well as the diseased glomerulus, in both humans and well-defined mouse models, to better understand this disease and to help discover improved methods of treatment.
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The heatmap shows gene-expression differences between normal needle biopsy samples and those of FSGS patients (P1-P10)
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