Yoshida Lab

Fukuda T., Takeda S., Xu R., Kimura A., Sato T., Ochi H., Shibata S., Yoshida Y., Zirong Gu., Bando W., Sunamura S., Ma C., Xu C., Fujita K., Shinomiya K., Hirai T., Asou Y., Enomoto M., Okano O., Okawa A. and Itoh H. Sema3A regulates bone mass accrual through sensory innervations. Nature, in press.

Deck M., Mailhes C., Chauvet S., Keita M., Niquille M., Yoshida M., Yoshida Y., Lebrand C., Mann F., Grove E., and Garel S. Pathfinding of corticothalamic axons relies on a rendezvous with thalamic projections. Neuron, 77, 472-84. 2013.

Katayama K., Leslie J.R., Lang R.A., Zheng Y., and Yoshida Y. Left-right locomotor circuitry depends upon RhoA-driven organization of the neuroepithelium in the developing spinal cord. Journal of Neuroscience. Jul 25;32(30):10396-407. 2012.

Yoshida Y. Semaphorin signaling in vertebrate neural circuit assembly (review article). Frontiers in Molecular Neuroscience, 5, 71. 2012.

Kuwajima T., Yoshida Y., Takegahara N., Kumanogoh A., Petros T.J., Jessell T.M., Sakurai T., and Mason C. Optic chiasm presentation of Semaphorin6D in context with Plexin-A1 and Nr-CAM promotes retinal axon crossing. Neuron, 74; 676-690. 2012.

Leslie J.R., Imai F., Zhou X., Lang R.A., Zheng Y., and Yoshida Y. RhoA is dispendable for axon guidance of sensory neurons in the mouse dorsal root ganglia. Frontiers in Molecular Neuroscience, 5, 67. 2012.

Leslie J.R., Imai F., Fukuhara K., Takegahara N., Rizvi T.A., Friedel R.H., Wang, F., Kumanogoh A., and Yoshida Y. Ectopic myelinating oligodendrocytes in the dorsal spinal cord as a consequence of altered semaphorin6D signaling inhibit synapse formation, Development, 138, 4085-95. 2011.

Matsuoka R.L., Chivatakarn O., Badea T.C., Samuels I.S., Cahill H., Katayama K, Suto F, Chédotal A., Neal P.S., Nathans J., Yoshida Y., Giger R.J., and Kolodkin A.L. Class 5 transmembrane semaphorins control mammalian inner retinal lamination, neurite arborisation, and function. Neuron, 71, 460-473. 2011.

Kim J., Ho W.J., Gaiano N., Yoshida, Y., and Gu C. Semaphoron3E-PlexinD1 signaling regulates VEGF function in developmental angiogenesis via a feedback mechanism. Genes & Dev, 25, 1399-411. 2011.

Katayama K., Melendez J., Baumann J., Leslie J., Chauhan B.K., Nemkul N., Lang R.A., Kuanm C.Y., Zheng Y. and Yoshida Y. Loss of RhoA in neural progenitor cells causes the disruption of adherens junctions and hyperproliferationProc Natl Acad Sci USA. 108, 7607-12. 2011.

Fukushima Y., Okada M., Kagawa1 S., Kataoka H., Hirashima M., Yoshida Y., Mann F., Gomi F., Nishida K., Negi A., Nishikawa S.I, and Uemura A. Sema3E–PlexinD1 signaling facilitates vascular regeneration by selectively suppressing disoriented angiogenesis in ischemic retinopathy in mice. J Clin Inves, 121, 1974-85. 2011.

Watanabe M., Suzuki T., Kim M., Abe Y., Yoshida Y., Sugano S., Yamamoto T. Coronin7 forms a novel E3 ubiquitin ligase complex to promote the degradation of the anti-proliferative protein Tob. FEBS Lett. 585, 65-70. 2011.

TakamatsuH., Takegahara N., NakagawaY., Tomura M., Taniguchi M., Friedel R.H., Rayburn H., Tessier-Lavigne M., Yoshida Y., OkunoT., Mizui M., Kang S., Nojima S., Tsujimura T, Nakatsuji Y., Katayama I., Toyofuku T., Kikutani H., Kumanogoh A. Semaphorins guide the entry of dendritic cells into the lymphatics by activating myosin II. Nature Immunology, 11, 594-600. 2010.

Tawarayama H., Yoshida Y., Suto F., Mitchell K., and Fujisawa H. Roles of Semaphorin-6B and Plexin-A2 in Lamina-Restricted Projection of Hippocampal Mossy Fibers. J Neurosci. 30, 7049-7060. 2010.

Nawabi H., Briançon-Marjollet A., Clark C., Sanyas I., Takamatsu H., Okuno T., Kumanogoh A., Bozon M., Takeshima K., Yoshida Y., Moret F., Abouzid K., and Castellani V. A midline switch of receptor processing regulates commissural axon guidance in vertebrates. Genes Dev, 24, 396-410. 2010.

Pecho-Vrieseling E., Sigrist M., Yoshida Y.,  Jessell T.M., and Arber S. Specificity of Monosynaptic Sensory-Motor Connections Encoded by Sema3e-PlexinD1 Repulsion. Nature, 459, 842-6. 2009.

Zhang Y., Degenhardt K.R., Lu M.M., Bennett J., Yoshida Y., and Epstein J.D. Endothelial inactivation of PlexinD1 results in congenital heart, vascular and skeletal defects. Developmental Biology. 325, 82-93. 2009.

Yoneda M., Suzuki T., Nakamura T., Ajima R., Yoshida Y., Kakuta S., Sudo K., Iwakura Y., Shibutani M., Mitsumori K., Yokota J., Yamamoto T. Deficiency of antiproliferative family protein Ana correlates with development of lung adenocarcinoma. Cancer Sci. 100, 225-32. 2009.

Ajima R., Akiyama T., Usui M., Yoneda M., Yoshida Y., Nakamura T., Minowa O., Noda M., Tanaka S., Noda T., and Yamamoto T. Osteoporotic bone formation in mice lacking tob2; involvement of Tob2 in RANK ligand expression and osteoclasts differentiation. FEBS Lett. 582, 1313-1318. 2008.

Arlotta P., Molyneaux B.J., Jabaudon D., Yoshida Y., and Macklis J.D. Ctip2 controls the differentiation of medium spiny neurons and the establishment of the cellular architecture of the striatum. J Neurosci. 28, 622-32. 2008.

Chauvet S., Cohen S., Yoshida Y., Fekrane L., Livet J., Gayet O., Segu L., Buhot M.C., Jessell T.M., Henderson C.E., and Mann F. Gating of sema3E/plexinD1 signaling by neuropilin-1 switches axonal repulsion to attraction during brain development. Neuron 56, 807-22. 2007.

Kanda T., Yoshida Y., Izu Y., Nifuji A., Ezuna Y., Nakashima K., and Noda M. PlexinD1 deficiency induces defects in axial skeletal morphogenesis. J. Cell Biochem. 101, 1329-37. 2007.

Yoshida Y., Han B., Mendelsohn M., and Jessell T.M. PlexinA1 signaling directs the segregation of proprioceptive sensory axons in the developing spinal cord. Neuron 52, 775-88. 2006.

Wilson J.M., Hartley R., Maxwell D.J., Todd A.J., Lieberam I., Kaltschmidt J.A., Yoshida Y., Jessell T.M., and Brownstone R.M. Conditional rhythmicity of ventral spinal interneurons defined by expression of the Hb9 homeodomain protein. J Neurosci. 25, 5710-9. 2005.

Gu C.*, Yoshida Y.*, Livet J., Reimert D.V., Mann F., Merte J., Henderson C.E., Jessell T.M., Kolodkin A.L., and Ginty D.D. Semaphorin 3E and plexin-D1 control vascular pattern independently of neuropilins. Science 307, 265-8. 2005. (* : equal contribution)

Kawamura-Tsuzuku J., Suzuki T., Yoshida Y., and Yamamoto T. Nuclear localization of Tob is important for regulation of its antiproliferative activity. Oncogene 23, 6630-8. 2004.

Nakamura T., Yao R., Ogawa T., Suzuki T., Ito C., Tsunekawa N., Inoue K., Ajima R., Miyasaka T., Yoshida Y., Ogura A., Toshimori K., Noce T., Yamamoto T., and Noda T. Oligo-astheno-teratozoospermia in mice lacking Cnot7, a regulator of retinoid X receptor beta. Nat Genet. 36, 528-33. 2004.

Usui M., Yoshida Y., Tsuji K., Oikawa K., Miyazono K., Ishikawa I., Yamamoto T., Nifuji A., and Noda M. Tob deficiency superenhances osteoblastic activity after ovariectomy to block estrogen deficiency-induced osteoporosis. Proc Natl Acad Sci USA. 101, 6653-8. 2004.

Iwanaga K., Sueoka N., Sato A., Sakuragi T., Sakao Y., Tominaga M., Suzuki T., Yoshida Y., K-Tsuzuku J., Yamamoto T., Hayashi S., Nagasawa K., and Sueoka E. Alteration of expression or phosphorylation status of tob, a novel tumor suppressor gene product, is an early event in lung cancer. Cancer Lett. 202, 71-9. 2003.

Nakazawa T., Watabe AM., Tezuka T., Yoshida Y., Yokoyama K., Umemori H., Inoue A., Okabe S., Manabe T., and Yamamoto T. p250GAP, a novel brain-enriched GTPase-activating protein for Rho family GTPases, is involved in the N-methyl-d-aspartate receptor signaling. Mol Biol Cell. 14, 2921-34. 2003.

Yoshida Y., von Bubnoff A., Ikematsu N., Blitz IL., Tsuzuku JK., Yoshida EH., Umemori H., Miyazono K., Yamamoto T., and Cho KW. Tob proteins enhance inhibitory Smad-receptor interactions to repress BMP signaling. Mech Dev. 120, 629-37. 2003.

Yoshida Y., Nakamura T., Komoda M., Satoh H., Suzuki T., Tsuzuku JK., Miyasaka T., Yoshida EH., Umemori H., Kunisaki RK., Tani K., Ishii S,. Mori S., Suganuma M., Noda T., and Yamamoto T. Mice lacking a transcriptional corepressor Tob are predisposed to cancer. Genes Dev. 17, 1201-6. 2003.

Usui M., Yoshida Y., Yamashita T., Tsuji K., Isao I., Yamamoto T., Nifuji A., and Noda M. Enhancing effect of Tob deficiency on bone formation is specific to bone morphogenetic protein-induced osteogenesis. J Bone Miner Res. 17, 1026-33. 2002.

Suzuki T., K-Tsuzuku J., Ajima R., Nakamura T., Yoshida Y., and Yamamoto T. Phosphorylation of three regulatory serines of Tob by Erk1 and Erk2 is required for Ras-mediated cell proliferation and transformation. Genes Dev. 16, 1356-70. 2002.

Yoshida Y., Hosoda E., Nakamura T., and Yamamoto T. Association of ANA, a member of the antiproliferative Tob family proteins, with a Caf1 component of the CCR4 transcriptional regulatory complex. Jpn J Cancer Res. 92, 592-6. 2001.

Suzuki T., Matsuda S., Tsuzuku J.K., Yoshida Y., and Yamamoto T. A serine/threonine kinase p90rsk1 phosphorylates the anti-proliferative protein Tob. Genes Cells. 6, 131-138. 2001.

Yoshida, Y., Tanakam S., Umemori, H., Minowa, O., Usui, M., Ikematsu, N., Hosoda, E., Imamura, T., Kuno, J., Yamashita, T., Miyazono, K., Noda, M., Noda, T., and Yamamoto, T. Negative regulation of BMP/Smad signaling by Tob in osteoblasts. Cell 103, 1085-97. 2000.

Ajima R., Ikematsu N., Ohsugi M., Yoshida Y., and Yamamoto T. Cloning and characterization of the mouse tob2 gene. Gene. 253, 215-220. 2000.

Ikematsu, N., Yoshida, Y., Kawamura-Tsuzuku, J., Ohsugi, M., Onda, M., Hirai, M., Fujimoto, J. and Yamamoto, T. Tob2, a novel anti-proliferative Tob/BTG1 family member, associates with a component of the CCR4 transcriptional regulatory complex capable of binding cyclin-dependent kinases. Oncogene 18, 7432-41. 1999.

Umemori, H., Kadowaki, Y., Hirosawa, K., Yoshida, Y., Hironaka, K., Okano, H., and Yamamoto, T. Stimulation of myelin basic protein gene transcription by Fyn tyrosine kinase for myelination. J. Neurosci. 19, 1393-97. 1999.

Yoshida, Y., Matsuda, S., Ikematsu, N., Kawamura-Tsuzuku, J., Inazawa, J., Umemori, H. and Yamamoto, T. ANA, a novel member of Tob/BTG1 family, is expressed in the ventricular zone of the developing central nervous system. Oncogene 16, 2687-93. 1998.

Yoshida, Y., Matsuda, S. and Yamamoto, T. Cloning and characterization of the mouse tob gene. Gene 191, 109-13. 1997.

Matsuda S., Kawamura-Tsuzuku J., Ohsugi M., Yoshida M., Emi M., Nakamura Y., Onda M., Yoshida Y., Nishiyama A., and Yamamoto T. Tob, a novel protein that interacts with p185erbB2, is associated with anti-proliferative activity. Oncogene. 12, 705-713. 1996.