Zorn Lab

Spence JR, Mayhew CN, Rankin SA, Kuhar MF, Vallance JE, Tolle K, Hoskins EE, Kalinichenko VV, Wells SI, Zorn AM, Shroyer NF, Wells JM. Directed differentiation of human pluripotent stem cells into intestinal tissue in vitro. Nature. 470:105-9. 2011.

Rankin SA, Kormish J, Jegga A, Kofron M, Zorn AM. A gene regulatory network controlling hhex transcription in the anterior endoderm of the organizer. Dev. Bio.351: 297-310. 2011.

Bowes JB, Snyder KA, Segerdell E, Jarabek CJ, Azam K, Zorn AM, Vize PD. Xenbase: gene expression and improved integration. NAR. 38: D607-12. 2010.

Hellsten U, Harland RM, Gilchrist MJ, Hendrix D, Jurka J, Kapitonov V, Ovcharenko I, Putnam NH, Shu S, Taher L, Blitz IL, Blumberg B, Dichmann DS, Dubchak I, Amaya E, Detter JC, Fletcher R, Gerhard DS, Goodstein D, Graves T, Grigoriev IV, Grimwood J, Kawashima T, Lindquist E, Lucas SM, Mead PE, Mitros T, Ogino H, Ohta Y, Poliakov AV, Pollet N, Robert J, Salamov A, Sater AK, Schmutz J, Terry A, Vize PD, Warren WC, Wells D, Wills A, Wilson RK, Zimmerman LB, Zorn AM, Grainger R, Grammer T, Khokha MK, Richardson PM, Rokhsar DS. The genome of the Western clawed frog Xenopus tropicalis. Science. 328(5978):633-6. 2010.

Kormish JD, Sinner D, Zorn AM. Interactions between SOX factors and Wnt/beta-catenin signaling in development and disease.Dev. Dyn. 239: 56-68. 2010.

Xu K, Chong D, Rankin SA, Zorn AM, Cleaver O. Rasip1 is required for endothelial cell motility, angiogenesis and vessel formation. Developmental Biology. 15: 269-79. 2009.

Lange AW, Keiser AR, Wells JM, Zorn AM, Whitsett JA. Sox17 promotes cell cycle progression and inhibits TGF-beta/Smad3 signaling to initiate progenitor cell behavior in the respiratory epithelium. PLoS ONE. 4:e5711. 2009.

Rankin SA, Hasebe T, Zorn AM, Buchholz RD. Improved Cre reporter transgenic Xenopus. Dev. Dyn. 238(9):2401-8. 2009.

Bowes JB, Snyder KA, Segerdell E, Jarabek CJ, Azam K, Zorn AM, Vize PD. Xenbase: gene expression and improved integration. NAR. 2010.

Zorn AM, Wells JW. Vertebrate endoderm Development and Organ Formation. Annual Review of Cell and Developmental Biology. 25:221-51. 2009.

Woodland HR, Zorn AM. The core endodermal gene network of vertebrates: Combining developmental precision with evolutionary flexibility. BioEssays. 30:1-9. 2008.

Costa RMB, Soto X, Chen Y, Zorn AM, Amaya E. Spib is required for primitive myeloid development in Xenopus. Blood. 12: 2287-96. 2008.

Li Y, Rankin SA, Sinner D, Kenney, AP, Krieg PA, Zorn AM. Sfrp5 coordinates foregut specification and morphogenesis by antagonizing both canonical and noncanonical Wnt11 signaling. Genes & Development. 22:3050-63. 2008.

Kirilenko P, Weierud FK, Zorn AM, Woodland HR. The efficiency of Xenopus primordial germ cell migration depends on the germplasm mRNA encoding the PDZ domain protein Grip2. Differentiation. 76(4):392-403. 2008.

Mir A, Kofron M, Zorn AM, Bajzer M, Haque M, Heasman J, Wylie CC. FoxI1e activates ectoderm formation and controls cell position in the Xenopus blastula. Development. 134:779-88. 2007.

McLin VA, Rankin SA, Zorn AM. Repression of Wnt/beta-catenin signaling in the anterior endoderm is essential for liver and pancreas development. Development. 134: 2207-2217. 2007.

Kirk EP, Sunde M, Costa MW, Rankin SA, Wolstein O, Castro ML, Butler TL, Hyun C, Guo G, Otway R, Mackay JP, Waddell LB, Cole AD, Hayward C, Keogh A, Macdonald P, Griffiths L, Fatkin D, Sholler GF, Zorn AM, Feneley MP, Winlaw DS, Harvey RP. Mutations in cardiac T-box factor gene TBX20 are associated with diverse cardiac pathologies, including defects of septation and valvulogenesis and cardiomyopathy. Amer Jour Hum Gen. 81: 280-291. 2007.

Sinner D, Kordich JJ, Opoka R Rankin SA, Lin S-J, Jonatan D, Zorn AM, Wells JM. Sox17 and Sox4 differentially regulate beta-catenin/T-cell factor activity and proliferation of colon carcinoma cells. Mol. Cell Biol. 27: 7802-7815. 2007.

Sartor MA, Zorn AM, Schwanekamp JA, Halbleib D, Karyala S, Howell ML, Dean GE, Medvedovic M, Tomlinson CR. A new method to remove hybridization bias for interspecies comparison of global gene expression profiles uncovers an association between mRNA sequence divergence and differential gene expression in Xenopus. Nucleic Acids Res. 5;34(1):185-200. Jan, 2006.

Park KS, Wells JM, Zorn AM, Wert SE, Whitsett JA. Sox17 influences the differentiation of respiratory epithelial cells. Dev Biol. 294:192-202. 2006.

Sinner D, Kirilenko P, Rankin S, Wei E, Howard L, Kofron M, Heasman J, Woodland HR, Zorn AM. Global analysis of the transcriptional network controlling Xenopus endoderm formation. Development. 133:19555-1966. 2006.

Maguire ML, Guler-Gane G, Nietlispach D, Raine ARC, Zorn AM, Standart N, Broadhurst RW. Solution structure and backbone dynamics of the KH-QUA2 region of the Xenopus STAR/GSG quaking protein. J Mol Biol. 348: 265-279. 2005.

Tao Q, Lloyd B, Lang S, Houston D, Zorn A, Wylie C. A novel G protein-coupled receptor, related to GPR4, is required for assembly of the cortical actin skeleton in early Xenopus embryos. Development. 132: 2825-36. 2005.

Park KS, Wells JM, Zorn AM, Wert SE, Laubach VE, Fernandez LG, Whitsett JA. Transdifferentiation of Ciliated Cells During Repair of the Respiratory Epithelium. Am J Respir Cell Mol Biol. 43: 151-157. 2005.

Liu Y, Festing M, Thompson JC, Hester M, Rankin S, El-Hodiri HM, Zorn AM, Weinstein M. Smad2 and Smad3 coordinately regulate craniofacial and endodermal development. Dev. Bio. 2004.

Sinner D, Rankin S, Lee M, Zorn AM. Sox17 and β-catenin cooperate to regulate the transcription of endodermal genes. Development. 131: 3069-3080. 2004.

Gilchrist M, Zorn AM, Voigt J, Smith JC, Papalopulu N, Amaya E. Defining a large set of full-length clones from a Xenopus tropicalis EST project. Dev. Bio. 271: 498-516. 2004.

Daniels M, Shimizu K, Zorn AM, Ohnuma S. Negative regulation of Smad2 by PIASy is required for proper Xenopus mesoderm formation. Development. 131: 5613-5626. 2004.

D’Souza A, Lee M, Taverner N, Mason J, Carruthers S, Smith JC, Amaya E, Papalopulu N, Zorn AM. Molecular components of the endoderm specification pathway in Xenopus tropicalis. Dev. Dyn. 226: 118-127. 2003.

McLin VA, Zorn AM. Organogenesis: making pancreas from liver. Cur. Biol. 13: R96-98. 2003.

Costa JMB, Mason J, Lee M, Amaya E, Zorn AM. Novel gene expression domains reveal early patterning of the Xenopus endoderm. GEP 3: 509-519. 2003.

Stennard FA, Costa MW, Elliott DA, Rankin S, Haast SJ, Lai D, McDonald LPA, Niederreither K, Dolle P, Bruneau BG, Zorn AM, Harvey RP. Cardiac T-box factor Tbx20 directly interacts with Nkx2-5, GATA4, and GATA5 in regulation of gene expression in the developing heart. Dev. Biol. 262: 206-224. 2003.

Standley HJ, Zorn AM, Gurdon JB. A dynamic requirement for community interactions during Xenopus myogenesis. Int.J. Dev. Biol. 3: 279-283. 2002.

Khokha MK, Chung C, Bustamante EL, Gaw LWK, Trott KA, Yeh J, Lim N, Lin JCY, Taverner N, Amaya E, Papalopulu N, Smith JC, Zorn AM, Harland RM, Grammer TC. Techniques and Probes for the Study of Xenopus tropicalis Development. Dev. Dyn. 225:499-510. 2002.

Ishikawa T, Tamai Y, Zorn AM, Yoshida H, Seldin MF, Nishikawa S, Taketo M. Mouse Wnt receptor gene Fzd5 is essential for yolk sac and placental angiogenesis. Development. 128:25-33. 2001.

Shimizu K, Bourillot P-Y, Nielsen SJ, Zorn AM, Gurdon JB. Swift is a novel BRCT domain coactivator of Smad2 in transforming growth factor beta signaling. Mol. Cell Biol. 21(12):3901-12. Jun, 2001.

Butler K, Zorn AM, Gurdon JB. Nonradioactive in situ hybridization to xenopus tissue sections. Methods. 23 (4): 303-312. 2001.

Standley HJ, Zorn AM, Gurdon JB. eFGF and its mode of action in the community effect during Xenopus myogenesis. Development. 128: 1347-1357. 2001.

Zorn AM, Mason J. Gene expression in the embryonic Xenopus liver. Mech. Dev. 103: 153-157. 2001.

Zorn AM. Wnt signalling: Antagonistic Dickkopfs. Current Biology. 11: R592-R595. 2001.

Zorn AM, Butler K, Gurdon JB. Anterior endomesoderm specification in Xenopus by Wnt/beta-catenin and TGF-beta signalling pathways. Dev. Biol. 209: 282-297. 1999.

Zorn AM, Barish G, Williams B, Lavander P, Klymkowsky M, Varmus HE. Regulation of Wnt signaling by Sox proteins: XSox17 alpha/beta and XSox3 physically interact with beta-catenin. Molecular Cell. 4: 487-498. 1999.