• Bioinformatics Core

    The objective of this core is to assist Digestive Health Center (DHC) investigators in the generation and use of genetic, genomic, and proteomic data for their ongoing and planned research initiatives. Faculty and staff from the Bioinformatics core will participate at many levels in planning, exploring, and converting DHC investigators' data into meaningful information and hypotheses by the use of appropriate genetic and statistical analyses and computational tools.

    Services:

    • Design of Gene Sequence and Expression Experiments
    • Quality Control, Normalization, and Statistical Analysis of Gene Expression Data (i.e. Microarray and RNA Seq)
    • Dissection of Regulatory Mechanisms by Computational Promoter Analysis
    • Quality Control, Normalization, and Statistical Analysis of Data Generated by Non-Expression DNA Microarray Technologies (i.e. SNP and Promoter Arrays)
    • Generate Clusters/Groupings of Environmental-Genetic/Chemical Toxin Responses that Exhibit Similar Gene Expression Changes
    • Create Gene and Protein Inventories for GI Development, Function and Disease
    • Investigator Training

    To obtain support contact Rebekah (Bekah) Karns, PhD (Rebekah.Karns@cchmc.org)

    Pricing:

    Consultation with Bioinformatics Staff on digestive disease projects is supported by the DHC. Extensive support requires further discussion with Bioinformatics Director.

    The DHC will subsidize the cost of a single Genespring and/or Avadis NGS license by providing $200 towards the total charge.  To obtain the software send a request to: software@cchmc.org In your request include you are a DHC member.

  • DHC logo

  • Contact Us

    Core Director
    Bruce Aronow, PhD
    Location S10.248
    Phone: 513-636-4865
    Email: bruce.aronow@cchmc.org

    Core Personnel
    Anil Jegga, DVM, MRes
    Location S10.232
    Phone: 513-636-0261
    Email: anil.jegga@cchmc.org

    Rebekah (Bekah) Karns, PhD
    Location S outside of room 10.238
    Phone: 513-636-1005
    Email: Rebekah.Karns@cchmc.org

  • Have you used the DHC Bioinformatics Core?

    Remember to acknowledge the use of the core facility in all publications by stating:
    "This project was supported in part by NIH P30 DK078392 (Bioinformatics Core of the Digestive Disease Research Core Center in Cincinnati)."