Digestive Health Center

  • Chronic Liver Disease

    Kathleen M. Campbell, MD
    Assistant Professor
    Medical Director of Pediatric Liver Transplant Program
    Department of Pediatrics; Division of Gastroenterology, Hepatology, & Nutrition

    Description of Research

    Dr. Campbell is working with the multi-center Studies in Pediatric Liver Transplantation Consortium to fully define the clinical and demographic factors associated with post-liver transplant kidney dysfunction, and to derive an accurate and non-invasive equation to estimate glomerular filtration rate in this specific patient population. In addition, she collaborates with Dr. John Bucuvalas to study immunologic tolerance and the withdrawal of immunosuppression following liver transplantation. She will also be investigating genetic markers that predict poor kidney function in children receiving calcineurin inhibitors using high-throughput NextGen sequencing.

    Collaborations

    In addition to collaboration with the SPLIT Consortium, Dr. Campbell is a center sub-PI for the NIH-funded Immunosuppression Withdrawal in Pediatric Liver Transplantation (iWith) planning grant, led by Dr. Sandy Feng from UCSF, and Dr. John Bucuvalas from CCHMC. She also participated in the institutional application – “Phenotypes, Genotypes and Quality Improvement – eMERGE at Cincinnati Children’s” – led by Dr. John Harley, Director, Center for Autoimmune Genomics Etiology at CCHMC. Projection of Core use: Biostatistical services and Gene and Protein Expression Core.

 
  • Research image.

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    Research image.

    Patient distribution of measured glomerular filtration rate (mGFR) by Chronic Kidney Disease Stage in children after liver transplantation. Figure from Am J Transplant, 2010: 10: 2673-2682.