Digestive Health Center

  • Inflammatory and Diarrheal Diseases

    James P. Franciosi, MD, MS, MSCE
    Assistant Professor
    Department of Pediatrics; Division of Gastroenterology, Hepatology, & Nutrition

    Description of Research

    Dr. Franciosi investigates disorders of gastrointestinal inflammation that include eosinophilic esophagitis and inflammatory bowel disease. One major research focus is to define and validate symptom and quality of life clinical outcome measurement tools in patients with eosinophilic esophagitis (EE). In collaboration with other investigators of the Cincinnati Center for Eosinophilic Disorders, Dr. Franciosi is working to develop the pediatric EE health related quality of life (PEEHRQoL™) and the Pediatric EE Symptom Severity Score (PEESS™) instruments. In addition, Dr. Franciosi has developed a multi-center web-based registry for patients with eosinophilic gastrointestinal conditions (www.regid.org) to capture clinical, pathologic and translational outcome measures as a basis for comparative effectiveness investigations.

    Collaborations

    Dr. Franciosi is collaborating with Dr. Rothenberg to investigate the clinical and translational outcomes that are important to patients with eosinophilic gastrointestinal disorders. Anticipated Core use: Bioinformatics and Integrative Morphology Cores.

 
  • Research image.

    click to enlarge

    Research image.

    A, Patients with 5-14 eosinophils/hpf & ≥15 were more likely to have basal layer hyperplasia than patients with less than 5 eosinophils (eos)/hpf (*P < .001) and less than 15 eosinophils/hpf (**P < 0.001), respectively. Examples of basal layer hyperplasia (lower arrow) and surface layering (upper arrow) (B), lamina propria fibrosis (arrow, C), and microabscesses (arrow, D) are shown. Figure from J Allergy Clin Immunol, 2010;126:112-119.