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James P. Franciosi, MD, MS, MSCEAssistant ProfessorDepartment of Pediatrics; Division of Gastroenterology, Hepatology, & Nutrition
Dr. Franciosi investigates disorders of gastrointestinal inflammation that include eosinophilic esophagitis and inflammatory bowel disease. One major research focus is to define and validate symptom and quality of life clinical outcome measurement tools in patients with eosinophilic esophagitis (EE). In collaboration with other investigators of the Cincinnati Center for Eosinophilic Disorders, Dr. Franciosi is working to develop the pediatric EE health related quality of life (PEEHRQoL™) and the Pediatric EE Symptom Severity Score (PEESS™) instruments. In addition, Dr. Franciosi has developed a multi-center web-based registry for patients with eosinophilic gastrointestinal conditions (www.regid.org) to capture clinical, pathologic and translational outcome measures as a basis for comparative effectiveness investigations.
Dr. Franciosi is collaborating with Dr. Rothenberg to investigate the clinical and translational outcomes that are important to patients with eosinophilic gastrointestinal disorders. Anticipated Core use: Bioinformatics and Integrative Morphology Cores.
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A, Patients with 5-14 eosinophils/hpf & ≥15 were more likely to have basal layer hyperplasia than patients with less than 5 eosinophils (eos)/hpf (*P < .001) and less than 15 eosinophils/hpf (**P < 0.001), respectively. Examples of basal layer hyperplasia (lower arrow) and surface layering (upper arrow) (B), lamina propria fibrosis (arrow, C), and microabscesses (arrow, D) are shown. Figure from J Allergy Clin Immunol, 2010;126:112-119.
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