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Xiaonan Han, PhDAssistant Professor Department of Pediatrics; Division of Gastroenterology, Hepatology, & Nutrition
Dr. Han’s research currently focuses on intestinal barrier dysfunction in inflammatory bowel disease (IBD). His laboratory has recently demonstrated that GM-CSF signaling in intestinal epithelial cells (IEC) is required for intestinal barrier function; furthermore, GM-CSF may maintain intestinal epithelial barrier function via epithelial STAT5 pathway. Dr. Han’s lab has created a series of cell-specific STAT5 knock out mice to study the role of STAT5 in the gastrointestinal tract. He is also interested in developing the herbal remedy for treatment of pediatric Crohn’s disease.
Dr. Han has used the Integrative Morphology, Gene and Protein Expression and Bioinformatics Cores in collaboration with Drs. Denson, Hogan, and Aronow to identify genomic signatures that predict response to treatment of Inflammatory Bowel Disease. Anticipated Core use: Integrative Morphology Core.
click image to enlarge
Top panel: Intestinal epithelial-specific STAT5 knockout mice (STAT5IEC KO) using cre-mediated recombination to delete stat5 locus in Intestinal epithelial cells (IEC). Bottom panel: IEC proliferation was determined using BrdU incorporation measured by IH; original magnification, × 200, n = 7. Submitted for publication.
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