Digestive Health Center

  • Inflammatory and Diarrheal Diseases

    Xiaonan Han, PhD
    Assistant Professor
    Department of Pediatrics; Division of Gastroenterology, Hepatology, & Nutrition

    Description of Research

    Dr. Han’s research currently focuses on intestinal barrier dysfunction in inflammatory bowel disease (IBD). His laboratory has recently demonstrated that GM-CSF signaling in intestinal epithelial cells (IEC) is required for intestinal barrier function; furthermore, GM-CSF may maintain intestinal epithelial barrier function via epithelial STAT5 pathway. Dr. Han’s lab has created a series of cell-specific STAT5 knock out mice to study the role of STAT5 in the gastrointestinal tract. He is also interested in developing the herbal remedy for treatment of pediatric Crohn’s disease. 

    Collaborations and Core Use

    Dr. Han has used the Integrative Morphology, Gene and Protein Expression and Bioinformatics Cores in collaboration with Drs. Denson, Hogan, and Aronow to identify genomic signatures that predict response to treatment of Inflammatory Bowel Disease. Anticipated Core use: Integrative Morphology Core.

 
  • Research image.

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    Research image.

    Top panel: Intestinal epithelial-specific STAT5 knockout mice (STAT5IEC KO) using cre-mediated recombination to delete stat5 locus in Intestinal epithelial cells (IEC). Bottom panel: IEC proliferation was determined using BrdU incorporation measured by IH; original magnification, × 200, n = 7. Submitted for publication.