Digestive Health Center

  • Inflammatory and Diarrheal Diseases

    Jennifer Kaplan, MD, MS
    Assistant Professor
    Department of Pediatrics; Division of Critical Care

    Description of Research

    Dr. Kaplan’s research focuses on understanding the inflammatory response associated with sepsis. The nuclear receptor PPARg is important in controlling the inflammatory response in animal models of sepsis and in critically ill children with sepsis. She demonstrated that in children with sepsis the adipokines adiponectin and resistin are altered. Dr. Kaplan’s current research focuses on the increased susceptibility of diet-induced obese mice to sepsis by focusing on the critical links between the inflammatory pathways in sepsis and obesity. 

    Collaborations and Core Use

    Dr. Kaplan is working with Drs. Zingarelli and Morrow studying the inflammatory pathways in obesity, sepsis and inflammatory bowel disease. Anticipated use of Cores: Integrative Morphology and Gene and Protein Expression Cores.

  • Research image.

    click image to enlarge

    Research image.

    Mice on a high fat diet have lower survival after sepsis. Mice were randomized to a high fat diet or a normal chow diet for 3 weeks. Polymicrobial sepsis was induced by cecal ligation and puncture at 3 weeks and survival was monitored for 30 hours. Survival curve demonstrates mice on a high fat diet for 3 weeks had a lower probability of survival compared to normal chow fed mice after CLP (p=0.009 by log rank test). Submitted for publication.