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Sean R. Moore, MD, MSAssistant Professor Department of Pediatrics; Division of Gastroenterology, Hepatology, & Nutrition
Dr. Moore’s research focuses on the cellular and molecular mechanisms by which a novel glutamine-based oral rehydration and nutrition therapy regulates intestinal barrier repair in patients with diarrhea and malnutrition. Alanyl-Glutamine is a dipeptide that forms the basis of a new oral rehydration and nutrition therapy that works as well as standard glucose-based oral rehydration therapy to treat dehydration from diarrhea and provides additional benefits to undernourished patients. The mechanism by which Alanyl-Glutamine provides these benefits is poorly understood and is the focus of Dr. Moore’s research. Preliminary data from his laboratory suggest that Alanyl-Glutamine improves weight gain and gastrointestinal symptoms by activating the Epidermal Growth Factor Receptor (EGFR) in intestinal epithelial cells. EGFR is a key regulator of the stability of the intestinal epithelium against pathogens, toxins, and pro-inflammatory molecules. To further define the role of EGFR in the mechanisms of intestinal repair by Alanyl-Glutamine ORNT, Dr. Moore’s laboratory uses molecular and genetic approaches in cell culture and in a weanling mouse model of malnutrition enteropathy.
Dr. Moore works with Drs. Cohen, Denson, and Hogan investigating intestinal barrier repair. Anticipated use of Cores: Integrative Morphology and Gene and Protein Expression Cores.
click image to enlarge
Jejunal histology (H&E x 200) in malnourished (regional diet) and nourished (control diet) and Alanyl-Glutamine (Ala-Gln) vs water-treated 6-week-old C57/Bl6 mice. Morphometric comparisons of villus height, crypt depth, and villous height:crypt depth ratio were highly significant (not shown). Figure in a manuscript submitted for publication.
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