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Timothy A. Pritts, MD, PhDAssociate Professor Department of Surgery
Dr. Pritts’ research interests revolve around the role of intestinal epithelial cells and the intestinal mucosa in the inflammatory response to injury and infection. Previous studies have examined NF-kB activation and cytokine production in the gut during endotoxemia, as well as the modulation of this response by heat shock proteins. His current studies aim to explore the role of acute inflammation on cytokine production in intestinal epithelia cells and mucosa. An additional interest is the effect of injury on intestinal mucosal structure and barrier function.
Dr. Pritts collaborates with Dr. Lentsch investigating the acute inflammatory response in intestinal mucosa and with Dr. Chip Montrose utilizing confocal/live microscopy services (a component of the Integrative Morphology Core).
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IL-1β-induced IL-8 production is potentiated in Caco-2 cells overexpressing C/EBP-β or δ. Caco-2 cells were transfected with expression plasmids for C/EBP-β or δ or C/EBP-β reversed (rev). Twenty-four hours after transfection, cells were treated for twenty-four hours with 0.5 ng/ml IL-1Β. *P <0.05 vs. IL-1β. Figure 6 from J. Cell Physiol, 2002; 192:64-70.
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