Digestive Health Center

  • Inflammatory and Diarrheal Diseases

    Kurt Schibler, MD
    Associate Professor
    Department of Pediatrics; Division of Neonatology

    Description of Research

    Dr. Schibler’s research interests are focused on the development of the innate immune system. Specifically he is studying the innate mucosal immunity and delineating the role of human milk in infant health. Additionally, Dr. Schibler is developing novel strategies for prevention and treatment of necrotizing enterocolitis.

    Collaborations and Core Use

    Dr. Schibler collaborates with Drs. Denson, Jiang, and Morrow examining glycan phenotype as well as glycosyltransferase gene expression in relation to the pathogenesis of both inflammatory bowel disease and necrotizing enterocolitis. Anticipated Core use: Gene and Protein Expression and Bioinformatics Core.

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    Dot plots of the salivary H OD values in the 383 study infants by survivorship status, birth weight, and gestational age. Genotype is indicated for each infant (black dots represent non-secretor [AA] genotype, red dots represent heterozygote secretor [AG] genotype, green dots represent homozygote secretor [GG] genotype, and blue dots represent unknown genotype). The gray line indicates the CART cutoff point for optimizing differences in death outcome. The H antigen value is lower in infants who died than in infants who survived (P<0.001). Figure from J Pediatr 2011;158:745-51.