Digestive Health Center

  • Obesity and the Digestive System

    Randy J. Seeley, PhD
    Director of the Metabolic Disease Institute
    Department of Internal Medicine; Division of Endocrinology, Diabetes and Metabolism

    Description of Research

    Dr. Seeley’s research has focused on the actions of various hormones in the regulation of food intake, body weight and the regulation of circulating fuels. In particular, he has focused upon the numerous hypothalamic and gastrointestinal peptides and their associated receptors that influence both energy intake as well as peripheral metabolic processes with a focus on developing new treatment strategies for obesity. A large part of his work includes dissecting the biological effects of various bariatric surgical procedures to cause weight loss and improve glucose control using rodent models.


    Dr. Seeley collaborates with Drs. Woods, Kohli, and D’Alessio studying the role of key gut hormones to regulate food intake and glucose regulation. He also works with Dr. Kohli examining the role that diets high in saturated fat and fructose have in the development of obesity and nonalcoholic steatohepatitis. Anticipated Core use: Integrative Morphology Core.

  • Research image.

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    Research image.

    Vertical sleeve gastrectomy (VSG) does not impair the ability to overeat or to regain body weight after caloric restriction. A. After 22 days of caloric restriction, all rats regained body weight to exceed prerestriction weight and did so along a similar trajectory. B. During first 24 hours of ad libitum feeding after the period of caloric restriction, all rats consumed significantly more calories than prerestriction baseline. Pair-fed (PF). Figure from Gastroenterology, 2010; 138:2426-36, 2436.e1-3.