Digestive Health Center

  • Chronic Liver Disease

    Kenneth E. Sherman, MD, PhD
    Professor and Director
    Department of Internal Medicine; Division of Digestive Diseases

    Description of Research

    Dr. Sherman’s research focuses on the interactions of hepatotropic viruses in immunosuppressed hosts. In particular, his laboratory investigates the relationship between hepatitis C virus (HCV) and immunodeficiency virus infection. He uses state of the art molecular techniques that include viral kinetic modeling in different stages of disease progression and the emergence and molecular genotypes of HCV quasi-species analysis in the context of well-defined clinical settings. To explore the underlying mechanisms of host response to a viral insult, he studies cellular and immune correlates of viral evolution. He is also actively involved in translational research utilizing antiviral and immunomodulatory therapies for patients with viral hepatitis.

    Collaborations and Core Use

    Dr. Sherman collaborates with Dr. Zucker identifying the association between serum bilirubin levels and the incidence of colorectal cancer. Additionally, Dr. Sherman works with Drs. Blackard and Shata on a clinical intervention trial in HCV/HIV co-infected subjects treated with antiretroviral therapy. Projection of Core use: Biostatistical services.

 
  • Research image.

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    Research image.

    Mean CD4 counts by fibrosis stage grouping (Ishak 1–3 vs 4–6) over period of treatment with pegylated interferon alfa-2a. Error bar represents standard error of mean. No significant difference between observed outcome at any time point or in group comparison. Figure 3 from J Viral Hepat, 2010; 17: 222-226.