Digestive Health Center

  • Core Director

    David P. Witte, MD
    Professor, Director of Pathology, Director of Integrative Morphology Core
    Department of Pediatrics; Division of Pathology

    Description of Research

    In addition to his role as Director of the Integrative Morphology Core, Dr. Witte is a co-investigator in several projects studying gene regulation of development and characterizing animal models of liver and intestinal disease. Dr. Witte’s background includes more than fifteen years of combined anatomic pathology training and professional pathology experience utilizing morphologic based methodology including anatomic dissection and macroscopic observation, light and electron microscopy, specialized histochemical staining techniques, immunohistochemistry, and characterizing gene expression patterns by in situ hybridization. Dr. Witte has been involved with the detailed characterization of the expression pattern of more than 25 developmentally regulated genes in the mouse embryo including homeobox containing transcription factor genes and other critical developmentally regulated genes necessary for implantation or normal organ morphogenesis and the detailed mapping of gene regulatory elements.

    Collaborations

    Dr. Witte collaborates with many of the investigators using the Integrative Morphology Core to advance the knowledge of the underlining mechanisms of digestive diseases.

 
  • Research image.

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    Research image.

    Sections of colons harvested from FibWT and Fibγ390-396A mice after 5d of dextran sodium sulfate. Leukocyte infiltrates (arrowhead) were more apparent in colons from control mice. The difference in leukocyte infiltration seemed to be primarily due to differences in macrophages (F4/80-staining red cells).  From Cancer Res 2010;70:2634-2643.