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Aaron M. Zorn, PhDAssociate ProfessorAssociate Director, Digestive Health CenterDepartment of Pediatrics; Division of Developmental BiologyVisit the Zorn Lab Site
Dr. Zorn’s long-term research goal is to understand the molecular mechanisms controlling the development of the liver, pancreas and gastrointestinal tract, which are derived from the embryonic endoderm. He uses frog and mouse embryos as model systems to investigate the genetic pathways underlying this poorly understood process of organogenesis. Dr. Zorn is applying a combination of molecular and embryological techniques, including microarray technology and transgenics, to uncover the molecular and cellular events controlling foregut organ development. Current investigations examine how transcription factors integrate signals from different growth factors to specify foregut progenitor cells and their development into the embryonic liver. He is also conducting a number of functional screens to identify novel genes involved in GI development. This research will help uncover the molecular basis of congenital diseases in these organ systems and the ability to regenerate therapeutically useful tissues from stem cells.
The Zorn lab collaborates extensively with Dr. Wells and his research team to translate embryological principles uncovered from animal models to the directed differentiation of human stem cells. Anticipated Core use: Integrative Morphology Core, Gene and Protein Expression Core, and Bioinformatics Core.
click image to enlarge
Expression of a hhex:gfp transgene marks the foregut progenitor cells in a Xenopus embryo. Figure in a manuscript submitted for publication.
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