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Lawrence M. Dolan, MD Director, Division of Endocrinology
investigates the natural history of obesity, insulin resistance, and diabetes mellitus with a focus on their effect on the development and progression of cardiovascular disease in youth.
Director, Division of Endocrinology
Director, Endocrinology Clinical Laboratory
Professor, UC Department of Pediatrics
Pediatric endocrinology; diabetes mellitus
Lawrence M. Dolan, MD, is board-certified in pediatrics and pediatric endocrinology. He has been on the faculty of Cincinnati Children's Hospital Medical Center in the Department of Pediatrics for the University of Cincinnati College of Medicine since 1983.
Dr. Dolan is a professor of pediatrics in the Division of Endocrinology. His research focuses on the epidemiology and genetics of obesity, insulin resistance, abnormal carbohydrate metabolism, diabetes and their relationships to the development and progression of cardiovascular disease.
Dr. Dolan received his bachelor of science degree from the University of San Francisco. He received his doctor of medicine degree from the University of California at Los Angeles.
Dr. Dolan completed his pediatric internship and residency at the University of Minnesota. He also served as chief resident. He obtained fellowship training in pediatric endocrinology at the University of Virginia.
Valenzuela JM, Smith LB, Stafford JM, D'Agostino RB Jr, Lawrence JM, Yi-Frazier JP, Seid M, Dolan LM. Shared decision-making among caregivers and health care providers of youth with type 1 diabetes. J Clin Psychol Med Settings. 2014 Sep;21(3):234-43.
Shah AS, Dabelea D, Talton JW, Urbina EM, D’Agostino RB, Wadwa RP, Marcovina S, Hamman RF, Daniels SR, Dolan LM. Smoking and Arterial Stiffness in Youth with Type 1 Diabetes: the SEARCH Cardiovascular Disease Study. J Pediatr. 2014 Jul;(1)165:110-6.
Lawrence JM, Imperatore G, Dabelea D, Mayer-Davis EJ, Linder B, Saydah S, Klingensmith GJ, Dolan L, Standiford DA, Pihoker C, Pettitt DJ, Talton JW, Thomas J, Bell Ra, D’Agostino RB Jr, SEARCH for Diabetes in Youth Study Group. Trends in Incidence of Type 1 Diabetes Among non-Hispanic White Youth in the United States, 2002-2009. Diabetes. 2014 Jun 4. Epub ahead of print.
Dabelea D, Mayer-Davis EJ, Saydah S, Imperatore G, Linder B, Divers J, Bell R, Badaru A, Talton JW, Cume T, Leise AD, Merchant AT, Lawrence JM, Reynolds K, Dolan L, Liu LL, Hamman RF, SEARCH for Diabetes in Youth Study. Prevalence of type 1 and type 2 diabetes among children and adolescents from 2001 to 2009. JAMA. 2014 May 7;311:1778-86.
Shah AS, Gao Z, Urbina EM, Kimball TR, Dolan LM. Prediabetes: The Effects on Arterial Thickness and Stiffness in Obese Youth. J Clin Endocrinol Metab. 2014 Mar;99(3):1037-43.
Dabelea D, Lawrence JM, Pihoker C, Dolan L, D’Agostino Jr RB, Marcovina S, Mayer-Davis EJ, SEARCH for Diabetes in Youth Study. Re: “Prevalence of Diagnosed and Undiagnosed Type 2 Diabetes Mellitus Among US Adolescents: Results from the Continuous NHANES, 1999-2010”. Am J Epidemiol. 2014 Feb 1;179:396-7.
Inge TH, Zeller MH, Jenkins TM, Helmrath M, Brandt ML, Michalsky MP, Harmon CM, Courcoulas A, Horlick M, Xanthacos SA, Dolan L, Mitsnefes M, Barnett SJ, Bunchar R, Teen-LABS Consortium. Perioperative Outcomes of Adolescents Undergoing Bariatric Surgery: The Teen-Longitudinal Assessment of Bariatric Surgery (Teen-LABS) Study. JAMA Pediatr. 2014 Jan;168:47-53.
Rohan JM, Rausch JR, Shroff Pendley J, Delamater A, Dolan L, Reeves G, Drotar D. Identification and Prediction of Group-Based Glycemic Control Trajectories during the Transition to Adolescence. Health Psychol. 2013 Nov 25. Epub ahead of print.
Corathers SD, Kichler J, Jones N, Houchen A, Jolly M, Morwessel N, Crawford P, Dolan LM, Hood KK. Improving Depression Screening for Adolescents with Type 1 Diabetes. Pediatrics. 2013 Nov;132(5):e1395-402.
Gordon SM, Davidson WS, Urbina EM, Dolan LM, Lu JL, Heink A, Zang H, Shah AS. The effects of type 2 diabetes on lipoprotein composition and arterial stiffness in male youth. Diabetes. 2013 Aug;62(8):2958-67.
SEARCH for Diabetes in Youth. Principal Investigator. Center for Disease Control and the National Institutes of Health. Sep 2010–Oct 2015. 3 (1U18DP002709).
Accelerated cardiovascular aging in Youth. Co-investigator. National Institutes of Health. Jan 2011–Dec 2015. R01-105591.
Adolescent Bariatric Surgery: Assessing Benefits and Risks. Co-investigator. National Institutes of Health. Apr 2012–Mar 2017. UO1DK072493.
Self-management of type 1 diabetes during adolescence. Co-investigator. National Institutes of Health. Jul 2013–Jun 2018. R01DK069486-06.
SEARCH for Air. Co-investigator. National Institutes of Health. Sep 2011–Jun 2015. RO1ES019168.
Philippe F. Backeljauw, MD Fellowship Program Director, Division of Endocrinology
Within the Division of Endocrinology, Dr. Backeljauw's research emphasis relates to children with growth disorders and Turner syndrome. Ongoing studies focus on IGF-I therapy in GH resistance syndromes, as well as assessment and treatment of Turner syndrome co-morbidities. His research efforts have resulted in more than 100 publications, including peer-reviewed original manuscripts, abstracts and textbook chapters.
Fellowship Program Director, Division of Endocrinology
Clinical Director, Cincinnati Growth Center
Director, Turner Syndrome Center of Cincinnati
Pediatric endocrinology; growth disorders; Turner syndrome
Dr. Backeljauw's research has focused on clinical trials evaluating the efficacy and safety of recombinant human IGF-I in patients with growth hormone insensitivity syndrome. These studies have led to the USFDA approval of IGF-I as a treatment for growth failure associated with primary IGF-I deficiency. The studies ended in 2012, and results have been published. He has also been involved in other multicenter studies of IGF-I therapy or combined growth hormone plus IGF-I therapy for idiopathic short stature. In collaboration with Dr. Meilan Rutter, they recently finished a comprehensive study looking at the efficacy and safety of IGF-I therapy in patients with Duchenne muscular dystrophy.
Another area of research for Dr. Backeljauw, during the last five years, is related to activities in the Turner Syndrome Center. We now have conducted several clinical research projects evaluating the cardiovascular pathology, hypertension, attention deficit disorder status, gonadectomy surgery outcomes, and, in particular, vasculopathy prevalence in our large cohort of patients with Turner syndrome.
Lawson S, Little I, Urbina E, Khoury P, Backeljauw PF. Vasculopathy in the young Turner syndrome population. Accepted for publication in JCEM, July 2014.
Sisley S, Backeljauw PF. Response to Letter to the Editor: Low incidence of pathology detection and high cost of screening in the evaluation of asymptomatic children with short stature. J Pediatr. 2013 Nov; 163(5):1535.
Chen J, Gutmark E, Myalavarapu G, Backeljauw PF, Gutmark-Little I, Gutmark E. J Biomech. Numerical investigation of mass transport through patient-specific deformed aortae. 2013 Oct 21. pii: S0021-9290(13)00485-5. [Epub ahead of print]
Backeljauw PF, Kuntze J, Frane J, Calikoglu A, Chernausek SD. The recommended dose for IGF-I therapy does not compromise long-term growth. Letter to the editor. J Clin Endocrinol Metab. July 18, 2013.
Sisley S, Vargas-Trujillo M, Khoury J, Backeljauw PF. Low incidence of pathology detection and high cost of screening in the evaluation of asymptomatic children with short stature. J Pediatr. 2013;163(4): 1045-1051.
Backeljauw PF, Chernausek SD, Calikoglu A, Kuntze J, Frane J. Adult height in patients with severe primary IGF-I deficiency. Horm Res Paediatr. 2013;80(1): 47-56.
Prahl Wittberg L, van Wyk S, Mihaescu M, Fuchs, L, Gutmark E, Backeljauw P, Gutmark-Little I. The impact of aortic arch geometry on flow characteristics. American Institute of Aeronautics and Astronautics, 51st AIAA Aerospace Sciences Meeting Proceedings. 2013;1-16.
Gutmark-Little I, Backeljauw P. Cardiac magnetic resonance imaging in Turner syndrome. Clinical Endocrinology. 2013;78, 646–658.
Gutmark-Little I, Hor K, Gottliebson W, Cnota J, Gottliebson WM, Backeljauw PF. Partial anomalous pulmonary venous return is common in Turner syndrome. J Pediatr Endocr and Met. 2012;25 (5-6), 435-440.
Bang P, Ahmed F, Argente J, Backeljauw P, Bettendorf M, Bona G, Coutant R, Rosenfeld RG, Walenkamp MJ, Savage MO. Identification and management of poor response to growth-promoting therapy in children with short stature. Clinical Endocrinology (Oxford). 2012;77, 169-181.
Nancy A. Crimmins, MD
is interested in genetic and environmental factors of early-onset obesity as well as timing of co-morbidities in toddlers and preschoolers with extreme obesity. She is also interested in the predictors of fatty liver disease in patients with obesity and type 2 diabetes. Dr. Crimmins is the local PI of TrialNet, a natural history study which focuses on the development of type 1 diabetes.
Assistant Professor, UC Department of Pediatrics
MD: Indiana University School of Medicine, 2000.
Residency: Pediatrics, Cincinnati Children's Hospital Medical Center, 2003.
Fellowship: Pediatric Endocrinology, Cincinnati Children's Hospital Medical Center, 2006.
Namjou B, Keddache M, Marsolo K, Wagner M, Lingren T, Cobb B, Perry C, Kennebeck S, Holm IA, Crimmins NA, Martin L, Solti I, Kohane IS, Harley JB. EMR-linked GWAS study: investigation of variation landscape of loci for body mass index in children. Frontiers in Genetics. 2013 Dec 3;4268.
Chuang J, Zellar MH, Inge T, Crimmins NA. Bariatric Surgery for Severe Obesity in Two Adolescents with Type 1 Diabetes. Pediatrics. 2013 Oct;132(4):e1031-4.
Kottyan LC, Woo JG, Keddache M, Banach W, Crimmins NA, Dolan LM, Martin LJ. Novel Variations in the Adiponectin Gene (ADIPOQ) May Affect Distribution of Oligomeric Complexes. Springerplus. 2012 Dec;1(1):66.
Pettitt DJ, Talton JW, Liese AD, Liu LL, Crimmins NA, West NA, D’Agostino RB, Kahn HS for the SEARCH for Diabetes in Youth Study Group. Comparison of Two Waist Circumference Measurement Protocols: The SEARCH for Diabetes in Youth Study. International Journal of Pediatric Obesity. 2012 Sept.
Maahs DM, Dabelea D, D’Agostino RB, Andrews JS, Shah AS, Crimmins NA, Mayer-Davis EJ, Marcovina S, Imperatore G, Wadwa RP, Daniels SR, Reynolds K, Hamman RF, Dolan LM. Glucose Control Predicts 2-Year Change in Lipid Profile in Youth with Type 1. Journal of Pediatrics. 2012 Jul 11.
Sung V, Beebe DW, Vandyke R, Fenchel MC, Crimmins NA, Kirk S, Hiscock H, Amin R, Wake M. Does sleep duration predict metabolic risk in obese adolescents attending tertiary services? A cross-sectional study. Sleep. 2011 Jul 1;34(7):891-8.
Guilfoyle SM, Crimmins NA, Hood KK. Blood glucose monitoring and glycemic control in adolescents with type 1 diabetes: meter downloads versus self-report. Pediatr Diabetes. 2011 Mar 11. Epub ahead of print.
Sabin MA, Clemens SL, Saffery R, McCallum Z, Campbell MW, Kiess W, Crimmins NA, Woo JG, Leong GM, Werther GA, Ukoumunne OC, Wake MA. New directions in childhood obesity research: how a comprehensive biorepository will allow better prediction of outcomes. BMC Med Res Methodol. 2010 Oct 22;10:100.
Andrew Dauber, MD, MMSc Program Director and Director of Translational Research, Cincinnati Center for Growth Disorders
Program Director and Director of Translational Research, Cincinnati Center for Growth Disorders
MD: Harvard Medical School, Boston, MA, 2000.
MS: Clinical Investigation, Harvard Medical School, Boston, MA 2008.
Residency: Pediatrics, Boston Combined Residency Program in Pediatrics, Boston Children's Hospital and Boston Medical Center, Boston, MA.
Chief Resident: Pediatrics, Boston Children's Hospital, Boston, MA, 2004-2005.
Fellowship: Pediatric Endocrinology, Boston Children's Hospital, Boston, MA.
Certification: Pediatrics, Pediatric Endocrinology
Nilsson O, Guo MH, Dunbar N, Popovic J, Flynn D, Jacobsen C, Lui JC, Hirschhorn JN, Baron J, Dauber A. Short stature, accelerated bone maturation, and early growth cessation due to heterozygous aggrecan mutations. J Clin Endocrinol Metab. 2014 Aug;99(8):E1510-8.
Kerns SL, Guevara-Aguirre J, Andrew S, Geng J, Guevara C, Guevara-Aguirre M, Guo M, Oddoux C, Shen Y, Zurita A, Rosenfeld RG, Ostrer H, Hwa V, Dauber A. A novel variant in CDKN1C is associated with intrauterine growth restriction, short stature, and early-adulthood onset diabetes. Clin Endocrinol Metab. 2014 Jul 24:jc20141949. Epub ahead of print.
Dauber A, Rosenfeld RG, Hirschhorn JN. Genetic Evaluation of Short Stature. J Clin Endocrinol Metab. 2014 Jun 10:jc20141506. Epub ahead of print.
Dauber A, Ercan A, Lee J, James P, Jacobs PP, Ashline DJ, Wang SR, Miller T, Hirschhorn JN, Nigrovic PA, Sackstein R. Congenital disorder of fucosylation type 2c (LADII) presenting with short stature and developmental delay with minimal adhesion defect. Hum Mol Genet. 2014 Jun 1;23(11):2880-7.
Batey L, Moon JE, Yu Y, Wu B, Hirschhorn JN, Shen Y, Dauber A. A novel deletion of IGF1 in a patient with idiopathic short stature provides insight Into IGF1 haploinsufficiency. J Clin Endocrinol Metab. 2014 Jan;99(1):E153-9.
Dauber A, Golzio C, Guenot C, Jodelka FM, Kibaek M, Kjaergaard S, Leheup B, Martinet D, Nowaczyk MJ, Rosenfeld JA, Zeesman S, Zunich J, Beckmann JS, Hirschhorn JN, Hastings ML, Jacquemont S, Katsanis N. SCRIB and PUF60 are primary drivers of the multisystemic phenotypes of the 8q24.3 copy-number variant. Am J Hum Genet. 2013 Nov 7;93(5):798-811.
Wang SR, Carmichael H, Andrew SF, Miller TC, Moon JE, Derr MA, Hwa V, Hirschhorn JN, Dauber A. Large-scale pooled next-generation sequencing of 1077 genes to identify genetic causes of short stature. J Clin Endocrinol Metab. 2013 Aug;98(8):E1428-37.
Abreu AP, Dauber A, Macedo DB, Noel SD, Brito VN, Gill JC, Cukier P, Thompson IR, Navarro VM, Gagliardi PC, Rodrigues T, Kochi C, Longui CA, Beckers D, de Zegher F, Montenegro LR, Mendonca BB, Carroll RS, Hirschhorn JN, Latronico AC, Kaiser UB. Central precocious puberty caused by mutations in the imprinted gene MKRN3. N Engl J Med. 2013 Jun 27;368(26):2467-75.
Dauber A, Lafranchi SH, Maliga Z, Lui JC, Moon JE, McDeed C, Henke K, Zonana J, Kingman GA, Pers TH, Baron J, Rosenfeld RG, Hirschhorn JN, Harris MP, Hwa V. Novel microcephalic primordial dwarfism disorder associated with variants in the centrosomal protein ninein. J Clin Endocrinol Metab. 2012 Nov;97(11):E2140-51.
Dauber A, Yu Y, Turchin MC, Chiang CW, Meng YA, Demerath EW, Patel SR, Rich SS, Rotter JI, Schreiner PJ, Wilson JG, Shen Y, Wu BL, Hirschhorn JN. Genome-wide association of copy-number variation reveals an association between short stature and the presence of low-frequency genomic deletions. Am J Hum Genet. 2011 Dec 9;89(6):751-9.
Deborah A. Elder, MD
Dr. Elder’s current research focus is beta-cell function and glucose tolerance in different diabetes types. Specifically, she follows glucose tolerance in the cystic fibrosis population and abnormalities found in those with chronic pancreatitis. Dr. Elder is also a key member of the Pancreatic Center and Lung Transplantation Center at Cincinnati Children's. These new divisions will have mechanisms to track patient clinical data and clinical outcomes.
Type 1 diabetes; type 2 diabetes; cystic-fibrosis-related diabetes; assessment of beta-cell function in the evaluation of total pancreatectomy and islet autotransplantation (TPAIT) in children with chronic pancreatitis; growth disorders; precocious puberty; pancreatic center member; cystic fibrosis and endocrine combined clinic; lung transplantation center member.
Auble B, Elder D, Gross A, Hillman JB. Differences in the Management of Adolescents with Polycystic Ovary Syndrome across Pediatric Specialties. J Pediatr Adolesc Gynecol. 2013 May 28.
Elder DA, Herbers P, Weis T, Standiford D, Woo JG, D’Alessio DA. Beta-cell function in adolescent and adults with newly diagnosed type 2 diabetes mellitus. J. Pediatr. June 2012;160(6):904-10.
Elder DA, Woo JG, D’Alessio DA. Impaired beta-cell sensitivity to glucose and maximal insulin secretory capacity in adolescents with type 2 diabetes. Ped Diabetes. 2010; 11(5):314-21.
Elder DA, D’Alessio DA, Eyal O, Mueller R, Smith FO, Kansra AR, Rose SR. Abnormalities in Glucose Tolerance Are Common in Children with Fanconi Anemia and Associated with Impaired Insulin Secretion. Pediatric Blood & Cancer. 2008; 51(2):256-60.
Elder DA, Wooldridge JL, Dolan LM, D’Alessio DA. Glucose Tolerance in Children and Adolescents with Cystic Fibrosis and No Prior History of Diabetes. J Pediatr. 2007;151(6):653-8.
Elder DA, Prigeon RL, Wadwa RP, Dolan LM, D’Alessio DA. Beta-cell Function, Insulin Sensitivity and Glucose Tolerance in Obese Diabetic and Nondiabetic Adolescents and Young Adults. J Clin Endocrinol Metab. 2006;91(1):185-91.
Eyal O, Naffaa LN, Elder DA. A Case of Macroprolactinoma and Elevated Insulin-Like Growth Factor-I in a Young Boy. Acta Paediatr. 2005;94(12):1852-6.
Elder DA, Roper MG, Henderson RC, Davenport ML. Kyphosis in a Turner Syndrome Population. Pediatrics. 2002;109(6):e93.
Elder DA, Kaiser-Rogers K, Aylsworth AS, Calikoglu AS. Type 1 diabetes mellitus in a patient with chromosome 22q11.2 deletion syndrome. American Journal of Medical Genetics. 2001; 101(1):17-9.
Elder DA, Karayal AF, D’Ercole AJ, Calikoglu AS. Effects of hypothyroidism on insulin-like growth factor-I expression during brain development in mice. Neuroscience Letters. 2000; 293(2):99-102.
Iris Gutmark-Little, MD
currently conducts research in an interdisciplinary project along with engineering, radiology, cardiology, and pulmonology. The first involves a study of the TS airway, imaged using MRI, then virtually reconstructed, and analyzed to measure air flow features. The overall aim is to assess the cause of airway disease and specific treatments for this poorly described problem in the TS patient group. Similarly, a second project is ongoing and involves modeling aortic blood flow properties from TS patients who have undergone MRI for clinical purposes. The overall aim of this project is to elucidate the cause and progression of aortic disease in TS women.
Turner syndrome; general pediatric endocrinology; growth; puberty; hypopituitarism
BS: Louisiana State University, Baton Rouge, Louisiana 2000.MD: Johns Hopkins University School of Medicine, Baltimore, Maryland 2004.Residency: Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio 2007.
Fellowship: Pediatric Endocrinology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio 2010.
Certification: General Pediatrics, American Board of Pediatrics, 2008; Pediatric Endocrinology, American Board of Pediatrics, pending 2011.
Lawson SA, Urbina EM, Gutmark-Little I, Khoury PR, Gao Z, Backeljauw PF. Vasculopathy in the young Turner syndrome population. J Clin Endocrinol Metab. 2014 Jun 24. Epub ahead of print.
Chen J, Gutmark EJ, Mylavarapu G, Backeljauw PF, Gutmark-Little I. Numerical investigation of blood flow through deformed aortae. J Biomech. 2014 Jan 22;47(2):544-52.
Gutmark-Little I, Backeljauw PF. Cardiac magnetic resonance imaging in Turner syndrome. Clin Endocrinol (Oxf). 2012 May;78(5):646-58.
Gutmark-Little I, Hor KN, Cnota J, Gottliebson WM, Backeljauw PF. Partial anomalous pulmonary venous return is common in Turner syndrome. J Pediatr Endocrinol Metab. 2012;25(5-6):435-40.
Kim HK, Gottliebson W, Hor K, Backeljauw P, Gutmark-Little I, Salisbury SR, Racadio JM, Helton-Skally K, Fleck R. Cardiovascular anomalies in Turner syndrome: spectrum, prevalence, and cardiac MRI findings in a pediatric and young adult population. AJR Am J Roentgenol. 2011 Feb;196(2):454-60.
Stuart Handwerger, MD
Regulation of gene expression in human placenta and uterine decidua during differentiation.
Visit the Handwerger Lab.
Handwerger S, Brar A. Paracrine/autocrine regulation of human placental lactogen gene. Biology of the Neonate. 2014.
Kessler CA, Stringer, Stanek J, Stringer K, Handwerger S. ETS1 induces human trophoblast differentiation. Endocrinology. 2014.
Sheridan R, Belundi C, Khoury J, Stanek J, Handwerger S. FOXO1 expression in villous trophoblast of preeclampsia and fetal growth restriction placentas. Histol Histpathol. 2014 Sept 9.
Xie H, Sun X, Piao Y, Jegga AG, Handwerger S, Ko MS, Dey SK. Silencing or amplification of endocannabinoid signaling in blastocysts via CB1 compromises trophoblast cell migration. J Biol Chem. 2012 Sep 14;287(38):32288-97.
Sheridan RM, Stanek J, Khoury J, Handwerger S. Abnormal expression of transcription factor AP-2α in pathologic placentas. Human Pathology. 2012 Nov;43(11):1866-74.
Schroeder J, Stanek J, Handwerger S. TEAD1 inhibits prolactin gene expression in cultured human uterine decidual cells. Molecular and Cellular Endocrinology. 2011;295:32-38.
Schroeder J, Kessler C, Handwerger S. TWIST1 markedly represses the decidualization of human uterine stromal cells. Endocrinology. 2011;152:4368-76.
Sherafat-Kazemzadeh R, Schroeder JK, Kessler CA, Handwerger S. Parathyroid Hormone-Like Hormone (PTHLH) Represses Decidualization of Human Uterine Fibroblast Cells by an Autocrine/Paracrine Mechanism. J. Clin. Endicrinol. Metab. 2010;96:102-25.
Tang M, Naidu D, Hearing P, Handwerger S, Tabibzadeh S. LEFTY, a member of the transforming growth factor-beta superfamily, inhibits uterine stromal differentiation: a novel autocrine role. Endocrinology. 2010;151:1320-30.
Handwerger S. New insights into the regulation of human cytotrophoblast cell differentiation Molecular and Cellular Endocrinology. Molecular and Cellular Endocrinology. 2010;323:94-104.
Jonathan C. Howell, MD, PhD
is a clinical endocrinologist who is interested in the study of endocrine defects among patients with hematological disorders and cancer. He studies inherent endocrine deficiencies in patients with congenital anemias and the late endocrine effects of chemotherapy, radiation, chronic transfusions, and chronic steroid therapy with the aim of improving outcomes of patients who have anemia disorders or who are cancer survivors.
Type 1 and type 2 diabetes mellitus; endocrinopathy in bone marrow failure syndromes; growth disorders; thyroid disorders
Jonathan C. Howell, MD, PhD, is board certified in both pediatrics and pediatric endocrinology. He has been on the faculty of Cincinnati Children’s Hospital Medical Center in the Department of Pediatrics for the University of Cincinnati College of Medicine since 2012.
Dr. Howell is an assistant professor of pediatrics in the Division of Endocrinology. His main clinical focus is diabetes as well as providing care for patients with endocrine disorders, including growth, thyroid, pituitary, pubertal, and adrenal dysfunction. Dr. Howell’s research focuses on the effects of congenital anemias and cancer on the endocrine system and the outcomes of chemotherapy, radiation, transfusions, and chronic steroid therapy on endocrine hormone function.
Dr. Howell received his Bachelor of Arts degree from Hanover College. He received his PhD from Indiana University and his MD from Indiana University School of Medicine.
Dr. Howell completed his pediatric internship and residency at Cincinnati Children’s Hospital Medical Center, where he also served as chief resident. He also obtained his fellowship training from Cincinnati Children’s.
BA:Hanover College, Hanover, IN, 1997.
PhD: Indiana University (Edward F. Srour, thesis adviser), Indianapolis, IN, 2003.
MD: Indiana University School of Medicine, Indianapolis, IN, 2005.
Residency: Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, 2005-2008.
Chief Residency: Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, 2008-2009.
Endocrinology Fellowship: Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, 2009-2012
Certification: Pediatrics, 2008; Pediatric Endocrinology, 2013.
McCracken, Kyle, Jonathan C. Howell, James M. Wells, Jason R. Spence. Generating human intestinal tissue from pluripotent stem cells in vitro. Nature Protocols. 2011;6(12): 1920-1928.
Howell, Jonathan C, James M. Wells. Generating intestinal tissue from stem cells: potential for research and therapy. Regenerative Medicine. 2011;6(6): 743-755.
Howell, Jonathan C, Mandi Cafasso, Philippe F. Backeljauw. Superior mesenteric artery syndrome as a presentation of Graves’ disease in adolescence. EndoTrends. 2011;17(3): 1-3.
Case, Jamie, Tamara L. Horvath, Jonathan C. Howell, Mervin C. Yoder and Edward F. Srour. Clonal multilineage differentiation of murine common pluripotent stem cells isolated from both skeletal muscle and adipose stromal cells. Annals of the New York Academy of Sciences. 2004;1044: 1-18.
Howell, Jonathan C., Wei-Hua Lee, Paul Morrison, Jin Zhong, Mervin C. Yoder, and Edward F. Srour. Pluripotent stem cells identified in multiple murine tissues. Annals of the New York Academy of Sciences. 2003. 996: 158-173.
Howell, Jonathan C, Mervin C. Yoder. Adult Stem Cell Plasticity Defined. NeoReviews. 2003;4(7): 181-186.
Royer, Cassandra L, Jonathan C. Howell, Paul R. Morrison, Edward F. Srour, Mervin C. Yoder. Muscle-derived CD45+Sca-1+c-kit- progenitor cells give rise to skeletal muscle myotubes in vitro. In Vitro Cellular and Developmental Biology -- Animal. 2003;38(9): 512-517.
Howell, Jonathan C, Mervin C. Yoder, Edward F. Srour. Hematopoietic potential of murine skeletal muscle-derived CD45-Sca-1+c-kit- cells. Experimental Hematology. 2002;30(8): 915-924.
Vivian Hwa, PhD Basic Research Director, Cincinnati Center for Growth Disorders
Basic Research Director, Cincinnati Center for Growth Disorders
Associate Professor, UC Department of Pediatrics
BS: University of Sydney, Sydney, Australia.
PhD: University of Illinois, Champaign-Urbana, IL.
Kern SL, Guevara-Aguirre J, Andrew S, Geng J, Guevara C, Guevara-Aguirre M, Guo M, Oddoux C, Shen Y, Zurita A, Rosenfeld RG, Ostrer H, Hwa V, Dauber A. A novel variant in CDKN1C is associated with intrauterine growth restriction, short stature, and early-adulthood onset diabetes. J Clin Endocrinol Metab. 2014 Jul 24. Epub ahead of print.
Feigerlova E, Swinyard M, Andrew SF, Derr MA, Farnsworth J, Rosenfeld RG, Hwa V. A novel GHR intronic variant c.266+83G>T, activates a cryptic 5’ splice site causing severe GHR deficiency and classical GH insensitivity syndrome. Horm Res Paediatr. 2013;80(6):397-405.
Varco-Merth B, Feigerlová E, Shinde Ujwal, Rosenfeld RG, Hwa V, Rotwein P. Severe growth deficiency is associated with STAT5b mutations that disrupt protein folding and activity. Mol Endocrinol. 2013 Jan;27(1):150-61.
Dauber A, LaFranchi SH, Maliga Z, Lui JC, Moon JE, McDeed C, Henke K, Zonana J, Kingman GA, Pers TH, Baron J, Rosenfeld RG, Hirschhorn JN, Harris MP, Hwa V. Novel Microcephalic Primordial Dwarfism Disorder Associated with Variants in the Centrosomal Protein Ninein. J Clin Endocrinol Metab. 2012 Nov;97(11):E2140-51.
Scalia PA, Martinez AS, Feigerlova E, Bezrodnik L, Gaillard MI, Di Giovanni D, Ballerini MG, Jasper HG, Heinrich JJ, Fang P, Domené HM, Rosenfeld RG, Hwa V. A novel missense mutation in the SH2 domain of the STAT5B gene results in a transcriptionally inactive STAT5b associated with severe IGF-I deficiency, immune dysfunction, and lack of pulmonary disease. J Clin Endocrinol Metab. 2012 May;97(5):E830-9.
Derr MA, Aisenberg J, Fang P, Tenenbaum-Rakover Y, Rosenfeld RG, Hwa V. The growth hormone receptor (GHR) c.899dupC mutation functions as a dominant negative: insights into the pathophysiology of intracellular GHR defects. J Clin Endocrinol Metab. 2011 Nov;96(11):E1896-904.
Fang P, Kofoed EM, Little BM, Ross RJM, Frank, SJ, Hwa V, Rosenfeld RG. A mutant STAT5b, associated with growth hormone insensitivity and IGF-I deficiency, cannot function as a signal transducer or transcription factor. J Clin Endocrinol Metab. 2006 Apr; 91(4):1526-34.
Hwa V, Little B, Adiyaman P, Kofoed E, Pratt KL, Ocal G, Berberoglu M, Rosenfeld RG. Severe growth hormone insensitivity resulting from total absence of signal transducer and activator of transcription 5b. J Clin Endocrinol Metab. 2005 Jul;90(7):4260-6.
Hwa V, Little B, Kofoed EM, Rosenfeld RG. Transcriptional regulation of insulin-like growth factor-I (IGF-I) by interferon-gamma (IFN-γ) requires STAT-5b. J Biol Chem. 2004 Jan 23;279(4):2728-36.
Kofoed EM*, Hwa V*, Little B, Woods KA, Buckway CK, Tsubaki J, Pratt KL, Bezrodnik L, Jasper H, Tepper A, Heinrich JJ, Rosenfeld RG. Growth hormone insensitivity associated with a STAT5b mutation. N Engl J Med. 2003 Sep 18:349(12):1139-47. *co-first authors
Jonathan D. Katz, PhD
is working to understand the role that autoreactive T lymphocytes play in the Immunopathogenesis of type 1 diabetes, the most common pediatric autoimmune disease. Major focuses include defining: (a) the control of autoreactive T cells via central and peripheral tolerance; (b) the role NKT cells play in regulating autoreactive T cells; and (c) the role dendritic cells play in activating and regulating autoreactive T cells in type 1 diabetes.
T cells; MHC, beta cell death; islet antigens
Jonathan D. Katz, PhD, focuses on autoimmune diabetes research. Autoimmune diabetes, also known as type 1 diabetes (T1D), is the most common pediatric autoimmune disease. Roughly 1/250 individuals develop T1D in the United States.There is currently no cure for T1D and the only treatment is daily exogenous insulin replacement therapy. Many T1D patients eventually develop secondary complications, such as hearth disease, blindness, peripheral neuropathy and renal failure.
Dr. Katz's work focuses on the role that autoreactive T lymphocytes play in the disease process. His lab interested in (1) the control of autoreactive T cells via central and peripheral tolerance, (2) the role NKT cells play in regulating autoreactive T cells, and (3) the role dendritic cells play in activating and regulating autoreactive T cells in T1D.
Most of his work uses the non-obese diabetic (NOD) mouse strain that spontaneously develops T1D with remarkable similar to the T1D seen in human patients. The availability of the NOD strain has allowed us to take a modern, reductionist molecular and cellular immunology approach to understanding the mechanism(s) and genetics underlying T1D susceptibility and disease progression. His lab makes extensive use of knockout, transgenic, regulated gene expression, targeted ablation, cell transfer and genomic studies the progression and regulation of T1D in the NOD mouse.
Katz JD, Ondr JK, Opoka RJ, Garcia Z, Janssen EM. Cutting edge: merocytic dendritic cells break T cell tolerance to beta cell antigens in nonobese diabetic mouse diabetes. J Immunol. 2010 Aug 15;185(4):1999-2003.
Pang S, Zhang L, Wang H, Yi Z, Li L, Gao L, Zhao J, Tisch R, Katz JD, Wang B. CD8(+) T cells specific for beta cells encounter their cognate antigens in the islets of NOD mice. Eur J Immunol. 2009 Oct;39(10):2716-24.
Saxena V, Ondr JK, Magnusen AF, Munn DH, Katz JD. The countervailing actions of myeloid and plasmacytoid dendritic cells control autoimmune diabetes in the nonobese diabetic mouse. J Immunol. 2007 Oct 15;179(8):5041-53.
Wojciechowski S, Tripathi P, Bourdeau T, Acero L, Grimes HL, Katz JD, Finkelman FD, Hildeman DA. Bim/Bcl-2 balance is critical for maintaining naive and memory T cell homeostasis. J Exp Med. 2007 Jul 9;204(7):1665-75.
Cain JA, Smith JA, Ondr JK, Wang B, Katz JD. NKT cells and IFN-gamma establish the regulatory environment for the control of diabetogenic T cells in the nonobese diabetic mouse. J Immunol. 2006 Feb 1;176(3):1645-54.
Vukkadapu SS, Belli JM, Ishii K, Jegga AG, Hutton JJ, Aronow BJ, Katz JD. Dynamic interaction between T cell-mediated beta-cell damage and beta-cell repair in the run up to autoimmune diabetes of the NOD mouse. Physiol Genomics. 2005 Apr 14;21(2):201-11.
Hutton JJ, Jegga AG, Kong S, Gupta A, Ebert C, Williams S, Katz JD, Aronow BJ. Microarray and comparative genomics-based identification of genes and gene regulatory regions of the mouse immune system. BMC Genomics. 2004 Oct 25;5(1):82.
Jane C. Khoury, PhD
is the senior biostatistician for the study of the epidemiology of stroke in Cincinnati, and is principal investigator for the biostatistical core of a Special Program Of Translational Research In Acute Stroke. She holds a joint appointment in the Division of Endocrinology and works with many of the faculty and fellows on study design and statistical methods in development of their research studies. Her personal research interests involve the effect of intra-uterine exposure to type 1 diabetes on childhood growth, metabolism and cardiac function.
Stroke, diabetes in pregnancy; research design and analysis.
Yolton K, Xu Y, Sucharew H, Succop P, Altaye M, Popelar A, Montesano MA, Calafat AM, Khoury JC. Impact of low-level gestational exposure to organophosphate pesticides on neurobehavior in early infancy: a prospective study. Environ Health. 2013 Sep 13;12(1):79.
Sucharew H, Khoury J, Moomaw CJ, Alwell K, Kissela BM, Belagaje S, Adeoye O, Khatri P, Woo D, Flaherty ML, Ferioli S, Heitsch L, Broderick JP, Kleindorfer D. Profiles of the National Institutes of Health Stroke Scale items as a predictor of patient outcome. Stroke. 2013 Aug;44(8):2182-7.
Khoury JC, Kleindorfer D, Alwell K, Moomaw CJ, Woo D, Adeoye O, Flaherty ML, Khatri P, Ferioli S, Broderick JP, Kissela BM. Diabetes Mellitus: a Risk Factor for Ischemic Stroke in a Large Bi-Racial Population. Stroke. 2013. 44(6):1500-1504.
Mahabee-Gittens EM, Xiao Y, Gordon JS, Khoury JC. The dynamic role of parental influences in preventing adolescent smoking initiation. Addict Behav. 2013 Jan 11;38(4):1905-1911.
Khoury JC, Dolan LM, VanDyke R, Rosenn B, Feghali M, Miodovnik M. Fetal development in women with diabetes: imprinting for a life-time?Journal of Maternal-Fetal & Neonatal Medicine. 2012; 25(1), 11-14.
VanDyke R, Ren Y, Sucharew HJ, Miodovnik M, Rosenn B, Khoury JC. Characterizing maternal glycemic control: a more informative approach using semiparametric regression. Journal of Maternal-Fetal & Neonatal Medicine. 2012; 25(1), 15-19.
Yolton K, Xu YY, Strauss D, Altaye M, Calafat AM, Khoury J. Prenatal exposure to bisphenol A and phthalates and infant neurobehavior. Neurotoxicology and Teratology. 2011; 33(5), 558-566.
Xu YY, Yolton K, Khoury J. Earliest Appropriate Time for Administering Neurobehavioral Assessment in Newborn Infants. Pediatrics. 2011;127(1), E69-E75.
Bollepalli S, Dolan LM, Miodovnik M, Feghali M, Khoury JC. Asymmetric large-for-gestational-age infants of type 1 diabetic women: Morbidity and abdominal growth. Am J Perinatol. 2010; 27(8), 603-610.
Kleindorfer D, Khoury J, Moomaw CJ, Alwell K, Woo D, Flaherty ML, Khatri P, Adeoye O, Ferioli S, Broderick JP, Kissela BM. Stroke Incidence is Decreasing in Whites, but Not in Blacks: A Population-Based Estimate of Temporal Trends in Stroke Incidence from the Greater Cincinnati/Northern Kentucky Stroke Study. Stroke. 2010;41(7):1326-31.
Hemorrhagic and Ischemic Stroke Among Blacks and Whites. Co-Investigator. R01 NINDS/NIH. Jan 2009-Dec 2014.
Recanalization Therapies and Markers of Stroke Outcome. Co-Investigator. P50 NINDS. Sep 2002-April 2015.
Neurobehavioral and Neuroimaging Effects of Traffic Exposure in Children. Co-Investigator. R01 NIH. July 2012-March 2017.
SEARCH for Diabetes in Youth, Phase 3: Registry Study. Biostatistician. Center for Disease Control & Prevention. Sep 2010-Sep 2015.
Improving post-discharge outcomes by facilitating family-centered transitions from hospital to home. Co-Investigator. PCORI. July 2014-June 2017.
Determine the Optimal Method for Handling Non-Detectable Values for Exposure Measurement in Epidemiologic Evaluation. Principal Investigator. Center for Clinical and Translational Science Training. May 2014-April 2015.
Sarah Lawson, MD
focuses on the progression of heart disease in the Turner syndrome population, assessing the endocrine needs in children who have received cranial radiation for oncology treatments, and genetics associated with septo-optic dysplasia.
BS: Lee University, Cleveland, TN, 2000.
MD: University of Kentucky, Lexington, KY, 2005.
Residency: Kentucky Children’s Hospital, Lexington, KY, 2005-2008.
Fellowship: Cincinnati Children’s Hospital, Cincinnati, OH.
Takahisa Nakamura, PhD
RNA-related inflammation in obesity and metabolic diseases
Dr. Nakamura received his PhD from the University of Tokyo in 2003. He completed postdoctoral training in the laboratory of Dr. Gökhan S. Hotamisligil at Harvard School of Public Health in 2013, followed by his faculty appointment at Cincinnati Children's Hospital in 2013.
PhD: University of Tokyo, 2003.
Postdoctoral Fellow: University of Tokyo, 2003-2006
Research Fellow: Harvard University, 2006-2010
Research Associate: Harvard University, 2010-2013
Takahisa Nakamura, Alessandro Arduini, Brenna Baccaro, Masato Furuhashi, and Gökhan S. Hotamisligil. Small molecule inhibitors of PKR improve glucose homeostasis in obese, diabetic mice. Diabetes. 2013 In press
Lu B, Nakamura T, Inouye K, Li J, Tang Y, Lundbäck P, Valdes-Ferrer SI, Olofsson PS, Kalb T, Roth J, Zou Y, Erlandsson-Harris H, Yang H, Ting JP, Wang H, Andersson U, Antoine DJ, Chavan SS, Hotamisligil GS, Tracey KJ. Novel role of PKR in inflammasome activation and HMGB1 release. Nature. 2012 Aug 20;488(7413):670-4. Morita M. Oike Y, Nagashima T, Kadomatsu T, Tabata M, Suzuki T, Nakamura T, Yoshida N, Okada M, Yamamoto T. Obesity resistance and increased hepatic expression of catabolism-related mRNAs in Cnot3(+/-) mice. EMBO J. 2011 Sep 6;30(22):4678-4691. Nakamura T, Furuhashi M, Li P, Cao H, Tuncman G, Sonenberg N, Gorgun CZ, Hotamisligil GS. Double-stranded RNA-dependent Protein Kinase Links Pathogen Sensing with Stress and Metabolic Homeostasis. Cell. 2010 Feb 5;140(3):338-48. Yoneda M, Suzuki T, Nakamura T, Ajima R, Yoshida Y, Kakuta S, Sudo K, Iwakura Y, Shibutani M, Mitsumori K, Yokota J, Yamamoto T. Deficiency of antiproliferative family protein Ana correlates with development of lung adenocarcinoma. Cancer Sci. 2009 Feb;100(2):224-232. Ajima R, Akiyama T, Usui M, Yoneda M, Yoshida Y, Nakamura T, Minowa O, Noda M, Tanaka S, Noda T, Yamamoto T. Osteoporotic bone formation in mice lacking tob2; involvement of Tob2 in RANK ligand expression and osteoclasts differentiation. FEBS Lett. 2008 Apr 16;582(9):1313-8. Morita M, Suzuki T, Nakamura T, Yokoyama K, Miyasaka T, Yamamoto T. Depletion of mammalian CCR4b deadenylase triggers elevation of the p27Kip1 mRNA level and impairs cell growth. Mol Cell Biol. 2007 Jul;27(13):4980-90. Nakamura T, Yao R, Ogawa T, Suzuki T, Ito C, Tsunekawa N, Inoue K, Ajima R, Miyasaka T, Yoshida Y, Ogura A, Toshimori K, Noce T, Yamamoto T, Noda T. Oligoasthenoteratozoospermia in mice lacking Cnot7, a regulator of retinoid X receptor beta. Nat Genet. 2004 May;36(5):528-33.Kimura H*, Nakamura T*, Ogawa T, Tanaka S, Shiota K. Transcription of mouse DNA methyltransferase 1 (Dnmt1) is regulated by both E2F-Rb-HDAC-dependent and -independent pathways. Nucleic Acids Res. 2003 Jun 15;31(12):3101-13. *These authors contributed equally to this work. Yoshida Y*, Nakamura T*, Komoda M, Satoh H, Suzuki T, Tsuzuku JK, Miyasaka T, Yoshida EH, Umemori H, Kunisaki RK, Tani K, Ishii S, Mori S, Suganuma M, Noda T, Yamamoto T. Mice lacking a transcriptional corepressor Tob are predisposed to cancer. Genes Dev. 2003 May 15;17(10):1201-6. *These authors contributed equally to this work.
Susan R. Rose, MD
investigates hypothalamic pituitary function and disorders of growth, puberty or thyroid hormone. She has special interest in the effects of neural injury on hypothalamic-pituitary function, such as after traumatic brain injury, cranial radiation, anoxia, iron overload.
Neuro-endocrinology; hypothalamic-pituitary injury; growth disorders; puberty disorders; thyroid disorders; late effects of cancer
Susan Rose is professor in the Division of Endocrinology at Cincinnati Children’s Hospital Medical Center and the University of Cincinnati. She has published over 100 review articles or chapters, and about 100 peer-reviewed articles. These include updating guidelines for care of congenital hypothyroidism and writing the chapter on thyroid for Fanaroff's and Avery's textbooks of neonatology. She’s served on the state newborn screening (NBS) committee in Tennessee. She is involved in long term follow up of newborn screening for CAH and congenital hypothyroidism with Region 4 and with the Federal Workgroup on NBS Standards.
She has clinical expertise and research interests in hypothalamic pituitary function, thyroid hormone disorders, and in disorders of growth or puberty. She has a special interest in the effects of central nervous system injury on hypothalamic-pituitary function. In addition, she has expertise and experience in evaluating the endocrine conditions associated with congenital bone marrow failure syndromes such as Fanconi anemia, Blackfan Diamond anemia, and Shwachman-Diamond syndrome. In addition, she is evaluating the endocrine consequences of hypothalamic-pituitary injury, including traumatic brain injury and injury from treatments for cancer, as well as comparing the relative efficacy of several treatments for precocious puberty. In this study, she will be developing growth curves specific to Fanconi Anemia, recognizing that healthy children with FA may not grow along the typical growth pattern of other healthy children.
MD: Case Western Reserve School of Medicine, 1980.
MEd: School Psychology, University of Dayton, 1972.
Residency: The Cleveland Clinic, 1983.
Fellowship: National Institutes of Health, 1986.
Certification: Pediatrics, 1985; Pediatric Endocrinology, 1986.
Auble BA, Makoroff K, Bollepalli S, Weis T, Colliers T, Khoury J, Rose SR. Hypopituitarism in pediatric survivors of inflicted traumatic brain injury. J Neurotrauma. 2014 Feb 15;31(4):321-6.
Myers KC, Rose SR, Rutter MM, Mehta PA, Cole T, Harris RE. Endocrine evaluation of children with and without Shwachman-Bodian-Diamond syndrome gene mutations and Shwachman-Diamond syndrome. J Pediatr. 2013 Jun;162(6):1235-40.
Rutter MM, Collins J, Rose SR, Woo JG, Sucharew H, Sawnani H, Hor KN, Cripe LH, Wong BL. Growth hormone treatment in boys with Duchenne muscular dystrophy and glucocorticoid-induced growth failure. Neuromuscul Disord. 2012 Dec;22(12):1046-56.
Rose SR, Myers K, Rutter MM, Mueller R, Khuory JC, Mehta PA, Harris RE, Davies SM. Endocrine phenotype of children and adults with Fanconi anemia. Pediatr Blood Cancer. 2012 Oct;59(4):690-6.
Merchant TE, Rose SR, Bosley C, Wu S, Xiong X, Lustig RH. Growth hormone secretion after conformal radiation therapy in pediatric patients with localized brain tumors. J Clin Oncol. 2011 Dec 20;29(36):4776-80.
Kaulfers AM, Backeljauw PF, Reifschneider K, Blum S, Michaud L, Weiss M, Rose SR. Endocrine dysfunction following traumatic brain injury in children. J Pediatr. 2010 Dec;157(6): 894-9.
Rose SR. Improved diagnosis of mild hypothyroidism using time-of-day normal ranges for thyrotropin. J Pediatr. 2010 Oct;157(4):662-7.
Slaughter JL, Meinzen-Derr J, Rose SR, Leslie ND, Chandrasekar R, Linard SM, Akinbi HT. The effects of gestational age and birth weight on false-positive newborn screening rates. Pediatrics. 2010 Nov;126(5):910-6.
Kazlauskaite R, Evans AT, Villabona CV, Abdu TAM, Ambrosi B, Atkinson AB, Choi CH, Courtney CH, Gonc EN, Maghnie M, Oelkers W, Rose SR, Soule SG, Tordjman K, Consortium for evaluation of corticotropin test in hypothalamic-pituitary insufficiency. Corticotropin tests for hypothalamic-pituitary adrenal insufficiency: A metaanalysis. J Clin Endocrinol Metab. 2008 Nov;93(11):4245-53.
Rose SR. Pharmacologic and physiologic regulators of the nocturnal TSH surge; A clinical research center study. Recent Advances and Research Updates. ISSN 0972-4699, 2007; 8:219-29.
Meilan M. Rutter, MD, FRACP
is a member of several multidisciplinary clinical teams, including the Neuromuscular Comprehensive Care Center and the Center for Disorders of Sex Development (DSD). Related research interests involve endocrine issues in Duchenne muscular dystrophy, currently focusing on a trial of insulin-like growth factor-I (IGF-I) therapy in this population, and participation in a multicenter trial of parental attitudes from having a child with a DSD.
Bone health and calcium metabolism; disorders of growth, puberty and sex development; endocrine function in cancer survivors; endocrine function in neuromuscular disorders
Insulin-like growth factor-1 (IGF-1) therapy in Duchenne Muscular Dystrophy
Meilan Rutter is board-certified in Pediatrics and Pediatric Endocrinology. She is an Assistant Professor of Pediatrics in the Division of Endocrinology, and joined the faculty of Cincinnati Children's Hospital Medical Center in 2008. Currently, Dr. Rutter is assistant director of the Pediatric Endocrinology Fellowship Program.
Dr. Rutter received her degrees of Bachelor of Medicine and Bachelor of Surgery (MB, BCh) from the University of Wales College of Medicine. She completed her training in Pediatrics in New Zealand, and was admitted to Fellowship of the Royal Australasian College of Physicians (FRACP) in 1995. She underwent fellowship training in Pediatric Endocrinology at Cincinnati Children's. She completed further pediatric residency training to achieve American Board of Pediatrics specialty and subspecialty board certification.
Dr. Rutter treats children and adolescents with endocrine disorders and diabetes mellitus. She serves as a consultant for the Neuromuscular Comprehensive Care Center and the Neuro-Oncology program at Cincinnati Children's. Additionally. she is a member of the Disorders of Sex Development interdisciplinary team.
MB, BCh: University of Wales College of Medicine, Cardiff, United Kingdom.FRACP: Royal Australasian College of Physicians, New Zealand.Residency: Auckland Children's Hospital and Dunedin Hospital, New Zealand; Cincinnati Children's, Cincinnati, OH.
Fellowship: Pediatric Endocrinology, Cincinnati Children's, Cincinnati, OH.
Certification: General Pediatrics, American Board of Pediatrics, 2002; Pediatric Endocrinology, American Board of Pediatrics, 2003; Pediatrics, Fellowship of the Royal Australasian College of Physicians, 1995.
Rose SR, Rutter MM, Mueller R, Harris M, Hamon B, Fletcher Bulluck A, Smith FO. Bone mineral density is normal in children with Fanconi anemia. Pediatric Blood & Cancer. 2011 Apr. Epub ahead of print.
Bianchi ML, Biggar D, Bushby K, Rogol AD, Rutter MM, Tseng B. Endocrine aspects of Duchenne Muscular Dystrophy. Neuromuscular Disorders. 2011;21(4):298-303.
Wong BL, Rutter MM, Rose SR, Clark E, Vonderhaar K. Growth hormone therapy in Duchenne Muscular Dystrophy. Best Evidence Statement, Cincinnati Children’s Hospital Medical Center, Cincinnati, Ohio. 2009.
Rutter MM. What is an endocrinologist and why is endocrine care important for Duchenne? Action Duchenne newsletter. 2009.
Murray R, Rutter MM, Racine M, Rose SR. Report on The Endocrine Society’s 90th Annual Meeting. Highlights. 2008;16(4):1-36.
Rutter MM, Racine M, Rose SR. Report on The Endocrine Society’s 89th Annual Meeting. Highlights. 2007;15(3):2-30.
Rutter MM, Rose SR. Long-term endocrine sequelae of childhood cancer. Curr Opin Pediatr. 2007 Aug;19(4):480-7.
Rutter MM, Markoff E, Clayton L, Akeno N, Zhao G, Clemens TL, Chernausek SD. Osteoblast-specific expression of insulin-like growth factor-1 in bone of transgenic mice induces insulin-like growth factor binding protein-5. Bone. 2005 Feb;36(2):224-31.
Rutter MM, Prahalad S, Passo M, Backeljauw PF. Idiopathic hypercalcemia and eosinophilic fasciitis: a novel association. J Pediatr Endocrinol Metab. 2004 Sep;17(9):1251-4.
Rutter MM, Smith EP. Pseudohypoparathyroidism type Ia: late presentation with intact mental development. J Bone Miner Res. 1998 Jul;13(7):1208-9.
Amy S. Shah, MD, MS
is a pediatric endocrinologist whose research focuses on the mechanisms that contribute to early onset cardiovascular and cerebrovascular disease in adolescents with obesity and type 2 diabetes. Dr. Shah’s laboratory work focuses on the contribution of high density lipoproteins (HDL) to protect against atherosclerosis and her clinical research utilizes uses noninvasive imaging modalities to measure the atherosclerotic burden in youth. She also sees patients in clinic with diabetes, endocrine concerns and lipid abnormalities.
Endocrinology; diabetes; lipid disorders
Amy S. Shah, MD, MS, is a board certified pediatric endocrinologist who research focuses on the risk factors that contribute to early atherosclerosis. Ongoing projects focus on understanding the role of lipids and lipoproteins to atherosclerosis and the use of non invasive imaging to assess early atherosclerosis. Dr. Shah's current research is funded by a K23 grant from the National Institutes of Health. Dr. Shah has received several prestigious awards including the International Society of Pediatric and Adolescent Diabetes Young Investigator Award.
MD: St. George’s University Medical School, Grenada, West Indies, 2004.
Pediatric Residency: Loyola University Medical Center, Maywood, IL, 2007.
Endocrine Fellowship: Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, 2010.
Research Fellowship: Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, 2011.
MS: Clinical Research, The University of Cincinnati, Cincinnati, OH, 2011.
Certifications: The American Board of Pediatrics, Subspeciality Board in Pediatric Endocrinology.
Shah AS, Dabelea D, Talton JW, Urbina EM, D`Agostino RB, Wadwa RP, Marcovina S, Hamman RF, Daniels SR, Dolan LM. Smoking and Arterial Stiffness in Youth with Type 1 Diabetes: The SEARCH CVD study. Journal of Pediatrics. 2014 Jul;165(1):110-6.
Shah AS, Gao Z, Urbina EM, Kimball TR, Dolan LM. Pre-diabetes: The Effects on Arterial Thickness and Stiffness in Obese Youth. Journal of Clinical Endocrinology and Metabolism. 2 2014 Mar;99(3):1037-43.
Shah AS, Urbina EM, Khoury PR, Kimball TR, Dolan LM. Lipids and lipoprotein ratios: The contribution to carotid intima media thickness in adolescents and young adults with type 2 diabetes mellitus. Journal of Clinical Lipidology. 2013 October;7(5):441-445.
Shah AS, Tan L, Lu JL, Davidson WS. The proteomic diversity of high density lipoproteins: Our emerging understanding of its importance in lipid transport and beyond. Journal of Lipid Research. 2013 Oct;54(10):2575-85.
Gordon SM, Davidson WS, Urbina EM, Dolan LM, Heink A, Zang H, Lu LJ, Shah AS. The effects of type 2 diabetes on lipoprotein composition and arterial stiffness in male youth. Diabetes. 2013 Aug;62(8):2958-67. ***With commentary published by von Eckardstein A, Nofer JR Diabetes August 2013 62:2662-2664.
Shah AS, Dolan LM, D’Agostino R, Standiford D. Davis C, Testaverde L, Pihoker C, Daniels SR, Urbina EM. Comparison of Mercury and Aneroid Blood Pressure Measurements in Youth. Pediatrics. 2012 May;129(5):e1205-10. PMID: 22508914
Shah AS, Dolan LM, Gao Z, Kimball TR, Urbina EM. Racial Differences in Arterial Stiffness Among Youth with Type 2 Diabetes. Pediatric Diabetes. 2012 Mar; 13(2):170-5.
Shah AS, Khoury PR, Dolan LM, Ippisch HM, Urbina EM, Daniels SR, Kimball, TR. The Effects of Obesity and Type 2 Diabetes Mellitus on Cardiac Structure and Function in Adolescents and Young Adults. Diabetologia. 2011 Apr; 54 (4):722-30.
Shah AS, Dolan LM, Gao Z, Kimball TR, Urbina EM. Clustering of Cardiovascular Risks: A Simple Method of Detecting Cardiovascular Risk in Youth. Pediatrics. 2011 Feb; 127(2):e312-8.
Shah AS, Dolan LM, Kimball TR, Gao Z, Khoury PR, Daniels SR, Urbina EM. Influence of Duration of Diabetes, Glycemic Control, and Traditional Cardiovascular Risk Factors on Early Atherosclerotic Vascular Changes in Adolescents and Young Adults with Type 2 Diabetes Mellitus. Journal of Clinical Endocrinology and Metabolism. 2009 Oct; 94(10):3740-5.
Peggy Joyce Stenger, DO
focuses on disorders of bone and calcium metabolism. She is a certified clinical densitometrist and conducts a specialty clinic for the evaluation and treatment of children with metabolic bone disease, including patients with hypophosphatemic rickets. She seeks to improve bone health by identifying and the etiology and factors contributing to multiple fractures in children.
BS: University of Texas, Arlington, Texas.
DO: Texas College of Osteopathic Medicine, Fort Worth, Texas.
Residency: Pediatrics, Children's Hospital of New Mexico, Albuquerque, NM.
Fellowship: Pediatric Endocrinology, Children's Hospital Medical Center, Cincinnati, OH.
CCD: International Society Clinical Densitometry.
Certification: General Pediatrics, American Board of Pediatrics 1989; Pediatric Endocrinology, American Board of Pediatrics 1999; International Society Clinical Densitometry 2007.
James M. Wells, PhD Director, Basic Research, Division of Endocrinology
Director, Basic Research, Division of Endocrinology
Director, Pluripotent Stem Cell Center
Understanding the development of the pancreas, and gastrointestinal organs; generating 3-dimensional human tissues from pluripotent stem cells and using these as human models of diabetes and digestive disease.
For more information, please visit the Wells lab web page.
The focus of his teams basic research has been to identify the molecular mechanisms involved in the embryonic development of endocrine cells including pancreatic beta cells and tissues of the gastrointestinal tract. Their translational projects have focused on identifying new approaches to improve child health in several ways: 1. To identify and use embryonic pathways to generate complex, three-dimensional organ tissues from pluripotent stem cells, 2. Use these tissues to develop new in vitro human models for diabetes and digestive disease research and 3. Develop long-term, therapeutic strategies for cell and tissue-replacement therapies.
BS: Biochemistry, Molecular and Cell Biology, University of Maine, Orono, ME, 1987.
PhD: Graduate program in Genetics, SUNY at Stony Brook, New York, 1995.
Postdoctoral Fellow: Harvard University, Cambridge MA, 1996 - 2001.
McCracken KW, Catá E, Crawford C, Sinagoga KL, Schumacher M, Mayhew CN, Zavros Y, Wells JM. Human pluripotent stem cell-derived gastric organoids: a model of gastric development and Helicobacter pylori infection. Nature. 2014. In press.
Watson CL, Mahe MM, Howell JC, Munera J, Sundaram N, Schweitzer J, Vallance JE, Shroyer NF, Wells JM, Helmrath MA. Human PSC-derived Intestinal Organoids Engraft to Form Mature Human Intestinal Tissue. Nat Med. 2014. In press.
Ji H, Zhang X, Oh S, Mayhew C, Ulm A, Somineni H, Ericksen M, Wells J, Khurana Hershey GK. Dynamic transcriptional and epigenomic reprogramming from pediatric nasal epithelial cells to induced pluripotent stem cells. JACI. 2014. In press.
Chlon TM, Hoskins EE, Mayhew CN, Wikenheiser-Brokamp KA, Davies SM, Mehta P, Myers KC, Wells JM, Wells, SI. High-Risk Human Papillomavirus E6 Protein Promotes Reprogramming of Fanconi Anemia Patient Cells through Repression of p53 but Does Not Allow for Sustained Growth of Induced Pluripotent Stem Cells. J Virol. 2014 Oct 1;88(19)11315-26.
Jonatan D, Spence JR, Method AM, Sinagoga K, Kofron M, Haataja L, Arvan P, Deutsch GH, Wells JM. Sox17 regulates insulin secretion in the normal and pathologic beta cell. PLoS One. 2014 Aug 21;9(8):e104675.
Schiesser JV, Wells JM. Generation of beta cells from human pluripotent stem cells: are we there yet? Ann N Y Acad Sci. 2014 Apr;1311:124-37.
Runck LA, Method A, Bischoff A, Levitt M, Peña A, Collins MH, Gupta A, Shanmukhappa S, Wells JM, Guasch G. Defining the molecular pathologies in cloaca malformation: similarities between mouse and human. Dis Model Mech. 2014 Apr;7(4):483-93.
Wells JM, Spence JR. How to make an intestine. Development. 2014 Feb;141(4):752-60.
Delgiorno KE, Hall JC, Takeuchi KK, Pan FC, Halbrook CJ, Washington MK, Olive KP, Spence JR, Sipos B, Wright CV, Wells JM, Crawford HC. Identification and manipulation of biliary metaplasia in pancreatic tumors. Gastroenterology. 2014 Jan;146(1):233-44.e5.
Suissa Y, Magenheim J, Stolovich-Rain M, Hija A, Collombat P, Mansouri A, Sussel L, Sosa-Pineda B, McCracken K, Wells JM, Heller RS, Dor Y, Glaser B. Gastrin: a distinct fate of neurogenin3 positive progenitor cells in the embryonic pancreas. PLoS One. 2013 Aug 5;8(8):e70397.
Investigation of regional identity in human intestinal stem cells. Principal investigator (along with Shroyer NF, PI and Helmrath M, PI). National Institutes of Health. Sep 2014 – Aug 2019. NIH U01DK103117.
Single Cell Dissection of Human Intestine Development. Principal Investigator. National Institutes of Health. Sep 2013 – Aug 2018. NIH 1R01DK098350.
Control of human endocrine cell development. Contact Principal Investigator. National Institutes of Health. Apr 2012 – Mar 2017. NIH 1R01DK092456-01.
Transcriptional Control of Placental Differentiation. Co-Investigator. National Institutes of Health. Feb 2011 – Jan 2016. NIH R01 HD065339.
KLF5 regulation of intestinal development and stem cell homeostasis. Co-Investigator. National Institutes of Health. Aug 2011 – Jul 2015. NIH 1R01 DK092306-01.
Nana-Hawa Yayah Jones, MD
Diversity and cultural competence; non-adherence in the pediatric population; information technology in healthcare; medical education
Adherence in youth with type 1 diabetes
Nana-Hawa Yayah Jones, MD, is a new clinical faculty in the division of pediatric endocrinology. Dr. Yayah Jones recently arrived in Cincinnati from St. Louis, Missouri where she completed both pediatric residency and endocrinology fellowship at Washington University's St. Louis Children's Hospital (SLCH). An additional year was spent at SLCH as a pediatric chief resident. During all the years of Dr. Yayah Jones's training she was active in fostering diversity among the medical trainees and in fact founded the Washington University Minority Medical Association (WUMMA), a group of medical trainees whose focus was on recruitment, retention and community service. As creator and president of WUMMA she became active in the resident and fellows diversity initiative created by the Barnes Jewish Hospital Center for Diversity and Cultural Competence. She mentored undergraduate student, medical students and residents throughout her training.
During fellowship she fostered a special interest in children with chronic illness who are non-adherent to their medical regimen. Dr. Yayah Jone's research efforts will be geared towards the non-adherence type 1 diabetic who is often prone to recurrent hospitalizations and diabetes complications.
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