Endocrinology

  • Research Faculty

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    Division Head

    A photo of Larry Dolan.

    Lawrence M. Dolan, MD Director, Division of Endocrinology

    focuses on the epidemiology of obesity, insulin resistance, and diabetes and the effect of the intrauterine environment on offspring with emphasis on how these processes affect the development and progression of cardiovascular disease in youth.

    513-636-4744

    Lawrence M. Dolan, MD

    Director, Division of Endocrinology

    Director, Endocrinology Clinical Laboratory

    Academic Information

    Professor, UC Department of Pediatrics

    Phone: 513-636-4744

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    Specialties

    Epidemiology and genetics of obesity; insulin resistance; abnormal carbohydrate metabolism; diabetes and their relationships to the development and progression of cardiovascular disease 

    Biography

    Lawrence M. Dolan, MD, is board-certified in pediatrics and pediatric endocrinology. He has been on the faculty of Cincinnati Children's Hospital Medical Center in the Department of Pediatrics for the University of Cincinnati College of Medicine since 1983.

    Dr. Dolan is a professor of pediatrics in the Division of Endocrinology. His research focuses on the epidemiology and genetics of obesity, insulin resistance, abnormal carbohydrate metabolism, diabetes and their relationships to the development and progression of cardiovascular disease.

    Dr. Dolan received his bachelor of science degree from the University of San Francisco. He received his doctor of medicine degree from the University of California at Los Angeles.

    Dr. Dolan completed his pediatric internship and residency at the University of Minnesota. He also served as chief resident. He obtained fellowship training in pediatric endocrinology at the University of Virginia.

    Education and Training

    BS: University of San Francisco, San Francisco, CA, 1971.

    MD: University of California at Los Angeles, Los Angeles, CA, 1976.

    Residency: University of Minnesota, Minneapolis, MN, 1976 to 1979. Chief Resident, 1979.

    Fellowship: University of Virginia, Charlottesville, VA.

    Certification: Pediatrics, 1982; Pediatric Endocrinology, 1983.

    Publications

    View PubMed Publications

    Grants

    Understanding Social Status Input on Adolescent Health. Co-Principal Investigator. National Institutes of Health. Dec 2007 - Nov 2011. #RO1HD41527.

    SEARCH Nutritional Ancillary Study of the SEARCH for Diabetes in Youth Study. Co-Principal Investigator. National Institutes of Health. Feb 2008 - Jan 2012. #RO1DK077949.

    SEARCH 3: Cohort Study to assess the incidence of acute and chronic diabetes related complications. Principal Investigator. National Institutes of Health. Sep 2010 - Oct 2015. #1U18DP002709.

    Accelerated Cardiovascular Aging in Youth. Co-Principal Investigator. National Institutes of Health. Jan 2011 -Dec 2015. #R01-105591.

    Faculty

    A photo of Phillipe Backeljauw.

    Philippe F. Backeljauw, MD

    has been involved in growth disorders-related clinical research for the last 15 to 20 years. He has been involved in the long term studies evaluating the efficacy and safety of a novel growth promoting agent - therapy with recombinant human IGF-I. He has, more recently, developed research efforts related to the health issues of children and adults with Turner syndrome, as part of his activities within the Cincinnati Turner Syndrome Multidisciplinary Center.

    513-636-4744
    philippe.backeljauw@cchmc.org

    Philippe F. Backeljauw, MD

    Academic Information

    Professor, UC Department of Pediatrics

    Phone: 513-636-4744

    Fax: 513-636-7486

    Email: philippe.backeljauw@cchmc.org

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    Specialties

    Growth disorders; disorders of bone and calcium metabolism; Turner syndrome

    Growth disorders; IGF-I therapy; Turner syndrome 

    Biography

    Within the Division of Pediatric Endocrinology, Dr. Backeljauw's clinical emphasis relates to children with growth problems and disorders of calcium and bone metabolism. He is also the medical director of the Turner Syndrome Multidisciplinary Center of Cincinnati. From a research perspective, Dr. Backeljauw is engaged in clinical research related to growth disorders. Ongoing studies focus on IGF-I therapy in GH resistance syndromes, as well as assessment and treatment of Turner syndrome co-morbidities. He is a collaborator in several other studies, including one on the prevalence of endocrinopathies after head injury and after cancer therapy. His research efforts have resulted in more than 70 publications, including peer-reviewed original manuscripts, abstracts, and textbook chapters.

    Education and Training

    MD: University of Ghent, Belgium.

    Residency: Pediatric and Adolescent Medicine, Cleveland Clinic Foundation Children's Hospital, Cleveland, OH.

    Fellowship: Pediatric Endocrinology, University of North Carolina, Chapel Hill, NC.

    Certification: Pediatrics, 1992; recertified, 1999. Pediatric Endocrinology, 1995; recertified, 2003.
    A photo of Nancy Crimmins.

    Nancy A. Crimmins, MD

    is interested in genetic and environmental factors of early-onset obesity as well as timing of co-morbidities in toddlers and preschoolers with extreme obesity. She is also interested in the predictors of fatty liver disease in patients with obesity and type 2 diabetes. Dr. Crimmins is the local PI of TrialNet, a natural history study which focuses on the development of type 1 diabetes.

    513-636-4744
    nancy.crimmins@cchmc.org

    Nancy A. Crimmins, MD

    Academic Information

    Assistant Professor, UC Department of Pediatrics

    Phone: 513-636-4744

    Fax: 513-636-7486

    Email: nancy.crimmins@cchmc.org

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    Specialties

    Clinical Interests

    Diabetes; obesity

    Research Interests

    Obesity: etiology and treatment; maturity onset diabetes of the young; epidemiology of glucose intolerance and diabetes

    Education and Training

    MD: Indiana University School of Medicine, 2000.

    Residency: Pediatrics, Cincinnati Children's Hospital Medical Center, 2003.

    Fellowship: Pediatric Endocrinology, Cincinnati Children's Hospital Medical Center, 2006.

    Publications

    View PubMed Publications
    A photo of Deborah A. Elder.

    Deborah A. Elder, MD

    is working to define the natural history of b-cell function in adolescents with T2DM a longitudinal assessment of the earliest insulin secretion (first phase insulin response) to intravenous glucose and the insulin response to intravenous arginine. Dr. Elder's current research will focus with children and adolescents with cystic fibrosis. Specifically, she will address their endocrinologic needs including diabetes, osteopenia, growth and puberty.

    513-636-4744
    deborah.elder@cchmc.org

    Deborah A. Elder, MD

    Academic Information

    Assistant Professor, UC Department of Pediatrics

    Phone: 513-636-4744

    Fax: 513-636-7486

    Email: deborah.elder@cchmc.org

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    Specialties

    Clinical Interests

    Diabetes; growth disorders; precocious puberty; calcium disorders 

    Research Interests 

    Researching type 2 diabetes in adolescents; intensified insulin therapy

    Education and Training

    BS: Michigan State University, 1991.

    MD: University of Kentucky College of Medicine, Lexington, KY, 1995.

    Residency: Indiana University Riley Hospital For Children, Indianapolis, IN, 1998.

    Fellowship: University of North Carolina at Chapel Hill, Chapel Hill, NC, 2001.

    Certification: Pediatric Endocrinology.

    Publications

    View PubMed Publications
    A photo of Iris Little.

    Iris Gutmark-Little, MD

    My current research is an interdisciplinary project along with engineering, radiology, cardiology, and pulmonology. The first involves a study of the TS airway, imaged using MRI, then virtually reconstructed, and analyzed to measure air flow features. The overall aim is to assess the cause of airway disease and specific treatments for this poorly described problem in the TS patient group. Similarly, a second project is ongoing and involves modeling aortic blood flow properties from TS patients who have undergone MRI for clinical purposes. The overall aim of this project is to elucidate the cause and progression of aortic disease in TS women.

    513-636-4744
    iris.little@cchmc.org

    Iris Gutmark-Little, MD

    Academic Information

    Assistant Professor, UC Department of Pediatrics

    Phone: 513-636-4744

    Email: iris.little@cchmc.org

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    Specialties

    Turner syndrome; growth disorders; thyroid disorders; pubertal disorders; general pediatric endocrinology

    Biography

    Iris Gutmark-Little, MD, is board-certified in Pediatrics and board-eligible in Pediatric Endocrinology. She has been on the faculty of Cincinnati Children's Hospital Medical Center in the Department of Pediatrics for the University of Cincinnati College of Medicine since 2010.

    Dr. Gutmark-Little is an assistant professor of pediatrics in the Division of Endocrinology. Her research focuses on the airway and great vessel anatomy and diseases in the Turner syndrome population.

    Dr. Gutmark-Little received her bachelor's of science in microbiology and chemistry from Louisiana State University. She received her doctor of medicine degree from the Johns Hopkins University School of Medicine.

    Dr. Gutmark-Little completed her pediatric internship and residency at Cincinnati Children’s Hospital Medical Center. She obtained fellowship training in Pediatric Endocrinology at Cincinnati Children’s Hospital Medical Center.

    Education and Training

    BS: Louisiana State University, Baton Rouge, Louisiana 2000.

    MD: Johns Hopkins University School of Medicine, Baltimore, Maryland 2004.

    Residency: Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio 2007.

    Fellowship: Pediatric Endocrinology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio 2010.

    Certification: General Pediatrics, American Board of Pediatrics, 2008; Pediatric Endocrinology, American Board of Pediatrics, pending 2011.

    Publications

    A photo of Stuart Handwerger.

    Stuart Handwerger, MD

    focuses on the transcriptional regulation of human placental development.  He examines the molecular mechanisms involved in the induction of the transcription factor AP-2alpha during the differentiation of villous cytotrophoblast cells from normal and pathologic placentas. His recent lab studies indicate that AP-alpha is a critical component of the transcription network controlling normal placental development.
    Visit the Handwerger Lab.

    513-636-4209
    stuart.handwerger@cchmc.org

    Stuart Handwerger, MD

    Academic Information

    Professor, UC Department of Pediatrics

    Phone: 513-636-4209

    Fax: 513-636-7486

    Email: stuart.handwerger@cchmc.org

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    Specialties

    Regulation of gene expression in human placenta and uterine decidua during differentiation.

    Visit the Handwerger Lab.

    Education and Training

    MD: University of Maryland School of Medicine, Baltimore, MD, 1964.

    Residency: Mt. Sinai Hospital, New York, NY, 1965 to 1966.

    Fellowship: Harvard Medical School, Children's Hospital Medical Center, Boston, MA, 1968 to 1969.

    Certification: Diplomate, American Board of Pediatrics, 1969; Subspecialty Boards, Pediatric Endocrinology, 1978.

    Publications

    View PubMed Publications
    A photo of Jonathan Howell.

    Jonathan C. Howell, MD, PhD

    is a clinical endocrinologist who also conducts basic science research in the lab of Dr. James Wells where he investigates the developmental biology of enteroendocrine cells in the intestine. His research is aimed at understanding the mechanisms that control the development and function of hormone producing cells in the human gut, which are sometimes altered in diabetes, through the study of intestinal tissue derived from human stem cells.

    513-636-4744
    jonathan.howell@cchmc.org

    Jonathan C. Howell, MD, PhD

    Academic Information

    Assistant Professor, UC Department of Pediatrics

    Phone: 513-636-4744

    Email: jonathan.howell@cchmc.org

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    Specialties

    Type 1 and Type 2 diabetes mellitus; endocrinopathy in bone marrow failure syndromes; growth disorders; thyroid disorders

    Visit the Howell Lab.

    Biography

    Jonathan C. Howell, MD, PhD, is board certified in pediatrics and board eligible in pediatric endocrinology. He has been on the faculty of Cincinnati Children’s Hospital Medical Center in the Department of Pediatrics for the University of Cincinnati College of Medicine since 2012.

    Dr. Howell is an assistant professor of pediatrics in the Division of Endocrinology. His main clinical focus is diabetes as well as providing care for patients with endocrine disorders, including growth, thyroid, pituitary, pubertal, and adrenal dysfunction. In 2012, he was awarded a William Cooper Procter Scholarship to support his academic career development. Dr. Howell’s research focuses on the mechanisms that control hormone cell development and function in human intestine and how it relates to diabetes and cystic fibrosis.

    Dr. Howell received his bachelor of arts degree from Hanover College. He received his PhD from Indiana University and his MD from Indiana University School of Medicine.

    Dr. Howell completed his pediatric internship and residency at Cincinnati Children’s Hospital Medical Center, where he also served as chief resident. He also obtained his fellowship training from Cincinnati Children’s.

    Education and Training

    BA:Hanover College, Hanover, IN, 1997.

    PhD: Indiana University (Edward F. Srour, thesis adviser), Indianapolis, IN, 2003.

    MD: Indiana University School of Medicine, Indianapolis, IN, 2005.

    Residency: Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, 2005-2008.

    Chief Residency: Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, 2008-2009.

    Endocrinology Fellowship: Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, 2009-2012

    Certification: Pediatrics, 2008.

    Publications

    A photo of Jonathan Katz.

    Jonathan D. Katz, PhD

    is working to understand the role that autoreactive T lymphocytes play in the Immunopathogenesis of type 1 diabetes, the most common pediatric autoimmune disease. Major focuses include defining: (a) the control of autoreactive T cells via central and peripheral tolerance; (b) the role NKT cells play in regulating autoreactive T cells; and (c) the role dendritic cells play in activating and regulating autoreactive T cells in type 1 diabetes.

    513-636-5306
    jonathan.katz@cchmc.org

    Jonathan D. Katz, PhD

    Academic Information

    Professor, UC Department of Pediatrics

    Phone: 513-636-5306

    Fax: 513-636-5355

    Email: jonathan.katz@cchmc.org

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    Specialties

    Clinical Interests

    T cells; MHC, beta cell death; islet antigens

    Research Interests

    Immunology, autoimmunity, type 1 diabetes

    Biography

    Jonathan D. Katz, PhD, focuses on autoimmune diabetes research. Autoimmune diabetes, also known as type 1 diabetes (T1D), is the most common pediatric autoimmune disease. Roughly 1/250 individuals develop T1D in the United States.There is currently no cure for T1D and the only treatment is daily exogenous insulin replacement therapy. Many T1D patients eventually develop secondary complications, such as hearth disease, blindness, peripheral neuropathy and renal failure.

    Dr. Katz's work focuses on the role that autoreactive T lymphocytes play in the disease process. His lab interested in (1) the control of autoreactive T cells via central and peripheral tolerance, (2) the role NKT cells play in regulating autoreactive T cells, and (3) the role dendritic cells play in activating and regulating autoreactive T cells in T1D.

    Most of his work uses the non-obese diabetic (NOD) mouse strain that spontaneously develops T1D with remarkable similar to the T1D seen in human patients. The availability of the NOD strain has allowed us to take a modern, reductionist molecular and cellular immunology approach to understanding the mechanism(s) and genetics underlying T1D susceptibility and disease progression. His lab makes extensive use of knockout, transgenic, regulated gene expression, targeted ablation, cell transfer and genomic studies the progression and regulation of T1D in the NOD mouse.

    Education and Training

    BS: University of California, Los Angeles, Calif., 1984.

    PhD: University of California, Los Angeles, Calif., 1990.

    Post-Doctoral Fellow: Université Louis Pasteur, Strasbourg, France, 1990-1995.

    Publications

    View PubMed Publications
    A photo of David Klein.

    David J. Klein, MD, PhD

    has had 30 years of research experience in the areas of diabetes and obesity.  His bench research began with explorations of the role of extracellular matrix changes in diabetic kidney disease.  During that time he began to perform clinical research by participating in the Diabetes Complications and Control Trial and Trialnet, national trials. His work now includes local and international projects in community obesity prevention and trials of new agents to treat diabetes in children (Liraglutide and Insulin Degludec).  His current research focus is the dramatic weight gain that accompanies the use of second-generation antipsychotics (SGAs) in children and adolescents with mental illness.  He and his collaborators have developed a database that is employed to determine risk factors for weight gain on SGAs and to validate treatment guidelines for its evaluation and management with metformin, the use of which he helped pioneer for this indication.  His plans include the design of novel predictors and treatments of SGA induced weight gain.

    513-636-4744
    david.klein@cchmc.org

    David J. Klein, MD, PhD

    Academic Information

    Associate Professor, UC Department of Pediatrics

    Phone: 513-636-4744

    Fax: 513-636-7486

    Email: david.klein@cchmc.org

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    Specialties

    Diabetes mellitus: intensive insulin management and pathophysiology of diabetes complications; obesity prevention and treatment; disorders of growth and development, with special focus on the use of growth hormone for the treatment of short stature associated with inflammatory bowel disease; early detection of renal disease in children with diabetes mellitus; effects of diabetes mellitus on renal proteoglycan synthesis

    Education and Training

    BS: Beloit College, Beloit, WI, 1974. 

    MD: Albert Einstein College of Medicine of Yeshiva University, Bronx, NY, 1977. 

    PhD: University of Minnesota, 1985. 

    Residency: University of Minnesota, Minneapolis, MN, 1980. 

    Fellowship: University of Minnesota, Minneapolis, MN, 1984.

    Certification: Pediatrics, 1982; Pediatric Endocrinology,1997; recertified 2004.

    Publications

    View PubMed Publications
    A photo of Sarah Lawson.

    Sarah Lawson, MD

    The progression of heart disease in the Turner Syndrome population, assessing the endocrine needs in children who have received cranial radiation for oncology treatments, and genetics associated with septo-optic dysplasia.

    513-636-4744
    sarah.lawson@cchmc.org

    Sarah Lawson, MD

    Academic Information

    Assistant Professor, UC Department of Pediatrics

    Phone: 513-636-4744

    Email: sarah.lawson@cchmc.org

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    Specialties

    Turner syndrome; endocrine disease related to oncologic pathology and treatment; septo-optic dysplasia.

    Biography

    Sarah Lawson, MD, is an assistant professor of pediatrics in the Division of Endocrinology. Her research has focused on identifying vascular changes, through non-invasive techniques, in the young Turner Syndrome population. This has been possible through the collaboration of Pediatric Endocrinology and Pediatric Cardiology.

    Dr. Lawson completed her undergraduate studies in biochemistry and biology with a minor in bible studies from Lee University, and received her MD from the University of Kentucky. After completion of her pediatric residency at the University of Kentucky, Dr. Lawson began her fellowship in pediatric endocrinology at Cincinnati Children’s Hospital Medical Center.

    Dr. Lawson’s clinical interests are in the areas of Turner syndrome, endocrine disease related to oncologic pathology and treatment, and septo-optic dysplasia.

    Education and Training

    BS: Lee University, Cleveland, TN, 2000.

    MD: University of Kentucky, Lexington, KY, 2005.

    Residency: Kentucky Children’s Hospital, Lexington, KY, 2005-2008.

    Fellowship: Cincinnati Children’s Hospital, Cincinnati, OH.

    A photo of Takahisa Nakamura.

    Takahisa Nakamura, PhD

    Research goal is to address questions concerning why and how inflammatory responses are initiated, coordinated, and thus involved in the development of obesity-induced metabolic diseases.

    513-636-4744
    takahisa.nakamura@cchmc.org

    Takahisa Nakamura, PhD

    Academic Information

    Assistant Professor, UC Department of Pediatrics

    Phone: 513-636-4744

    Email: takahisa.nakamura@cchmc.org

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    Specialties

    RNA-related inflammation in obesity and metabolic diseases 

    Biography

    Dr. Nakamura received his PhD from the University of Tokyo in 2003. He completed postdoctoral training in the laboratory of Dr. Gökhan S. Hotamisligil at Harvard School of Public Health in 2013, followed by his faculty appointment at Cincinnati Children's Hospital in 2013.

    Education and Training

    PhD: University of Tokyo, 2003.

    Postdoctoral Fellow: University of Tokyo, 2003-2006

    Research Fellow: Harvard University, 2006-2010

    Research Associate: Harvard University, 2010-2013

    Publications

    View PubMed Publications

    Grants

    Functional analysis of PKR, JNK, and RISC in metabolic inflammation and homeostasis. Principal Investigator. American Heart Association, Scientist Development Grant. Jan 2012 – Dec 2014.

    Analysis of pathogenic double-stranded RNA in chronic inflammatory diseases. Principal Investigator. Japan Science and Technology Agency, PRESTO. Feb 2013 – Mar 2016.
    A photo of Susan Rose, MD.

    Susan R. Rose, MD

    is evaluating the endocrine conditions associated with congenital bone marrow failure syndromes such as Fanconi anemia, Blackfan Diamond anemia, and Shwachman Diamond syndrome. In addition, she is evaluating the endocrine consequences of hypothalamic-pituitary injury, including traumatic brain injury and injury from treatments for cancer, as well as comparing the relative efficacy of several treatments for precocious puberty.

    513-636-4744
    susan.rose@cchmc.org

    Susan R. Rose, MD

    Academic Information

    Professor, UC Department of Pediatrics

    Phone: 513-636-4744

    Email: susan.rose@cchmc.org

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    Specialties

    Hypothalamic pituitary function; thyroid; disorders of growth or puberty; endocrine function in cancer survivors after head injury

    Education and Training

    MD: Case Western Reserve School of Medicine, 1980.

    MEd: School Psychology, University of Dayton, 1972.

    Residency: The Cleveland Clinic, 1983.

    Fellowship: National Institutes of Health, 1986.

    Certification: Pediatrics, 1985; Pediatric Endocrinology, 1986.

    Publications

    View PubMed Publications

    Grants

    Hypopituitarism in survivors of traumatic brain injury. Primary Investigator. Pfizer Global Pharmaceuticals. 2008 - 2012.
    A photo of Meilan Rutter, MD.

    Meilan M. Rutter, MD, FRACP

    is a member of several multidisciplinary clinical teams, including the Neuromuscular Comprehensive Care Center and the Center for Disorders of Sex Development (DSD). Related research interests involve endocrine issues in Duchenne muscular dystrophy, currently focusing on a trial of insulin-like growth factor-I (IGF-I) therapy in this population, and participation in a multicenter trial of parental attitudes from having a child with a DSD.

    513-636-4744
    meilan.rutter@cchmc.org

    Meilan M. Rutter, MD, FRACP

    Academic Information

    Assistant Professor, UC Department of Pediatrics

    Phone: 513-636-4744

    Fax: 513-636-7486

    Email: meilan.rutter@cchmc.org

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    Specialties

    Clinical Interests

    Bone health and calcium metabolism; disorders of growth, puberty and sex development; endocrine function in cancer survivors; endocrine function in neuromuscular disorders

    Research Interests

    Insulin-like growth factor-1 (IGF-1) therapy in Duchenne Muscular Dystrophy

    Biography

    Meilan Rutter is board-certified in Pediatrics and Pediatric Endocrinology. She is an Assistant Professor of Pediatrics in the Division of Endocrinology, and joined the faculty of Cincinnati Children's Hospital Medical Center in 2008. Currently, Dr. Rutter is assistant director of the Pediatric Endocrinology Fellowship Program.

    Dr. Rutter received her degrees of Bachelor of Medicine and Bachelor of Surgery (MB, BCh) from the University of Wales College of Medicine. She completed her training in Pediatrics in New Zealand, and was admitted to Fellowship of the Royal Australasian College of Physicians (FRACP) in 1995. She underwent fellowship training in Pediatric Endocrinology at Cincinnati Children's. She completed further pediatric residency training to achieve American Board of Pediatrics specialty and subspecialty board certification.

    Dr. Rutter treats children and adolescents with endocrine disorders and diabetes mellitus. She serves as a consultant for the Neuromuscular Comprehensive Care Center and the Neuro-Oncology program at Cincinnati Children's. Additionally. she is a member of the Disorders of Sex Development interdisciplinary team.

    Education and Training

    MB, BCh: University of Wales College of Medicine, Cardiff, United Kingdom.

    FRACP: Royal Australasian College of Physicians, New Zealand.

    Residency: Auckland Children's Hospital and Dunedin Hospital, New Zealand; Cincinnati Children's, Cincinnati, OH.

    Fellowship: Pediatric Endocrinology, Cincinnati Children's, Cincinnati, OH.

    Certification: General Pediatrics, American Board of Pediatrics, 2002; Pediatric Endocrinology, American Board of Pediatrics, 2003; Pediatrics, Fellowship of the Royal Australasian College of Physicians, 1995.

    Publications

    View PubMed Publications
    A photo of Amy Shah.

    Amy Sanghavi Shah, MD, MS

    is an endocrinologist who has clinical and translational research programs in lipids and cardiovascular disease. Her interests include molecular aspects of high density lipoprotein (HDL) and its protective effects on early cardiovascular disease in children and adolescents.  She also uses noninvasive imaging techniques to assess the cardiovascular burden in the setting of obesity and diabetes. 

    513-636-4744
    amy.shah@cchmc.org

    Amy Sanghavi Shah, MD, MS

    Academic Information

    Assistant Professor, UC Department of Pediatrics

    Phone: 513-636-4744

    Fax: 513-636-7486

    Email: amy.shah@cchmc.org

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    Specialties

    Lipid and cholesterol disorders; endocrine disorders; type 1 and type 2 diabetes; cardiovascular disease

    Biography

    Dr. Shah's interests focus on cardiovascular risk factors and their effects on early atherosclerosis. 
    Dr. Shah has presented her research at national meetings and has published several manuscripts in this area.

    Education and Training

    BA: Biology, University of Texas at Austin.

    MS: University of Cincinnati, Cincinnati OH.

    MD: St. George's University.

    Residency: Loyola University Medical Center.

    Fellowship: Cincinnati Children's Hospital Medical Center.

    Certification: Pediatrics, 2007.

    Publications

    Grants

    Role of High Density Lipoprotein Subspecies in Adolescents with Type 2 Diabetes. Co-Principal Investigator. University of Cincinnati. Jan 2011 - Sep 2011.

    DASH for Diabetes Controlled Feeding Study. Co- Principal Investigator. Clinical & Translational Research Center. Jun 2011 - Dec 2011.

    A photo of Peggy Stenger.

    Peggy Joyce Stenger, DO

    focuses on disorders of bone and calcium metabolism. She is a certified clinical densitometrist and conducts a specialty clinic for the evaluation and treatment of children with metabolic bone disease, including patients with hypophosphatemic rickets. She seeks to improve bone health by identifying and the etiology and factors contributing to multiple fractures in children.

    513-636-4744
    peggy.stenger@cchmc.org

    Peggy Joyce Stenger, DO

    Academic Information

    Assistant Professor, UC Department of Pediatrics

    Phone: 513-636-4744

    Fax: 513-636-7486

    Email: peggy.stenger@cchmc.org

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    Specialties

    Disorders of bone and calcium metabolism; disorders of thyroid, puberty, growth; disorders of pituitary and adrenal; diabetes

    Biography

    Peggy J. Stenger, DO, is board-certified in Pediatrics and Pediatric Endocrinology. She has been in the Division of Endocrinology at Cincinnati Children’s since 1999. Prior to that she worked in the Babies Milk Fund at Norwood through the Department of General Pediatrics, Cincinnati Children’s Hospital Medical Center.

    She is an Assistant Professor of Pediatrics in the Division of Endocrinology. Her primary interest is in disorders of bone and calcium metabolism. She is a certified clinical densitometrist, especially interested in disorders of high bone mass.

    Dr. Stenger received her bachelor of science in biology from the University of Texas in Arlington, Texas. She received her residency training at the University of New Mexico Children’s Hospital in Albuquerque where she also served as Chief Resident. She obtained pediatric endocrinology fellowship training at Cincinnati Children’s Hospital Medical Center in Cincinnati, Ohio.

    Dr. Stenger has previously served in the Indian Health Service at Gallup Indian Medical Center, Gallup, New Mexico. Prior to coming to Cincinnati, she was on the clinical faculty in General Pediatrics at the University of New Mexico Children’s Hospital in Albuquerque. While there, she served on the New Mexico State Board of the American Diabetes Association. She was instrumental in organization of diabetes clinics at the University of New Mexico and worked in diabetes outreach clinics throughout the state.

    Education and Training

    BS:  University of Texas, Arlington, Texas.

    DO: Texas College of Osteopathic Medicine, Fort Worth, Texas.

    Residency: Pediatrics, Children's Hospital of New Mexico, Albuquerque, NM.

    Fellowship: Pediatric Endocrinology, Children's Hospital Medical Center, Cincinnati, OH.

    CCD:  International Society Clinical Densitometry.

    Certification: General Pediatrics, American Board of Pediatrics 1989; Pediatric Endocrinology, American Board of Pediatrics 1999; International Society Clinical Densitometry 2007.

    A photo of James Wells, PhD.

    James M. Wells, PhD Director, Basic Research, Division of Endocrinology

    researches the molecular mechanisms of endoderm organogenesis in mouse and humans. The goal of this work is to identify the molecular basis of congenital defects affecting the pancreas, liver, and biliary system and to direct the differentiation of pluripotent stem cells (PSCs) into therapeutic cells for replacement therapies, such as transplantable pancreatic beta cells for patients with type-1 diabetes.
    Visit the Wells Lab.

    513-636-8767
    james.wells@cchmc.org

    James M. Wells, PhD

    Director, Basic Research, Division of Endocrinology

    Director, Pluripotent Stem Cell Center

    Academic Information

    Professor, UC Department of Pediatrics

    Phone: 513-636-8767

    Fax: 513-636-4317

    Email: james.wells@cchmc.org

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    Specialties

    identifying the molecular mechanisms involved in the development of the pancreas, liver and biliary system; replacement therapies, such as transplantable pancreatic beta cells for patients with type-1 diabetes; regeneration of adult tissues

    Visit the Wells Lab.

    Biography

    The focus of his teams basic research has been to identify the molecular mechanisms involved in the embryonic development of endocrine cells including pancreatic beta cells and tissues of the gastrointestinal tract. Their translational projects have focused on identifying new approaches to improve child health in several ways: 1. To identify and use embryonic pathways to generate complex, three-dimensional organ tissues from pluripotent stem cells, 2. Use these tissues to develop new in vitro human models for diabetes and digestive disease research and 3. Develop long-term, therapeutic strategies for cell and tissue-replacement therapies.

    Education and Training

    BS: Biochemistry, Molecular and Cell Biology, University of Maine, Orono, ME, 1987.

    PhD: Graduate program in Genetics, SUNY at Stony Brook, New York, 1995.

    Postdoctoral Fellow: Harvard University, Cambridge MA, 1996 - 2001. 

    Publications

    View Dr. Wells PubMed Publications.

    Grants

    Single Cell Dissection of Human Intestine Development. Principal Investigator. National Institutes of Heath. Sept 2013 – Aug 2018. NIH 1R01DK098350.

    Control of human endocrine cell development. Contact Principal Investigator. National Institutes of Heath. April 2012 – March 2017. NIH 1R01DK092456-01.

    Develop Innovative Translational Tools to Study Enteroendocrine Function in Human Intestine and Applications to Diabetes Drug Discovery. Principal Investigator. Eli Lilly Internal Sponsors: Drs. Melissa Thomas and Hsiu Chiung-Yang. Dec 2011 – Nov 2013.

    Generating Human Intestinal Organoids with an ENS. Principal Investigator. National Institutes of Health. Sept 2012 – Aug 2014. NIH 1U18NS080815-01.

    Generating 3-D lung organoids in vitro. Principal Investigator. National Institutes of Health. Sept 2012 – Aug 2014. NIH 1R21 HL115372-01.

    KLF5 regulation of intestinal development and stem cell homeostasis. Co-Investigator. National Institutes of Health. Aug 2011 – July 2015. NIH 1R01 DK092306-01.

    Transcriptional Control of Placental Differentiation. Co-Investigator. National Institutes of Health. Feb 2011 – Jan 2016. NIH R01 HD065339.

    A photo of Nana-Hawa Yayah Jones.

    Nana-Hawa Yayah Jones, MD

    focuses on adherence in the management of type 1 diabetes and addressing barriers to care in children with chronic disease.

    513-636-4744
    nana.jones@cchmc.org

    Nana-Hawa Yayah Jones, MD

    Academic Information

    Assistant Professor, UC Department of Pediatrics

    Phone: 513-636-4744

    Fax: 513-636-7486

    Email: nana.jones@cchmc.org

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    Specialties

    Clinical Interests

    Diversity and cultural competence; non-adherence in the pediatric population; information technology in healthcare; medical education

    Research Interests

    Adherence in youth with type 1 diabetes 

    Biography

    Nana-Hawa Yayah Jones, MD, is a new clinical faculty in the division of pediatric endocrinology. Dr. Yayah Jones recently arrived in Cincinnati from St. Louis, Missouri where she completed both pediatric residency and endocrinology fellowship at Washington University's St. Louis Children's Hospital (SLCH). An additional year was spent at SLCH as a pediatric chief resident. During all the years of Dr. Yayah Jones's training she was active in fostering diversity among the medical trainees and in fact founded the Washington University Minority Medical Association (WUMMA), a group of medical trainees whose focus was on recruitment, retention and community service. As creator and president of WUMMA she became active in the resident and fellows diversity initiative created by the Barnes Jewish Hospital Center for Diversity and Cultural Competence. She mentored undergraduate student, medical students and residents throughout her training.

    During fellowship she fostered a special interest in children with chronic illness who are non-adherent to their medical regimen. Dr. Yayah Jone's research efforts will be geared towards the non-adherence type 1 diabetic who is often prone to recurrent hospitalizations and diabetes complications.

    Education and Training

    MD: University of Louisville School of Medicine, Louisville, KY, 2002.

    Residency: Pediatrics, Washington University, St. Louis Children’s Hospital, St. Louis, MO, 2005.

    Chief Residency: Pediatrics, Washington University, St. Louis Children’s Hospital, St. Louis, MO, 2006.

    Fellowship: Pediatrics, Washington University, St. Louis Children’s Hospital, St. Louis, MO, 2009.