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Researchers know that the production of billions of blood cells each hour is required to maintain normal health. While a great deal is understood about the factors controlling the final steps of this production, the initial steps involving the survival, proliferation and differentiation of hematopoietic stem and progenitor cells remain unclear. In part, this is due to the low number of hematopoietic stem cells (estimated to be one in ~20,000 nucleated cells of the bone marrow).
Our program is studying the biology of hematopoietic stem and progenitor cells to understand the factors regulating normal proliferation and differentiation of these cells and determinants of abnormal differentiation and growth in leukemia.
These studies utilize state-of-the-art molecular methods and rely heavily on gene-targeted and transgenic mice. Knowledge gained from these studies will have important implications for understanding pathological conditions associated with genetic diseases and for designing improved methods to grow and expand these cells in the laboratories.
FacultyJose Cancelas, MD, PhD - program leaderMarie-Dominique Filippi, PhDHartmut Geiger, PhD
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Reprinted with permission from Science, Volume 294, Number 5542, Issue of 19 October 2001. Copyright 2003, AAAS.
Reprinted with permission from Science, Volume 302, Number 5644, Issue of 17 October 2003. Copyright 2003, AAAS.
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