Andreassen Lab

 
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    Cellular phenotypes are shown which support the conclusion that Fanconi anemia proteins are recruited in response to DNA damage, and that they promote chromosome stability and normal cell cycle progression in the presence of DNA interstrand crosslinking agents. (Left) ATR (green), which has an important role in responding to replication stress, colocalizes with FANCD2 (red) after treatment of cells with MMC. Colocalization is indicated by a yellow or yellow-green signal. (Center) Radial chromosomes (red asterisks) induced by MMC in fibroblasts from an FA patient. (Right) Cell cycle histograms of FA-G and corrected fibroblasts treated with MMC. Adapted, in part, from P.R. Andreassen et al. (2004) Genes & Dev. 18: 1958-1963.
  • Contact Us

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    For information regarding the Andreassen Lab contact:

    Dr. Paul Andreassen
    513-636-0499
    Paul.Andreassen@cchmc.org

    Experimental Hematology and Cancer Biology
    Office location: S7.419