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The Cancelas research lab studies hematopoietic stem cells (HSC), which are able to self-renew and differentiate into all functional types of blood cells. HSC attract clinical interest because of their potential use in stem cell and gene therapy and because of their involvement in leukemia. Current focus is on the molecular determinants that regulate the proliferation, survival, homing and retention of hematopoietic stem cells in relation to the so-called “stem cell niche” in benign and malignant hematopoiesis. We also investigate red cell storage and pathogen inactivation. We develop and validate new red cell-containing products with improved safety and efficacy profile for use in massive transfusion protocols. We recruit students from the molecular and developmental biology program.
Jose A. Cancelas, MD, PhD, is deputy director of Hoxworth Blood Center, division director of Research. and medical director, Cellular Therapies; he is program leader, Stem Cell Biology Program, and director, Flow Cytometry Core Facility, experimental hematology and cancer biology, Cincinnati Children’s; Professor of pediatrics, the University of Cincinnati; and faculty member, graduate programs in molecular and developmental biology, cell and cancer biology, immunobiology, and medical scientist training program, University of Cincinnati.
See a list of recent publications from the Cancelas lab.
Learn more about who works in the Cancelas lab.
Jose A. Cancelas Perez, MD, PhD
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