Cancelas Lab

Prada CE, Jousma E, Rizvi TA, et al. Neurofibroma-associated macrophages play roles in tumor growth and response to pharmacological inhibition. Acta Neuropathol. 2013 Jan;125(1):159-68. PMID: 23099891.

Dumont LJ*, Cancelas JA*, Dumont DF, et al. A randomized controlled trial evaluating recovery and survival of 6% dimethyl sulfoxide-frozen autologous platelets in healthy volunteers. Transfusion. 2013 Jan;53(1):128-37. PMID 22671278.

Dumont LJ*, Cancelas JA*, Graminske S, et al. In vitro and in vivo quality of leukocyte-reduced apheresis platelets stored in a new platelet additive solution. Transfusion. 2012 Epub Aug 6. (*both authors contributed equally) PMID 22882530.

Taniguchi Ishikawa E,Cancelas JA. Lack of communication rusts and ages stem cells. Cell Cycle. 2012 Sep 1;11(17):3149-3150. PMID 22894903.

Geiger H, Pawar SA, Kerschen EJ, et al. Pharmacological targeting of the thrombomodulin-activated protein C pathway mitigates radiation toxicity. Nat Med. Jul 2012;18(7):1123-9. PMID 22729286.

Chang KH, Sanchez-Aguilera A, Shen S, et al.Vav3 collaborates with p190-BCR-ABL in lymphoid progenitor leukemogenesis, proliferation and survival. Blood. 2012 Jul 26;120(4):800-11. PMID 22692505 PMC 3412345.

Taniguchi Ishikawa E, Gonzalez-Nieto D, Ghiaur G, et al. Connexin-43 prevents hematopoietic stem cell senescence through transfer of reactive oxygen species to bone marrow stromal cells. Proc Natl Acad Sci USA. 2012 Jun 5;109(23):9071-6. PMID 22611193 PMC 3384185.

Konstantinidis DG, Pushkaran S, Johnson JF, Cancelas JA, Manganaris S, Harris CE, Williams DA, Zheng Y, Kalfa TA. Signaling and cytoskeletal requirements in erythroblast enucleation. Blood. 2012 Jun 21;119(25):6118-27. PMID 22461493 PMC 3383020.

Gonzalez-Nieto D, Li L, Köhler A, et al.Connexin-43 in the osteogenic BM niche regulates its cellular composition and the bidirectional traffic of hematopoietic stem cells and progenitors. Blood. 2012 May 31;119(22):5144-54. Epub Apr 12, 2012. PMID 22498741, PMC 3369607.

Sengupta A, Ficker A, Dunn S, et al. Bmi1 reprograms chronic myelogenous leukemia B-lymphoid progenitors to become B-ALL-initiating cells. Blood. 2012 Jan12;119(2):494-502. PMID 22101899, PMC 3257014.

Cancelas JA, Sengupta A. A conundrum in mammalian hematopoietic stem cell polarity. Cell Cycle. 2011 Dec 15;10(24):4191-2. (Editorial). PMID 22157228.

Cancelas JA. On how Rac controls hematopoietic stem cell activity. Transfusion. 2011 Nov;51 (Suppl 4):153S-9S. PMID 22074626, PMC 3308685.

Cancelas JA, Dumont LJ, Rugg N, et al. Stored red blood cell viability is maintained after treatment with a second generation S-303 pathogen inactivation process. Transfusion. 2011 Nov;51(11):2367-76. PMID 21569044.

Sengupta A, Duran MA, Ishikawa E, et al. Atypical protein kinase C (aPKCζ and aPKCλ) is dispensable for mammalian hematopoietic stem cell activity and blood formation. Proc Natl Acad Sci (USA). 108:9957-9962. 2011.

Cancelas JA. Adhesion, migration, and homing of murine hematopoietic stem cells and progenitors. Methods Mol Biol. 750:187-96. 2011.

Cancelas JA, Rugg N, Fletcher D, et al. In vivo viability of stored red blood cells derived from riboflavin plus ultraviolet light-treated whole blood. Transfusion. 51(7):1460-8. Jul, 2011.

Cancelas JA, Rugg N, Worsham DN, et al. Infusion of P-Capt prion filtered red cell products demonstrate acceptable in vivo viability and no evidence of neoantigen formation. Transfusion. Apr 14, Epub. 2011.

Cancelas JA, Dumont LJ, Rugg N, et al. Stored red blood cell viability is maintained after treatment with a second generation S-303 pathogen inactivation process. Transfusion. May 13, Epub. 2011.

Mayes DA, Rizvi TA, Cancelas JA, et al. Perinatal or adult Nf1 inactivation using tamoxifen-inducible PlpCre each cause neurofibroma formation. Cancer Res. 2011 Jul 1;71(13):4675-85.

Shang X, Cancelas JA, Li L, et al. R-Ras and Rac GTPase crosstalk regulates hematopoietic progenitor cell migration, homing and mobilization. J Biol Chem. Jul 8;286(27):24068-78. 2011.

van der Meer PF, Cancelas JA, Cardigan R, et al. for the BEST Collaborative. Evaluation of overnight hold of whole blood at room temperature before component processing: effect of red blood cell (RBC) additive solutions on in vitro RBC measures. Transfusion. 51(Suppl 1):15S–24S. 2011.

van der Meer PF, Cancelas JA, Vassallo RR, et al. Evaluation of the overnight hold of whole blood at room temperature, before component processing: platelets (PLTs) from PLT-rich plasma. Transfusion. 51(Suppl 1):45S–49S. 2011.

Cardigan R, van der Meer PF, Pergande C, et al. Coagulation factor content of plasma produced from whole blood stored for 24 hours at ambient temperature: results from an international multicenter BEST Collaborative study. Transfusion. 51(Suppl 1):50S–57S. 2011.

Sengupta A, Arnett J, Dunn S, et al. Rac2 GTPase deficiency depletes BCR-ABL+ leukemic stem cells and progenitors in vivo. Blood. 116 (1): 81-4. 2010.

Sengupta A, Cancelas JA. Cancer stem cells: a stride towards cure? J Cell Physiol. 2010.

Ryan MA, Nattamai KJ, Xing E, et al. Pharmacological inhibition of EGFR signaling enhances  G-CSF induced hematopoietic stem cell mobilization. Nat Med. 16(10):1141-6. 2010.

Mulloy JC, Cancelas JA, Filippi MD, et al. Rho GTPases in hematopoiesis and hemopathies. Blood. 115(5):936-47. 2010.

Cancelas JA, Williams DA. Rho GTPases in hematopoietic stem cell functions. Curr Opin Hematol. 16(4):249-54. 2009.

Milsom MD, Lee AW, Zheng Y, Cancelas JA. Fanca^-/- hematopoietic stem cells demonstrate a mobilization defect which can be overcome by administration of the Rac inhibitor NSC23766. Haematologica. 94:1011-5. 2009.

Wu J, Williams JP, Rizvi TA, et al. Plexiform and dermal neurofibromas and pigmentation are caused by Nfl loss in desert hedgehog-expressing cells. Cancer Cell. 13(2):105-16. 2008.

Yamada Y, Sanchez-Aguilera A, Brandt EB, et al. FIP1L1/PDGFR synergizes with SCF to induce systemic mastocytosis in a murine model of chronic eosinophilic leukemia / hypereosinophilic syndrome. Blood. 112(6):2500-7. 2008.

Williams JP, Wu J, Johansson G, Rizvi TA, et al. Nf1 mutation expands an EGFR-dependent peripheral nerve progenitor that confers neurofibroma tumorigenic potential. Cell Stem Cell. 3(6):658-669. 2008.

Thomas EK*, Cancelas JA*, Chae H-D, et al. Rac guanosine triphosphatases represent integrating molecular therapeutic targets for BCR-ABL-induced myeloproliferative disease. *Contributed equally.Cancer Cell. 12(5):467-78. 2007.

Williams DA, Cancelas JA. Leukaemia: Niche retreats for stem cells. Nature. 444(7121):827-8. 2006.

Cancelas JA, Williams DA. Stem cell mobilization by ß2-agonists. Nat Med. 12(3):278-9. 2006.

Yamada Y, Rothenberg ME, Lee AW, et al. The FIP1L1-PDGFRα fusion gene cooperates with IL-5 to induce murine hypereosinophilic syndrome (HES)/chronic eosinophilic leukemia (CEL)-like disease. Blood. 107(10):4071-9. 2006.

Cancelas JA, Lee AW, Prabhakar R, et al. RacGTPases differentially integrate signals regulating hematopoietic stem cell localization. Nat Med. 11(8):886-91. 2005.

Gu Y, Filippi MD, Cancelas JA, et al. Hematopoietic cell regulation by Rac1 and Rac2 guanosine triphosphatases. Science. 302:445-9. 2003.