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S Kumar, C Perkins, J Xu, F Guo, D Snapper, F. Finkelman, Y Zheng, M-D Filippi. Cdc42 regulates neutrophil polarity via the Wiskott Aldrich Syndrome protein. Blood; 120(17):3563-74. 2012.
M C Florian, K Dörr, A Niebel, D Daria, H Schrezenmeier, M Rojewski, M-D Filippi, K Scharffetter-Kochanek, Y Zheng, H Geiger. Cdc42 activity regulates hematopoietic stem cell ageing and rejuvenation. Cell Stem Cell. 10:520-530. 2012.
E E. Bosco, S Kumar, F Marchioni, J Biesiada, M Kordos, K Szczur , J Meller, W Seibel, A Mizrahi, E Pick, M-D Filippi*, Yi Zheng*. Rational design of small molecule inhibitors targeting the Rac GTPase - p67phox signaling axis in inflammation. Chemistry and Biology, 19, 228-242. 2012. *co-corresponding authors.
K Singbartl, J Bishop, Xiaoyan Wen, R Murugan, S Chandra, M-D Filippi, John A. Kellum. Differential effects of kidney-lung cross-talk during acute kidney injury and bacterial pneumonia. Kidney International, 80:633-644. 2011.
J. C. Mulloy, J. A. Cancelas, M-D Filippi, T.A. Kalfa, F. Guo, and Y. Zheng. Rho GTPases in hematopoiesis and hemopathies- Review. Blood, 115:936-947. 2010.
K Szczur, Y Zheng, M-D Filippi. Rho GTPase CDC42 maintains neutrophil polarity axis during directed migration by regulating CD11b integrin signals. Blood, 114: 4527-4537. 2009.
H Xu, S Eleswarapu, H Geiger, K Szczur, D Deira, Y Zheng, J Settleman, E Srour, D. A. Williams, M-D Filippi. Loss of The Rho GTPase Activating Protein p190-B enhances hematopoietic stem cell engraftment. Blood, 114, 3557-3566. 2009.
A Köhler, V Schmithorst, M-D Filippi, M. A. Ryan, D Daria, M Gunzer, and H Geiger. Altered cellular dynamics and endosteal location of aged hematopoietic stem cells revealed by time-lapse intravital imaging in long bones. Blood, 114:290-298. 2009.
Y. Gu, I. T. W. Harley, L. A. Bremer, B. J. Aronow, I. Vietor, L. A. Huber, J. B. Harley, J. R. Kilpatrick, C. D. Langefeld, A. H. Williams, A. G. Jegga, J. Chen, M. Wills-Karp, S. Hasan Arshad, S. L. Ewart, C. L. Thio, L. M. Flick, M-D. Filippi, H. L. Grimes, M. L. Drumm, G. R. Cutting, M. R. Knowles & C. L. Karp. Modification of Cystic Fibrosis Lung Disease Severity by Polymorphisms in Genes Regulating Neutrophil Function. Nature, 458:1039-4102. 2009.
R Marsh, A Lucky, T Walsh, C Pacheco, M Rinaldi, E Mailler-Savage, A Puel, J-L Casanova, J Bleesing, M-D Filippi, D A Williams, M Daines, A Filipovich. Metarhizium Anisopliae in a Patient with Hypohidrotic Ectodermal Dysplasia and Immune Deficiency. Letter to Editor The Pediatric Infectious Disease Journal, 27: 283-284. 2008.
D. Daria, M-D Filippi, E. Knudsen, R. Faccio, T. Kalfa, H. Geiger. The retinoblastoma tumor suppressor is critical for hematopoietic cell functions. Blood, 111, 1894-1902. 2008.
K. R. Monk, J. Wu, J. P. Williams, B.A. Meinhardt, M.E. Fitzgerald, M-D. Filippi, N. Ratner. Mast cells can contribute to axon-glial dissociation and fibrosis in peripheral nerve. Neuron Glial Biology, 3:233-244. 2007.
K. Uchida, D Beck, T Yamamoto, P-Y Berclaz, S. Abe, M.K. Staudt. B.C. Carey, M-D Filippi, S Wert, L Denson, J Puchalski, D.M. Hauck, B.C. Trapnell. Disruption of GM-CSF signaling is associated with human phagocyte immunodeficiency. N Engl J Med, 356:567-579. 2007.
P-Y Berclaz, B Carey, M-D Filippi, K Wernke Dollries, N Geraci, S Cush, T Richardson, M O’Connor, C Hermoyian, T Korfhagen, JA Whitsett, BC Trapnell. GM-CSF regulates a PU.1-dependent transcriptional program determining the pulmonary response to LPS. Am J respire Cell Mol Biol, 36:114-121. 2007.
M-D Filippi, K Szczur, C.E. Harris, P-Y Berclaz. The Rho GTPase Rac1 is critical for neutrophil migration into the lung. Blood, 109: 1257 – 1264 # corresponding author
K Sczcur, H Xu, S Atkinson, Y Zheng, M-D Filippi. Rho GTPase CDC42 regulates directionality and random movement via distinct MAPK pathways in neutrophils. Blood, 108: 4205 – 4213. 2007.
M-D Filippi, C.E. Harris, J. Meller, Y. Gu, Y. Zheng, D.A. Williams. Localization of Rac2 specifies superoxide generation, actin polarity and chemotaxis in neutrophils. Nature Immunology, 5, 744-751. 2004.
Y. Gu*, M-D. Filippi*, J.E. Siefring, E.P. Williams, A. Jasti, R, Prabhakar, D.J. Kwiatkowski, D.A. Williams. Hematopoietic cell regulation by Rac1 and Rac2 Guanosine Triphosphatase. Science, 302, 345-449. 2003. * contributed equally
Sachin Kumar, M-D Filippi. Molecular Regulation of Granulopoiesis. Chapter 2013.
Editor of “Stem Cell Migration” M-D Filippi, co-editor Hartmut Geiger. Humana Press series of Methods in Molecular Biology. 2011;750.
Regulation of Neutrophil Migration and Polarity1R01 HL090676-02 (PI – Filippi)03/01/10-02/28/15 4.2 calendar monthsNIHTotal direct cost $1,250,000
1R21 HL104458-02(PI – Filippi)08/01/10-07/31/13 2.4 calendar monthsNIHTotal direct cost $1,250,000
Center for Excellence in Molecular Hematology1P30 DK090971(PI – Zheng) Co-Director – Xenotransplant and Transgenic Mouse Core9/30/10-06/30/15 0.6 calendar monthsNIHTotal direct cost $3,572,110
Role of Cytomegalovirus Latency in Atherosclerosis1R01 AI087683 (PI – Cardin) 8/01/12-7/31/16 0.36 calendar monthsNIHTotal direct cost $1,250,000
Innovation Fund Award(PI – Zheng) 8/01/12-7/31/14CCHMC$100,000 per year
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