Mulloy Lab

E-mail this page

(All fields required)

Recipient's email address

Please enter a valid email.

Your name

Please enter your name.

Your email address

Please enter a valid email.

Mulloy Lab

Meet the Mulloy Lab
Susumu Goyama

Research Fellow
susumu.goyama@cchmc.org
Susumu is interested in developing better disease models for myeloid malignancies, and is investigating functional collaboration between leukemia fusion proteins (MLL-AF9, AML1-ETO, CBFb-SMMHC) and mutated oncogenes (C-KIT, C-CBL, RUNX1, etc.) in human cord blood CD34+ cells.

Shan Lin

Graduate Student
Shan.Lin@cchmc.org
Shan works with Kevin Link to investigate the mechanism underlying the functional differences of various AE mutants in leukemia development, and plans to investigate the role of Dnmt1 in leukemogenesis.

Benjamin Mizukawa

Research Instructor
Benjamin.mizukawa@cchmc.org
Benjamin graduated from the University of Utah School of Medicine and came to Cincinnati Children’s for residency training in pediatrics and fellowship training in Hematology/Oncology. He studies the role of the Rac family of small Rho GTPases in myeloid leukemogenesis. His work explores targeting Cdc42 to displace the leukemic stem cell from its protective microenvironment.

James Mulloy, PhD

Associate Professor
james.mulloy@cchmc.org
Jim’s interest is in the mechanism of transformation used by different leukemia fusion oncoproteins found in human AML, in particular the Core Binding Factor fusions and the MLL fusions. The genes targeted by these chromosomal translocations play critical roles in normal hematopoiesis and also in leukemogenesis. Together, these genetic aberrations account for 25-30% of all human AML cases. The Mulloy lab is developing relevant in vivo models of human leukemia using leukemia fusion gene expression in primary human blood stem cells. His lab has developed a “next generation” mouse that is superior for expanding human leukemia samples in vivo. They are using this model in chemotherapy studies to establish a system for testing experimental compounds for efficacy against human leukemia. Other work in the lab is focused on the molecular signals downstream of the leukemia fusion oncoproteins. These studies are aimed at gaining a better understanding of the mechanism of action of these leukemia oncogenes to assist in identifying novel molecules for therapeutic targeting.

Janet Schibler

Research Assistant II
janet.schibler@cchmc.org
Janet is working with Susumu Goyama to study the interactions of CBL and its mutants in MA9 and AE cells. She also assists in various other projects in the lab and helps maintain the mouse colony.

Christina Sexton

Research Assistant II
Christina.sexton@cchmc.org
Christina is responsible for maintaining mouse colonies and assisting with experiments in the lab.

Mahesh Shrestha

Research Assistant IV
mahesh.shrestha@cchmc.org
Mahesh is working on a collaborative investigation of the role of Decitabine, a cytosine analog, in shifting latency in a leukemia mouse model. Mahesh also assists Benjamin Mizukawa in his research projects in determining the roles of Rac and Cdc42 in leukemogenesis.

Mark Wunderlich

Senior Research Assistant
mark.wunderlich@cchmc.org
Mark is characterizing a new strain of NOD/SCID mouse, the NSGS mouse, as a tool for xenograft studies of human AML and normal hematopoiesis. The lab is currently using this xenograft AML model to study chemotherapeutic potential of novel small molecule inhibitors.

Susumu Goyama

Shan Lin

Benjamin Mizukawa

James Mulloy

Janet Schibler

Christina Sexton

Mahesh Shrestha

Mark Wunderlich

click to enlarge

3333 Burnet Avenue, Cincinnati, Ohio 45229-3026 | 1-513-636-4200 | 1-800-344-2462 | TTY:1-513-636-4900

New to Cincinnati Children’s or live outside of the tri-state area? 1-877-881-8479

© 1999-2013 Cincinnati Children's Hospital Medical Center