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Staff ScientistDr. Bessho is interested in the molecular basis of diversity of clinical phenotype in patients with biliary atresia. Combining analyses from patients with complementary studies in an experimental model of biliary atresia, he is elucidating molecular networks associated with clinical phenotype in biliary atresia.
Pediatric Gastroenterologist, Staff Hepatologist, Director of Research, Director of the Digestive Health CenterDr. Jorge Bezerra investigates the genetic, cellular and molecular basis of biliary atresia and other cholangiopathies in children. He studies diseased tissues and uses complementary animal models to identify causes of liver injury and to develop new therapies to stop progression of liver disease.
Clinical Fellow, Pediatric GastroenterologyDr. Dipaola is investigating the cellular phenotype of peribiliary glands and the role of peribiliary glands in the setting of duct injury in biliary atresia.
Research FellowDr. Li investigates the role of CD4+ T cells in the pathogenesis of biliary atresia. Her research focuses on the interplay among cytokines, transcription factors and innate cells during activation, differentiation, and expansion of CD4+ T cells in disease pathogenesis.
Research Assistant IVReena explores several high-throughput multi-gene sequencing technologies to discover genetic mutations in children with inherited syndromes of intrahepatic cholestasis. She also studies molecular and inflammatory signatures categorizing heterogeneous populations of patients with biliary atresia.
Research Assistant IIJanet is investigating the role of complement cascade in the pathogenesis of biliary atresia. Using a mouse model, she is conducting a series of experiments to determine the role of iC3b, C5b-9 and complement receptors C3aR and C5aR in bile duct epithelial injury and obstruction.
Clinical FellowDr. Sheridan’s research focuses on the molecular and cellular basis of hepatobiliary injury in human and experimental models of liver and biliary disease, with special interest in the pathogenesis of biliary atresia.
Instructor of PediatricsDr. Shivakumar is investigating the mechanistic role of innate immunity in the pathogenesis of biliary atresia focusing on NK- and T-cells and complement components in the initiation and propagation of inflammatory duct injury and obstruction.
Research Assistant IIIStephanie is investigating the role of small molecules and ligands in the pathogenesis of Biliary Atresia. Using a mouse model and in vitro systems, she is conducting a series of experiments to effectors of bile duct epithelial injury and obstruction.Bachelors of Science, Ohio State University, Ohio, 2008Masters of Science, University of Cincinnati, Ohio, 2010
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