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The overall goal of Dr. Bucuvalas’ research and clinical work is to ensure the best possible outcomes as defined by patient experience and value for pediatric liver transplant recipients. We conduct research in pursuit of new discoveries and improvements to the health care delivery system to make it possible to provide the best possible care. Liver transplantation is a life-saving intervention for children and adolescents with irreversible end stage liver disease, and studies conducted in the lab are directly related to gaps in knowledge for best outcomes for liver transplant recipients.
Dr. Bucuvalas has an extensive background in transplant hepatology, and has published broadly on outcomes following liver transplantation. His significant experience in quality improvement efforts informs his role as the director of the Integrated Solid Organ Transplant Program. His strong ties with the pediatric liver transplant community permit him to develop and investigate new ways to improve the outcome for pediatric liver transplant patients.
Clarridge KE, Conway EE, Bucuvalas J. Hypothyroidism and iodine deficiency in an infant requiring total parenteral nutrition. JPEN. Journal of parenteral and enteral nutrition. 2014; 38(7):901-4.
Ng V, Nicholas D, Dhawan A, Yazigi N, Ee L, et al. Development and validation of the pediatric liver transplantation quality of life: a disease-specific quality of life measure for pediatric liver transplant recipients. The Journal of pediatrics. 2014; 165(3):547-55.e7.
Danziger-Isakov L, Bucavalas J. Current prevention strategies against cytomegalovirus in the studies in pediatric liver transplantation (SPLIT) centers. American journal of transplantation. 2014; 14(8):1908-11.
Sorensen LG, Neighbors K, Martz K, Zelko F, Bucuvalas JC, et al. Longitudinal study of cognitive and academic outcomes after pediatric liver transplantation.The Journal of pediatrics. 2014; 165(1):65-72.e2.
Bezerra JA, Spino C, Magee JC, Shneider BL, Rosenthal P, et al. Use of corticosteroids after hepatoportoenterostomy for bile drainage in infants with biliary atresia: the START randomized clinical trial. JAMA. 2014; 311(17):1750-9.
DiPaola F, Grimley M, Bucuvalas J. Pediatric acute liver failure and immune dysregulation. The Journal of pediatrics. 2014; 164(2):407-9.
Alonso EM, Martz
K, Wang D, Yi MS, Neighbors K, Varni JW, Bucuvalas JC. Factors predicting health-related quality of life in pediatric liver transplant recipients in the functional outcomes group. Pediatr Transplant. 2013 Nov;17(7):605-11.
Kirkendall E, Nguyen H, Schaffzin JK, Bucuvalas J, Bracke T, Seid M,
Ashby M, Foertmeyer N, Brunner L, Lesko A, Barclay C, Lannon C, Muething S. Electronic health record identification of nephrotoxin exposure and associated acute kidney injury. Pediatrics. 2013 Sep;132(3):e756-67.
Dhawan A, Alonso E, Narkewicz MR, Shneider BL, Rodriguez-Baez N, Olio DD,
Karpen S, Bucuvalas J, Lobritto S, Rand E, Rosenthal P, Horslen S, Ng V,
Subbarao G, Kerkar N, Rudnick D, Lopez MJ, Schwarz K, Romero R, Elisofon S, Doo
E, Robuck PR, Lawlor S, Belle SH. Intravenous N-acetylcysteine in pediatric patients with nonacetaminophen acute liver failure: a placebo-controlled clinical trial. Hepatology. 2013 Apr;57(4):1542-9.
Bucuvalas J, Filipovich L, Yazigi N, Narkewicz MR, Ng V, Belle SH, Zhang S, Squires RH. Immunophenotype Predicts Outcome in Pediatric Acute Liver Failure. J Pediatr Gastroenterol Nutr. 2013 Mar;56(3):311-5.
Ng VL, Alonso EM, Bucuvalas JC, et al. Health Status of Children Alive 10 Years after Pediatric Liver Transplantation Performed in the US and Canada: Report of the Studies of Pediatric Liver Transplantation Experience. J Pediatr. 2012 May;160(5):820-6.e3.Englesbe RM , Kelly B, Goss J, Fecteau A, Mitchell J, Andrews W, Krapohl G, Magee J, Mazariegos G, Horslen S and Bucuvalas J. Reducing Pediatric Liver Transplant Complications: A Potential Roadmap for Transplant Quality Improvement Initiatives within North America. American Journal of Transplantation, 12:2301-2306. 2012.
Grippa, F., Gloor, P.A., Bucuvalas, J.C. and Palazzolo, M. Supporting development efforts of clinical care teams. Int. J. Organisational Design and Engineering, Vol. 2,No. 2, pp.149–166. 2012.
The Banff Working Group on Liver Allograft Pathology. Importance of Liver Biopsy Findings in Immunosuppression Management: Biopsy Monitoring and Working Criteria for patients with Operational Tolerance (OT). Liver Transplantation. 2012 Oct;18(10):1154-70.
Kamath, B; Yin W, Miller H, Anand R, Rand E, Alonso E, Bucuvalas J. Outcomes of liver transplantation for patients with Alagille syndrome: the studies of pediatric liver transplantation experience.Liver Transplantation. 2012 Aug;18(8):940-8.
Akimova T, Kamath B, Goebel J, Meyers K, Rand E, Hawkins A, Levine M, Bucuvalas J, Hancock W. Differing Effects of Rapamycin or Calcineurin Inhibitor on T-Regulatory Cells in Pediatric Liver and Kidney Transplant Recipients. Am Journal of Transplantation. 2012 Dec;12(12):3449-61.
L.G. Sorensen; K. Neighbors; K. Martz; F. Zelko, Bucuvalas JC, and Alonso EM.Intellectual and Academic Outcomes after Pediatric Liver Transplantation: Functional Outcomes Group.Am J Transpla. 2011 Feb;11(2):303-11.
Alonso EM, Limbers CA, Neighbors K, Martz K, Bucuvalas JC, Webb T, and Varni JW.Cross-sectional Analysis of Health-Related Quality of Life in Pediatric Liver Transplant Recipients.J Pediatr. 2011 May;15(3):245-53.
Limbers CA, Neighbors K, Martz K, et al. Health-related quality of life in pediatric liver transplant recipients compared with other chronic disease groups.Pediatr Transplant. 2011 May;15(3):245-53.
Varni JW, Limbers CA, Sorensen LG, et al.Cognitive Functioning Scale in pediatric liver transplant recipients: feasibility, reliability, and validity. Qual Life Res PedsQL. 2011 Aug;20(6):913-21.
Campbell KM, Ng V, Magee J, Goebel J, Anand R, Martz K, and Bucuvalas J. Glomerular filtration rate following pediatric liver transplantation -- the SPLIT experience. Am J Transplant. 2010 Dec;10(12):2673-82.
Bucuvalas JC and Anand R. Treatment with Immunoglobulin Improves Outcome for Pediatric Liver Transplant Recipients. Liver Transplantation. 2009 Nov;15(11):1564-9.
John C. Bucuvalas, MDProfessorUC Department of
Integrated Solid Organ Transplant Program, Cincinnati Children's Hospital Medical CenterMailing Address:Cincinnati Children's Hospital Medical Center3333 Burnet AvenueCincinnati, Ohio 45229
Phone: 513-803-1791Fax: 513-636-7805
Andre HawkinsSenior Clinical Research Coordinator
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