Cohen-Steinbrecher Lab

Mitchell Cohen, MD

Professor and Vice Chairman of Pediatrics for Clinical Affairs
Director, Gastroenterology, Hepatology and Nutrition
Interested in the role of the guanylyl cyclase pathway in intestinal secretion and regulation of inflammation.  He is working to understand how guanylyl cyclase C, guanylin and uroguanylin mediate mucosal gene expression, intestinal barrier function and experimental colitis.  These interactions have potential clinical roles in the treatment of both irritable bowel syndrome and inflammatory bowel disease.

 

Eleana Harmel-Laws, MS

Research Assistant IV
Received her master’s of science degree from the University of Kentucky in 2004 for analysis of the effects of PCB exposure on liver function of freshwater fish.
Email: eleana.laws@cchmc.org

 

Elizabeth Mann, PhD

Research Associate, Division of Pediatric Gastroenterology, Hepatology and Nutrition
Earned her degree from the State University of New York at Buffalo, Roswell Park Division. She is working to identify and characterize novel receptors, which in addition to the guanylate cyclase (GC-C) receptor, mediate the biological activity of guanylin and uroguanylin.
Email: elizabeth.mann@cchmc.org

 

Kris Steinbrecher, PhD

Assistant Professor of Pediatrics
Interested in cell signaling events and transcription factors that regulate intestinal epithelial cell responses to infection and inflammation.  His laboratory is focused on understanding the role of guanylate cyclase proteins, glycogen synthase kinase 3beta and NF-κB in experimental colitis and intestinal tumorigenesis.